Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Pharmacology & Pharmacy
Daniel Kwon, Zhengxing Zhang, Jutta Zeisler, Hsiou-Ting Kuo, Kuo-Shyan Lin, Francois Benard
Summary: The study developed a radiotracer [Ga-68]Ga-BL31 targeting CXCR4, which showed lower kidney retention and excellent imaging contrast, making it suitable for PET imaging and radioligand therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Domenico Albano, Francesco Dondi, Matteo Bauckneht, Manuela Albertelli, Rexhep Durmo, Angelina Filice, Annibale Versari, Silvia Morbelli, Alfredo Berruti, Francesco Bertagna
Summary: This study combined [Ga-68]-DOTA-peptides and [F-18]FDG-PET/CT findings to differentiate typical and atypical pulmonary carcinoids and investigate their prognostic role. The dual-tracer analysis effectively distinguished tumor types and had prognostic implications for patient outcomes.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Daniel Kwon, Jerome Lozada, Zhengxing Zhang, Jutta Zeisler, Richel Poon, Chengcheng Zhang, Aron Roxin, Kuo-Shyan Lin, David Perrin, Francois Benard
Summary: C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancer and plays a role in metastasis and poor prognosis. Two new radiotracers, BL08 and BL09, demonstrate high tumor uptake and visualization, showing potential for CXCR4-targeted PET imaging with improved contrast ratios compared to existing radioligands.
MOLECULAR PHARMACEUTICS
(2021)
Review
Oncology
Jordan Eber, Cyrille Blondet, Clara Le Fevre, Isabelle Chambrelant, Fabrice Hubele, Olivier Morel, Delphine Antoni, Georges Noel
Summary: Radiotherapy can unintentionally expose the heart to radiation, leading to cardiac damage. Early detection and monitoring of radiation-induced heart disease are crucial, and nuclear medicine imaging techniques show promise in detecting subclinical effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ian Alberts, Jan-Niklas Huenermund, Christos Sachpekidis, Clemens Mingels, Viktor Fech, Karl Peter Bohn, Axel Rominger, Ali Afshar-Oromieh
Summary: Digital PET/CT demonstrated a higher detection rate for pathological lesions compared with analogue PET/CT, with an improved true-positive rate and without increased diagnostic uncertainty, rate of non-specific lesions, or reduced interrater reliability.
EUROPEAN RADIOLOGY
(2021)
Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Article
Immunology
Matthew F. L. Parker, Marina Lopez-Alvarez, Aryn A. Alanizi, Justin M. Luu, Ilona Polvoy, Alexandre M. Sorlin, Hecong Qin, Sanghee Lee, Sarah J. Rabbitt, Priamo A. Pichardo-Gonzalez, Alvaro A. Ordonez, Joseph Blecha, Oren S. Rosenberg, Robert R. Flavell, Joanne Engel, Sanjay K. Jain, Michael A. Ohliger, David M. Wilson
Summary: The study compared the performance of PET radiotracers in a rat model of VDO. [11C]PABA and [18F]FDS were evaluated for their ability to distinguish Staphylococcus aureus, the most common non-tuberculous pathogen in VDO, from Escherichia coli.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ioannis D. Apostolopoulos, Nikolaos D. Papathanasiou, Dimitris J. Apostolopoulos, George S. Panayiotakis
Summary: This paper reviews recent applications of Generative Adversarial Networks (GANs) in Positron Emission Tomography (PET) imaging. It extensively describes GAN architectures and their various applications in PET imaging, and presents a hundred articles addressing PET imaging applications such as attenuation correction, de-noising, scatter correction, removal of artefacts, image fusion, high-dose image estimation, super-resolution, segmentation, and cross-modality synthesis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Silvia Valtorta, Denise Toscani, Martina Chiu, Andrea Sartori, Angela Coliva, Arianna Brevi, Giuseppe Taurino, Matteo Grioni, Livia Ruffini, Federica Vacondio, Franca Zanardi, Matteo Bellone, Rosa Maria Moresco, Ovidio Bussolati, Nicola Giuliani
Summary: The study investigated the potential use of Gln as a PET tracer in MM, validating [F-18](2S,4R)-4-FGln as a new PET tracer in preclinical models, providing a rationale for designing studies in MM patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Pierpaolo Alongi, Alessandro Stefano, Albert Comelli, Alessandro Spataro, Giuseppe Formica, Riccardo Laudicella, Helena Lanzafame, Francesco Panasiti, Costanza Longo, Federico Midiri, Viviana Benfante, Ludovico La Grutta, Irene Andrea Burger, Tommaso Vincenzo Bartolotta, Sergio Baldari, Roberto Lagalla, Massimo Midiri, Giorgio Russo
Summary: By analyzing the textural features of [F-18]FDG PET/CT images, radiomics models can be proposed to predict disease progression and survival outcome in metastatic colorectal cancer patients.
APPLIED SCIENCES-BASEL
(2022)
Review
Oncology
Xing Ma, Ying Ding, Wenliang Li, Qiang Li, Hui Yang
Summary: Gastrointestinal (GI) cancers are the second leading cause of cancer related deaths worldwide. Neuroendocrine neoplasms (NENs) are rare tumors that originate from peptidergic neurons and neuroendocrine cells, and are difficult to diagnose at earlier stages due to their wide anatomical distribution and complex clinical features. Nuclear medicine imaging techniques, which rely on the tissue-specific uptake of radiolabeled tracers, can easily identify NENs tissues and have emerged as a promising tool for diagnosis and treatment. The somatostatin receptor (SSTR), frequently expressed in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), is a potential target for tumor-targeted therapies and radiography.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ana Carolina do A. H. de Souza, Hendrik J. Harms, Laurel Martell, Courtney Bibbo, Meagan Harrington, Kyle Sullivan, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Marie Foley Kijewski, Mi-Ae Park, Alejandro Meretta, Christopher Breault, Nathaniel Roth, Alexis Poitrasson-Riviere, Prem Soman, Grant T. Gullberg, Marcelo F. Di Carli
Summary: This study aimed to validate the accuracy of Tc-99m-sestamibi SPECT in quantifying MBF and MFR, as well as evaluate its reproducibility. The results showed that using splines in SPECT imaging improved the correlation with N-13-ammonia positron emission tomography and demonstrated good test/retest reproducibility.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Engineering, Biomedical
Abhijit J. Chaudhari, Ramsey D. Badawi
Summary: Nuclear medical imaging devices are typically optimized for whole-body imaging, but application-specific devices with superior technical characteristics have shown promise for organ imaging in niche applications. Efforts are needed to overcome design limitations and gather data to define the clinical value of these devices.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
