Review
Pharmacology & Pharmacy
Roshana Saghafian Larijani, Nazanin Shabani Ravari, Navid Goodarzi, Shahram Akhlaghpour, Samaneh Saghafian Larijani, Mohammad Reza Rouini, Rassoul Dinarvand
Summary: Primary liver cancer is the fourth most common cause of cancer-related mortality worldwide, with hepatocellular carcinoma being the most prevalent histological type. Among various therapeutic options, transarterial chemoembolization is an efficient option for patients with intermediate stage HCC. Different embolic materials used in the TACE procedure have their own pros and cons.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ying He, Wangchun Lin, Zhongjie Cai, Yufan Huang, Maojin You, Meisheng Lei, Ruijia Chen
Summary: Results from this study suggest that the combination of TACE and lenvatinib is a cost-effective treatment option for patients with advanced HCC compared to lenvatinib alone, from the perspective of the Chinese healthcare system. However, the cost-effectiveness may vary in low-income provinces in China.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Miao-Ling Chen, Chun-Xue Wu, Jian-Bo Zhang, Hao Zhang, Yuan-Dong Sun, Shi-Lin Tian, Jian-Jun Han
Summary: The study found that HCC patients who received metformin treatment had better overall survival and progression-free survival. Metformin use, BCLC stage, and BMI were independent predictors of OS. PSM analysis showed that the metformin group had longer median OS and PFS compared to the non-metformin group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Hamzah Adwan, Moath Adwan, Thomas J. Vogl
Summary: Image-guided interventional treatments play an important role in treating HCC. Percutaneous thermal ablation is suitable for early-stage HCC, and transarterial therapies are recommended for intermediate-stage HCC. This study found that the combination therapy of bland lipiodol-based transarterial embolization (TAE) and microwave ablation (MWA) had better survival rates compared to MWA alone in treating HCC.
Article
Medicine, Research & Experimental
Tamas Benkoe, Julia Koenig, Jens M. Theysohn, Clemens Schotten, Fuat H. Saner, Juergen Treckmann, Sonia Radunz
Summary: This study compared the recurrence of HCC after liver transplantation following TACE or radioembolization bridging treatment. The results showed no significant difference in HCC recurrence and overall survival between the radioembolization group and TACE group. Multivariable analysis found recipient age, gender, tumor necrosis, and microvascular invasion to be associated with HCC recurrence.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Philippe Icard, Luca Simula, Zherui Wu, Diana Berzan, Philippe Sogni, Anthony Dohan, Raphael Dautry, Antoine Coquerel, Hubert Lincet, Mauro Loi, David Fuks
Summary: Hepatocellular carcinoma is the third leading cause of cancer death in men globally, with poor prognosis and limited sensitivity to conventional treatments. Targeting the Warburg effect to increase drug delivery into tumors may improve treatment effectiveness.
DRUG RESISTANCE UPDATES
(2021)
Review
Oncology
Wei Zhang, Zhangkan Huang, Xu Che
Summary: This study compared the outcomes of emergency hepatectomy (EH) and delayed hepatectomy (DH) following transarterial embolization (TAE) in patients with spontaneously ruptured hepatocellular carcinoma (HCC). The results showed that DH patients had a lower in-hospital mortality rate compared to EH patients. There were no significant differences in postoperative complications, recurrence, peritoneal metastasis, and survival rates between the two treatment groups.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jibing Liu, Zhijuan Wu, Jianxin Zhang, Yinfa Xie, Peng Sun, Huiyong Wu, Xu Chang, Lin Zhang, Fengyong Liu
Summary: This study found that the combination of TACE and PSE in treating HCC patients was effective, with the PSE group showing better survival outcomes compared to the N-PSE group, especially for patients with severe hypersplenism.
Article
Oncology
Derek Manas, Jon K. Bell, Stuart Mealing, Heather Davies, Hannah Baker, Hayden Holmes, Richard A. Hubner
Summary: The study suggests that TheraSphere treatment may be a potentially cost-effective option for patients with early to intermediate stage HCC, with TheraSphere patients predicted to gain more QALYs compared to other treatments. The base case ICERs for TheraSphere were 17,300 pound, 17,279 pound and 23,020 pound per QALY gained compared to TAE, cTACE and DEB-TACE, respectively.
Article
Pharmacology & Pharmacy
Jin Woo Choi, Song Yi Lee, Eun Ju Cho, Da In Jeong, Dae-Duk Kim, Hyo-Cheol Kim, Hyun-Jong Cho
Summary: In this study, CO2 gas generating PLGA microspheres loaded with tanespimycin were designed for rapid drug release in the treatment of hepatocellular carcinoma. By incorporating sodium bicarbonate into the microspheres, immediate release of the drug in response to hypoxia was achieved, leading to higher antiproliferative and apoptotic effects in cancer cells. The use of these microspheres in transarterial chemoembolization resulted in complete therapeutic response in tumor-bearing rats.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Gastroenterology & Hepatology
Nitipon Simasingha, Wasu Tanasoontrarat, Torpong Claimon, Supatsri Sethasine
Summary: The combination therapy of dexamethasone and N-acetylcysteine can effectively prevent post-embolization syndrome and liver decompensation in patients with intermediate-stage hepatocellular carcinoma undergoing transarterial chemoembolization. This combination therapy significantly reduces the occurrence of post-embolization syndrome without inducing liver decompensation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Guoliang Shao, Jingwen Wang, Xiaoying Zhou, Guojun Sun, Zuojun Dong
Summary: This study conducted a cost-effectiveness analysis of drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) and conventional transcatheter arterial chemoembolization (cTACE) for the treatment of hepatocellular carcinoma (HCC) in China. The results showed that DEB-TACE is more cost-effective than cTACE for HCC patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Polymer Science
Hui-Wen Chan, Yi-Hsuan Lo, Deng-Yuan Chang, Jia-Je Li, Wen-Yi Chang, Chih-Hao Chen, Chih-Hsien Chang, Chuan-Lin Chen, Hsin-Ell Wang, Ren-Shyan Liu, Chun-Yi Wu
Summary: This study successfully developed radiometal-labeled chitosan microspheres (In-111/Lu-177-DTPA-CMS) for transarterial radioembolization (TARE) treatment of hepatocellular carcinoma (HCC). The results demonstrated that Lu-177-DTPA-CMS effectively reduced the size of hepatoma and showed potential as a superior theranostic pair for clinical hepatoma treatment.
Review
Oncology
Joseph W. Franses, Andrew X. Zhu
Summary: Hepatocellular carcinoma is a deadly malignancy and a growing cause of cancer-related deaths worldwide. Although curative surgical resection is the standard treatment for eligible patients, most patients experience recurrence within five years after surgery.
CLINICAL CANCER RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Wu, Julius Chapiro, Ajay Malhotra
Summary: Through cost-effectiveness evaluation of different tumor imaging response criteria in hepatocellular carcinoma patients, the study demonstrates qEASL to be the most cost-effective assessment criterion, leading to substantial cost savings compared to RECIST and mRECIST.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2021)
Article
Peripheral Vascular Disease
Brendan C. Cline, Adam Zuchowski, Shawn M. Gage, Jonathan G. Martin, James Ronald, Kevin W. Southerland, Jeffrey H. Lawson, Ellen D. Dillavou, Charles Y. Kim
Summary: This study assessed the feasibility and outcomes of HeRO graft insertion across stent interstices. The results showed high technical success rate and patency rate, providing an effective vascular access for upper extremity patients.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisabeth Seyferth, Rui Dai, James Ronald, Jonathan G. Martin, Alan A. Sag, Nicholas Befera, Waleska M. Pabon-Ramos, Paul Suhocki, Tony P. Smith, Charles Y. Kim
Summary: This study aimed to assess the ischemic adverse events following particle embolization as a second-line treatment for acute lower gastrointestinal bleeding (LGIB). The results showed a clinical success rate of 68.9% and an ischemia-related adverse events rate of 5.3% for particle embolization.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
James H. Helzberg, Alice Parish, Donna Niedzwiecki, Charles Y. Kim, Yuval A. Patel, Julius M. Wilder, Andrew J. Muir
Summary: This study aimed to identify predictors of mortality following the TIPS procedure, with a specific focus on race and ethnicity. The findings suggest significant racial disparities in in-hospital outcomes, with black patients experiencing higher mortality rates and longer hospital stays.
BMJ OPEN GASTROENTEROLOGY
(2022)
Review
Surgery
Jeremy M. Sharib, John M. Creasy, Benjamin Wildman-Tobriner, Charles Kim, Hope Uronis, Shiaowen David Hsu, John H. Strickler, Sepideh Gholami, Michael Cavnar, Ryan P. Merkow, Peter Kingham, Nancy Kemeny, Sabino Zani, William R. Jarnagin, Peter J. Allen, Michael D'Angelica, Michael E. Lidsky
Summary: This review provides a comprehensive guide to the implantation of HAI pump, including common technical pitfalls and their solutions. It also discusses the identification and management of common postoperative complications. Early identification and aggressive intervention can rescue the majority of patients from complications, ensuring safe and effective delivery of HAI therapy.
Article
Gastroenterology & Hepatology
Zachary Spiritos, Anthony Horton, Alice Parish, Donna Niedzwiecki, Geargin Wilson, Charles Y. Kim, Daniel Wild
Summary: Acute gastrointestinal bleeding is a common reason for emergency department visits and hospital admissions. CT angiography (CTA) has become an important tool in evaluating acute GI bleeding. This study aimed to identify patient and clinical characteristics that predict CTA results. The results showed that a drop in hemoglobin from baseline was significantly associated with a positive CTA.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
James Ronald, Branten Page, Charles Y. Kim, Chandler A. Long
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Review
Oncology
Dimitrios Moris, Manisha Palta, Charles Kim, Peter J. Allen, Michael A. Morse, Michael E. Lidsky
Summary: Intrahepatic cholangiocarcinoma (ICC) is a common primary liver tumor, and the choice of treatment depends on the patient's condition. Doublet chemotherapy with gemcitabine and cisplatin has been the most effective first-line regimen, but triplet regimens and immunotherapy may also be effective. Combining systemic therapy with locoregional therapies and molecular targeted therapy have been developed to improve the treatment outcomes. Recent data showed that combining durvalumab with standard cytotoxic therapy improved survival in ICC patients.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alan A. Sag, William A. L. Sperduto, William Eward, James Ronald, Haley Davis, Xiaoyin Sara Jiang, David S. Enterline, Julia Visgauss, Brian Brigman, C. Rory Goodwin, Yawar J. Qadri, Charles Y. Kim
Summary: In radiofrequency ablation, the presence of metal instrumentation does not significantly affect the temperature of the ablation zone or non-target tissue.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
James Ronald, Charles Y. Kim, Meghana Konanur, Rui Dai, Nicholas Befera, James Knutson, Brendan C. Cline
Summary: This study describes a technique to create a coaxial, self-expanding stent graft inside a constraining, bare-metal, balloon-expandable stent. The key steps are performed on a back table and the resulting construct is deployed using standard unsheathing maneuvers. The study shows that this technique can effectively reduce the diameter of transjugular intrahepatic portosystemic shunt (TIPS), increase the portosystemic pressure gradient, and improve hepatic encephalopathy.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Peripheral Vascular Disease
Theodore H. Yuo, Charles Y. Kim, Dheeraj K. Rajan, Vandana D. Niyyar, Marianna Murea, Ellen D. Dillavou, Peter R. Bream, Lesley C. Dinwiddie, Stephen E. Hohmann, Karen Woo, Tushar Vachharajani, Cynthia Roberts, Christie Gooden, George W. J. Wright, Andrew J. Hogan, Nicole C. Ferko, Erin Kahle, Diana Clynes, Charmaine E. Lok
Summary: This study aimed to develop a cosmesis scale to evaluate the cosmetic appearance of hemodialysis arteriovenous accesses. The scale, developed through a modified Delphi process, consists of two components for clinicians and patients to assess various aspects of AV access appearance. The findings suggest that cosmesis is an important factor in the experience of ESKD patients.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Buchholz, Brendan C. Cline, Jonathan G. Martin, Charles Y. Kim, James Ronald
Summary: This study compared the diagnostic accuracy and adverse event rates of intravascular ultrasound-guided transvenous biopsy (TVB) with computed tomography-guided percutaneous needle biopsy (PNB) for retroperitoneal lymph nodes. The results showed that both methods had similar diagnostic accuracy and adverse event rates, indicating that intravascular ultrasound-guided TVB may be as safe and effective as conventional biopsy approaches.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Rui Dai, Charles Y. Kim, Debra L. Sudan, Scott S. Perkins, James W. Tamas, Paul V. Suhocki
CLINICAL ENDOSCOPY
(2023)
Letter
Cardiac & Cardiovascular Systems
Vikram F. Gupta, G. Chad Hughes, Tony P. Smith, Charles Y. Kim
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vikram F. Gupta, Andre Agassi, Jonathan G. Martin, Brendan C. Cline, Charles Y. Kim, James Ronald
Summary: Using intravascular ultrasound (IVUS) guidance during transjugular intrahepatic portosystemic shunt (TIPS) creation can result in reduced laboratory evidence of acute liver injury. IVUS cases had lower CTCAE grades on postprocedural day 1, fewer adverse events, and a higher likelihood of discharge on postprocedural day 1.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)