Article
Agriculture, Dairy & Animal Science
Vasileia Angelou, Dimitra Psalla, Chrysostomos Dovas, George M. Kazakos, Christina Marouda, Kyriakos Chatzimisios, Zacharenia Kyrana, Evangelia Moutou, Maria Karayannopoulou, Lysimachos G. Papazoglou
Summary: This study investigated the efficacy of autologous platelet-rich plasma (PRP) infiltration in open wounds in cats. The results showed that PRP infiltration promoted faster and better wound healing, as well as improved perfusion. This is the first study to focus on the topical application of PRP in treating open wounds in laboratory cats, and the results are encouraging, demonstrating faster healing in the PRP group.
Article
Biophysics
Ting Wang, Wanwan Yi, Yu Zhang, Hang Wu, Hengwei Fan, Jiulong Zhao, Shige Wang
Summary: In recent years, the healing of chronic wounds has become a challenging problem in clinical practice. This study aimed to address the challenges in wound care by designing a dual-network hydrogel composed of sodium alginate and platelet-rich plasma. The hydrogel showed a three-dimensional network structure and exhibited the potential for cell proliferation and vascular regeneration. When applied to wound skin in rats, the hydrogel effectively promoted wound closure. Overall, this strategy offers a simple and feasible approach for overcoming the shortcomings of conventional wound dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Dermatology
Shenyu Zhu, Jianfeng Gao, Wenbo Yu, Jianxian Xiong
Summary: A meta-analysis was conducted to evaluate the effect of platelet-rich plasma (PRP) on sternal wound healing (SWH) in cardiac surgery (CS) patients. A total of 1098 relevant studies were reviewed, and 11 studies were included in the analysis, involving 8961 CS patients. The results showed that PRP significantly reduced the incidence of sternal wound infection (SWI), including deep and superficial SWI, compared to the control group. However, caution is needed due to the low sample size of some studies included in the meta-analysis.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shangzhi Li, Qi Dong, Xiaotong Peng, Yun Chen, Hongjun Yang, Weilin Xu, Yanteng Zhao, Pu Xiao, Yingshan Zhou
Summary: A self-healing nanocomposite hydrogel based on hyaluronic acid has been developed, which exhibits good strength, self-healing ability, and the potential to load platelet-rich plasma (PRP) for promoting skin wound healing.
Article
Engineering, Biomedical
Chao Cai, Huimin Zhu, Yujie Chen, Xiuqun Yuan, Hezhou Liu, Zhi Yang
Summary: Hydrogels are widely used in biological medicine due to their safety and softness. However, conventional hydrogels have drawbacks such as low strength and poor anti-freezing. In this study, a composite adhesive organohydrogel with improved properties was developed by incorporating bacterial cellulose and platelet-rich plasma into a hybrid gel network. The organohydrogel showed excellent antifreeze properties and long-term water retention, as well as strong tissue adhesion. The introduction of bacterial cellulose also increased the tensile strength of the organohydrogel. Additionally, the PRP-loaded organohydrogel promoted wound healing through the release of growth factors.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Dermatology
Ankita Tuknayat, Gurvinder Pal Thami, Mala Bhalla, Jasleen Kaur Sandhu
Summary: PRP treatment for melasma shows significant efficacy in reducing mMASI score, regardless of patients' skin type, gender, and type of melasma. Patient self-evaluation indicates high satisfaction with the results. No significant side effects were reported during the treatment.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Giselle Ramos-Gonzalez, Lianeth Salazar, Olga Wittig, Dylana Diaz-Solano, Jose E. Cardier
Summary: Cellular therapy and platelet-rich plasma have different effects on skin wound healing, with cellular therapy showing potential for promoting wound repair and platelet-rich plasma acting as an excellent scaffold for tissue engineering.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Oncology
Ji Won Kim, Tri Ho Minh, Jeong Mi Kim, Mi Eun Choi, Eun Jeong Jeon, Jin-Mi Park, Young-Mo Kim, Jeong-Seok Choi
Summary: Intralesional injection of activated PRP concentrate has potential for tongue regeneration, wound healing, and neural regeneration with minimal scarring after partial glossectomy. The PRP group showed reduced wound scar contracture, promoted wound healing, and less inflammation and wound fibrosis compared to the hemiglossectomy group. Immunohistochemical staining revealed more intense S100 and neurofilament expressions in the hemiglossectomy + PRP group compared to the hemiglossectomy group.
Article
Biotechnology & Applied Microbiology
Seo-Young Choi, Soochong Kim, Kyung-Mee Park
Summary: This study evaluated the initial healing effects of PRP gel and PRF on deep corneal wounds. The results showed that PRP gel promoted vascular healing and myofibroblast production, contributing to corneal remodeling. However, the use of PRF was not recommended due to its potential complications during tissue healing.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Biomedical
Kui Xu, Sijie Deng, Yabin Zhu, Wei Yang, Weizhen Chen, Liang Huang, Chi Zhang, Ming Li, Lijiao Ao, Yibo Jiang, Xiangyu Wang, Qiqing Zhang
Summary: This study introduces a platelet rich plasma (PRP) loaded multifunctional hydrogel with reactive oxygen species (ROS) and glucose dual-responsive property, which can accelerate diabetic wound healing. The hydrogel possesses several desirable properties and can release cytokines to promote wound healing in an oxidative stress or hyperglycemia state.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Ophthalmology
Yuichi Okumura, Takenori Inomata, Keiichi Fujimoto, Kenta Fujio, Jun Zhu, Ai Yanagawa, Hurramhon Shokirova, Yoshitomo Saita, Yohei Kobayashi, Masahi Nagao, Hirofumi Nishio, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Ken Nagino, Yasutsugu Akasaki, Kunihiko Hirosawa, Tianxiang Huang, Mizu Kuwahara, Akira Murakami
Summary: This study found that PRP eye-drops stored for 4 weeks promoted corneal epithelial wound healing with higher levels of growth factors compared to AS eye-drops, while maintaining sterility. This suggests that this preparation has the potential to treat refractory keratoconjunctival epithelial disorders.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Cell Biology
Edward J. Calabrese, Rachna Kapoor, Gaurav Dhawan, Vittorio Calabrese
Summary: Platelet-rich plasma is widely accepted for wound healing, showing unique hormetic-like concentrations in its complex mixtures, making it a new area for biomedical research and applications.
WOUND REPAIR AND REGENERATION
(2022)
Article
Physics, Applied
Anastasiya O. Solovieva, Elizaveta S. Permyakova, Konstantin Ershov, Ksenia Bakhareva, Svetlana M. Miroshnichenko, Philipp Kiryukhantsev-Korneev, Anton S. Konopatsky, Josef Polcak, Dmitry Shtansky, Anton M. Manakhov
Summary: COOH plasma polymer layers deposited onto polycaprolactone (PCL) nanofibers can accelerate diabetic wound healing, showing promising clinical applications.
PLASMA PROCESSES AND POLYMERS
(2022)
Article
Chemistry, Applied
Ya Zhang, Zi-Li Wang, Ze-Peng Deng, Zi-Lin Wang, Fei Song, Li-Li Zhu
Summary: Diabetes often leads to difficult-to-heal wounds, but platelet rich plasma (PRP) has great potential for diabetic wound treatment. An injectable, self-healing, and non-specific tissue-adhesive hydrogel was designed as an encapsulation and delivery platform for PRP. The hydrogel inhibits PRP enzymolysis and enables sustained release of growth factors, which enhances cell proliferation and migration in vitro, and accelerates healing of full thickness wounds of diabetic skins in vivo.
CARBOHYDRATE POLYMERS
(2023)
Article
Cell & Tissue Engineering
Nesrine Ebrahim, Arigue A. Dessouky, Ola Mostafa, Amira Hassouna, Mohamed M. Yousef, Yasmin Seleem, Eman Abd El Aziz M. El Gebaly, Mona M. Allam, Ayman Samir Farid, Bayan A. Saffaf, Dina Sabry, Ahmed Nawar, Ahmed A. Shoulah, Ahmed H. Khalil, Sami F. Abdalla, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Rabab F. Salim
Summary: The combined therapy of PRP and ADSCs significantly accelerated wound healing in experimentally induced diabetic rats by modulating the Notch signaling pathway, promoting angiogenesis, and enhancing EPSC proliferation.
STEM CELL RESEARCH & THERAPY
(2021)