Article
Oncology
Mingming Zhang, Xiaoru Hu, Ye Kang, Wanfeng Xu, Xianghong Yang
Summary: The study found that fasting blood glucose levels are not significantly associated with overall survival of patients with pancreatic cancer, with only CA199 > 1000 being independently correlated with survival. The median survival in the normal glucose group was 20.5 months, while in the high blood glucose group it was 14.2 months, with no significant difference between the two groups.
Article
Oncology
Noemie Ravalet, Amelie Foucault, Frederic Picou, Martin Gombert, Emmanuel Renoult, Julien Lejeune, Nicolas Vallet, Sebastien Lachot, Emmanuelle Rault, Emmanuel Gyan, Marie C. Bene, Olivier Herault
Summary: The study proposes the clinical use of unexploited research parameters for early detection of subclinical MDS by triggering blood smear examination. By identifying critical research parameters of white blood cells and calculating an MDS-likelihood score, early detection of MDS patients in the general population can be achieved through automated analysis on the DxH 800 hematology analyzer.
Article
Medicine, General & Internal
Toshiaki Iba, Tomohiro Sawada, Yutaka Kondo, Kenta Kondo, Jerrold H. Levy
Summary: This study investigated the pathophysiologic changes in bone marrow and blood cells in a rat heatstroke model. The findings showed that heatstroke causes platelet aggregation, leukocyte injury, and cell death. These changes were milder and reversible in sublethal heatstroke. The appearance of immature cells may result from damage to the bone marrow microenvironment. These findings have important implications for potential diagnostic and therapeutic considerations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ji-Hoon Sim, Yong-Seok Park, Seungil Ha, Sung-Hoon Kim, Joung Uk Kim
Summary: Preoperative red blood cell distribution width (RDW) is strongly associated with high mortality in surgery for metastatic brain tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Laura L. Y. Tan, Valerie T. W. Chew, Nicholas Syn, Ek-Khoon Tan, Ye-Xin Koh, Jin-Yao Teo, Peng-Chung Cheow, Prema Raj Jeyaraj, Pierce K. H. Chow, Chung-Yip Chan, Alexander Y. F. Chung, London L. P. J. Ooi, Brian K. P. Goh
Summary: The objective of this study was to determine if receiving intraoperative blood transfusion was a significant prognostic factor for overall and recurrence-free survival after curative resection of hepatic cellular carcinoma (HCC). In a retrospective review of 1092 patients who underwent curative liver resection, it was found that intraoperative blood transfusion had no significant impact on the survival outcomes in patients with primary HCC.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Parasitology
Tera Pijnacker, Richard Bartels, Martin van Leeuwen, Erik Teske
Summary: This study aimed to identify ADVIA hematology analyzer parameters that suggest B. cants parasitemia in dogs and develop a predictive model. Both conventional statistical methods and machine learning methods were used, and important parameters including platelet count, mean platelet volume, and percentage of large unstained cells were identified. The study successfully formulated models with high sensitivity and specificity, suggesting that the algorithms can be easily integrated into laboratories using ADVIA analyzers to screen for Babesia parasitemia in dogs.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Natalia Popowicz, Hui Min Cheah, Cynthia Gregory, Alina Miranda, Ian M. Dick, Y. C. Gary Lee, Jenette Creaney
Summary: The study demonstrates the prognostic significance of NLR in malignant pleural effusions for predicting survival in MPE patients. The association with prognosis in the fluid is primarily driven by the presence of neutrophils.
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Medicine, General & Internal
Dilber Uzun Ozsahin, Mubarak Taiwo Mustapha, Basil Bartholomew Duwa, Ilker Ozsahin
Summary: This study aims to automate and accurately classify malaria parasites using a deep learning framework, report the most appropriate peripheral blood smear, and evaluate model performance. The proposed model performs best when using thick peripheral blood smears, providing important insights for improved accuracy and rapid diagnosis.
Article
Medicine, General & Internal
Yuan-Mao Huang, Yan-Ni Wang, Yi Zheng, Li-Li Pan, Yang Li, Jing-Gang Li, Shao-Yuan Wang
Summary: The clearance time of peripheral blood blasts has important prognostic value for the CR rate, RFS, and OS of AML patients. PBBC is an independent prognostic factor for CR, RFS, and OS in AML patients, and the white blood cell count can affect the CR rate of patients after 5 days of induction chemotherapy.
Article
Oncology
Yuhua Feng, Yiping Liu, Meizuo Zhong, Leyuan Wang
Summary: This study investigated the predictive values of complete blood counts in patients with primary central nervous system lymphoma (PCNSL). It found that factors such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI) were associated with patient age and Memorial Sloan Kettering Cancer Center (MSKCC) scores, and higher values were linked to shorter progression-free survival and overall survival. A CBC score model integrating these factors accurately stratified patients into different risk groups, providing a promising predictive system for PCNSL patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zeljko Debeljak, Ann-Christin Niehoff, Ana Bandjak, Dario Mandic, Bojana Bosnjak, Marija Heffer, Stefan Mrdenovic, Ivana Markovic, Milorad Zjalic, Vatroslav Seric
Summary: This study aimed to develop and evaluate matrix-assisted laser desorption ionization time-of-flight mass spectrometry imaging of blood smears. Different blood plasma removal, matrix deposition, and instrumental settings were evaluated, and the study sets the foundations for future application of this technique in clinical diagnostics and research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Thomas C. Hanff, Yuhui Zhang, Robert S. Zhang, Michael V. Genuardi, Maria Molina, Rhondalyn C. McLean, Jeremy A. Mazurek, Monique S. Tanna, Joyce W. Wald, Pavan Atluri, Michael A. Acker, Lee R. Goldberg, Payman Zamani, Edo Y. Birati
Summary: Peak oxygen consumption during exercise (peak Vo(2)) is a significant prognostic marker for long-term survival after heart transplantation. Each standard deviation increase in post-transplant percent predicted peak Vo(2) (%Vo(2)) is associated with a 32% decrease in mortality. A %Vo(2) below 29%, 64%, and 88% predicted less than 80% survival at 5, 10, and 15 years, respectively.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Rabiah Al-qudah, Ching Y. Suen
Summary: The research utilized deep neural networks to train on a synthetic blood smears dataset to classify different white blood cell and platelet subtypes, achieving high accuracy. Moreover, an Enhanced Incremental Training scheme was proposed for training deep networks, which improved classification accuracy significantly.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Analytical
Luis Vogado, Rodrigo Veras, Kelson Aires, Flavio Araujo, Romuere Silva, Moacir Ponti, Joao Manuel R. S. Tavares
Summary: This article introduces a convolutional neural network named LeukNet, trained on 18 image datasets with an accuracy of 98.61%. Cross-dataset experiments show that our method has better generalization ability and outperforms current state-of-the-art methods.
Article
Veterinary Sciences
Lilani I. Munasinghe, Beverly A. Kidney, Valerie MacDonald-Dickinson, Victoria S. Larson, Marion L. Jackson, Nicole J. Fernandez
VETERINARY CLINICAL PATHOLOGY
(2015)
Article
Education, Scientific Disciplines
Amy L. Warren, Tyrone L. Donnon, Catherine R. Wagg, Heather Priest, Nicole J. Fernandez
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2018)
Article
Education, Scientific Disciplines
Nicole J. Fernandez, Catherine R. Wagg, Amy L. Warren
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2018)
Article
Veterinary Sciences
K. Koblinger, K. Hecker, J. Nicol, A. Wasko, N. Fernandez, R. Leguillette
EQUINE VETERINARY JOURNAL
(2014)
Article
Veterinary Sciences
J. Chisholm, D. De Rantere, N. J. Fernandez, A. Krajacic, D. S. J. Pang
LABORATORY ANIMALS
(2013)
Article
Veterinary Sciences
Nicole J. Fernandez, Jennifer L. Davies, Jose Diaz, Tim Spotswood
VETERINARY CLINICAL PATHOLOGY
(2013)
Article
Veterinary Sciences
Nicole J. Fernandez, Kent G. Hecker, Cornelia V. Gilroy, Amy L. Warren, Renaud Leguillette
VETERINARY CLINICAL PATHOLOGY
(2013)
Article
Veterinary Sciences
Nicole J. Fernandez, Cornelia Gilroy, Catherine R. Wagg, Grace P. S. Kwong, Marie-France Roy
VETERINARY CLINICAL PATHOLOGY
(2019)
Article
Education, Scientific Disciplines
Nicole J. Fernandez, Marina Fischer, Hilary Burgess, Benjamin W. Elwood, Ryan M. Dickinson, Melissa Meachem, Amy L. Warren
Summary: The results of this study suggest that arts-based training may improve student observational skills, particularly in describing art images.
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2021)
Article
Education, Scientific Disciplines
Nicole J. Fernandez, Ryan M. Dickinson, Hilary Burgess, Melissa Meachem
Summary: This study investigated the Tolerance of Ambiguity (TOA) in veterinary students using the TAVS scale, revealing a significant increase in TOA across the clinical pathology course. The findings suggest that students are being taught and learning how to cope with ambiguity through real-life cases used in teaching. However, there was no correlation found between TOA and final course grades.
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2021)
Article
Education, Scientific Disciplines
Nicole J. Fernandez, Marina Fischer, Ryan M. Dickinson, Hilary Burgess, Melissa Meachem, Benjamin W. Elwood, Amy L. Warren
Summary: The study compared fine arts-based and pathology-based observation training in a veterinary cytology course, finding that pathology-based training led to better cytology descriptions immediately after training. Both types of training improved observational skills, but explicit observation training may be more beneficial for veterinary students.
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2022)
Editorial Material
Veterinary Sciences
Sheena W. Wong, Nicole J. Fernandez, Kevin Cosford, Anthony P. Carr
VETERINARY CLINICAL PATHOLOGY
(2022)
Article
Veterinary Sciences
Arefeh Ravanbakhsh, Khawaja Ashfaque Ahmed, Valerie MacDonald-Dickinson, Nicole J. Fernandez, Melissa D. Meachem, Ryan M. Dickinson
Summary: The study demonstrates reduced neutrophil oxidative burst and phagocytic activity in dogs with lymphoma and non-lymphoma malignancies following chemotherapy treatment. However, there is no significant correlation between neutrophil numbers and function.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2021)
Article
Veterinary Sciences
Nicole J. Fernandez, Marie-France Roy
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2019)