Review
Pharmacology & Pharmacy
Shahin Shams, Joseph M. Martinez, John R. D. Dawson, Juan Flores, Marina Gabriel, Gustavo Garcia, Amanda Guevara, Kaitlin Murray, Noah Pacifici, Maxemiliano V. Vargas, Taylor Voelker, Johannes W. Hell, Judith F. Ashouri
Summary: Rheumatoid arthritis is a debilitating autoimmune disease with serious consequences, and despite advancements in treatment, many patients still have inadequate response or intolerable side effects. New pharmacological treatments and bioengineering approaches are being explored to improve therapy for this systemic autoimmune disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Wenxuan Ren, Lei Zhao, Ying Sun, Xichang Wang, Xiaoguang Shi
Summary: HMGB1 and TLRs play crucial roles in autoimmune diseases, and their upregulation is associated with the occurrence and development of these diseases. Inhibiting the functions of HMGB1 and TLRs can suppress the progression of inflammation, making them important therapeutic targets for autoimmune diseases.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Honghong Duan, Zhengrong Jiang, Lijun Chen, Xuefeng Bai, Huiyao Cai, Xinna Yang, Huibin Huang
Summary: The novel TSHR-CAR-T therapy has demonstrated the ability to recognize and eliminate TRAb-producing B lymphocytes, offering a promising immunotherapeutic approach for antibody-mediated autoimmune diseases including GD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Manqiqige Su, Chongbo Zhao, Sushan Luo
Summary: This study reviewed the developments of CAR-based therapies in autoimmune diseases and provided future perspectives on optimizing the performance of CAR-based therapies.
AUTOIMMUNITY REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Karin Fetter, Markus Weigel, Benjamin Ott, Moritz Fritzenwanker, Sebastian Stricker, Jan de Laffolie, Torsten Hain
Summary: Dysbiosis of the gut microbiome and pathological immune response contribute to the development of Crohn's disease, and genetic mutations play an important role. Environmental factors can influence the composition of the gut microbiome, and therapeutic approaches aim to modulate microbial composition and increase species diversity.
Review
Biochemistry & Molecular Biology
Ju Hun Suh, Hyeon Su Joo, Eun Be Hong, Hyeon Ji Lee, Jung Min Lee
Summary: Exosomes, as an advanced therapeutic strategy for treating an overactive immune system, are gaining attention and have the potential to be applied in the treatment of various inflammatory and autoimmune diseases, showing promising prospects for the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rouven Schulz, Medina Korkut-Demirbas, Gloria Colombo, Sandra Siegert
Summary: This study introduces a chemogenetic approach to study G protein-coupled receptors (GPCRs) by designing GPCR chimeras that can mimic the functions of the target receptors without knowing their immediate ligands. The researchers demonstrate the successful use of this approach in studying the beta 2-adrenergic receptor in microglia and its role in inflammation. The results show that the chimeric receptors exhibit similar responses to the endogenous receptors in terms of signaling pathways and cellular processes. This new approach allows for the investigation of cell type-specific pathways without the need for known ligands.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Roshini Fernando, Oshadi Caldera, Terry J. Smith
Summary: Thyroid-associated ophthalmopathy (TAO) is a disfiguring and potentially blinding autoimmune component of Graves' disease, driven by autoantibodies targeting the TSHR/IGF-IR complex. Teprotumumab, an anti-IGF-IR inhibitor, attenuates expressions of MHC II and B7 proteins in CD34(+) fibrocytes, potentially by reducing gene transcriptional activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
Jeffrey L. Cummings, M. Isabel Gonzalez, Martyn C. Pritchard, Patrick C. May, Leticia M. Toledo-Sherman, Glenn A. Harris
Summary: Tauopathies are neurodegenerative disorders characterized by the aggregation of tau protein. There are currently no effective treatments, but several drug candidates are in clinical trials and there is evidence that therapeutic approaches may slow disease progression or improve symptoms.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Marta Sidoryk-Wegrzynowicz, Lidia Struzynska
Summary: Multiple sclerosis is an autoimmune inflammatory disease of the central nervous system that leads to progressive disability of patients. Glial cells and P2X7 receptors play crucial roles in the inflammatory reaction in the pathological process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Juan L. Paris, Alejandro Baeza
Summary: Nano- and microparticles have attracted attention for delivering therapeutic molecules, particularly in their interaction with the immune system. Selective targeting towards specific cell types and controlled co-delivery of active molecules using these particles can lead to the development of various therapeutic strategies for different pathological scenarios.
Review
Immunology
Le Han, Lingling Zhang
Summary: CCR7 is a receptor expressed on various cells and its interaction with CCL21 plays a crucial role in cell migration. The CCL21/CCR7 axis is strongly associated with disease severity in autoimmune diseases. Disrupting the interaction between CCL21 and CCR7 could reduce cell migration and alleviate disease severity. This review highlights the importance of the CCL21/CCR7 axis as a potential therapeutic target for autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jake Burton, Jesus A. Siller-Farfan, Johannes Pettmann, Benjamin Salzer, Mikhail Kutuzov, P. Anton van der Merwe, Omer Dushek
Summary: Chimeric antigen receptors (CARs) have lower sensitivity to antigens presented on antigen-presenting cells (APCs) compared to T cell receptors (TCR), but nearly identical sensitivity to purified protein antigens. Engaging CD2 or LFA-1 can significantly improve TCR sensitivity, but has minimal effect on CAR sensitivity. Fusion of CAR variable domains to the TCR CD3 epsilon subunit (TRuC) or exchanging TCR alpha beta variable domains for those of the CAR (STAR or HIT) can partially or fully restore antigen sensitivity, respectively, by enhancing their ability to exploit CD2 and LFA-1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Endocrinology & Metabolism
Andrea Lora Kossler, Raymond Douglas, Chrysoula Dosiou
Summary: Thyroid eye disease (TED) is a sight-threatening autoimmune condition with limited treatment options. However, targeted biologic therapies, such as teprotumumab, have emerged as effective alternatives to traditional steroid regimens. Collaborative efforts between endocrinologists and ophthalmologists in developing personalized treatment plans can enhance safety and outcomes for TED patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Rebecca F. Budgett, Geor Bakker, Eugenia Sergeev, Kirstie A. Bennett, Sophie J. Bradley
Summary: This article discusses the potential of mGlu(5) as a therapeutic target for neurodegenerative diseases and its role in neuroinflammatory responses, providing new possibilities for the treatment of neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Allison E. Fetz, Marko Z. Radic, Gary L. Bowlin
Summary: The study showed that modulation of IgG adsorption can increase or decrease the release of NETs by neutrophils, indicating a functional link between IgG and NET formation. The release of NETs induced by electrospun biomaterials is largely regulated by IgG adsorption, engagement of Fc gamma RIIIb, and signaling through TAK1.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Maximilian Ackermann, Hans-Joachim Anders, Rostyslav Bilyy, Gary L. Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andres Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J. Kaplan, Jason S. Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A. Manfredi, Christian Maueroeder, Norma Maugeri, Ioannis Mitroulis, Luis E. Munoz, Teluguakula Narasaraju, Elisabeth Naschberger, Indira Neeli, Lai Guan Ng, Marko Z. Radic, Konstantinos Ritis, Patrizia Rovere-Querini, Mirco Schapher, Christine Schauer, Hans-Uwe Simon, Jeeshan Singh, Panagiotis Skendros, Konstantin Stark, Michael Stuerzl, Johan van der Vlag, Peter Vandenabeele, Ljubomir Vitkov, Maren von Koeckritz-Blickwede, Cansu Yanginlar, Shida Yousefi, Alexander Zarbock, Georg Schett, Martin Herrmann
Summary: SARS-CoV-2 infection poses a major threat to multiple organs, with severe cases showing dysregulated immune responses. The imbalance between neutrophil extracellular trap (NET) formation and degradation plays a central role in the pathophysiology of severe COVID-19 cases. Therapeutic strategies targeting dysregulated NET formation or degradation may benefit severe COVID-19 patients.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Multidisciplinary Sciences
Sarah Esther Chang, Allan Feng, Wenzhao Meng, Sokratis A. Apostolidis, Elisabeth Mack, Maja Artandi, Linda Barman, Kate Bennett, Saborni Chakraborty, Iris Chang, Peggie Cheung, Sharon Chinthrajah, Shaurya Dhingra, Evan Do, Amanda Finck, Andrew Gaano, Reinhard Gessner, Heather M. Giannini, Joyce Gonzalez, Sarah Greib, Margrit Guendisch, Alex Ren Hsu, Alex Kuo, Monali Manohar, Rong Mao, Indira Neeli, Andreas Neubauer, Oluwatosin Oniyide, Abigail Elizabeth Powell, Rajan Puri, Harald Renz, Jeffrey M. Schapiro, Payton A. Weidenbacher, Rich Wittman, Neera Ahuja, Ho-Ryun Chung, Pras Jagannathan, Judith James, Peter S. Kim, Nuala J. Meyer, Kari Nadeau, Marko Radic, William H. Robinson, Upinder Singh, Taia T. Wang, E. John Wherry, Chrysanthi Skevaki, Eline T. Luning Prak, Pj Utz
Summary: In hospitalized COVID-19 patients, approximately 50% have detectable autoantibodies primarily targeting autoantigens associated with rare disorders. Additionally, a subset of autoantibodies develop de novo following SARS-CoV-2 infection.
NATURE COMMUNICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Marko Radic, Indira Neeli, Tony Marion
Summary: Cell engineering has the potential to revolutionize the treatment of previously intractable diseases, such as autoimmune diseases, by purposefully controlling cell functions through the expression of chimeric antigen receptors.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Article
Immunology
Karen B. Whittington, Amanda Prislovsky, Jacob Beaty, Lorraine Albritton, Marko Radic, Edward F. Rosloniec
Summary: By engineering an HLA-DR1 chimeric Ag receptor (CAR), researchers have produced CD8(+) CAR T cells that specifically target CD4(+) T cells in an Ag-specific manner. These CAR T cells have shown the ability to inhibit the development of autoimmune arthritis in a mouse model, suggesting their potential as a highly specific therapeutic approach for autoimmune disease.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Avtar S. Meena, Pradeep K. Shukla, Briar Bell, Francesco Giorgianni, Rebeca Caires, Carlos Fernandez-Pena, Sarka Beranova, Eitaro Aihara, Marshall H. Montrose, Mehdi Chaib, Liza Makowski, Indira Neeli, Marko Z. Radic, Valeria Vasquez, Jonathan H. Jaggar, Julio F. Cordero-Morales, RadhaKrishna Rao
Summary: Intestinal epithelial tight junction disruption is a key factor in alcohol-induced endotoxemia, systemic inflammation, and organ damage. TRPV6, a Ca2+-permeable channel, is responsible for the elevation of intracellular Ca2+, intestinal barrier dysfunction, and systemic inflammation induced by alcohol. Inhibiting or deficient TRPV6 can attenuate alcohol-induced barrier dysfunction and Ca2+ influx.
Editorial Material
Immunology
Dragana Odobasic, Clare Louise Hawkins, Marko Radic
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell Biology
Marko Radic, Sylviane Muller
Summary: Innate immunity responds to infections and inflammatory stimuli through interactions between cells, stimuli, and receptors. The endogenous peptide LL-37 plays roles as a defensin and alarmin, and has direct effects on neutrophils and extracellular traps (NETs). The structural flexibility and adaptability of LL-37 are crucial for its functions.
Article
Immunology
Ya Wang, Klaus Schughart, Tiana Maria Pelaia, Tracy Chew, Karan Kim, Thomas Karvunidis, Ben Knippenberg, Sally Teoh, Amy L. Phu, Kirsty R. Short, Jonathan Iredell, Irani Thevarajan, Jennifer Audsley, Stephen Macdonald, Jonathon Burcham, Anthony McLean, Benjamin Tang, Maryam Shojaei
Summary: This study aimed to identify specific genes and pathways underlying differences in the disease spectrum and outcomes of COVID-19 through in-depth analysis of whole blood transcriptomics in a large cohort of patients. The results showed distinct gene expression profiles between mild, moderate, and severe COVID-19 cases, with severe cases exhibiting down-regulation of adaptive immune response pathways, activation of neutrophil pathways, and activation of blood coagulation pathways. These findings provide valuable candidates for future biomarker discovery.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Marko Z. Radic, Moncef Zouali
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vasuki Silva, Marko Radic
Summary: Excessive neutrophil influx and activation during respiratory infections, such as the ongoing SARS CoV-2 pandemic, lead to the release of neutrophil extracellular traps (NETs) and granule contents that can damage lung tissues. Proteases released by neutrophils not only participate in NET release, but also facilitate viral spike protein binding and infection spread. The absence of the protease inhibitor alpha-1-antitrypsin (AAT) or mutations in the SERPINA-1 gene, which encodes AAT, contribute to lung remodeling, fibrosis, and increased susceptibility to severe COVID-19.
Letter
Medicine, General & Internal
Teluguakula Narasaraju, Amita Krishnappa, Marko Radic, Vincent T. K. Chow
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Biology
Indira Neeli, Maryam Moarefian, Jayalakshmi Kuseladass, Nishant Dwivedi, Caroline Jones, Marko Radic
Summary: The response of neutrophils to integrin engagement stimulates the activity of PAD4, leading to histone and profilin deimination, which play a crucial role in cell adhesion and chemotaxis.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Immunology
Murali K. Mamidi, Jifeng Huang, Kazuhito Honjo, Ran Li, Edlue M. Tabengwa, Indira Neeli, Nar'asha L. Randall, Manasa V. Ponnuchetty, Marko Radic, Chuen-Miin Leu, Randall S. Davis
Summary: Immunotherapeutic targeting and pharmacologic inhibition have significantly changed the approach to B cell malignancies, with FCRL1 playing a central role in B cell signaling and being overexpressed in B cell diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
