Orthogonal engineering of synthetic T cell states to enhance cancer immunotherapy

Orthogonal engineering of adoptively transferred CD8(+) T cells to co-express two cytokines - an IL-2R beta/gamma-biased IL-2 variant and the proinflammatory alarmin IL-33 - induces an exhaustion-resistant synthetic cell state with potent anti-tumor efficacy in the absence of host pre-conditioning.

Automated summary

Orthogonal engineering of adoptively transferred CD8(+) T cells to co-express two cytokines - an IL-2R beta/gamma-biased IL-2 variant and the proinflammatory alarmin IL-33 - induces an exhaustion-resistant synthetic cell state with potent anti-tumor efficacy in the absence of host pre-conditioning.