Article
Biochemistry & Molecular Biology
Derya Osmaniye, Arzu Hidir, Begum Nurpelin Saglik, Serkan Levent, Yusuf Ozkay, Zafer Asim Kaplancikli
Summary: Aromatase inhibitors are widely used in breast cancer treatment. This study synthesized novel pyrimidine-triazole derivatives and demonstrated the significant anticancer and aromatase inhibitory activities of compounds 5c and 5g. Docking studies revealed the importance of the triazole ring in aromatase inhibition.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Medicinal
Abdulrahman G. Alhamzani, Tarek A. Yousef, Mortaga M. Abou-Krisha, M. S. Raghu, K. Yogesh Kumar, M. K. Prashanth, Byong-Hun Jeon
Summary: This study designed and synthesized triazine-linked triazole compounds and evaluated their anticonvulsant abilities. The results showed that some of these compounds exhibited significant anticonvulsant activity and could serve as potential novel anticonvulsant agents. Computational analysis also supported the pharmacophoric characteristics of these compounds. Therefore, these triazine-linked triazole analogues may contribute to future research and development.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Mahmoud A. Alelaimat, Mahmoud A. Al-Sha'er, Haneen A. Basheer
Summary: Trisubstituted 1,3,5-triazine derivatives have biological benefits in reducing inflammation and fighting cancer. A series of unique sulfonamide-triazine hybrid molecules were synthesized using the solvent-free/neat fusion method, and their novel structures were identified through spectroscopic analyses. Promising anticancer activity was observed in compound 34, which showed high inhibition against the PI3K alpha enzyme and potential for developing targeted anticancer compounds.
Article
Chemistry, Medicinal
Emre Mentese, Adem Guner, Elifsu Polatli, Mustafa Emirik, Hakan Bektas, Bahittin Kahveci
Summary: This study reported the synthesis of coumarin derivatives containing the triazole ring and investigated their anticancer activities, showing strong cytotoxic effects against various cancer cell lines. In silico studies were also conducted to explore the binding interactions of the molecules.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Physical
Kurls E. E. Anwer, Galal H. H. Sayed, Ramadan M. M. Ramadan
Summary: Ethyl-2-cyano-2-(2-(3-nitrophenyl)hydrazono)acetate was synthesized and used as a versatile reagent for the synthesis of different heterocyclic compounds. Various techniques were used for the synthesis of the derivatives, and physical parameters were calculated for comparison. The compounds were characterized by elemental analyses and spectroscopic tools, and the molecular geometries were studied using density functional theory. Antibacterial and cytotoxicity screening were performed, and molecular docking revealed potential DNA binding.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Musa Erdogan, Ferah Comert Onder
Summary: A library of novel anticancer molecules was designed and synthesized, and their anticancer potentials were tested in breast cancer cell lines. Compounds 13, 14, and 18 showed high cytotoxicity and blocked cell migration. Molecular docking and dynamics simulations suggested that these compounds could be potential inhibitor candidates. A pharmacophore model was generated and used to screen approved drugs for potential alternatives.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Leila Emami, Sara Sadeghian, Ayyub Mojaddami, Soghra Khabnadideh, Amirhossein Sakhteman, Hossein Sadeghpour, Zeinab Faghih, Masood Fereidoonnezhad, Zahra Rezaei
Summary: In this study, we synthesized nineteen novel 1,2,4-triazole derivatives and confirmed their structures using spectroscopic techniques. The cytotoxic activities of the synthesized compounds were evaluated against human cancer cell lines, and several compounds showed promising cytotoxic activity against the Hela cell line. The safety of these compounds was also assessed, and they exhibited proper selectivity against normal and cancerous cell lines. Additionally, molecular docking studies were conducted to understand the binding modes and mechanisms of these derivatives in the binding pocket of the aromatase enzyme as a potential target.
Article
Biochemistry & Molecular Biology
Min Zou, Jiawen Li, Bo Jin, Mingsheng Wang, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao, Liyun Zheng
Summary: Dual targeting of EGFR/HER2 receptors is an attractive strategy for cancer therapy. Compound 6d, a 4-anilinoquinoline-3-carbonitrile derivative, showed significant antiproliferative activity against SK-BR-3 and A431 cell lines, with potency comparable to Lapatinib and higher than Neratinib. Molecular docking studies indicated the binding modes of compound 6d in EGFR and HER2 binding sites, suggesting it as a potential candidate for further investigation as a potent anticancer agent.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Natalie Oberhuber, Hindole Ghosh, Bianca Nitzsche, Prasad Dandawate, Michael Hoepfner, Rainer Schobert, Bernhard Biersack
Summary: New N-alkylindole-substituted 2-(pyrid-3-yl)-acrylonitriles and their (p-cymene)Ru(II) piano-stool complexes were synthesized and found to exhibit potent antiproliferative activity in various cancer models. Some of the derivatives showed lower IC50 values than clinically relevant multikinase inhibitors gefitinib and sorafenib, indicating their potential as novel therapeutic agents for cancer treatment. The investigation of drug mechanism in HCT-116 p53-knockout colon cancer cells revealed that the derivatives induced apoptotic caspase-3/7 activity, ROS formation, and anti-angiogenic properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Menier Al-Anazi
Summary: The study synthesized a series of thiadiazole-triazole-thiazolidinone hybrids and evaluated their cytotoxicity against various cancer cell lines. The compounds with the most potent activity were identified, and the structure-activity relationship was analyzed to explain their anticancer efficacy.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Anil Kumar Sabhavath, Sarasija Madderla, Ravinder Dharavath, Vishnu Thumma, Gugulothu Thara, Srinivas Gundu, Ashok Dongamanti
Summary: This study describes a simple and convenient one-pot three-component method to synthesize 1,2,3-triazole-based 2,3-dihydrofuran derivatives. The method offers advantages such as high yield, short reaction time, and ease of operation, while using a green method and an eco-friendly catalyst. In vitro anticancer activity screening showed that most of the target compounds exhibited promising activity.
Article
Environmental Sciences
M. V. K. Reddy, K. Y. Rao, G. Anusha, G. M. Kumar, A. G. Damu, Kakarla Raghava Reddy, Nagaraj P. Shetti, Tejraj M. Aminabhavi, Peddiahgari Vasu Govardhana Reddy
Summary: By exploring the inhibitory activities and antioxidant properties of various derivatives against AChE and BuChE enzymes, some compounds were found to exhibit selective AChE inhibition and strong affinity to bind with the AChE enzyme under physiological conditions, providing potential drug targets for treating Alzheimer's disease.
ENVIRONMENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sujana Oggu, Parameswari Akshinthala, Naresh Kumar Katari, Laxmi Kumari Nagarapu, Srimannarayana Malempati, Rambabu Gundla, Sreekantha Babu Jonnalagadda
Summary: A library of 1,2,3-triazole-incorporated 1,3,4-oxadiazole-triazine derivatives (9a-j) was designed, synthesized, and tested for anticancer activity. The compounds showed remarkable anticancer activity against prostate, lung, and breast cancer cell lines, with IC50 values ranging from 0.16 ± 0.083 μM to 11.8 ± 7.46 μM. Compound 9d, with a 4-pyridyl moiety, exhibited exceptional anticancer activity against multiple cancer cell lines.
Article
Biochemistry & Molecular Biology
Victor Premsagar Miriyala, Prakash Raj Thommandru, Jajula Kashanna, Varadhi Govinda, Guguloth Ravi, Ravada Kishore
Summary: A library of new coumarin-1,2,3-triazole hybrids was synthesized and screened for their cytotoxicity against human breast cancer MCF-7 and lung cancer A-549 cell lines. Compound 7b (p-bromo) showed the best activity against both cell lines, followed by compound 7f (o-methoxy).
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Dharmasothu Veeranna, Lakavath Ramdas, Guguloth Ravi, Sushmitha Bujji, Vishnu Thumma, Jadav Ramchander
Summary: A novel series of compounds were synthesized and tested for their anticancer activity against human cancer cell lines. Some of the compounds showed stronger activity than the standard reference drug and exhibited remarkable binding affinity and key interactions in molecular docking studies.
Article
Optics
Safa A. Badawy, Rui Su, Ahmed A. Fadda, Ehab Abdel-Latif, Ahmed El-Shafei, Mohamed R. Elmorsy
Summary: The study focused on the influence of the (N-benzothiazolyl)-cyanoacetamide structure on the co-adsorption properties of SA17-20, and discussed their effects on the optical and electrochemical properties.
Article
Chemistry, Organic
Kaiwan O. Rashid, Khaled S. Mohamed, M. Abd El Salam, Ehab Abdel-Latif, Ahmed A. Fadda, Mohamed R. Elmorsy
Summary: A series of interesting N-(4-chlorophenyl)-2-phenoxyacetamide derivatives were synthesized and their structures were confirmed by spectroscopic techniques. Some of these compounds exhibited good insecticidal efficacy.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Physical
Aya Atef El-Sawi, Ibrahim Hassan Habib, Mohamed Ramadan Elmorsy, Asmat Ullah, Rehab Omar El-Attar, Abdel-Rahman Hassan Abdel-Rahman, El-Sayed Ibrahim El-Desoky, Mohamed Ahmed Abozeid
Summary: In this study, heteroatom-doped polycyclic aromatic hydrocarbons with excellent optoelectronic properties were successfully synthesized through base-catalyzed cascade reaction. The synthesized compounds were found to have a decreased energy gap, indicating their potential in semiconducting and light-harvesting applications. Additionally, they exhibited good thermal stability, qualifying them for various organic electronic applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Mohamed R. Elmorsy, Safa A. Badawy, Abdullah Y. A. Alzahrani, Ali El-Rayyes
Summary: Four novel acetohydrazonoyl cyanide compounds (5-8) with a triphenylamine moiety as an electron donor for dye-sensitized solar cells (DSSCs) were designed and synthesized. The compounds were well characterized and their properties were extensively investigated and compared to N-719 dye. The highest photovoltaic conversion efficiency was achieved by compound 8 (PCE, eta = 5.17%) due to its high photocurrent and photovoltage. It was used as a co-sensitizer along with N-719 to improve the performance of the cell.
Article
Chemistry, Organic
Mohamed R. Elmorsy, Mariam Eltoukhi, Ahmed A. Fadda, Ehab Abdel-Latif, Miral A. Abdelmoaz
Summary: This research focuses on the synthesis of carbazole-thiazolidinone derivatives and their cytotoxicity against three different cell lines. The compounds 3b and 5c show the most effective antitumor activity against the tested cell lines.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Applied
Mohamed R. Elmorsy, Safa A. Badawy, Ehab Abdel-Latif, Mohammed A. Assiri, Tarik E. Ali
Summary: A series of new metal-free D-D-pi-A dyes (TMS-1-4) based on triphenylamine (TPA) and carbazole (Cz) have been designed and used in dye-sensitized solar cells (DSSCs) as strong donor species. These dyes exhibit strong absorption ability, which shows promise in improving the performance of DSSCs.
Article
Chemistry, Physical
Hend M. Abdel-Wahed, Ahmed A. Fadda, Ehab Abdel-Latif, Soha M. Abdelmageed, Mohamed R. Elmorsy
Summary: In this study, a series of novel porphyrin derivatives, 8, 12, and 16, were synthesized in high yields. These derivatives have different aromatic substituents at the peripheral position. The structures of the compounds were confirmed by elemental and spectral analyses. Based on density functional theory (DFT) calculations, the porphyrins 8, 12, and 16 show suitable thermodynamics properties to be used as sensitizers in dye-sensitized solar cells (DSSCs). Analysis of the DSSC's performance using DFT reactivity indices shows that a more efficient DSSC can be built by correlating cell efficiency with molecular properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Mohamed R. Elmorsy, Safa A. Badawy, Kholoud E. Salem, Ahmed A. Fadda, Ehab Abdel-Latif
Summary: The synthesis of metal-free organic sensitizers is crucial for obtaining low-cost, high-efficiency dye-sensitized solar cells. In this study, the photovoltaic analysis of four carbazole organic sensitizers with a D-A architecture was conducted, showing that these sensitizers can achieve broader light-harvesting ability and higher photovoltaic efficiency.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Ahmed S. Radwan, Mohamed R. Elmorsy, Ehab Abdel-Latif, Mohamed M. Makhlouf, Safa A. Badawy
Summary: This investigation presents the synthesis and design of four innovative organic dyes (MRS-1-4) as co-sensitizers for dye-sensitized solar cells (DSSCs), which enhance the photovoltaic performance of the cells. Characterization and evaluation of the dyes' photovoltaic performance were conducted using various techniques. The co-sensitization of MRS-1-4 dyes with N719 led to a significant improvement in the power conversion efficiency of the cells.
Article
Chemistry, Applied
Safa A. Badawy, Ehab Abdel-Latif, Mohammed A. Assiri, Tarik E. Ali, Mohamed R. Elmorsy
Summary: Dye-sensitized solar cells (DSSCs) using hydrazonothiazole dyes (MHS-1-4) have shown promising potential for greenhouse applications. These dyes absorb light in the green region and transmit light in the red and blue regions, making them suitable for plant growth. The MHS-4 DSSCs achieved a high power conversion efficiency of 8.85%, a short-circuit photocurrent density of 17.90 mA cm-2, and a maximum incident monochromatic photonto-electron conversion efficiency (IPCE) of 80%. Additionally, the DSSCs based on MHS-4 demonstrated excellent long-term stability, maintaining constant power conversion efficiency after 1000 hours of exposure to sunlight.
Article
Materials Science, Multidisciplinary
Ghada A. Abdelwahab, Mohamed A. Ismail, Ahmed A. Fadda, Mohamed R. Elmorsy
Summary: This study introduces five new bithienylnicotinonitrile-based organic dyes (coded GA-1-5) designed for use in dye-sensitized solar cells (DSSCs). The researchers conducted a detailed analysis of the dyes' characteristics and found that they exhibit intense UV-vis absorption and high molar extinction coefficients, making them ideal for use in DSSCs. When tested, devices co-sensitized with the dyes showed significantly improved power conversion efficiencies (PCEs) compared to DSSCs sensitized with N3 alone. These findings represent a significant advancement in solar cell technology, paving the way for more efficient and sustainable energy solutions.
Article
Chemistry, Multidisciplinary
Heba M. El-Shafeai, Safa A. Badawy, Mohamed A. Ismail, Ehab Abdel-Latif, Ahmed A. Fadda, Mohamed R. Elmorsy
Summary: This article reports the synthesis, description, and demonstration of dye-sensitive solar cell sensitizers containing bifuran/ biphenyl derivatives with different electron acceptor units. The photophysical, electrochemical, and photovoltaic properties were examined for eight new organic dyes compared to the N3 metal dye. The solar cells based on HB-1-8 showed overall power conversion efficiencies of 2.93-5.51%, with HB-3 exhibiting the highest efficiency.
Article
Nanoscience & Nanotechnology
Samar E. Mahmoud, Ahmed A. Fadda, Ehab Abdel-Latif, Mohamed R. Elmorsy
Summary: A new series of metal-free organic dyes with dual anchors were synthesized for application in DSSC, showing high efficiency with dye SM4 as a sensitizer.
NANOSCALE RESEARCH LETTERS
(2022)