The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization

Identification, Characterization, and Application of Three Enoate Reductases from Pseudomonas putida in In Vitro Enzyme Cascade Reactions

(2014) Christin Peters et al.   ChemCatChem

Enoyl acyl carrier protein reductase (FabI) catalyzed asymmetric reduction of the CC double bond of α,β-unsaturated ketones: preparation of (R)-2-alkyl-cyclopentanones

(2014) Ji Liu et al.   CHEMICAL COMMUNICATIONS

New developments in ‘ene’-reductase catalysed biological hydrogenations

(2014) Helen S Toogood et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Highly Enantioselective Reduction of α-Methylated Nitroalkenes

(2013) Edyta Burda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An enoate reductase Achr-OYE4 from Achromobacter sp. JA81: characterization and application in asymmetric bioreduction of C=C bonds

(2013) Hai-Bo Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis of Robalzotan, Ebalzotan, and Rotigotine Precursors via the Stereoselective Multienzymatic Cascade Reduction of α,β-Unsaturated Aldehydes

(2013) Elisabetta Brenna et al.   JOURNAL OF ORGANIC CHEMISTRY

Evaluation of Several Routes to Advanced Pregabalin Intermediates: Synthesis and Enantioselective Enzymatic Reduction Using Ene-Reductases

(2013) Sébastien Debarge et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum

(2013) David J. Mansell et al.   ACS Catalysis

Crystal Structure Determination and Mutagenesis Analysis of the Ene Reductase NCR

(2012) Sabrina Reich et al.   CHEMBIOCHEM

Revisiting the Enantioselective Sequence Patterns in Enoate Reductases

(2012) Thomas Classen et al.   ChemCatChem

Nicotinamide-Dependent Ene Reductases as Alternative Biocatalysts for the Reduction of Activated Alkenes

(2012) Katharina Durchschein et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Combination of CC Bond Formation by Wittig Reaction and Enzymatic CC Bond Reduction in a One-Pot Process in Water

(2011) Marina Kraußer et al.   ChemCatChem

Enzymatic reductions for the chemist

(2011) Frank Hollmann et al.   GREEN CHEMISTRY

Enoate reductases from non conventional yeasts: Bioconversion, cloning, and functional expression in Saccharomyces cerevisiae

(2011) Stefano Raimondi et al.   JOURNAL OF BIOTECHNOLOGY

Asymmetric Bioreduction of Alkenes Using Ene–Reductases YersER and KYE1 and Effects of Organic Solvents

(2011) Yanto Yanto et al.   ORGANIC LETTERS

Enoate Reductase-Mediated Preparation of Methyl (S)-2-Bromobutanoate, a Useful Key Intermediate for the Synthesis of Chiral Active Pharmaceutical Ingredients

(2011) Elisabetta Brenna et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Reductions of Baylis–Hillman Adducts

(2011) Adam Z. Walton et al.   ACS Catalysis

Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans

(2010) Nina Richter et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

(2010) Helen S. Toogood et al.   ChemCatChem

Asymmetric Synthesis of O-Protected Acyloins Using Enoate Reductases: Stereochemical Control through Protecting Group Modification

(2010) Christoph K. Winkler et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recombinant Δ4,5-Steroid 5 β-Reductases as Biocatalysts for the Reduction of Activated CC-Double Bonds in Monocyclic and Acyclic Molecules

(2009) Edyta Burda et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Reduction of Activated Alkenes by Pentaerythritol Tetranitrate Reductase: Specificity and Control of Stereochemical Outcome by Reaction Optimisation

(2009) Anna Fryszkowska et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalysis with Thermostable Enzymes: Structure and Properties of a Thermophilic ‘ene’-Reductase related to Old Yellow Enzyme

(2009) Björn V. Adalbjörnsson et al.   CHEMBIOCHEM

Structure-Based Insight into the Asymmetric Bioreduction of the CC Double Bond of α,β-Unsaturated Nitroalkenes by Pentaerythritol Tetranitrate Reductase

(2008) Helen S. Toogood et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Bioreduction of Activated C=C Bonds UsingZymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1–3 from Yeasts

(2008) Mélanie Hall et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Opposite Stereochemical Courses for Enzyme-Mediated Alkene Reductions of an Enantiomeric Substrate Pair

(2008) Despina J. Bougioukou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermostable variants constructed via the structure-guided consensus method also show increased stability in salts solutions and homogeneous aqueous-organic media

(2008) E. Vazquez-Figueroa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Parallel kinetic resolution of active esters using designer oxazolidin-2-ones derived from phenylglycine

(2008) Sameer Chavda et al.   TETRAHEDRON-ASYMMETRY

Asymmetric bioreduction of α,β-unsaturated nitriles and ketones

(2008) Birgit Kosjek et al.   TETRAHEDRON-ASYMMETRY

Reduction of aliphatic nitro groups using an obligately anaerobic whole cell biocatalyst

(2007) Hassan Korbekandi et al.   ENZYME AND MICROBIAL TECHNOLOGY

Enzyme activation for organic solvents made easy

(2007) Anne L. Serdakowski et al.   TRENDS IN BIOTECHNOLOGY