Article
Clinical Neurology
Katrine B. Andersen, Allan K. Hansen, Anna Christina Schacht, Jacob Horsager, Hanne Gottrup, Henriette Klit, Erik H. Danielsen, Kathleen L. Poston, Nicola Pavese, David J. Brooks, Per Borghammer
Summary: In this study, the relationship between synaptic density and glucose metabolism in Lewy body disease patients was investigated using PET and other techniques. The results showed that the magnitude of reduced glucose uptake exceeded the magnitude of reduced cortical synaptic density.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Negin Holland, Maura Malpetti, Timothy Rittman, Elijah E. Mak, Luca Passamonti, Sanne S. Kaalund, Frank H. Hezemans, P. Simon Jones, George Savulich, Young T. Hong, Tim D. Fryer, Franklin Aigbirhio, John T. O'Brien, James B. Rowe
Summary: The relationship between in vivo synaptic density and molecular pathology in primary tauopathies, especially in progressive supranuclear palsy and corticobasal degeneration, is investigated in this study. It is found that there is a biphasic correlation between synaptic density and molecular pathology, with regions rich in synapses more vulnerable to pathological aggregates accumulation, followed by synaptic loss as a response to the molecular pathology. These findings contribute to a better understanding of the pathophysiology of primary tauopathies and may inform the design of future clinical trials.
Article
Clinical Neurology
Katrine B. Andersen, Allan K. Hansen, Malene F. Damholdt, Jacob Horsager, Casper Skjaerbaek, Hanne Gottrup, Henriette Klit, Erik H. Danielsen, David J. Brooks, Per Borghammer
Summary: This study evaluated synaptic density in PD and dementia patients using in vivo PET imaging and found widespread cortical reduction in DLB/PDD subjects. The results suggest that synaptic density loss contributes to cognitive impairment in nPD and DLB/PDD.
MOVEMENT DISORDERS
(2021)
Article
Endocrinology & Metabolism
Ming-Kai Chen, Adam P. Mecca, Mika Naganawa, Jean-Dominique Gallezot, Takuya Toyonaga, Jayanta Mondal, Sjoerd J. Finnema, Shu-fei Lin, Ryan S. O'Dell, Julia W. McDonald, Hannah R. Michalak, Brent Vander Wyk, Nabeel B. Nabulsi, Yiyun Huang, Amy F. T. Arnsten, Christopher H. van Dyck, Richard E. Carson
Summary: We conducted a comparison study on the synaptic density and metabolism in AD and CN participants using [C-11]UCB-J PET and [F-18]FDG PET, finding a similar reduction in the medial temporal lobe but a discordant reduction in neocortical regions, with higher correlations between synaptic density and metabolism in the former.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Xiaotian T. Fang, Takuya Toyonaga, Ansel T. Hillmer, David Matuskey, Sophie E. Holmes, Rajiv Radhakrishnan, Adam P. Mecca, Christopher H. van Dyck, Deepak Cyril D'Souza, Irina Esterlis, Patrick D. Worhunsky, Richard E. Carson
Summary: This study demonstrates that human brain synaptic density can be characterized into organized covariance patterns. Additionally, the findings suggest that multiple synaptic density source networks are associated with age, highlighting the potential utility of ICA in identifying biologically relevant synaptic density source networks.
Article
Clinical Neurology
Maura Malpetti, Negin Holland, P. Simon Jones, Rong Ye, Thomas E. Cope, Tim D. Fryer, Young T. Hong, George Savulich, Timothy Rittman, Luca Passamonti, Elijah Mak, Franklin I. Aigbirhio, John T. O'Brien, James B. Rowe
Summary: Research shows that pre-symptomatic carriers of C9orf72 mutation exhibit reduced synaptic density in the thalamus compared to controls, and there is extensive synaptic loss in the frontal temporal regions of symptomatic patients with frontotemporal dementia. Therefore, the use of [C-11]UCB-J PET may aid in early assessment, monitoring of disease progression, and evaluation of new preventive treatment strategies.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Endocrinology & Metabolism
Majken B. Thomsen, Jan Jacobsen, Thea P. Lillethorup, Anna C. Schacht, Mette Simonsen, Marina Romero-Ramos, David J. Brooks, Anne M. Landau
Summary: The study evaluated the use of [11C]UCB-J PET as an in vivo biomarker of regional cerebral synaptic SV2A density in rat lesion models of neurodegeneration. Results showed that [11C]UCB-J PET provides a good in vivo marker of synaptic SV2A density and can be useful for monitoring the synaptic responses to potential neuroprotective agents over time in models of neurodegeneration.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katrine B. Andersen, Allan K. Hansen, Karoline Knudsen, Anna Christina Schacht, Malene F. Damholdt, David J. Brooks, Per Borghammer
Summary: The study using PET imaging found widespread cortical reduction of synaptic density in older adults, but the reduction did not persist after corrections. Regional differences in glucose metabolism and synaptic density were observed, suggesting a non-uniform relationship between the two variables in the human brain and implications for neuroenergetics.
NUCLEAR MEDICINE AND BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Samuel Booth, Kye Won Park, Chong Sik Lee, Ji Hyun
Summary: A FDG-PET based SVM classifier showed potential in accurately predicting the risk of dementia development in patients with Parkinson's disease with mild cognitive impairment. The model demonstrated high sensitivity and specificity in distinguishing PDD converters from stable MCI patients, and was validated with independent data sets.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Thanaphong Phongpreecha, Brenna Cholerton, Syed Bhukari, Alan L. L. Chang, Davide De Francesco, Melan Thuraiappah, Dana Godrich, Amalia Perna, Martin G. Becker, Neal G. Ravindra, Camilo Espinosa, Yeasul Kim, Eloise Berson, Samson Mataraso, Sharon J. J. Sha, Edward J. Fox, Kathleen S. Montine, Laura D. Baker, Suzanne Craft, Lon White, Kathleen L. Poston, Gary Beecham, Nima Aghaeepour, Thomas J. Montine
Summary: This study used statistical tools and machine learning to predict 17 neuropathologic lesions based on 381 clinical features of 6518 individuals. The results showed high prediction performance for certain lesions. Some clinical features were strongly associated with multiple neurodegenerative diseases, while others were specific to certain lesions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Marian Shahid, Ashley Rawls, Veronica Ramirez, Sephira Ryman, Veronica E. Santini, Laurice Yang, Sharon J. Sha, Jacob N. Hall, Thomas J. Montine, Amy Lin, Lu Tian, Victor W. Henderson, Brenna Cholerton, Maya Yutsis, Kathleen L. Poston
Summary: This study aimed to investigate pareidolias in patients across the Lewy body disease spectrum. Illusory responses were studied in 300 participants, and it was found that cognitively impaired LB patients were more likely to endorse illusory responses compared to other groups. The Noise Pareidolia Task can be used to screen for unobtrusive pareidolias in LB patients before the onset of hallucinations and delusions.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sephira G. Ryman, Nicholas Shaff, Andrew Dodd, Stephanie Nitschke, Christopher Wertz, Kayla Julio, Gerson Suarez Cedeno, Amanda Deligtisch, Erik Erhardt, Henry Lin, Andrei Vakhtin, Kathleen L. Poston, Rawan Tarawneh, Sarah Pirio Richardson, Andrew Mayer
Summary: This study aimed to investigate cerebrovascular dysfunction in participants with Parkinson's disease (PD) compared to healthy controls (HC) using functional magnetic resonance imaging (fMRI) and vasodilatory challenges. The results showed that PD participants had reduced and delayed cerebrovascular reactivity, which may be associated with chronic hypoxia, neuroinflammation, and protein aggregation. Cerebrovascular reactivity may serve as an important biomarker and target for future interventions in PD.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Niels Okkels, Jacob Horsager, Miguel A. Labrador-Espinosa, Frederik O. Hansen, Katrine B. Andersen, Mie Kristine Just, Tatyana D. Fedorova, Casper Skjaerbaek, Ole L. Munk, Kim V. Hansen, Hanne Gottrup, Allan K. Hansen, Michel J. Grothe, Per Borghammer
Summary: This study used [18F]FEOBV PET tracer to study the cholinergic topography of the healthy human brain. The results showed the highest tracer binding in the striatum, thalamic nuclei, and basal forebrain. The spatial distribution of the tracer correlated well with immunohistochemical and gene expression data.
Article
Clinical Neurology
Carla Abdelnour, Kathleen L. Poston
Summary: Patients with neurodegenerative movement disorders can develop cognitive impairment which is associated with decreased quality of life, higher caregiver burden, and earlier institutionalization. Evaluating cognitive performance in these patients is important for diagnosis, management, prognosis, and support. This review discusses the cognitive impairment profile in different movement disorders and provides neurologists with practical guidance and evaluation tools.
SEMINARS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas E. H. Justesen, Per Borghammer, Joel Aanerud, Peter Hovind, Lisbeth Marner
Summary: The commonly used antidepressant sertraline has been found to interfere with the results of [F-18]FE-PE2I PET, leading to reduced binding in the caudate nucleus. It is recommended to take sertraline treatment into account when performing [F-18]FE-PE2I PET, especially in patients with apparent globally reduced PE2I binding. Consideration should be given to pausing sertraline treatment, particularly for doses above 50 mg/day.
Article
Clinical Neurology
Charlotte B. B. Stewart, David Ledingham, Victoria K. K. Foster, Kirstie N. N. Anderson, Sahana Sathyanarayana, Debra Galley, Nicola Pavese, Jacopo Pasquini
Summary: Autonomic dysfunction is common in early Parkinson's Disease and tends to worsen over time. Many patients experience multiple autonomic symptoms, including gastrointestinal, cardiovascular, and urinary dysfunction. The severity of autonomic dysfunction is associated with the severity of olfactory dysfunction and motor impairment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Thanaphong Phongpreecha, Dana Godrich, Eloise Berson, Camilo Espinosa, Yeasul Kim, Brenna Cholerton, Alan L. Chang, Samson Mataraso, Syed A. Bukhari, Amalia Perna, Koya Yakabi, Kathleen S. Montine, Kathleen L. Poston, Elizabeth Mormino, Lon White, Gary Beecham, Nima Aghaeepour, Thomas J. Montine
Summary: The study proposes a framework for defining cognitive resilience (CR) as a continuous variable for each neuropsychological test, aiming to address discrepancies and shortcomings of the current CR definition. The framework clarifies the relationship between CR and closely related terms and provides insights into the underlying mechanisms of CR.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Jacopo Pasquini, Gunther Deuschl, Alessandro Pecori, Stefano Salvadori, Roberto Ceravolo, Nicola Pavese
Summary: This study conducted a comprehensive longitudinal analysis on tremor in de-novo PD patients, revealing that tremor severity increases over time and the response to medication varies. The findings provide an evidence-based framework for future pathophysiological and interventional studies on PD tremor.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Katrine B. Andersen, Allan K. Hansen, Anna Christina Schacht, Jacob Horsager, Hanne Gottrup, Henriette Klit, Erik H. Danielsen, Kathleen L. Poston, Nicola Pavese, David J. Brooks, Per Borghammer
Summary: In this study, the relationship between synaptic density and glucose metabolism in Lewy body disease patients was investigated using PET and other techniques. The results showed that the magnitude of reduced glucose uptake exceeded the magnitude of reduced cortical synaptic density.
MOVEMENT DISORDERS
(2023)