Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides inEscherichia coli

Bioinspired Strategy for the Ribosomal Synthesis of Thioether-Bridged Macrocyclic Peptides in Bacteria

(2014) Nina Bionda et al.   ACS Chemical Biology

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

(2014) Daniel S. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structured Cyclic Peptides That Bind the EH Domain of EHD1

(2014) Alissa J. Kamens et al.   BIOCHEMISTRY

How proteins bind macrocycles

(2014) Elizabeth A Villar et al.   Nature Chemical Biology

Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation

(2014) Jessica M. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A bidirectional fluorescent two-hybrid system for monitoring protein–protein interactions

(2013) Ida Karin Nordgren et al.   Molecular BioSystems

Bicycle synthesis through peptide macrocyclization using aziridine aldehydes followed by late stage disulfide bond installation

(2013) Benjamin K. W. Chung et al.   MedChemComm

Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction

(2012) Varun Dewan et al.   ACS Chemical Biology

A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity

(2012) Oliver Demmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects of Cyclic Lipodepsipeptide Structural Modulation on Stability, Antibacterial Activity, and Human Cell Toxicity

(2012) Nina Bionda et al.   ChemMedChem

Recombinant production of rhesus θ-defensin-1 (RTD-1) using a bacterial expression system

(2012) Andrew Gould et al.   Molecular BioSystems

Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation

(2012) Kazuhiro Iwasaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phage display libraries of differently sized bicyclic peptides

(2012) Inmaculada Rentero Rebollo et al.   MedChemComm

Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

(2011) Marco Bartoloni et al.   CHEMICAL COMMUNICATIONS

Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

(2011) Avinash Muppidi et al.   CHEMICAL COMMUNICATIONS

Highly Efficient and More Generalcis- andtrans-Splicing Inteins through Sequential Directed Evolution

(2011) Julia H. Appleby-Tagoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

(2011) Eric Marsault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolution of cyclic peptide protease inhibitors

(2011) T. S. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siamese Depsipeptides: Constrained Bicyclic Architectures

(2009) Javier Ruiz-Rodríguez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid selection of cyclic peptides that reduce α-synuclein toxicity in yeast and animal models

(2009) Joshua A Kritzer et al.   Nature Chemical Biology

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

Inhibition of HIV Budding by a Genetically Selected Cyclic Peptide Targeting the Gag−TSG101 Interaction

(2008) Ali Tavassoli et al.   ACS Chemical Biology

Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological Consequences

(2008) Huan-Xiang Zhou et al.   Annual Review of Biophysics

Ribosomal Synthesis of Bicyclic Peptides via Two Orthogonal Inter-Side-Chain Reactions

(2008) Yusuke Sako et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY