Journal
RESEARCH IN VETERINARY SCIENCE
Volume 156, Issue -, Pages 81-87Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2023.02.002
Keywords
Medulla; Bovine alpha-herpesviruses; Gene expression; Infectious cycle
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In this study, we investigated the virological findings, microscopic lesions, and gene expression changes related to innate immunity, cell cycle, and apoptosis in the cervical medulla of calves experimentally infected with BoAHV-1 and BoAHV-5. This research contributes to the understanding of the differential neuropathogenesis of these alpha-herpesviruses in cattle.
Bovine herpesvirus (BoAHV) types 1 and 5 are closely-related neurotropic alpha-herpesviruses. BoAHV-1 generally causes respiratory and genital disease but can occasionally cause encephalitis. BoAHV-5 is the causative agent of non suppurative meningoencephalitis in calves. During neuroinvasion, both viruses reach the central and peripheral nervous system. While brain alterations are well-described, the changes that occur in the medulla have not been fully detailed. In this work, we integrated and analyzed the virological findings, the microscopic lesions and the changes that occur in the expression of genes related to the innate immunity, cell cycle and apoptosis in the cervical medulla of calves experimentally-infected with BoAHV-1 and BoAHV-5. This will contribute to the understanding of the differential neuropathogenesis of these alpha-herpesviruses of cattle.
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