Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems

Ferrostatin‐1 modulates dysregulated kidney lipids in acute kidney injury

(2022) Lucía Martín‐Saiz et al.   JOURNAL OF PATHOLOGY

Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease

(2022) Zahra Shaghaghi et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

miR-3587 Inhibitor Attenuates Ferroptosis Following Renal Ischemia-Reperfusion Through HO-1

(2022) Wenqiang Tao et al.   Frontiers in Molecular Biosciences

Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations

(2022) Mark A. Greenough et al.   CELL DEATH AND DIFFERENTIATION

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

(2022) Abdel Ali Belaidi et al.   MOLECULAR PSYCHIATRY

Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction

(2022) Sai Ma et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IFNγ enhances ferroptosis by increasing JAK‑STAT pathway activation to suppress SLCA711 expression in adrenocortical carcinoma

(2022) Xinbo Yu et al.   ONCOLOGY REPORTS

HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation

(2022) Shangting Han et al.   Oxidative Medicine and Cellular Longevity

MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1

(2022) Cairong Zhu et al.   Analytical Cellular Pathology

Resveratrol Attenuate Myocardial Injury by Inhibiting Ferroptosis Via Inducing KAT5/GPX4 in Myocardial Infarction

(2022) Jing Liu et al.   Frontiers in Pharmacology

Ferroptosis and Acute Kidney Injury (AKI): Molecular Mechanisms and Therapeutic Potentials

(2022) Qi Feng et al.   Frontiers in Pharmacology

Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 Axis

(2022) Yuehong Shen et al.   Frontiers in Pharmacology

Suppression of lncRNA Gm47283 attenuates myocardial infarction via miR-706/ Ptgs2/ferroptosis axis

(2022) Feng Gao et al.   Bioengineered

ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury

(2022) Yue Wang et al.   Redox Biology

A Novel Prognostic Ferroptosis-Related Long Noncoding RNA Signature in Clear Cell Renal Cell Carcinoma

(2022) Zhixun Bai et al.   Journal of Oncology

Seven ferroptosis-specific expressed genes are considered as potential biomarkers for the diagnosis and treatment of cigarette smoke-induced chronic obstructive pulmonary disease

(2022) Zhiwei Lin et al.   Annals of Translational Medicine

Ferroptosis-related long non-coding RNA signature predicts the prognosis of bladder cancer

(2022) Jian Hou et al.   BMC CANCER

miR-494-3p Promotes Erastin-Induced Ferroptosis by Targeting REST to Activate the Interplay between SP1 and ACSL4 in Parkinson’s Disease

(2022) Jianjun Ma et al.   Oxidative Medicine and Cellular Longevity

Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines

(2022) Xiao-Yu Song et al.   TOXICOLOGY IN VITRO

Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer’s disease mice and glutamate-injured HT22 cells

(2022) Sixia Yang et al.   Chinese Medicine

Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

(2022) Zhifu Cui et al.   Frontiers in Immunology

Ferroptosis and Autophagy-Related Genes in the Pathogenesis of Ischemic Cardiomyopathy

(2022) Yue Zheng et al.   Frontiers in Cardiovascular Medicine

Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol

(2022) Meilan Xue et al.   BIOMEDICINE & PHARMACOTHERAPY

Therapeutic Insights on Ferroptosis in Parkinson's disease

(2022) Komal Thapa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quercetin Protects against MPP+/MPTP-Induced Dopaminergic Neuron Death in Parkinson’s Disease by Inhibiting Ferroptosis

(2022) Zhi-Hao Lin et al.   Oxidative Medicine and Cellular Longevity

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition

(2022) Laura Mahoney-Sanchez et al.   Cell Reports

Exploring the key ferroptosis-related gene in the peripheral blood of patients with Alzheimer’s disease and its clinical significance

(2022) Xiaonan Wang et al.   Frontiers in Aging Neuroscience

Nuciferine protects against folic acid‐induced acute kidney injury by inhibiting ferroptosis

(2021) Danyu Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia.

(2021) Rudy Birsen et al.   HAEMATOLOGICA

Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis

(2021) XinDong Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease

(2021) Xinrong Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Loganin Attenuates the Severity of Acute Kidney Injury Induced by Cisplatin through the Inhibition of ERK Activation in Mice

(2021) Dong-Uk Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Clinical Significance of Iron Overload and Iron Metabolism in Myelodysplastic Syndrome and Acute Myeloid Leukemia

(2021) Sarah Weber et al.   Frontiers in Immunology

Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis

(2021) Eleonora Ficiarà et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

(2021) Qiujie Wang et al.   Cell Death & Disease

Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance

(2021) Sze Kiat Tan et al.   Cancer Discovery

Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis

(2021) Hongrong Ding et al.   Journal of Cachexia Sarcopenia and Muscle

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1

(2021) Na Kong et al.   Acta Pharmaceutica Sinica B

Ferroptosis in Ovarian Cancer: A Novel Therapeutic Strategy

(2021) Lanyu Li et al.   Frontiers in Oncology

Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis

(2021) Shichuan Hu et al.   Acta Biomaterialia

Comprehensive analysis of new prognostic signature based on ferroptosis-related genes in clear cell renal cell carcinoma

(2021) Bin Zheng et al.   Aging-US

A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma

(2021) Yingkai Hong et al.   BMC CANCER

Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury

(2021) Yinyin Ye et al.   FASEB JOURNAL

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

(2021) Shuo Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

CLTRN, Regulated by NRF1/RAN/DLD Protein Complex, Enhances Radiation Sensitivity of Hepatocellular Carcinoma Cells Through Ferroptosis Pathway

(2021) Yin Yuan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targetting ferroptosis for blood cell-related diseases

(2021) Zhe Chen et al.   JOURNAL OF DRUG TARGETING

The role of regulated necrosis in endocrine diseases

(2021) Wulf Tonnus et al.   Nature Reviews Endocrinology

Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

(2021) Yongfa Zhang et al.   Frontiers in Cellular Neuroscience

Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines

(2021) Jiashuo Zheng et al.   Cell Death & Disease

Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

(2021) Wulf Tonnus et al.   Nature Communications

Identification and Validation of a Ferroptosis-Related Long Non-coding RNA Signature for Predicting the Outcome of Lung Adenocarcinoma

(2021) Zhiyuan Zheng et al.   Frontiers in Genetics

CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma

(2021) Bowen Li et al.   Frontiers in Oncology

Identification of a prognostic ferroptosis-related lncRNA signature in the tumor microenvironment of lung adenocarcinoma

(2021) Yugang Guo et al.   Cell Death Discovery

Development and Validation of a Random Forest Diagnostic Model of Acute Myocardial Infarction Based on Ferroptosis-Related Genes in Circulating Endothelial Cells

(2021) Chen Yifan et al.   Frontiers in Cardiovascular Medicine

Atorvastatin treatment ameliorates cardiac function and remodeling induced by isoproterenol attack through mitigation of ferroptosis

(2021) Dong Ning et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imeglimin prevents heart failure with preserved ejection fraction by recovering the impaired unfolded protein response in mice subjected to cardiometabolic stress

(2021) Hiroki Kitakata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury

(2021) Tao Liu et al.   BIOMATERIALS

Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury

(2021) Qin M. Chen   FREE RADICAL BIOLOGY AND MEDICINE

Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway

(2021) Xiangming Liu et al.   PHYTOMEDICINE

Iron overload compromises preimplantation mouse embryo development

(2021) Xiaopan Chen et al.   REPRODUCTIVE TOXICOLOGY

A Novel Prognostic Signature Based on Ferroptosis-Related Genes Predicts the Prognosis of Patients With Advanced Bladder Urothelial Carcinoma

(2021) Xiaoqi Li et al.   Frontiers in Oncology

Regulated Necrosis in Pulmonary Disease: A Focus on Necroptosis and Ferroptosis

(2020) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endometriosis: The Role of Iron Overload and Ferroptosis

(2020) Shu-Wing Ng et al.   Reproductive Sciences

SIAH2-mediated and organ-specific restriction of HO-1 expression by a dual mechanism

(2020) Shashipavan Chillappagari et al.   Scientific Reports

Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro

(2020) Chun-Yu Liu et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

(2020) Rushdia Yusuf et al.   BLOOD

Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis

(2020) Pan Meng et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The osteoprotective effects of artemisinin compounds and the possible mechanisms associated with intracellular iron: A review of in vivo and in vitro studies

(2020) Jian Zhang   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Time Course of Changes in Sorafenib‐Treated Hepatocellular Carcinoma Cells Suggests Involvement of Phospho‐Regulated Signaling in Ferroptosis Induction

(2020) Emily G. Werth et al.   PROTEOMICS

Identification of Pannexin 2 as a Novel Marker Correlating with Ferroptosis and Malignant Phenotypes of Prostate Cancer Cells

(2020) Duwu Liao et al.   OncoTargets and Therapy

Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction

(2020) Isabel Weigand et al.   Cell Death & Disease

ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma

(2020) Ji Feng et al.   ACTA PHARMACOLOGICA SINICA

Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice

(2020) Yufang Song et al.   CELL BIOLOGY AND TOXICOLOGY

Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells

(2020) Yuxue Shang et al.   CELLULAR SIGNALLING

Ferroptosis in Liver Diseases: An Overview

(2020) Martina Maria Capelletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Mechanisms of Ferroptosis and Its Role in Pulmonary Disease

(2020) Ningning Tao et al.   Oxidative Medicine and Cellular Longevity

Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice

(2020) Xi Zhao et al.   TOXICOLOGY

The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?

(2020) Lihong Mao et al.   Cell Death & Disease

Quercetin alleviates acute kidney injury by inhibiting ferroptosis

(2020) Yue Wang et al.   Journal of Advanced Research

Saponin Formosanin C-induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells

(2020) Pin-Lun Lin et al.   Antioxidants

Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5

(2020) Zhiqian Liu et al.   Cell Death Discovery

Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system

(2020) Mingming Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeted inhibition of Rev‐erbα/β limits ferroptosis to ameliorate folic acid‐induced acute kidney injury

(2020) Lianxia Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lymph: (Fe)rrying Melanoma to Safety

(2020) Amanda W. Lund et al.   CANCER CELL

Hyperandrogenism and insulin resistance modulate gravid uterine and placental ferroptosis in PCOS-like rats

(2020) Yuehui Zhang et al.   JOURNAL OF ENDOCRINOLOGY

A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis

(2020) Zuli Wang et al.   MOLECULAR THERAPY

Cancer cells stock up in lymph vessels to survive

(2020) Barbara M. Grüner et al.   NATURE

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis

(2020) Yani Wang et al.   Oxidative Medicine and Cellular Longevity

Computational repositioning of dimethyl fumarate for treating alcoholic liver disease

(2020) Ye Zhang et al.   Cell Death & Disease

Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease

(2020) Jun Liu et al.   ACS Medicinal Chemistry Letters

miR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2/PGE2 pathway

(2020) Yuchen Li et al.   Stem Cell Research & Therapy

USP22 Protects Against Myocardial Ischemia–Reperfusion Injury via the SIRT1-p53/SLC7A11–Dependent Inhibition of Ferroptosis–Induced Cardiomyocyte Death

(2020) Shuxian Ma et al.   Frontiers in Physiology

Programmed cell death in alcohol-associated liver disease

(2020) Tatsunori Miyata et al.   Clinical and Molecular Hepatology

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

(2020) Wei Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis

(2020) Yajie Li et al.   HUMAN REPRODUCTION

Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases

(2020) Orjon Rroji et al.   NEUROBIOLOGY OF DISEASE

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

(2020) Hongdong Ma et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis

(2020) Jingjing Liu et al.   TOXICOLOGY

Proteome Analysis of CD4+ T Cells Reveals Differentially Expressed Proteins in Infertile Polycystic Ovary Syndrome Patients

(2020) Fatemeh Nasri et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage

(2019) Jieru Wan et al.   JOURNAL OF INVESTIGATIVE MEDICINE

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

(2019) Núria DeGregorio-Rocasolano et al.   Frontiers in Neuroscience

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

(2019) Scott Ayton et al.   MOLECULAR PSYCHIATRY

Regulated necrosis in kidney ischemia-reperfusion injury

(2019) Aspasia Pefanis et al.   KIDNEY INTERNATIONAL

Endocrine Diseases and the Liver

(2019) Miguel Malespin et al.   Clinics in Liver Disease

Phospholipid oxidation products in Ferroptotic Myocardial Cell Death

(2019) Aleksandra Stamenkovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Radiation-Induced Lung Injury

(2019) Alexander N. Hanania et al.   CHEST

Malignant Melanoma: Autoimmunity and Supracellular Messaging as New Therapeutic Approaches

(2019) Ion G. Motofei   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy

(2019) Milad Ashrafizadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1

(2019) Xuan Li et al.   Journal of Inflammation-London

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Cell Death in the Kidney

(2019) Giovanna Priante et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

(2019) Shu-Wing Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocellular carcinoma: Mechanisms of progression and immunotherapy

(2019) Yu Jiang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

(2019) Masahiro Yoshida et al.   Nature Communications

STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma

(2019) Yuanyang Lai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

(2019) Xiaoqing Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Effect of Abnormal Iron Metabolism on Osteoporosis

(2019) Jingmin Che et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Iron and leukemia: new insights for future treatments

(2019) Fang Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

(2019) Dominic P. Del Re et al.   PHYSIOLOGICAL REVIEWS

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects

(2019) Bin Chen et al.   BRAIN RESEARCH BULLETIN

Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

(2019) Lianjiu Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Emerging Role of Ferroptosis in Acute Kidney Injury

(2019) Zhaoxin Hu et al.   Oxidative Medicine and Cellular Longevity

Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis

(2019) Alexia Belavgeni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective

(2019) Paul J. Derry et al.   PROGRESS IN NEUROBIOLOGY

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

(2019) Mara Gagliardi et al.   Cell Death & Disease

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence

(2019) Jinsen Lu et al.   Scientific Reports

LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells

(2019) Wenchuan Qi et al.   Scientific Reports

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulatory Phenomena in the Glutathione Peroxidase Superfamily

(2019) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes

(2019) Natticha Sumneang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

(2019) Yansheng Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

(2018) Bei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ENPP2 protects cardiomyocytes from erastin-induced ferroptosis

(2018) Yu-Ting Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Regulated Cell Death Seen through the Lens of Islet Transplantation

(2018) Antonio Bruni et al.   CELL TRANSPLANTATION

Ferroptosis is associated with oxygen-glucose deprivation/reoxygenation-induced Sertoli cell death

(2018) Li Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cell growth potential drives ferroptosis susceptibility in rhabdomyosarcoma and myoblast cell lines

(2018) Silvia Codenotti et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy

(2018) Seema Patel   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

Cell death-based approaches in treatment of the urinary tract-associated diseases: a fight for survival in the killing fields

(2018) Diego Martin-Sanchez et al.   Cell Death & Disease

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

(2018) Haider H. Dar et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders

(2018) Jia-rui Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma

(2018) Kexin Zhang et al.   MOLECULAR CARCINOGENESIS

Initiation of follicular atresia: gene networks during early atresia in pig ovaries

(2018) Jinbi Zhang et al.   REPRODUCTION

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

(2018) Jun-Lin Liu et al.   Frontiers in Neuroscience

Lipid storage and lipophagy regulates ferroptosis

(2018) Yuansong Bai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner

(2018) Chao Bian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

Tissue plasminogen activator-based nanothrombolysis for ischemic stroke

(2017) Shan Liu et al.   Expert Opinion on Drug Delivery

Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma

(2017) Weijun Ou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic obstructive pulmonary disease

(2017) Klaus F Rabe et al.   LANCET

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

NADPH oxidases in Parkinson’s disease: a systematic review

(2017) Karim Belarbi et al.   Molecular Neurodegeneration

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Meta-analysis of the association between serum iron levels and Parkinson's disease: Evidence from 11 publications

(2016) Junjie Jiao et al.   BRAIN RESEARCH

Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

(2016) Xiaofang Sun et al.   HEPATOLOGY

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis

(2016) Tanja Krainz et al.   ACS Central Science

Ferroptosis: a novel cell death form will be a promising therapy target for diseases

(2015) Di Wu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

(2015) Marie-Helene Larraufie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Increased lung cancer mortality rates in the Chinese population from 1973-1975 to 2004-2005: An adverse health effect from exposure to smoking

(2015) Xiu-Yi Zhi et al.   CANCER

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

(2015) Irina Ingold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

(2015) Mai Matsushita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ferroptosis is Involved in Acetaminophen Induced Cell Death

(2015) Tamás Lőrincz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells

(2015) Edna Ooko et al.   PHYTOMEDICINE

The Neuroprotective Role of Ferrostatin-1 Under Rotenone-Induced Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2015) Parijat Kabiraj et al.   PROTEIN JOURNAL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Caspase-Independent Cell Death Is Involved in the Negative Effect of EGF Receptor Inhibitors on Cisplatin in Non-Small Cell Lung Cancer Cells

(2013) H. Yamaguchi et al.   CLINICAL CANCER RESEARCH

Osteoporosis-associated Fracture and Diabetes

(2013) Salila Kurra et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Development of the Hematopoietic System and Disorders of Hematopoiesis that Present During Infancy and Early Childhood

(2013) Karen S. Fernández et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study

(2013) Irene Pichler et al.   PLOS MEDICINE

The Ubiquity of Iron

(2012) Perry A. Frey et al.   ACS Chemical Biology

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Acute kidney injury

(2012) Rinaldo Bellomo et al.   LANCET

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

(2011) Yasuhiro Terasaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

(2011) A. T. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Particulate Matter in Cigarette Smoke Alters Iron Homeostasis to Produce a Biological Effect

(2008) Andrew J. Ghio et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ferritins: A family of molecules for iron storage, antioxidation and more

(2008) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY