A first-in-class POLRMT specific inhibitor IMT1 suppresses endometrial carcinoma cell growth

Endometrial cancer

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The mitochondrial RNA polymerase POLRMT promotes skin squamous cell carcinoma cell growth

(2022) Yulong Wang et al.   Cell Death Discovery

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Variations in incidence and mortality rates of endometrial cancer at the global, regional, and national levels, 1990–2019

(2021) Baoxia Gu et al.   GYNECOLOGIC ONCOLOGY

The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth

(2021) Tong Zhou et al.   Cell Death & Disease

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen

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Activation of oxidative phosphorylation in TP53-inactive endometrial carcinomas with a poor prognosis

(2021) Nobutaka Takahashi et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Endometrial cancer

(2021) Vicky Makker et al.   Nature Reviews Disease Primers

Targeting Mitochondrial Metabolism and RNA Polymerase POLRMT to Overcome Multidrug Resistance in Cancer

(2021) Hui-Jing Yu et al.   Frontiers in Chemistry

Identification of mitochondrial RNA polymerase as a potential therapeutic target of osteosarcoma

(2021) Qi-cai Han et al.   Cell Death Discovery

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Keap1-targeting microRNA-941 protects endometrial cells from oxygen and glucose deprivation-re-oxygenation via activation of Nrf2 signaling

(2020) Shu-ping Li et al.   Cell Communication and Signaling

I-BET726 suppresses human skin squamous cell carcinoma cell growth in vitro and in vivo

(2020) Zhengjun Liu et al.   Cell Death & Disease

The therapeutic value of SC66 in human renal cell carcinoma cells

(2020) Ming Xu et al.   Cell Death & Disease

Small-molecule inhibitors of human mitochondrial DNA transcription

(2020) Nina A. Bonekamp et al.   NATURE

Endometrial Cancer

(2020) Karen H. Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNase H1 directs origin-specific initiation of DNA replication in human mitochondria

(2019) Viktor Posse et al.   PLoS Genetics

Keratinocyte growth factor protects endometrial cells from oxygen glucose deprivation/re-oxygenation via activating Nrf2 signaling

(2018) Xuting Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

Itraconazole-Induced Inhibition on Human Esophageal Cancer Cell Growth Requires AMPK Activation

(2018) Min-Bin Chen et al.   MOLECULAR CANCER THERAPEUTICS

Triptonide inhibits human nasopharyngeal carcinoma cell growth via disrupting Lnc-RNA THOR-IGF2BP1 signaling

(2018) Shu-sheng Wang et al.   CANCER LETTERS

Ginseng Rh2 protects endometrial cells from oxygen glucose deprivation/re-oxygenation

(2017) Xiao-Fang Tang et al.   Oncotarget

Endometrial cancer

(2016) Philippe Morice et al.   LANCET

Mitochondrial DNA copy number variation across human cancers

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Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Targeting mitochondrial RNA polymerase in acute myeloid leukemia

(2015) Fernando N. Bralha et al.   Oncotarget

Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells

(2012) Federica Sotgia et al.   CELL CYCLE

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

(2012) Ahmed F. Salem et al.   CELL CYCLE

Availability, not respiratory capacity governs oxygen consumption of solid tumors

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Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

(2012) Y. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers

(2011) Man Yu   LIFE SCIENCES

Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

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