A population of stem cells with strong regenerative potential discovered in deer antlers

The annual regrowth of deer antlers provides a valuable model for studying organ regeneration in mammals. We describe a single-cell atlas of antler regrowth. The earliest-stage antler initiators were mesenchymal cells that express the paired related homeobox 1 gene (PRRX1+ mesenchymal cells). We also identified a population of antler blastema progenitor cells (ABPCs) that developed from the PRRX1+ mesenchymal cells and directed the antler regeneration process. Cross-species comparisons identified ABPCs in several mammalian blastema. In vivo and in vitro ABPCs displayed strong self-renewal ability and could generate osteochondral lineage cells. Last, we observed a spatially well-structured pattern of cellular and gene expression in antler growth center during the peak growth stage, revealing the cellular mechanisms involved in rapid antler elongation.

Automated summary

The annual regrowth of deer antlers serves as a valuable model for studying organ regeneration in mammals. This study presents a single-cell atlas of antler regrowth and identifies the key cell populations involved in the process. The findings reveal the cellular mechanisms and gene expression patterns associated with rapid antler elongation.