Review
Multidisciplinary Sciences
Kate Alford, Stephanie Daley, Sube Banerjee, Jaime H. Vera
Summary: Quality of life is an important endpoint in disease management, particularly in chronic conditions like HIV. Cognitive impairments have a broad impact on quality of life, but there is a lack of research in this area. Studies have found that individuals living with HIV-associated neurocognitive disorders generally have poorer quality of life.
Article
Infectious Diseases
Sven Breitschwerdt, Carolynne Schwarze-Zander, Ahmad Al Tayy, Julia Mutevelli, Jan-Christian Wasmuth, Jurgen K. Rockstroh, Christoph Boesecke
Summary: Vaccination rates among PLWH are higher compared to the general German population, but the implementation of EACS guidelines is not fully executed, emphasizing the need to improve vaccination rates.
Article
Audiology & Speech-Language Pathology
Piers Dawes, Jenna Littlejohn, Anthea Bott, Siobhan Brennan, Simon Burrow, Tammy Hopper, Emma Scanlan
Summary: Hearing impairment often occurs together with dementia, and audiologists should be prepared to meet the specific needs of people living with dementia. This review provides best practice recommendations for the assessment and rehabilitation of hearing impairment in dementia patients, while also highlighting areas for further research.
Article
Geriatrics & Gerontology
Chiaki Ura, Tsuyoshi Okamura, Mika Sugiyama, Fumiko Miyamae, Mari Yamashita, Riko Nakayama, Ayako Edahiro, Tsutomu Taga, Hiroki Inagaki, Madoka Ogawa, Shuichi Awata
Summary: As Japanese society ages, the isolation of older people and the challenges faced by people with cognitive impairment living in the community are increasing. This study found that 29.3% of people with cognitive impairment had discontinued community living three years after the baseline survey. Meeting the needs for housing support and rights protection is crucial for older individuals with cognitive impairment to continue living in the community. Both social and medical interventions are important for building age-friendly communities.
Article
Infectious Diseases
Maria Mazzitelli, Mattia Trunfio, Alessandra Coin, Lolita Sasset, Jacopo Farina, Monica Brundu, Vincenzo Scaglione, Maria Devita, Giuseppe Sergi, Anna M. Cattelan
Summary: This study investigated the clinical impact of anticholinergic burden in people with HIV. The results showed that about one-fourth of the participants were exposed to at least one anticholinergic drug, and more than one-fourth experienced anticholinergic signs or symptoms. The study also found that polypharmacy and specific comorbidities increased the risk of developing anticholinergic signs or symptoms. The assessment tools ABS and ADS performed the best in predicting the presence of anticholinergic signs or symptoms.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Pariya L. Fazeli, Amanda L. Willig, Vitor Oliveira, Thomas W. Buford, David E. Vance, Greer Burkholder, Heidi M. Crane, Christine Horvat Davey, Julia Fleming, Allison R. Webel
Summary: Middle-aged and older people living with HIV are more likely to experience cognitive impairment and engage in lower levels of physical activity than HIV-negative individuals. This study examined the association between accelerometry-measured physical activity and cognitive functioning in a sample of 75 HIV-positive individuals. The findings suggest that engaging in light physical activity, performed in bouts of at least 10 minutes, is associated with better cognitive performance. However, further research is needed to understand the dose-response associations between physical activity and cognitive trajectories, the specific effects of physical activity on different cognitive domains, and the underlying neural mechanisms.
Article
Virology
Letizia Santinelli, Giacomo Rossi, Giorgia Gioacchini, Ranieri Verin, Luca Maddaloni, Eugenio N. Cavallari, Francesca Lombardi, Alessandra Piccirilli, Stefano Fiorucci, Adriana Carino, Silvia Marchiano, Chiara M. Lofaro, Sara Caiazzo, Massimo Ciccozzi, Carolina Scagnolari, Claudio M. Mastroianni, Giancarlo Ceccarelli, Gabriella d'Ettorre
Summary: Functional and structural damage of the intestinal mucosal barrier contribute to microbial translocation in HIV-1 patients. In this study, long-term virologically suppressed HIV-1 patients underwent oral bacteriotherapy, which resulted in improvements in gut microbiota composition, mitochondrial function, and the integrity of the intestinal mucosa.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Oncology
Jose-Tomas Navarro, Jose Molto, Gustavo Tapia, Josep-Maria Ribera
Summary: HIV-infected individuals have a higher risk of developing Hodgkin lymphoma, with the presence of Epstein-Barr virus playing a crucial role in its etiology. Treatment similar to the general population, including the use of cART and chemotherapy, is recommended for optimal prognosis. Interdisciplinary collaboration between hemato-oncologists and HIV specialists is essential for the management of potential drug interactions and overlapping toxicities.
Article
Immunology
Jennifer O. Lam, Craig E. Hou, Paola Gilsanz, Catherine Lee, Alexandra N. Lea, Derek D. Satre, Michael J. Silverberg
Summary: A study conducted in the United States found a high prevalence of undiagnosed cognitive impairment among people with HIV who are receiving antiretroviral therapy. This cognitive impairment is associated with difficulties in instrumental activities of daily living (IADL).
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Philip S. Amara, Zaeema Naveed, Christopher S. Wichman, Howard S. Fox, Lorena Baccaglini
Summary: The study found a negative association between HIV-associated neurocognitive impairment (NCI) and health-related quality of life (HRQoL), particularly in terms of mental health. Besides depression, employment status also influenced this association.
Article
Clinical Neurology
Clotilde Allavena, Frederic Bastides, Anne Moroy, Stephanie Occhipinti, Francois Durand, Guillaume Barriere, Jean-Arthur Micoulaud-Franchi, Jade Ghosn
Summary: Sleep disturbances are common in people living with HIV, but their management remains insufficient. A DELPHI consensus research project was conducted in France to establish best practice. The project resulted in 24 statements reaching consensus, including recommendations for regular assessment of sleep quality and quantity, consideration of hypnotic treatment, and changing ARV administration time when necessary.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jeffrey V. Lazarus, Kelly Safreed-Harmon, Adeeba Kamarulzaman, Jane Anderson, Ricardo Baptista Leite, Georg Behrens, Linda-Gail Bekker, Sanjay Bhagani, Darren Brown, Graham Brown, Susan Buchbinder, Carlos Caceres, Pedro E. Cahn, Patrizia Carrieri, Georgina Caswell, Graham S. Cooke, Antonella d'Arminio Monforte, Nikos Dedes, Julia del Amo, Richard Elliott, Wafaa M. El-Sadr, Maria Jose Fuster-Ruiz de Apodaca, Giovanni Guaraldi, Tim Hallett, Richard Harding, Margaret Hellard, Shabbar Jaffar, Meaghan Kall, Marina Klein, Sharon R. Lewin, Ken Mayer, Jose A. Perez-Molina, Doreen Moraa, Denise Naniche, Denis Nash, Teymur Noori, Anton Pozniak, Reena Rajasuriar, Peter Reiss, Nesrine Rizk, Juergen Rockstroh, Diana Romero, Caroline Sabin, David Serwadda, Laura Waters
Summary: Despite improvements in identifying, diagnosing, treating, and achieving viral suppression among people living with HIV, many still experience a higher burden of multimorbidity and poorer health-related quality of life compared to those without HIV. Stigma and discrimination worsen these outcomes. A global multidisciplinary group of HIV experts developed a consensus statement highlighting the importance of health systems addressing key issues to provide integrated, person-centered healthcare for PLHIV throughout their lives, moving beyond the focus on viral suppression.
NATURE COMMUNICATIONS
(2021)
Article
Health Care Sciences & Services
Kate Alford, Stephanie Daley, Sube Banerjee, Elizabeth Hamlyn, Daniel Trotman, Jaime H. Vera
Summary: This study aims to contribute evidence toward an understanding of health-related quality of life (HRQoL) and identify domains of HRQoL in people living with HIV (PLWH) with cognitive impairment (CI). Seven interrelated domains of HRQoL were identified, each defined by specific descriptive components.
QUALITY OF LIFE RESEARCH
(2022)
Article
Immunology
Lea D. Keng, Alan Winston, Caroline A. Sabin
Summary: While life expectancies of people with HIV (PWH) have increased through the successes of antiretroviral treatment, cognitive impairment remains a pressing concern. This study aims to explore the heterogeneity and estimate the global cognitive impairment burden in PWH.
Review
Oncology
Mar Masia, Ana Gutierrez-Ortiz de la Tabla, Felix Gutierrez
Summary: Cancer is more prevalent and diagnosed at later stages in people with HIV, highlighting the need for personalized cancer screening strategies in HIV care settings.
Article
Health Policy & Services
E. J. Beck, S. Mandalia, P. Yfantopoulos, C. Jones, S. Bremner, D. Fatz, J. Vera, J. Whetham
Summary: The implementation of EmERGE Pathway of Care in Brighton, UK was found to be efficient for people living with medically stable HIV. The use of an App for communication between individuals and caregivers reduced outpatient visits and annual costs. However, the costs of anti-retroviral drugs remained the main component of overall costs. The extension of EmERGE to other chronic conditions could potentially result in greater efficiencies.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Review
Health Policy & Services
Adele Munsami, Anna J. Dreyer, Goodman Sibeko, Hetta Gouse, Sam Nightingale, John A. Joska
Summary: Mental health and neurocognitive functioning are important concerns for people living with HIV, but healthcare workers in Africa lack knowledge about the relationship between HIV and NCI. There is a gap in training interventions addressing NCI in Africa, and further research is needed to develop and evaluate training interventions for healthcare workers delivering HIV services in this setting.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Immunology
Angharad G. Davis, Anna J. Dreyer, Christine Albertyn, Mpumi Maxebengula, Cari Stek, Sean Wasserman, Suzaan Marais, Kathleen Bateman, Mark Solms, John Joska, Robert J. Wilkinson, Sam Nightingale
Summary: This study systematically assessed the frequency and nature of cognitive impairment in adult tuberculous meningitis patients and found that it has an impact on functioning and medication adherence.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Natalie St Clair-Sullivan, Kiersten Simmons, Richard Harding-Swale, Thomas Levett, Matthew Maddocks, Jonathan Roberts, Daniel Trotman, Deokhee Yi, Jaime H. Vera, Katherine Bristowe
Summary: This study aimed to explore the perceptions of older people living with HIV and HIV professionals towards frailty and routine screening for frailty. The study found that frailty was described as a series of losses around mobility, social inclusion, independence, and mental acuity. People living with HIV found it acceptable to explicitly use the word "frail" during screening if approached sensitively and provided with information and support. HIV professionals, on the other hand, had concerns about using the word "frail" for fear of causing distress or offense.
Article
Infectious Diseases
Tom J. Levett, Jaime H. Vera, Christopher Jones, Stephen Bremner, Agathe Leon, Josip Begovac, Ludwig Apers, Margarida Borges, Sime Zekan, Eugenio Teofilo, Felipe Garcia, Jennifer Whetham
Summary: This study aimed to evaluate frailty, falls and perceptions of ageing among clinically stable individuals with HIV who were engaged with remote healthcare delivered via a novel smartphone application. The results showed that frailty, falls and ageing dissatisfaction were uncommon but still present in this younger cohort, and were associated with pain and mood symptoms.
Article
Clinical Neurology
Andrew W. Barritt, Esther Das, Nadine Morley, Matthew Seymour, Romi Saha, Jaime Vera, Sriram Vundavalli, Sabina Dizdarevic, Richard Nicholas, Joseph R. Berger, Leonora K. Fisniku
Summary: This case describes a patient with relapsing-remitting multiple sclerosis who developed progressive multifocal leukencephalopathy (PML) after 6 years on fingolimod. The patient was treated with a combination therapy, including pembrolizumab, which showed promising results in managing PML.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Editorial Material
Clinical Neurology
Gladys Maestre, Maria Carrillo, Raj Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Kazeem Akinwande, Joshua Akinyemi, Rufus Akinyemi, Onoja Akpa, Suvarna Alladi, Ricardo Allegri, Raul Arizaga, Faheem Arshad, Oyedunni Arulogun, David Ndetei, Olusegun Baiyewu, Thomas Issac, Tarek Bellaj, Judith Boshe, Carol Brayne, David Brodie-Mends, Richard Brown, Jennifer Cahn, Nkouonlack Cyrille, Albertino Damasceno, Ranil de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Bernard Fongang, Stefania Forner, Rob Friedland, Noe Garza, Antoine Gbessemehlan, Eliza (Eleni-Zacharoula) Georgiou, Riadh Gouider, Ishtar Govia, Lea Grinberg, Maelenn Guerchet, Seid Gugssa, Joy Louise Gumikiriza-Onoria, Deborah Gustafson, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Ozama Ismail, Thomas Issac, Linus Joensson, Celestin Kaputu, Wambui Karanja, Jackline Karungi, Desire Tshala-Katumbay, Brian Kunkle, Joseph H. Lee, Iracema Leroi, Raphaella Lewis, Gill Livingston, Francisco Lopera, Kamada Lwere, Facundo Manes, Lingani Mbakile-Mahlanza, Pedro Mena, Bruce Miller, Athanase Millogo, Abdul Mohamed, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David Ndetei, Sam Nightingale, Alfred K. Njamnshi, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius Ogeng'o, Adesola Ogunniyi, Maira Okada De Oliveira, Njideka Okubadejo, Martin Orrell, Akintunde Orunmuyi, Mayowa Owolabi, Stella Paddick, Margaret A. Pericak-Vance, Zvezdan Pirtosek, Felix Potocnik, Bill Preston, Rema Raman, Kirti Ranchod, Mie Rizig, Monica Rosselli, Roy Deepa, Upal Roy, Marufjon Salokhiddinov, Mary Sano, Fred Sarfo, Claudia L. Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire Sexton, Ingmar Skoog, Peter St George-Hyslop, Claudia Suemoto, Jeremy Tanner, Prekshya Thapa, Kamadore Toure, Valentine Ucheagwu, Chinedu Udeh-Momoh, Victor Valcour, Jeffery Vance, Mathew Varghese, Jaime Vera, Richard Walker, Wendy Weidner, Walsh Sebastian, Patrice Whitehead Gay, Henrik Zetterberg, Yared Zewde
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Arish Mudra Rakshasa-Loots, Nicholas J. Bakewell, David J. Sharp, Magnus Gisslen, Henrik Zetterberg, Jasmini Alagaratnam, Ferdinand W. N. M. Wit, Neeltje A. Kootstra, Alan Winston, Peter A. Reiss, Caroline A. H. Sabin, Jaime H. Vera
Summary: People living with HIV are at increased risk for depression, and certain biomarkers of central and peripheral inflammation, such as MIG, TNF-alpha, MIP1-alpha, and IL-6, may mediate the association between HIV and depressive symptoms.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Kelly K. O'Brien, Darren A. Brown, Kiera McDuff, Natalie St Clair-Sullivan, Patricia Solomon, Soo Chan Carusone, Lisa McCorkell, Hannah Wei, Susie Goulding, Margaret O'Hara, Catherine Thomson, Niamh Roche, Ruth Stokes, Jaime H. Vera, Kristine M. Erlandson, Colm Bergin, Larry Robinson, Angela M. Cheung, Brittany Torres, Lisa Avery, Ciaran Bannan, Richard Harding
Summary: This study aimed to describe the episodic nature of disability among adults living with Long COVID. Using online semi-structured interviews and participant visual illustrations, a qualitative descriptive study was conducted. Participants were recruited through collaborator community organizations in Canada, Ireland, UK, and USA. The findings showed that disability experiences among adults living with Long COVID are characterized by fluctuations in health challenges, which may be unpredictable in nature. The results can inform healthcare and rehabilitation for individuals with Long COVID.
Article
Medicine, General & Internal
Herbert Chabwera Nyirenda, Marksman Foloko, Carolyn Bolton-Moore, Jaime Vera, Anjali Sharma
Summary: Research conducted on adolescent boys and young men in urban Lusaka highlighted the impact of gender and rural-urban disparities on their HIV testing behaviors. The study emphasizes the importance of creating targeted interventions that address the specific needs and barriers faced by this population in accessing HIV prevention and treatment services.
Article
Infectious Diseases
Kate Alford, Sube Banerjee, Stephanie Daley, Elizabeth Hamlyn, Daniel Trotman, Jaime H. Vera
Summary: This study aimed to validate and assess a comprehensive set of illness-specific health-related quality of life (HRQL) domains in people living with HIV (PLWH) with cognitive symptoms. Findings revealed poor HRQL across domains in the majority of PLWH with cognitive symptoms, providing targets for intervention development and clinical action to maintain or improve HRQL in this population.
JOURNAL OF THE INTERNATIONAL ASSOCIATION OF PROVIDERS OF AIDS CARE
(2023)