Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 73, Issue 3, Pages 327-332Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glw194
Keywords
TERC gene; Coronary heart disease; Gene-diet interaction
Categories
Funding
- Fundacion Patrimonio Comunal Olivarero, Junta de Andalucia (Consejeria de Salud, Consejeria de Agricultura y Pesca, Consejeria de Innovacion, Ciencia y Empresa)
- Diputaciones de Jaen y Cordoba
- Centro de Excelencia en Investigacion sobre Aceite de Oliva y Salud
- Ministerio de Medio Ambiente, Medio Rural y Marino, Gobierno de Espana
- European community (NUTRITECH European Integrated Project) [289511]
- Plan Nacional de I + D + I
- ISCIII-Subdireccion General de Evaluacion
- Fondo Europeo de Desarrollo Regional (FEDER) [FIS PI10/01041, AGL2012/39615, PI13/00185]
- Ministerio de Ciencia e Innovacion [AGL2009-122270]
- Consejeria de Salud, Junta de Andalucia [PI-0058/10, PI-0206/13]
- Proyecto de Excelencia, Consejeria de Economia, Innovacion, Ciencia y Empleo [CVI-7450]
- Merck Serono
- Fundacion (Clinical research in Cardiometabolic)
- ISCIII research contract (Programa Rio-Hortega)
- Spanish Ministry of Economy and Competitiveness (MINECO)
- Pro-CNIC Foundation
- Severo Ochoa Center of Excellence (MINECO) [SEV-2015-0505]
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Leukocyte telomere length (LTL) attrition has been associated with age-related diseases. Telomerase RNA Component (TERC) genetic variants have been associated with LTL; whereas fatty acids (FAs) can interact with genetic factors and influence in aging. We explore whether variability at the TERC gene locus interacts with FA profile and two healthy diets (low-fat diet vs Mediterranean diet [MedDiet]) modulating LTL, glucose metabolism, and inflammation status in coronary heart disease (CHD) patients. Inflammation status (high-sensitivity C-reactive protein [hsCRP], glucose metabolism-glucose, insulin, and glycated hemoglobin [HbA1c], and homeostasis model assessment of insulin resistance [HOMA-IR]), LTL, FAs, and single nucleotide polymorphisms (SNPs) of the TERC gene (rs12696304, rs16847897, and rs3772190) were determined in 1,002 patients from the CORDIOPREV study (NCT00924937). We report an interaction of the TERC rs12696304 SNP with monounsaturated fatty acid (MUFA) affecting LTL (p interaction = .01) and hsCRP (p interaction = .03). Among individuals with MUFA levels above the median, CC individuals showed higher LTL and lower hsCRP than G-allele carriers. Moreover, MedDiet interacted with TERC rs12696304 SNP (p interaction = .03). Specifically, CC individuals displayed a greater decrease in hsCRP than G-allele carriers. These results were not adjusted for multiple statistical testing and p less than .05 was considered significant. Our findings suggest that the TERC rs12696304 SNP interacts with MUFA improving inflammation status and telomere attrition related with CHD. Moreover, the MedDiet intervention improves the inflammatory profile in CC individuals compared with the G-allele carriers. These interactions could provide a right strategy for personalized nutrition in CHD patients.
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