Article
Agriculture, Dairy & Animal Science
Charles-Antoine Assenmacher, Matthew Lanza, James C. Tarrant, Kristin L. Gardiner, Eric Blankemeyer, Enrico Radaelli
Summary: Routine manipulation and handling of laboratory mice can cause physical harm and confounding effects on research outcomes. Our study provides a comprehensive overview of the main pathological changes associated with these procedures, with an emphasis on traumatic osteoarticular lesions. Training research personnel on appropriate mouse handling techniques could help reduce the frequency of these lesions and their impact on animal wellbeing and study reproducibility.
Article
Behavioral Sciences
Valeria Mazza, Anja Guenther
Summary: The ability to produce innovative behavior is crucial for animals to cope with environmental challenges. In this study, urban striped field mice were found to be better problem solvers compared to rural individuals, despite differences in exploratory behavior and interaction with experimental set-ups.
Review
Veterinary Sciences
Jasmine M. Clarkson, Jessica E. Martin, Dorothy E. F. McKeegan
Summary: This article focuses on the welfare challenges and potential improvements in killing laboratory rodents. It suggests avoiding the use of carbon dioxide (CO2) unless its high-throughput advantage is essential. The article also highlights the need for better training programs and specialist tools for physical methods, as well as addressing the lack of cohesion in international regulations and guidelines.
LABORATORY ANIMALS
(2022)
Article
Engineering, Biomedical
Elizabeth M. M. McNeil, Michael J. J. Reilly, Donna M. M. Wilder, Meghan A. A. Benton, Joseph B. B. Long, Venkata Siva Sai S. Sajja
Summary: The biomechanical effects and efficacy of personal protective equipment in mitigating injuries caused by blast overpressure are still unclear. This study examined the intrathoracic pressure changes in response to blast wave exposure and evaluated the effectiveness of a soft-armor vest in reducing these perturbations. Results showed significant increases in thoracic cavity pressures compared to blast wave, with esophageal measurements being more affected than carotid measurements. The soft-armor vest minimally altered the pressure parameters and energy content. This study provides insights into the relationship between external blast conditions and biomechanical responses in the thoracic cavity, with and without personal protective equipment.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Computer Science, Information Systems
Meng Chen, Yifan Liu, John Chung Tam, Ho-yin Chan, Xinyue Li, Chishing Chan, Wen J. Li
Summary: Researchers have developed wireless AI-powered IoT sensors for monitoring the behaviors of laboratory mice. These sensors can accurately recognize common mice behaviors and improve tracking accuracy using machine learning algorithms. This work has the potential to revolutionize animal behavioral tracking methodology.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Article
Veterinary Sciences
Lena Bohn, Louisa Bierbaum, Niklas Kaestner, Vanessa Tabea von Kortzfleisch, Sylvia Kaiser, Norbert Sachser, S. Helene Richter
Summary: This study investigated the effect of novelty when applying structural enrichment to laboratory mice. The results showed that mice with access to structurally enriched environments spent more time in the enriched cages and entered them faster than mice without any structural enrichment. There was only one significant difference between novelty and complexity conditions, with novelty mice spending more time in their extra cages during week 3. Further research is needed to explore the potential benefits of novelty beyond complexity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Jasmine M. Clarkson, Dorothy E. F. McKeegan, Julian Sparrey, Francesco Marchesi, Matthew C. Leach, Jessica E. Martin
Summary: The study shows that hypobaric hypoxia via gradual decompression can induce a non-recovery state in anesthetized laboratory mice. Regardless of the decompression rate and shape, this method effectively achieves the desired outcome, with slower decompression rates requiring longer time for mice to reach a non-recovery state, and gradual and linear shaped profiles prolonging the process.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Carly I. I. O'Malley, Raina Hubley, Carly Moody, Patricia V. V. Turner
Summary: Nonaversive or low stress handling techniques can reduce fear and stress in research rodents, ultimately improving study data quality. However, the uptake of these techniques has been slow in the USA and Canada. Laboratory animal professionals understand the benefits of low stress handling, with animal welfare being more emphasized by Canadian participants and improved research data and reduced stress being mentioned more by doctoral level professionals. The primary barriers to implementing low stress handling are researcher attitudes, time constraints, and training personnel properly and consistently.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Chi-Hui Tsao, Kuan-Yu Wu, Nicole Ching Su, Andrew Edwards, Guo-Jen Huang
Summary: This study evaluated the sex difference and variability in mouse behavior and adult neurogenesis through a series of behavioral tests and immunolabeling. The results showed no significant difference between males and females in most tests, suggesting that sex difference does not significantly influence these commonly used behavioral tests nor adult neurogenesis under basal conditions. The study suggests considering the inclusion of female mice in future experiments.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Michael W. Brunt, Lucia Amendola, Daniel M. Weary
Summary: Evidence suggests that CO2 induces negative affective states in rodents, yet it is still commonly used for euthanasia. Many professionals believe there are better alternatives to CO2, but face operational limitations in implementing them. New research is needed to address these barriers.
LABORATORY ANIMALS
(2021)
Article
Agriculture, Dairy & Animal Science
Dietmar Zechner, Benjamin Schulz, Guanglin Tang, Ahmed Abdelrahman, Simone Kumstel, Nico Seume, Rupert Palme, Brigitte Vollmar
Summary: The study demonstrates that scientists cannot rely on a single method when assessing animal welfare, but need to combine multiple methods. The ability of these methods to differentiate between healthy and diseased animals varies depending on the specific surgical interventions and gastrointestinal diseases. This lack of generalizability highlights the importance of using a combination of methods for accurate assessment of animal wellbeing.
Article
Cardiac & Cardiovascular Systems
Margaret H. Hastings, Jonathan J. Herrera, J. Sawalla Guseh, Bjarni Atlason, Nicholas E. Houstis, Azrul Abdul Kadir, Haobo Li, Cedric Sheffield, Anand P. Singh, Jason D. Roh, Sharlene M. Day, Anthony Rosenzweig
Summary: Acute and chronic animal models of exercise are commonly used in research to study the cardiovascular response and benefits of exercise, as well as to explore novel therapeutic pathways. This review discusses the approaches for assessing cardiovascular function during acute exercise challenges and the use of common rodent exercise conditioning models. It also explores the potential of studying feeding in the Burmese python as a model for exercise-like physiological adaptation.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Paulina Misztak, Magdalena Sowa-Kucma, Patrycja Panczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowak
Summary: Chronic stress is a key factor in the development of depressive symptoms. The combination of fluoxetine and zinc induces a more pronounced antidepressant effect in the chronic restraint stress model. Zinc supplementation enhances the effectiveness of fluoxetine and plays a role in epigenetic regulation.
Article
Biology
J. M. Clarkson, J. E. Martin, J. Sparrey, M. C. Leach, D. E. F. McKeegan
Summary: The use of carbon dioxide (CO2) gas for killing laboratory mice in scientific research presents ethical concerns. In this study, we investigated the use of gradual decompression with hypobaric hypoxia as an alternative method. The results suggest that gradual decompression may provide a more humane way of killing laboratory mice.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Laura Wittek, Chadi Touma, Tina Nitezki, Thomas Laeger, Stephanie Kraemer, Jens Raila
Summary: Housing mice in metabolic cages can induce a significant stress response, especially due to the cold housing conditions. This study aimed to reduce stress during metabolic cage housing by comparing an innovative metabolic cage with a commercially available metabolic cage and a control cage. The innovative metabolic cage showed promising results in reducing cold stress and improving animal welfare.
Article
Chemistry, Multidisciplinary
Seung Eun Yu, Seyong Chung, Hyun-Su Ha, Dae-Hyun Kim, Sewoom Baek, Tae Young Kim, Songhyun Lee, Hyo-Jin Yoon, Soon Won Chung, Jung Bok Lee, Young Min Shin, Hye-Seon Kim, Si Young Kim, Joon-Sang Park, Chang-Soo Kim, Hak-Joon Sung
Summary: The navigation of nanoparticles to target sites in blood flow disturbance combined with CDK9-targeting peptide display on nanovesicles and liposomes has significantly improved the diagnostic paradigm in vascular medicine. This study demonstrates an unprecedented nanotheranostic function for future clinical applications by effectively preventing irreversible occlusion process in pre-stenotic vessels and suppressing vascular stenosis through anti-CDK9 signaling post-targeting.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Veterinary Sciences
Won-Jong Lee, Junyoung Kim, Chang-Hwan Moon, TaeHeum Eom, DongJu Son, Seungmin Lee, Haebeom Lee, Seong-Mok Jeong, Dae-Hyun Kim
Summary: Mitral regurgitation is a common heart disease in small-breed dogs. Mitral repair surgery, including artificial chorda tendineae implantation and mitral annuloplasty, has become the main treatment. The use of a Hegar dilator during mitral annuloplasty can improve the accuracy and reproducibility of the surgery.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
J. Kim, D. -h. Kim, H. Jee, J. Hwang, J. Yoon
Summary: Pulmonic stenosis (PS) is a common congenital heart disease in dogs, often associated with an aberrant coronary artery (CA). This study presents a case of a Boston terrier with PS diagnosed for the first time through CTA, revealing valve and supravalvular PS with an aberrant CA. CTA may be helpful in identifying CA anomalies and establishing treatment plans in PS cases.
JOURNAL OF VETERINARY CARDIOLOGY
(2021)
Article
Veterinary Sciences
Yoonho Roh, Daehyun Kim, Seongmok Jeong, Haebeom Lee
Summary: This study assessed the accuracy of transsphenoidal hypophysectomy using 3D printed patient-specific guides in small-breed dogs. The results showed that the use of patient-specific guides resulted in high precision in terms of the position accuracy and favorable outcomes in the shape, size, and position of the surgical window.
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
Aryung Nam, Sung-Hwa Hong, Hyun-Choul Jee, Won-Jong Lee, Hyunwook Myung, Dae-Hyun Kim
Summary: This case report describes a Toy Poodle with acute tetraparesis caused by a spinal cord lesion due to metastatic mammary adenocarcinoma. Surgical resection of the lesion resulted in significant improvement of the patient's symptoms. This highlights the importance of identifying the primary tumor of metastatic vertebral tumors and the necessity of palliative surgery to enhance the patient's quality of life.
VETERINARNI MEDICINA
(2022)
Article
Multidisciplinary Sciences
Hye-Seon Kim, Hyun-Su Ha, Dae-Hyun Kim, Deok Hyeon Son, Sewoom Baek, Jeongeun Park, Chan Hee Lee, Suji Park, Hyo-Jin Yoon, Seung Eun Yu, Jeon Il Kang, Kyung Min Park, Young Min Shin, Jung Bok Lee, Hak-Joon Sung
Summary: The stemness of BMSCs is maintained by hypoxia. Oxygen level increases from vessel-free cartilage to hypoxic bone marrow to vascularized bone, affecting the differentiation of BMSCs. Low oxygen promotes stemness and chondrogenesis, while high oxygen promotes osteogenesis. The transition from low to high oxygen in vivo suggests a developmental mechanism-driven solution to promote chondrogenesis to osteogenesis in the skeletal system.
Article
Agriculture, Dairy & Animal Science
Chang-Hwan Moon, Kyung-Min Kim, Won-Jong Lee, Woo-Jin Kim, Seok-Min Lee, Ho-Jung Choi, Hae-Beom Lee, Seong-Mok Jeong, Dae-Hyun Kim
Summary: This report describes a successful surgical treatment of a dog with cor triatriatum dexter using partial venous inflow occlusion under mild hypothermia. The case demonstrates the feasibility of partial venous inflow occlusion under mild hypothermia for achieving curative resection of cor triatriatum dexter in dogs.
Article
Veterinary Sciences
Won-Jong Lee, Chang-Hwan Moon, Wonkyoung Yoon, Mihyung Kim, Woo-Jin Kim, Kyung-Min Kim, Haebeom Lee, Seong-Mok Jeong, Jae Hyeon Yu, Dae-Hyun Kim
Summary: This report presents two cases of open-heart surgery using Del-Nido cardioplegia, which induced temporary cardiac arrest without any complications. Veterinary heart surgeons should consider Del-Nido cardioplegia as an option for temporary cardiac arrest during open-heart surgery with cardiopulmonary bypass.
JOURNAL OF VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Jiyoung Park, Changhwan Moon, Dae-Hyun Kim, Hae-Beom Lee, Seong Mok Jeong
Summary: This case report demonstrates the clinical practicality of laparoscopic colopexy in managing rectal prolapse in small-breed dogs. The procedure successfully treated the prolapse without complications and resulted in a good postoperative outcome.
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2022)
Article
Veterinary Sciences
Chang-Hwan Moon, Woo-Jin Kim, Won-Jong Lee, Kyung-Min Kim, Hae-Beom Lee, Seong-Mok Jeong, Dae-Hyun Kim
Summary: This report describes a rare complication of ductal ligation in a dog, where granulomatous inflammation and pericarditis were induced by silk granulomas. Surgical ligation of the ductus arteriosus is typically performed using non-absorbable silk sutures. While silk granuloma formation associated with this procedure has rarely been reported in veterinary medicine, this case highlights the importance of recognizing granulomatous inflammation as a potential postoperative complication and the effectiveness of pericardiectomy in relieving clinical symptoms.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Jiyoung Park, Aryung Nam, Hae-Beom Lee, Seong Mok Jeong, Dae-Hyun Kim
Summary: This article reports a case of bladder leiomyosarcoma in a 10-year-old male Shih Tzu dog. The diagnosis was made through double-contrast cystography and ultrasonography, and the patient recovered well after partial cystectomy without any evidence of recurrence or metastasis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Hanjung Lee, Haebeom Lee, Keyyeon Lee, Yoonho Roh, Seongmok Jeong, Daehyun Kim, Jaemin Jeong
Summary: This study presents a case of iatrogenic sciatic nerve injury in a small Maltese dog. The dog suffered nerve injury after hip joint surgery and was successfully treated with nerve repair, resulting in almost complete recovery of sensation and walking function in the hind leg after 2.5 years.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Yoonho Roh, Jaemin Jeong, Youngjin Jeon, Daehyun Kim, Seongmok Jeong, Haebeom Lee
Summary: This report describes a case of defect reconstruction after hemipelvectomy for a cat with an osteoma, using a 3D-printed pelvic endoprosthesis and micro total hip replacement (mTHR). The cat recovered well post-surgery and regained normal weight and defecation two years later.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Chang-Hwan Moon, Hyun-Ah Min, Hae-Beom Lee, Seong-Mok Jeong, Dae-Hyun Kim
Summary: This report describes a rare case of retroperitoneal metastasis of primary cutaneous apocrine adenocarcinoma in a dog. The patient underwent surgical excision and had no recurrence or metastasis during the follow-up period. This highlights the importance of wide resection in reducing the risk of local invasion or distant metastasis, even in rare cases of malignant apocrine gland tumors in dogs.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Yoon-Ho Roh, Jeong-Nam Kim, Pill-Moo Byun, Dae-Hyun Kim, Seong-Mok Jeong, Hae-Beom Lee
Summary: Symphyseal distraction osteotomy (SDO) with a polymethyl methacrylate (PMMA) spacer is an effective surgical treatment for cats with pelvic stenosis. In this study, a 2-year-old castrated male Korean domestic shorthair feline with urethral obstruction due to ischiocavernosus muscle (IM) tension was successfully treated with SDO and IM release, resulting in excellent functional restoration without any complications during the 12-month long-term follow-up.
VETERINARY SCIENCES
(2021)