Article
Oncology
Deshuai Ren, Xiaoyu Zhuang, Yanxin Lv, Yun Zhang, Jiazhi Xu, Fengquan Gao, Dagang Chen, Yu Wang
Summary: This study found that FAM84B is highly expressed in glioma tissues and inhibits the proliferation of glioma cells through regulating the cell cycle pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shikai Gui, Peng Chen, Yu Liu, Qiaorong Chen, Tianxiang Cheng, Shulong Lv, Tong Zhou, Zhen Song, Juexian Xiao, Wei He, Shengtao Yuan, Zujue Cheng
Summary: This study identified that high TUBA1C expression correlates with poor outcomes in glioma patients, and knocking down TUBA1C can suppress glioma cell proliferation via cell cycle arrest, potentially serving as a therapeutic biomarker.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hongyu Wang, Ruiqin Han, Qiao Li, Wei Kang, Qiang Dong, Hang Yin, Liang Niu, Junqiang Dai, Yunji Yan, Yuanping Su, Xuan Yao, He Zhang, Guoqiang Yuan, Yawen Pan
Summary: In this study, we found that EEF1E1 plays a crucial role in regulating the cell cycle and cell proliferation in glioma cells. It downregulates the expression of PTEN and modulates downstream cell cycle-related proteins through the PTEN/AKT signaling pathway. Our findings demonstrate that EEF1E1 knockdown effectively inhibits glioma cell proliferation, suggesting that EEF1E1 could serve as a potential therapeutic target for glioma treatment with significant clinical implications.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Fengqin Ding, Ping Chen, Pengfei Bie, Wenhua Piao, Quan Cheng
Summary: The study identified HOXA5 as a key factor in glioma cell proliferation, where high expression is associated with unfavorable clinical features and worse clinical outcomes. Differences in CNVs and SNPs profiles further confirmed its role in glioma aggressiveness.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Summary: The study revealed that the enhanced cell adhesion ability of mMDSC in the GBM microenvironment is linked to tumor promotion, and targeting Integrin (31) and DPP-4 to interfere with mMDSC may be an effective way to alleviate immune suppression driven by myeloid cells in GBM.
Article
Oncology
Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao, Xingchun Gou
Summary: The study showed that CACUL1 overexpression in glioma tissues promoted cell proliferation, suppressed apoptosis, and induced cell cycle arrest. Knockdown of CACUL1 hindered cell proliferation and induced apoptosis in glioblastoma cells, suggesting a potential oncogenic role for CACUL1 in gliomas.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Oncology
Zheng Zhu, Jiao Wang, Juan Tan, Yue-Liang Yao, Zhi-Cheng He, Xiao-Qing Xie, Ze-Xuan Yan, Wen-Juan Fu, Qing Liu, Yan-Xia Wang, Tao Luo, Xiu-Wu Bian
Summary: The study revealed that high expression of CAPS in glioma is associated with poor survival. CAPS promotes glioma proliferation by regulating the cell cycle and interacts with MYPT1 to affect PLK1 phosphorylation. The PLK1 inhibitor volasertib enhances the therapeutic effect of temozolomide in glioma.
JOURNAL OF PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Marco D'Ario, Rafael Tavares, Katharina Schiessl, Benedicte Desvoyes, Crisanto Gutierrez, Martin Howard, Robert Sablowski
Summary: The study reveals that cell size variability in the Arabidopsis shoot stem cell niche is corrected by adjusting the growth period before DNA synthesis. KRP4 and FBL17 proteins play key roles in removing excess cell cycle regulators, ensuring daughter cells are born with comparable amounts of KRP4. This suggests a potential mechanism where a cell cycle regulator associated with mitotic chromosomes can read DNA content as a cell size-independent scale.
Article
Biochemistry & Molecular Biology
Sunisa Yoodee, Paleerath Peerapen, Sirikanya Plumworasawat, Visith Thongboonkerd
Summary: ARID1A is a newly discovered tumor suppressor gene commonly observed in human cells and frequently lost or defective in many cancers. Down-regulation of ARID1A in human endothelial cells directly induces angiogenesis by regulating angiopoietin-2 secretion and endothelial cell activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Zigui Chen, Xin Yan, Changfeng Miao, Longyang Liu, Su Liu, Ying Xia, Weiyi Fang, Dandan Zheng, Qisheng Luo
Summary: This study provides evidence that MYH9 plays an important role in glioma by promoting cell proliferation and temozolomide resistance. Mechanistically, MYH9 inhibits the ubiquitination and degradation of NAP1L1, leading to activation of c-Myc and increased expression of CCND1/CDK4, which contributes to temozolomide resistance and proliferation in glioma cells. Additionally, upregulation of MYH9 is associated with poor prognosis in glioma patients. Targeting MYH9 could be a potential therapeutic strategy for glioma treatment in the future.
CANCER CELL INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Jialin Wang, Zhendong Liu, Cheng Zhang, Hongbo Wang, Ang Li, Binfeng Liu, Xiaoyu Lian, Zhishuai Ren, Wang Zhang, Yanbiao Wang, Bo Zhang, Bo Pang, Yanzheng Gao
Summary: High expression of HOXD11 is significantly associated with survival and clinical characteristics of glioma patients, serving as a potential biomarker for targeted therapy and prognostic assessment. Knockout of HOXD11 can inhibit proliferation and invasion of glioma cells, altering cell behavior.
Article
Multidisciplinary Sciences
Roberta Azzarelli, Aoibheann McNally, Claudia Dell'Amico, Marco Onorati, Benjamin Simons, Anna Philpott
Summary: Glioblastoma (GBM) growth is driven by a subpopulation of stem/progenitor cells, and re-engaging their capacity for cell differentiation could be a potential therapeutic approach. The transcription factor ASCL1 plays a role in normal brain development and is expressed in a subset of GBM cells, but fails to initiate full differentiation. Phosphorylation of ASCL1 and deletion of the differentiation inhibitor ID2 enhance the efficiency of ASCL1-driven differentiation and cell cycle exit in GBM cells.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Fang Cao, Xiangping Xia, Yinchun Fan, Qian Liu, Jiancheng Song, Qiang Zhang, Yu Guo, Shengtao Yao
Summary: The study revealed a correlation between the expression level of PLK2 and the malignancy of gliomas, with high expression associated with poor prognosis. RNF180 may influence glioma cell apoptosis by regulating the ubiquitination of PLK2. Knocking down of PLK2 may suppress glioma development through inhibition of cell proliferation and promotion of cell apoptosis.
Article
Cell Biology
Feng Wang, Ma-ChiCheng Bao, Jing Xu, Lan-Lan Shi, Rui-Ze Niu, Ting-Hua Wang, Jia Liu
Summary: The study aimed to investigate the effect of Scutellarin on glioma by downregulating BIRC5. The results showed that the expression of BIRC5 in glioma tissues was significantly higher than that in normal brain tissues. Scutellarin significantly reduced tumor growth and improved animal survival. It also downregulated the expression of BIRC5 in U251 cells, leading to increased apoptosis and inhibited cell proliferation. These findings suggest that Scutellarin promotes apoptosis and inhibits proliferation of glioma cells by downregulating BIRC5 expression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mengxue Jiang, Zhijian Kuang, Yaohui He, Yin Cao, Tingyan Yu, Jidong Cheng, Wen Liu, Wei Wang
Summary: This study reveals that SNAPIN plays a crucial role in regulating insulin secretion and beta cell proliferation, with its expression influenced by age and diabetes. The function of SNAPIN is achieved through its impact on cell cycle regulation, suggesting it might be a potential pharmacotherapeutic target for diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
