Article
Orthopedics
Naicheng Diao, Fei Yu, Bo Yang, Lifeng Ma, Heyong Yin, Ai Guo
Summary: This study investigated the relationship between changes in hip-knee-ankle (HKA) angle and hindfoot alignment after total knee arthroplasty (TKA) for varus knee osteoarthritis. The results showed that HFA was significantly adjusted by 3 months after TKA, and the change in HFA was weakly correlated with the change in HKA angle, with age impacting this correlation. In patients under 65 years old, there was a greater correlation between changes in HFA and HKA angle, while no correlation was observed in patients above 65 years old.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Jean-Yves Jenny, Florent Baldairon
Summary: The purpose of this study was to analyze and quantify the changes in native coronal alignment of TKA patients according to different alignment goals. The study found that, except for the kinematic alignment technique, the various alignment techniques induced significant changes in the pre-arthritic anatomy of the TKA patients. Surgeons should be aware of these modifications when performing TKA surgery.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Health Care Sciences & Services
Cheng Gu, Yurong Mao, Haiyan Dong, Yu Cui, Ming Fu
Summary: Static alignment does not significantly affect postoperative gait function after TKA. Dynamic alignment allows for better prediction of risk factors for prosthesis lifespan.
Article
Orthopedics
Jean-Yves Jenny, Florent Baldairon, Michael T. Hirschmann
Summary: This study aimed to analyze the coronal alignment of a large population of patients undergoing total knee arthroplasty using a modern classification of knee phenotypes found in a non-osteoarthritic population. The distribution of functional knee phenotypes in patients undergoing total knee arthroplasty was found to be different from those in a reference non-osteoarthritic population, with a wider distribution in the OA group.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Orthopedics
Michele D'Amato, Nienke M. Kosse, Ate B. Wymenga
Summary: This study found no correlation between clinical outcomes and joint line restoration of the femur, tibia, or HKA in patients after TKA. Leaving the prosthesis with some degrees of undercorrection on the coronal plane while maintaining the phenotype was not associated with better clinical results compared to TKA overcorrection. However, patients with a medial open TJLA had better clinical outcomes than patients with a lateral open TJLA.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Multidisciplinary Sciences
Haresh Rengaraj Rajamohan, Tianyu Wang, Kevin Leung, Gregory Chang, Kyunghyun Cho, Richard Kijowski, Cem M. Deniz
Summary: Current assessment methods for knee osteoarthritis (OA) lack comprehensive information to accurately predict outcomes. In this study, deep learning (DL) risk assessment models were developed using baseline knee MRI to predict the progression of knee OA to total knee replacement (TKR) over a 108-month follow-up period. DL models using MRI showed higher diagnostic performance than traditional models using clinical risk factors or knee radiographs. The ensemble DL models combining MRI and radiograph data achieved the highest AUCs, indicating superior predictive ability.
SCIENTIFIC REPORTS
(2023)
Article
Orthopedics
Tracy L. Kinsey, Christopher D. Melton, Ormonde M. Mahoney
Summary: The removal of posterior osteophytes in total knee arthroplasty (TKA) can help correct alignment deformities and reduce the need for soft-tissue releases or adjustments to planned bone resection. Studies on 57 TKAs showed that posterior osteophyte volume is correlated with the severity of deformity, and removal of osteophytes can restore functional alignment to a neutral position.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Medicine, General & Internal
Corrado Sosio, Nicolo Rossi, Paolo Sirtori, Ricardo Ciliberto, Michele Davide Maria Lombardo, Giuseppe Michele Peretti, Laura Mangiavini
Summary: The combination of kinematic alignment and a medial pivot TKA implant allows for fast recovery and good clinical and functional outcomes for at least 2 years of follow-up, independent of final limb alignment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Taghi Ramazanian, Shi Yan, Pouria Rouzrokh, Cody C. Wyles, Thomas J. O. Byrne, Michael J. Taunton, Hilal Maradit Kremers
Summary: This study compared HKA angle distribution in early and advanced knee osteoarthritis patients and found that patients undergoing total knee arthroplasty had a wider alignment distribution and more severe varus and valgus alignment. HKA angle was strongly associated with gender and body mass index.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Chan Zeng, Ryan C. Koonce, Heather M. Tavel, Suzanne E. Argosino, Denise A. Kiepe, Ella E. Lyons, Morgan A. Ford, Claudia A. Steiner
Summary: This study developed and validated a predictive model for discharge disposition following TKA, including 8 risk factors related to rehabilitation arrangements. Patients with a neurological disorder and mobility/balance issue had the highest likelihood of discharge to post-acute care facilities.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
M. Ruehling, S. M. Kirschbaum, C. Perka, F. Graef
Summary: About 25% of patients developed ankle pain after TKA. Standing radiographs of the ankle and a gait analysis could help detect malaligned TT or pathological gait in patients complaining about ankle symptoms after TKA.
BONE & JOINT JOURNAL
(2023)
Article
Orthopedics
Stephanie Huber, Jennyfer A. A. Mitterer, Sascha M. M. Vallant, Sebastian Simon, Florian Hanak-Hammerl, Gilbert M. M. Schwarz, Antonio Klasan, Jochen G. G. Hofstaetter
Summary: This study analyzed preoperative knee morphology using Artificial Intelligence and found gender-specific differences in the distribution of knee alignment. The findings regarding the Coronal Plane Alignment of the Knee (CPAK) and Functional Phenotype classification may have implications for future surgical planning.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Ittai Shichman, Erel Ben-Ari, Ethan Sissman, Christian Oakley, Ran Schwarzkopf
Summary: This study aimed to evaluate postoperative changes in the coronal alignment of the ankle joint in patients undergoing total knee arthroplasty (TKA) for different degrees of knee deformity. The study found that there were significant changes in ankle alignment in the group with a valgus correction of 10 degrees or more. However, regardless of the degree of knee deformity correction, TKA did not result in significant changes in the tibiotalar tilt angle. These findings have important implications for assessing candidates for TKA and considering potential causes of postoperative ankle pain.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Matthew A. Follett, Prerna Arora, William J. Maloney, Stuart B. Goodman, James Huddleston, Derek F. Amanatullah
Summary: The technical differences between simultaneous and staged total knee arthroplasties (TKAs) can affect the clinical and radiographic outcomes. The study found that the second knee in simultaneous TKAs had a higher risk of establishing the mechanical axis outside neutral compared to staged TKAs. Staged TKAs had an increased risk of deep venous thrombosis. There were no significant differences in perioperative complications and range of motion between the two procedures.
JOURNAL OF ARTHROPLASTY
(2022)
Review
Chemistry, Multidisciplinary
Federica Rosso, Roberto Rossi, Umberto Cottino, Federico Dettoni, Matteo Bruzzone, Davide Edoardo Bonasia
Summary: Three-dimensional (3D) printing has gained popularity in various medical fields, including orthopedic surgeries such as spine surgery, oncology, acetabular fracture treatment, and total hip arthroplasty (THA). The use of 3D-printed models in pre-operative planning for knee surgery, specifically total knee arthroplasty (TKA), has not been fully explored. This study aims to evaluate the potential application of 3D-printed models in complex primary and revision TKA, compared to standard planning.
APPLIED SCIENCES-BASEL
(2022)
Article
Pharmacology & Pharmacy
Emi Goto, Takeo Hata, Masami Nishihara, Masashi Neo, Mitsuhiko Iwamoto, Kosei Kimura, Masahiro Goto, Yoshiyuki Rikitake
Summary: This study aimed to clarify the incidence and risk factors of infusion-related reactions (IRRs) caused by trastuzumab in breast cancer patients and verify the preventive effects of dexamethasone. The results showed that premedication with dexamethasone lowered the risk of trastuzumab-induced IRRs. Future studies are needed to determine the optimal dose of dexamethasone to prevent IRRs and the impact of dexamethasone on the efficacy of trastuzumab in breast cancer.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Shunsuke Sezaki, Shuhei Otsuki, Kuniaki Ikeda, Takashi Ishitani, Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Kaito Nakamura, Masashi Neo
Summary: This study investigates the impact of scaffold implantation size on stress distribution and evaluates its mechanical and biomechanical properties. The results suggest that the implantation of the PGA scaffold can be a viable alternative to partial meniscectomy, and it is recommended to implant the PGA scaffold up to 20% of the defect size.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Orthopedics
Akihiko Hasegawa, Teruhisa Mihata, Nobuyuki Yamamoto, Norimasa Takahashi, Kazumasa Takayama, Akihiro Uchida, Masashi Neo
Summary: This study examined the relationship between postoperative graft integrity and clinical outcomes in patients with irreparable rotator cuff tears. The results showed that the thickness and tear size of the graft can affect the clinical outcomes. Patients with large graft tears had inferior postoperative clinical scores compared to those with intact grafts of sufficient thickness.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Pharmacology & Pharmacy
Ryosuke Ota, Takeo Hata, Atsushi Hirata, Takeshi Hamada, Masami Nishihara, Masashi Neo, Takahiro Katsumata
Summary: This retrospective cohort study examined the interaction between methotrexate and glucocorticoids in patients with rheumatoid arthritis using bDMARDs. The results showed that the interaction between the doses of methotrexate and glucocorticoids significantly influenced the risk of bacterial infections. Higher doses of glucocorticoids were a significant risk factor for bacterial infections when high doses of methotrexate were used.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Letter
Clinical Neurology
Kaito Nakamura, Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Takashi Ishitani, Shuhei Otsuki, Masashi Neo
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Kaito Nakamura, Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Takashi Ishitani, Shuhei Otsuki, Masashi Neo
Summary: This retrospective case-control study found an association between global spinal malalignment and rapid progression of hip arthrosis. Significant differences were identified in pelvic tilt, sagittal vertical axis, and T1 pelvic angle between the rapid progression group and the non-rapid progression group. Logistic regression analysis and ROC curve analysis showed that pelvic tilt, sagittal vertical axis, and T1 pelvic angle were predictive of rapid progression of hip arthrosis.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Yoshihiro Hirai, Hiroaki Shima, Kosho Togei, Toshito Yasuda, Masashi Neo
Summary: Hallux valgus surgery and open reduction of the lesser metatarsophalangeal joints with metatarsal shortening osteotomy can help treat severe hallux valgus with lesser metatarsophalangeal joint dislocation effectively.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Clinical Neurology
Hiromichi Hirai, Takashi Fujishiro, Toma Yano, Takuya Obo, Masahiro Mizutani, Yoshitada Usami, Sachio Hayama, Yoshiharu Nakaya, Atsushi Nakano, Masashi Neo
Summary: The reliability, validity, and minimum clinically important difference (MCID) of the FES-I for evaluating impaired body balance in patients with CCM were examined. The FES-I demonstrated acceptable internal consistency and good convergent validity, and the established thresholds of MCID can help clinicians recognize the clinical significance of changes in patient status.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Orthopedics
Tomohiro Okayoshi, Yoshinori Okamoto, Hitoshi Wakama, Shuhei Otsuki, Masashi Neo
Summary: This study aimed to evaluate the association between the flexion-extension gap difference and patient-reported outcome measures after total knee arthroplasty (TKA). The results showed that patients with a greater flexion-extension gap difference were more likely to perceive their knee joint as "natural". The study findings suggest that the flexion-extension gap difference has a significant impact on patient satisfaction and joint function after TKA.
Article
Clinical Neurology
Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Kaito Nakamura, Takafumi Saika, Shuhei Otsuki, Masashi Neo
Summary: This study evaluated the association between preoperative global alignment and proportion score and low back pain after total hip arthroplasty. The results showed that patients with a relative pelvic version below -7 degrees and a relative lumbar lordosis below -15 degrees were more likely to experience low back pain after THA. The measurement of relative pelvic version may be a useful predictor of THA outcome.
EUROPEAN SPINE JOURNAL
(2023)
Article
Nutrition & Dietetics
Yoko Urashima, Tatsuya Ueno, Chiyuki Takeda, Hiroshi Kusaba, Rina Tanaka, Karin Noda, Kanako Kawakami, Takuo Murakami, Aoi Kawaguchi, Yuka Suemitsu, Kazuya Urashima, Kaoru Suzuki, Kazumi Kurachi, Masami Nishihara, Masashi Neo, Michiaki Myotoku, Takuro Kobori, Tokio Obata
Summary: Casein, digested soy protein, and dextrin decrease the gastric absorption of phenytoin, while digested casein further reduces the absorption by weakening tight junctions. On the other hand, digested casein and dextrin increase the permeability rate of phenytoin. These findings provide guidance for selecting enteral nutrients for orally administered phenytoin.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Orthopedics
Yoshinori Okamoto, Hitoshi Wakama, Junya Matsuyama, Kaito Nakamura, Takafumi Saika, Shuhei Otsuki, Masashi Neo
Summary: The study aimed to assess the association between the psoas muscle index (PMI) and total hip arthroplasty (THA) outcomes. Results showed that PMI is associated with THA outcomes and can be useful when discussing THA expectations with patients.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)