RAD51 bypasses the CMG helicase to promote replication fork reversal

Mechanism for inverted-repeat recombination induced by a replication fork barrier

(2022) Léa Marie et al.   Nature Communications

The Initiation of Eukaryotic DNA Replication

(2022) Alessandro Costa et al.   Annual Review of Biochemistry

CHK1 phosphorylates PRIMPOL to promote replication stress tolerance

(2022) Kavi P. M. Mehta et al.   Science Advances

Strand annealing and motor driven activities of SMARCAL1 and ZRANB3 are stimulated by RAD51 and the paralog complex

(2022) Swagata Halder et al.   NUCLEIC ACIDS RESEARCH

RADX prevents genome instability by confining replication fork reversal to stalled forks

(2021) Archana Krishnamoorthy et al.   MOLECULAR CELL

Distinct pathways of homologous recombination controlled by the SWS1–SWSAP1–SPIDR complex

(2021) Rohit Prakash et al.   Nature Communications

Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions

(2021) María J. Cabello-Lobato et al.   Cell Reports

A conserved mechanism for regulating replisome disassembly in eukaryotes

(2021) Michael Jenkyn-Bedford et al.   NATURE

HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

(2020) Gongshi Bai et al.   MOLECULAR CELL

The plasticity of DNA replication forks in response to clinically relevant genotoxic stress

(2020) Matteo Berti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Precise tuning of gene expression levels in mammalian cells

(2019) Yale S. Michaels et al.   Nature Communications

Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase

(2019) Michael R. Wasserman et al.   CELL

Replication-Coupled DNA Repair

(2019) David Cortez   MOLECULAR CELL

PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

(2019) Annabel Quinet et al.   MOLECULAR CELL

Non-enzymatic roles of human RAD51 at stalled replication forks

(2019) Jennifer M. Mason et al.   Nature Communications

RADX Modulates RAD51 Activity to Control Replication Fork Protection

(2018) Kamakoti P. Bhat et al.   Cell Reports

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading

(2018) Ravindra Amunugama et al.   Cell Reports

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity

(2017) Marko Vujanovic et al.   MOLECULAR CELL

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

(2017) Arun Mouli Kolinjivadi et al.   MOLECULAR CELL

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection

(2017) Karina Zadorozhny et al.   Cell Reports

WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress

(2016) Giuseppe Leuzzi et al.   EMBO JOURNAL

Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex

(2016) Fengshan Liang et al.   Cell Reports

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype

(2016) Carolyn G. Marsden et al.   PLoS Genetics

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

(2015) Anderson T. Wang et al.   MOLECULAR CELL

A unique binding mode enables MCM2 to chaperone histones H3–H4 at replication forks

(2015) Hongda Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

(2015) Najim Ameziane et al.   Nature Communications

A unique binding mode enables MCM2 to chaperone histones H3–H4 at replication forks

(2015) Hongda Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FBH1 Catalyzes Regression of Stalled Replication Forks

(2015) Kasper Fugger et al.   Cell Reports

High-affinity DNA-binding Domains of Replication Protein A (RPA) Direct SMARCAL1-dependent Replication Fork Remodeling

(2015) Kamakoti P. Bhat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase

(2014) Jianhong Chen et al.   NUCLEIC ACIDS RESEARCH

A structure-specific nucleic acid-binding domain conserved among DNA repair proteins

(2014) A. C. Mason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

(2014) Marija Maric et al.   SCIENCE

Polyubiquitylation drives replisome disassembly at the termination of DNA replication

(2014) Sara Priego Moreno et al.   SCIENCE

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling

(2013) Gérald Lossaint et al.   MOLECULAR CELL

Substrate-Selective Repair and Restart of Replication Forks by DNA Translocases

(2013) Rémy Bétous et al.   Cell Reports

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Rad51 Is an Accessory Factor for Dmc1-Mediated Joint Molecule Formation During Meiosis

(2012) V. Cloud et al.   SCIENCE

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2

(2008) P. S. Malik et al.   NUCLEIC ACIDS RESEARCH