Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology

An optogenetics- and imaging-assisted simultaneous multiple patch-clamp recording system for decoding complex neural circuits

(2015) Guangfu Wang et al.   Nature Protocols

Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

(2014) Jinsoo Seo et al.   CELL

Canonical Organization of Layer 1 Neuron-Led Cortical Inhibitory and Disinhibitory Interneuronal Circuits

(2014) Alice J. Lee et al.   CEREBRAL CORTEX

Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model

(2014) C.-S. Lim et al.   GENES & DEVELOPMENT

Memory Enhancement by Targeting Cdk5 Regulation of NR2B

(2014) Florian Plattner et al.   NEURON

The organization of two new cortical interneuronal circuits

(2013) Xiaolong Jiang et al.   NATURE NEUROSCIENCE

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Mammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures

(2013) H. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder

(2012) K. R. Myers et al.   JOURNAL OF NEUROSCIENCE

The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of Cdk5

(2012) Yi-Rong Peng et al.   NEUROPHARMACOLOGY

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

The Structure and Function of the Eukaryotic Ribosome

(2012) D. N. Wilson et al.   Cold Spring Harbor Perspectives in Biology

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

Utility of Combinations of Biomarkers, Cognitive Markers, and Risk Factors to Predict Conversion From Mild Cognitive Impairment to Alzheimer Disease in Patients in the Alzheimer's Disease Neuroimaging Initiative

(2011) Jesus J. Gomar   ARCHIVES OF GENERAL PSYCHIATRY

Cyclin-Dependent Kinase 5 Activator p25 Is Generated During Memory Formation and Is Reduced at an Early Stage in Alzheimer's Disease

(2011) Olivia Engmann et al.   BIOLOGICAL PSYCHIATRY

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

(2011) Jing Wu et al.   CELL

Hippocampal long-term depression is enhanced, depotentiation is inhibited and long-term potentiation is unaffected by the application of a selective c-Jun N-terminal kinase inhibitor to freely behaving rats

(2011) Honghong Yang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity

(2011) Ananya Mitra et al.   NATURE NEUROSCIENCE

Cdk5: a multifaceted kinase in neurodegenerative diseases

(2011) Zelda H. Cheung et al.   TRENDS IN CELL BIOLOGY

Outcome over seven years of healthy adults with and without subjective cognitive impairment

(2010) Barry Reisberg et al.   Alzheimers & Dementia

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease

(2010) C. R. Jack et al.   BRAIN

Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation

(2010) Danielle M Evers et al.   NATURE NEUROSCIENCE

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

(2010) Rita J. Guerreiro et al.   NEUROBIOLOGY OF AGING

CDK5 Serves as a Major Control Point in Neurotransmitter Release

(2010) Sung Hyun Kim et al.   NEURON

Ras and Rap Signaling in Synaptic Plasticity and Mental Disorders

(2010) Ruth L. Stornetta et al.   NEUROSCIENTIST

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

(2009) Binggui Sun et al.   Cell Stem Cell

The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors

(2009) N. Nadif Kasri et al.   GENES & DEVELOPMENT

Amyloid beta from axons and dendrites reduces local spine number and plasticity

(2009) Wei Wei et al.   NATURE NEUROSCIENCE

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

Activity Patterns Govern Synapse-Specific AMPA Receptor Trafficking between Deliverable and Synaptic Pools

(2009) Anders Kielland et al.   NEURON

The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses

(2008) Gina G. Turrigiano   CELL

Ras Signaling Mechanisms Underlying Impaired GluR1-Dependent Plasticity Associated with Fragile X Syndrome

(2008) H. Hu et al.   JOURNAL OF NEUROSCIENCE

Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid- -Mediated Cortical Synaptic Dysfunction

(2008) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity

(2008) Daniel P. Seeburg et al.   NEURON