Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 17, Issue 5, Pages 333-341Publisher
ZHEJIANG UNIV
DOI: 10.1631/jzus.B1500247
Keywords
Cardiac ankyrin repeat protein (CARP); Cardiovascular disease; Cardiac development
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Funding
- National Natural Science Foundation of China [31171392]
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Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.
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