Creating the “Dew Drop on a Rose Petal”: the Molecular Pathogenesis of Varicella-Zoster Virus Skin Lesions

Development of a skin- and neuro-attenuated live vaccine for varicella

(2022) Wei Wang et al.   Nature Communications

The Biology of Varicella-Zoster Virus Replication in the Skin

(2022) Cristina Tommasi et al.   Viruses-Basel

A Variant Allele in Varicella-Zoster Virus Glycoprotein B Selected during Production of the Varicella Vaccine Contributes to Its Attenuation

(2022) Tomohiko Sadaoka et al.   mBio

Exocytosis of Progeny Infectious Varicella-Zoster Virus Particles via a Mannose-6-Phosphate Receptor Pathway without Xenophagy following Secondary Envelopment

(2020) James H. Girsch et al.   JOURNAL OF VIROLOGY

A Novel Human Skin Tissue Model To Study Varicella-Zoster Virus and Human Cytomegalovirus

(2020) Megan G. Lloyd et al.   JOURNAL OF VIROLOGY

Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis

(2020) Stefan L. Oliver et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function

(2019) Dallas Jones et al.   PLoS Pathogens

Functional paralysis of human natural killer cells by alphaherpesviruses

(2019) Tessa Mollie Campbell et al.   PLoS Pathogens

Transmission of Vaccine-Strain Varicella-Zoster Virus: A Systematic Review

(2019) Mona Marin et al.   PEDIATRICS

Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin

(2019) Cristina Tommasi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

OUP accepted manuscript

(2018)   JOURNAL OF INFECTIOUS DISEASES

Age-Associated Differences in Infection of Human Skin in the SCID Mouse Model of Varicella-Zoster Virus Pathogenesis

(2018) Leigh Zerboni et al.   JOURNAL OF VIROLOGY

Varicella zoster virus productively infects human natural killer cells and manipulates phenotype

(2018) Tessa Mollie Campbell et al.   PLoS Pathogens

Distinctive Roles for Type I and Type II Interferons and Interferon Regulatory Factors in the Host Cell Defense against Varicella-zoster Virus

(2018) Nandini Sen et al.   JOURNAL OF VIROLOGY

The C-terminus of varicella-zoster virus glycoprotein M contains trafficking motifs that mediate skin virulence in the SCID-human model of VZV pathogenesis

(2018) Leigh Zerboni et al.   VIROLOGY

Infection and Functional Modulation of Human Monocytes and Macrophages by Varicella-Zoster Virus

(2018) Jarrod J. Kennedy et al.   JOURNAL OF VIROLOGY

Exocytosis of Varicella-Zoster Virus Virions Involves a Convergence of Endosomal and Autophagy Pathways

(2016) Erin M. Buckingham et al.   JOURNAL OF VIROLOGY

Deep Sequencing of Distinct Preparations of the Live Attenuated Varicella-Zoster Virus Vaccine Reveals a Conserved Core of Attenuating Single-Nucleotide Polymorphisms

(2016) Daniel P. Depledge et al.   JOURNAL OF VIROLOGY

Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral ReplicationIn Vitroand Skin PathogenesisIn Vivo

(2016) Sylvie François et al.   JOURNAL OF VIROLOGY

The Glycoprotein B Cytoplasmic Domain Lysine Cluster Is Critical for Varicella-Zoster Virus Cell-Cell Fusion Regulation and Infection

(2016) Edward Yang et al.   JOURNAL OF VIROLOGY

Varicella zoster virus infection

(2015) Anne A. Gershon et al.   Nature Reviews Disease Primers

Molecular mechanisms of varicella zoster virus pathogenesis

(2014) Leigh Zerboni et al.   NATURE REVIEWS MICROBIOLOGY

Single-Cell Mass Cytometry Analysis of Human Tonsil T Cell Remodeling by Varicella Zoster Virus

(2014) Nandini Sen et al.   Cell Reports

RNA-seq Analysis of Host and Viral Gene Expression Highlights Interaction between Varicella Zoster Virus and Keratinocyte Differentiation

(2014) Meleri Jones et al.   PLoS Pathogens

The Cytoplasmic Domain of Varicella-Zoster Virus Glycoprotein H Regulates Syncytia Formation and Skin Pathogenesis

(2014) Edward Yang et al.   PLoS Pathogens

ORF11 Protein Interacts with the ORF9 Essential Tegument Protein in Varicella-Zoster Virus Infection

(2013) X. Che et al.   JOURNAL OF VIROLOGY

Identification of a Hydrophobic Domain in Varicella-Zoster Virus ORF61 Necessary for ORF61 Self-Interaction, Viral Replication, and Skin Pathogenesis

(2013) L. Wang et al.   JOURNAL OF VIROLOGY

Deep Sequencing of Viral Genomes Provides Insight into the Evolution and Pathogenesis of Varicella Zoster Virus and Its Vaccine in Humans

(2013) Daniel P. Depledge et al.   MOLECULAR BIOLOGY AND EVOLUTION

Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche

(2013) Guiomar Solanas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An immunoreceptor tyrosine-based inhibition motif in varicella-zoster virus glycoprotein B regulates cell fusion and skin pathogenesis

(2013) S. L. Oliver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Varicella-Zoster Virus ORF12 Protein Activates the Phosphatidylinositol 3-Kinase/Akt Pathway To Regulate Cell Cycle Progression

(2012) XueQiao Liu et al.   JOURNAL OF VIROLOGY

The Attenuated Genotype of Varicella-Zoster Virus Includes an ORF0 Transitional Stop Codon Mutation

(2012) G. A. Peters et al.   JOURNAL OF VIROLOGY

3D Reconstruction of VZV Infected Cell Nuclei and PML Nuclear Cages by Serial Section Array Scanning Electron Microscopy and Electron Tomography

(2012) Mike Reichelt et al.   PLoS Pathogens

Autophagosome Formation during Varicella-Zoster Virus Infection following Endoplasmic Reticulum Stress and the Unfolded Protein Response

(2011) J. E. Carpenter et al.   JOURNAL OF VIROLOGY

Mutagenesis of Varicella-Zoster Virus Glycoprotein I (gI) Identifies a Cysteine Residue Critical for gE/gI Heterodimer Formation, gI Structure, and Virulence in Skin Cells

(2011) S. L. Oliver et al.   JOURNAL OF VIROLOGY

Structure-function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropism

(2011) S. E. Vleck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis

(2011) N. Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and functional characterization of the Varicella zoster virus ORF11 gene product

(2011) Xibing Che et al.   VIROLOGY

Entrapment of Viral Capsids in Nuclear PML Cages Is an Intrinsic Antiviral Host Defense against Varicella-Zoster Virus

(2011) Mike Reichelt et al.   PLoS Pathogens

Disruption of PML Nuclear Bodies Is Mediated by ORF61 SUMO-Interacting Motifs and Required for Varicella-Zoster Virus Pathogenesis in Skin

(2011) Li Wang et al.   PLoS Pathogens

Varicella-Zoster Virus Glycoprotein E Is a Critical Determinant of Virulence in the SCID Mouse-Human Model of Neuropathogenesis

(2010) L. Zerboni et al.   JOURNAL OF VIROLOGY

The Alphaherpesvirus US3/ORF66 Protein Kinases Direct Phosphorylation of the Nuclear Matrix Protein Matrin 3

(2010) A. Erazo et al.   JOURNAL OF VIROLOGY

The Varicella-Zoster Virus ORFS/L (ORF0) Gene Is Required for Efficient Viral Replication and Contains an Element Involved in DNA Cleavage

(2010) B. B. Kaufer et al.   JOURNAL OF VIROLOGY

Impact of Varicella-Zoster Virus on Dendritic Cell Subsets in Human Skin during Natural Infection

(2010) J. H. Huch et al.   JOURNAL OF VIROLOGY

Varicella-Zoster Virus Immediate-Early Protein 62 Blocks Interferon Regulatory Factor 3 (IRF3) Phosphorylation at Key Serine Residues: a Novel Mechanism of IRF3 Inhibition among Herpesviruses

(2010) N. Sen et al.   JOURNAL OF VIROLOGY

Insulin Degrading Enzyme Induces a Conformational Change in Varicella-Zoster Virus gE, and Enhances Virus Infectivity and Stability

(2010) Qingxue Li et al.   PLoS One

Genome-Wide Mutagenesis Reveals That ORF7 Is a Novel VZV Skin-Tropic Factor

(2010) Zhen Zhang et al.   PLoS Pathogens

Valrubicin in a Topical Formulation Treats Psoriasis in a Xenograft Transplantation Model

(2009) Cecilia Rosada et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mutagenesis of Varicella-Zoster Virus Glycoprotein B: Putative Fusion Loop Residues Are Essential for Viral Replication, and the Furin Cleavage Motif Contributes to Pathogenesis in Skin Tissue In Vivo

(2009) S. L. Oliver et al.   JOURNAL OF VIROLOGY

Varicella-Zoster Virus Infection Induces Autophagy in both Cultured Cells and Human Skin Vesicles

(2009) M.-N. Takahashi et al.   JOURNAL OF VIROLOGY

Anti-Glycoprotein H Antibody Impairs the Pathogenicity of Varicella-Zoster Virus in Skin Xenografts in the SCID Mouse Model

(2009) S. E. Vleck et al.   JOURNAL OF VIROLOGY

Regulation of the ORF61 Promoter and ORF61 Functions in Varicella-Zoster Virus Replication and Pathogenesis

(2009) L. Wang et al.   JOURNAL OF VIROLOGY

The Replication Cycle of Varicella-Zoster Virus: Analysis of the Kinetics of Viral Protein Expression, Genome Synthesis, and Virion Assembly at the Single-Cell Level

(2009) M. Reichelt et al.   JOURNAL OF VIROLOGY

Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infection

(2009) B. Berarducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection

(2009) Mir A. Ali et al.   VIROLOGY

Development of Varicella Vaccine

(2008) Michiaki Takahashi et al.   JOURNAL OF INFECTIOUS DISEASES

Functions of the ORF9-to-ORF12 Gene Cluster in Varicella-Zoster Virus Replication and in the Pathogenesis of Skin Infection

(2008) X. Che et al.   JOURNAL OF VIROLOGY

Deletion of the First Cysteine-Rich Region of the Varicella-Zoster Virus Glycoprotein E Ectodomain Abolishes the gE and gI Interaction and Differentially Affects Cell-Cell Spread and Viral Entry

(2008) B. Berarducci et al.   JOURNAL OF VIROLOGY

Functions of Varicella-Zoster Virus ORF23 Capsid Protein in Viral Replication and the Pathogenesis of Skin Infection

(2008) V. Chaudhuri et al.   JOURNAL OF VIROLOGY

Discordant varicella-zoster virus glycoprotein C expression and localization between cultured cells and human skin vesicles

(2008) Johnathan Storlie et al.   VIROLOGY