Article
Biochemistry & Molecular Biology
Tadahiro Suenaga, Yasuko Mori, Tatsuo Suzutani, Hisashi Arase
Summary: This study reveals the importance of sialic acid-binding immunoglobulin-like lectin 7 (Siglec-7) in Varicella-zoster virus (VZV) infection of human primary monocytes. The interaction between glycoprotein B (gB) and Siglec-7 is regulated by Siglec-7 cis-ligands, which play a crucial role in VZV infection.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Shivam K. Purohit, Carolyn Samer, Hamish E. G. McWilliam, Renee Traves, Megan Steain, Brian P. McSharry, Paul R. Kinchington, David C. Tscharke, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Summary: This study demonstrates that varicella zoster virus suppresses the expression of antigen presentation molecule MR1, highlighting the intricate temporal relationship between infection and ligand availability. The study also suggests that VZV likely encodes multiple viral genes targeting MR1.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Oncology
Katsuhiro Yoshikawa, Mitsuaki Ishida, Hirotsugu Yanai, Koji Tsuta, Mitsugu Sekimoto, Tomoharu Sugie
Summary: The expression of CAF PD-L1 is associated with a better prognosis in patients with TNBC, and the 73-10 assay may be the most suitable primary antibody for immunostaining CAF PD-L1.
Article
Pathology
Shih-Yao Lin, Jen-Fan Hang, Chiung-Ru Lai, I-San Chan, Ying-Chu Shih, Ling-Yu Jiang, Yen-Hou Chang, Yi-Jen Chen
Summary: Ovarian clear cell carcinoma (OCCC), a chemoresistant ovarian cancer, has a modest response to anti-PD-1/PD-L1 therapies. Loss of MHC class I may contribute to immune evasion and resistance to anti-PD-1/PD-L1 therapies in OCCC. CD8(+) tumor-infiltrating lymphocytes (TILs) and PD-L1 positivity using Combined Positive Score may have a negative prognostic value.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Arne Strand, San-Tai Shen, Diana R. Tomchick, Junmei Wang, Chyung-Ru Wang, Johann Deisenhofer
Summary: The presentation of antigenic peptides to T-cell receptors is crucial for the adaptive immune response. Through crystal structure determination and molecular dynamics simulations, researchers found that conformational differences within one microsecond during molecular dynamics simulations of peptide complexes with H2-M3 could be crucial to T-cell discrimination. Specifically, peptide ligands with alanine or threonine at position 6 partially exiting the binding groove could play a key role in the immune response initiation by T cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Oncology
Mohamed Hassan, Vu Trung, Deepa Bedi, Sage Shaddox, Dilip Gunturu, Clayton Yates, Pran Datta, Temesgen Samuel
Summary: Topoisomerase inhibitors are used to treat cancer and can activate signaling pathways that affect cell survival and immune cell functions. However, the lack of response to immunotherapy in some types of colorectal cancer is still not well understood. This study investigated the effects of topoisomerase inhibitors on cell cycle and apoptosis, as well as the expression of PD-L1 and MHC I in colorectal cancer cells. The results showed that inhibition of NF-kappa B or DDR could enhance cell death and increase MHC I expression, while PD-L1 expression was moderately affected. Furthermore, adaptive tolerance to topoisomerase inhibition led to altered cell cycle response and reduced expression of PD-L1 and MHC I. Therefore, targeting DDR pathways, PD-L1, MHC I, or other immune regulators in colorectal cancer cells may improve their visibility to immune cells and enable effective combination therapy with immunotherapy.
Article
Oncology
Kento Kawasaki, Kazuhiro Noma, Takuya Kato, Toshiaki Ohara, Shunsuke Tanabe, Yasushige Takeda, Hijiri Matsumoto, Seitaro Nishimura, Tomoyoshi Kunitomo, Masaaki Akai, Teruki Kobayashi, Noriyuki Nishiwaki, Hajime Kashima, Naoaki Maeda, Satoru Kikuchi, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Summary: The PD-1/PD-L1 axis plays a crucial role in tumor immunosuppression, and the mutual enhancement of PD-L1 expression between cancer cells and CAFs leads to tumor immunosuppression. PD-L1-expressing CAFs may be promising targets for cancer therapy, inhibiting tumor progression and improving host tumor immunity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Tinglei Huang, Fuli Li, Xiaojiao Cheng, Jianzheng Wang, Wenhui Zhang, Baiwen Zhang, Yao Tang, Qingli Li, Cong Zhou, Shuiping Tu
Summary: In this study, it was demonstrated that inhibiting the Wnt/β-catenin signaling pathway enhances the efficacy of PD-L1 blockade therapy, overcoming immune resistance mediated by CAFs. Knocking out PD-L1 in BMFs can restore sensitivity to PD-L1 blockade therapy in BMF-mixed tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Gayathri Heenatigala Palliyage, Parinya Samart, Sharan Bobbala, Liying W. Rojanasakul, Jayme Coyle, Karen Martin, Patrick S. Callery, Yon Rojanasakul
Summary: This study investigated the potential biomarker programmed death-ligand 1 (PDL-1) for cancer-associated fibroblasts (CAFs)-induced chemoresistance in non-small cell lung cancer (NSCLC). The results showed that chemotherapy-stimulated CAFs promote tumorigenic and stem cell-like properties of NSCLC cells, leading to chemoresistance. Upregulation of PDL-1 expression in chemotherapy-treated CAFs is associated with poor prognosis, and silencing PDL-1 expression suppresses CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance.
Review
Medicine, Research & Experimental
Danni Li, Xuran Li, Jun Zhao, Fei Tan
Summary: Molecular imaging has the potential to play a role in the diagnosis of head and neck squamous cell carcinoma, and early tumor identification can help with treatment. Targeted therapy has already been proven effective in some cases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Keywan Mortezaee, Jamal Majidpoor, Sajad Najafi, Davood Tasa
Summary: Resistance to immune checkpoint inhibitors is a major challenge in cancer immunotherapy, as immune evasion is a complex event that occurs in cold immune environments. More research is needed to understand the mechanisms of immune escape in different types of tumors and develop strategies to enhance tumor sensitivity to anti-PD-(L)1 therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Kaya E. Witte, Jesco Pfitzenmaier, Jonathan Storm, Melanie Lutkemeyer, Clara Wimmer, Wiebke Schulten, Nele Czaniera, Marvin Geisler, Christine Forster, Ludwig Wilkens, Cornelius Knabbe, Fritz Mertzlufft, Barbara Kaltschmidt, Jan Schulte Am Esch, Christian Kaltschmidt
Summary: Prostate cancer stem cells exhibit different NF-kappa B signaling pathways, with some being efficiently killed by tumor necrosis factor, potentially aiding in the optimization of personalized treatment options for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Vicki Traina-Dorge, Lara A. Doyle-Meyers, Robert Sanford, Jennifer Manfredo, Anna Blackmon, Mary Wellish, Stephanie James, Xavier Alvarez, Cecily Midkiff, Brent E. Palmer, Eileen Deharo, Don Gilden, Ravi Mahalingam
JOURNAL OF VIROLOGY
(2015)
Article
Immunology
Anna M. Blackmon, Christina N. Como, Andrew N. Bubak, Teresa Mescher, Dallas Jones, Maria A. Nagel
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Microbiology
Dallas Jones, Christina N. Como, Lichen Jing, Anna Blackmon, Charles Preston Neff, Owen Krueger, Andrew N. Bubak, Brent E. Palmer, David M. Koelle, Maria A. Nagel
Article
Immunology
Andrew N. Bubak, Cheryl Beseler, Christina N. Como, Christina M. Coughlan, Noah R. Johnson, James E. Hassell, Anna M. Burnet, Teresa Mescher, D. Scott Schmid, Colin Coleman, Ravi Mahalingam, Randall J. Cohrs, Timothy D. Boyd, Huntington Potter, Ali H. Shilleh, Holger A. Russ, Maria A. Nagel
Summary: This study found that VZV infection increases levels of amyloidogenic peptides and amyloid in CSF and qHPNCs, indicating a potential role in persistent arterial inflammation in VZV vasculopathy. Additionally, a novel proviral function of amylin was identified during infection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Andrew N. Bubak, Teresa Mescher, Michael Mariani, Seth E. Frietze, James E. Hassell, Christy S. Niemeyer, Christina N. Como, Anna M. Burnet, Prem S. Subramanian, Randall J. Cohrs, Ravi Mahalingam, Maria A. Nagel
Summary: VZV antigen was detected in temporal arteries of GCA patients, suggesting a potential role for virus infection in GCA pathogenesis. RNA sequencing revealed enrichment of viral infection pathways and immune activation in GCA TAs, while control samples also showed viral pathways and vascular remodeling processes, indicating early infection progression.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Ophthalmology
Christina N. Como, Andrew N. Bubak, Anna M. Blackmon, Dallas Jones, Niklaus H. Mueller, Richard Davidson, Maria A. Nagel
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)