Article
Biochemistry & Molecular Biology
Tomoyuki Makino, Kouji Izumi, Hiroaki Iwamoto, Suguru Kadomoto, Atsushi Mizokami
Summary: This study aims to investigate the impact of preoperative sarcopenia and hypoalbuminemia on the survival outcome of patients with nonmetastatic renal cell carcinoma. Retrospective analysis of 288 Japanese patients at Kanazawa University Hospital revealed that the concurrent presence of sarcopenia and hypoalbuminemia was associated with shorter overall survival and metastasis-free survival.
Article
Oncology
Takeshi Tsutsumi, Kazumasa Komura, Takeshi Hashimoto, Ryu Muraoka, Naoya Satake, Tomohisa Matsunaga, Takuya Tsujino, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki, Kiyoshi Takahara, Teruo Inamoto, Yoshio Ohno, Haruhito Azuma
Summary: The study demonstrated that in Asian patients with localized RCC undergoing nephrectomy, males with higher BMI had longer cancer-specific survival rates compared to those with lower BMI, while no significant difference was observed in females.
Article
Multidisciplinary Sciences
Jose Preza-Fernandes, Pedro Passos, Miguel Mendes-Ferreira, Adriana R. Rodrigues, Alexandra Gouveia, Avelino Fraga, Rui Medeiros, Ricardo Ribeiro
Summary: Increasing evidence suggests that local fat depots play a role in cancer outcomes. This study found that increased area of perirenal adipose tissue is associated with improved progression-free survival and overall survival in renal cell carcinoma patients, which may explain the obesity paradox in this cancer type. These findings could help assess disease progression and mortality risk in renal cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Benjamin N. Schmeusser, Henry Biermann, Edouard H. Nicaise, Adil A. Ali, Dattatraya H. Patil, Eric Midenberg, Talia Helman, Manuel Armas-Phan, Reza Nabavizadeh, Shreyas S. Joshi, Vikram M. Narayan, Mehmet A. Bilen, Sarah P. Psutka, Kenneth Ogan, Viraj A. Master
Summary: This study evaluates the association between low creatinine to cystatin-C ratio (Cr/Cys-C) and overall survival (OS) and recurrence-free survival (RFS) in patients with renal cell carcinoma (RCC) treated with nephrectomy. The results suggest that low Cr/Cys-C is associated with inferior oncologic outcomes and may serve as a serum biomarker for the presence of sarcopenia in this patient population.
Article
Oncology
Qiuchen Liu, Jiajian Yang, Xin Chen, Jiakang Yang, Xiaojun Zhao, Yuhua Huang, Yuxin Lin, Jinxian Pu
Summary: Preoperative sarcopenia is significantly associated with neutrophil-to-lymphocyte ratio (NLR) in patients with renal cell carcinoma (RCC). A novel nomogram has been developed to predict overall survival (OS) and provide personalized therapeutics for RCC patients. The nomogram shows good discrimination and calibration, and performs better than other methods in prognostic prediction.
FRONTIERS IN ONCOLOGY
(2022)
Letter
Medicine, General & Internal
Aparna Sharma, Ranjit K. Sahoo, Atul Batra, Archie Bleyer, Toni K. Choueiri, Thomas Powles
Summary: Adding adjuvant pembrolizumab after nephrectomy can significantly improve disease-free survival in patients with renal-cell carcinoma, but there are concerns regarding the arbitrary duration of 12 months of adjuvant treatment. Many patients discontinued treatment due to adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyewon Choi, Young Sik Park, Kwon Joong Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Jin Mo Goo, Soon Ho Yoon
Summary: This study investigated the association between baseline adipopenia and outcomes in patients with early-stage NSCLC. The results showed that adipopenia was associated with a reduced 5-year overall survival rate, indicating a potential risk for non-cancer-related death.
Article
Surgery
Shuqiu Chen, Ting He, Si Sun, Jianping Wu, Bin Xu, Weipu Mao, Ming Chen
Summary: The aim of this study was to investigate the prognostic role of the dynamics of sarcopenia in the pre- to postoperative period for patients with renal cell carcinoma (RCC) undergoing laparoscopic nephrectomy. The study found that sarcopenia dynamics were a better predictor of overall survival (OS) and cancer-specific survival (CSS) in patients with RCC compared to pre- and postoperative sarcopenia alone, with patients in the group showing both pre- and postoperative non-sarcopenia having the best OS and CSS.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Melih Balci, Zachary A. Glaser, Sam S. Chang, S. Duke Herrell, Daniel A. Barocas, Kirk A. Keegan, Kelvin A. Moses, Matthew J. Resnick, Joseph A. Smith, David F. Penson, Kristen Scarpato, Peter E. Clark
Summary: The study investigated the relationship between gender, BMI, and prognosis in renal cell carcinoma patients. Higher BMI was associated with better overall survival and recurrence-free survival, especially in male patients. Female patients did not show a significant relationship between BMI and oncologic outcomes.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
J. S. F. Maurits, J. P. M. Sedelaar, K. K. H. Aben, L. A. L. M. Kiemeney, A. Vrieling
Summary: Higher visceral adipose tissue (VAT) and total adipose tissue (TAT) are associated with lower tumor stage in renal cell cancer (RCC), possibly due to weight loss or cancer cachexia.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Michelle I. Higgins, Dylan J. Martini, Dattatraya H. Patil, Reza Nabavizadeh, Sean Steele, Milton Williams, Shreyas S. Joshi, Vikram M. Narayan, Aarti Sekhar, Sarah P. Psutka, Kenneth Ogan, Mehmet Asim Bilen, Viraj A. Master
Summary: The study revealed that low muscle mass and markers of inflammation were associated with an increased risk of recurrence and death in patients with localized RCC after surgery.
Article
Medicine, Research & Experimental
Tomoyuki Makino, Kouji Izumi, Hiroaki Iwamoto, Suguru Kadomoto, Yoshifumi Kadono, Atsushi Mizokami
Summary: The impact of preoperative sarcopenia on the oncological outcome of surgically treated non-metastatic RCC was investigated in this study. The presence of sarcopenia was associated with larger tumor size, worse pathological tumor stage and grade, and more frequent lymphovascular invasion. Sarcopenia was found to be a significant factor indicating poor survival prognosis in patients with non-metastatic RCC treated surgically.
Article
Orthopedics
Jongjin Lee, Seong-Il Bin, Jong-Min Kim, Bum-Sik Lee, Taehyeon Jeon, Kinam Bae, Donghyok Kim
Summary: This study investigated the effect of BMI on the survivorship of lateral meniscal allograft transplantation (MAT). It found that patients with a high BMI have inferior survivorship after lateral MAT and weight loss before surgery may improve survival rates.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Abdulla A. Damluji, Maha Alfaraidhy, Noora AlHajri, Namit N. Rohant, Manish Kumar, Christina Al Malouf, Samira Bahrainy, Min Ji Kwak, Wayne B. Batchelor, Daniel E. Forman, Michael W. Rich, James Kirkpatrick, Ashok Krishnaswami, Karen P. Alexander, Gary Gerstenblith, Peggy Cawthon, Christopher R. deFilippi, Parag Goyal
Summary: Sarcopenia refers to the loss of muscle strength, mass, and function, commonly aggravated by chronic comorbidities. It is associated with faster progression of cardiovascular diseases, increased mortality risk, falls, and reduced quality of life, especially among older adults. The underlying causes of sarcopenia include an imbalance between anabolic and catabolic muscle processes, as well as neuronal degeneration.
Article
Oncology
Jongpil Lee, Jungyo Suh, Cheryn Song, Dalsan You, In Gab Jeong, Bumsik Hong, Jun Hyuk Hong, Choung Soo Kim, Hanjong Ahn
Summary: Preoperative sarcopenia in patients with organ-confined renal cell carcinoma undergoing radical nephrectomy is associated with poorer overall and cancer-specific survival rates, making it an independent risk factor for all-cause and cancer-specific mortality.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Sarah P. Psutka, Mark Heidenreich, Stephen A. Boorjian, George C. Bailey, John C. Cheville, Suzanne B. Stewart-Merrill, Christine M. Lohse, Thomas D. Atwell, Brian A. Costello, Bradley C. Leibovich, R. Houston Thompson
Review
Oncology
Sarah P. Psutka, Viraj A. Master
Article
Oncology
Roman Gulati, Todd M. Morgan, Teresa A'mar, Sarah P. Psutka, Jeffrey J. Tosoian, Ruth Etzioni
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Oncology
Adam J. Gadzinski, Sarah P. Psutka
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2020)
Editorial Material
Oncology
Sarah P. Psutka
Article
Oncology
Leonidas N. Diamantopoulos, Sarah K. Holt, Ali R. Khaki, Rishi R. Sekar, Adam Gadzinski, Yaw A. Nyame, Funda Vakar-Lopez, Maria S. Tretiakova, Sarah P. Psutka, John L. Gore, Daniel W. Lin, George R. Schade, Andrew C. Hsieh, John K. Lee, Todd Yezefski, Michael T. Schweizer, Heather H. Cheng, Evan Y. Yu, Lawrence D. True, Robert B. Montgomery, Petros Grivas, Jonathan L. Wright
Summary: The study found that the pathologic response to neoadjuvant chemotherapy was similar between micropapillary bladder carcinoma and conventional urothelial carcinoma. Although micropapillary bladder carcinoma presents with more aggressive features, it is not associated with worse outcomes compared to conventional urothelial carcinoma. Further research is needed to better understand the biological mechanisms behind the aggressive features of micropapillary bladder carcinoma and the role of neoadjuvant chemotherapy in this histological variant.
CLINICAL GENITOURINARY CANCER
(2021)
Article
Oncology
Michelle I. Higgins, Dylan J. Martini, Dattatraya H. Patil, Reza Nabavizadeh, Sean Steele, Milton Williams, Shreyas S. Joshi, Vikram M. Narayan, Aarti Sekhar, Sarah P. Psutka, Kenneth Ogan, Mehmet Asim Bilen, Viraj A. Master
Summary: The study revealed that low muscle mass and markers of inflammation were associated with an increased risk of recurrence and death in patients with localized RCC after surgery.
Editorial Material
Urology & Nephrology
Pauline Filippou, Brian Shuch, Sarah P. Psutka
Review
Urology & Nephrology
Michelle Higgins, J. Peter Marquardt, Viraj A. Master, Florian J. Fintelmann, Sarah P. Psutka
Summary: Body composition analysis (BCA) uses objective anthropometric data to inform urologic prognostication and treatment decisions. Machine learning (ML) has the potential to automate and scale accurate BCA, relying on convolutional neural networks to analyze images. This review discusses the use of ML in BCA and its translation into clinical practice.
EUROPEAN UROLOGY FOCUS
(2021)
Letter
Urology & Nephrology
Logan G. Briggs, Sara Parke, Paul A. Bain, Sarah P. Psutka
Editorial Material
Urology & Nephrology
Sarah P. Psutka, Todd Morgan, Maarten Albersen, Jean-Nicolas Cornu, Giacomo Novara, Elizabeth Plimack, Piet Ost, James W. F. Catto
Review
Urology & Nephrology
Logan G. Briggs, Chanan Reitblat, Paul A. Bain, Sara Parke, Ny-Ying Lam, Jonathan Wright, James W. F. Catto, Robert J. Copeland, Sarah P. Psutka
Summary: This study systematically assessed the therapeutic validity and efficacy of prehabilitation exercise programs before urologic cancer surgery. While these programs improve cardiorespiratory fitness and quality of life, their impact on surgical outcomes remains inconclusive.
Article
Oncology
Amir Ishaq Khan, Sarah P. Psutka, Dattatraya H. Patil, Gordon Hong, Milton A. Williams, Mehmet A. Bilen, Aarti Sekhar, Haydn T. Kissick, Vikram M. Narayan, Shreyas S. Joshi, Kenneth Ogan, Viraj A. Master
Summary: Sarcopenia and high systemic inflammation are independently associated with poor OS after CN, providing potential use in preoperative risk stratification.
Article
Oncology
Yuanquan Yang, Sarah P. Psutka, Anish B. Parikh, Mingjia Li, Katharine Collier, Abdul Miah, Sherry Mori, Megan Hinkley, Scott S. Tykodi, Evan Hall, John A. Thompson, Ming Yin
Summary: The combination of immune checkpoint inhibitor/tyrosine kinase inhibitor (ICI/TKI) is a new standard of care for the initial treatment of metastatic renal cell carcinoma (mRCC), but its efficacy and toxicity beyond the first-line setting are still uncertain.
Article
Medicine, Research & Experimental
Sarah P. Psutka, Susan Veleber, Jonathan Siman, Samia Jannat, Sarah Holt, Jonathan L. Wright, Heather Greenlee
Summary: This study describes a pilot randomized controlled trial testing the use of acupuncture to reduce serious adverse events and treatment interruptions in patients with bladder cancer. A total of 45 patients will be recruited and randomized into treatment and control groups for pre-procedure acupuncture in a Urology Clinic to assess feasibility and efficacy. Feasibility assessments include recruitment, retention, protocol adherence, adverse events monitoring, and impact on clinic workflow, with efficacy measures focusing on various patient-reported outcomes and healthcare utilization. Trial results will guide the development of a larger multi-center trial for further testing of the protocol.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2022)