Article
Oncology
Yangyang Wang, Wei Zhang, Hongbin Ge, Xu Han, Jiangchao Wu, Xuqi Sun, Ke Sun, Wanyue Cao, Chao Huang, Jingsong Li, Qi Zhang, Tingbo Liang
Summary: Tumor micronecrosis is a histopathological feature that predicts poor prognosis in patients with hepatocellular carcinoma (HCC). This study aimed to evaluate the role of tumor micronecrosis in liver transplantation for HCC. The findings suggest that HCC patients with tumor micronecrosis have worse prognosis and tumor micronecrosis can help predict recurrence-free survival after liver transplantation.
Article
Oncology
Zhancheng Qiu, Weili Qi, Youwei Wu, Lingling Li, Chuan Li
Summary: This study examines the impact of public insurance status on the survival outcomes of HCC patients after liver resection in China. The results show that underinsured HCC patients have worse survival outcomes after liver resection. This may be due to the limited access to care for underinsured patients, but further exploration is needed for conclusive evidence.
Article
Endocrinology & Metabolism
Yang Zhang, Yi Zhang, Taiyu He, Guangliang Liu, Minjie Duan, Jian Huang, Christy Huang, Scott Lowe, Dazhi Ke, Xiaozhu Liu, Junyi Cao
Summary: Liver resection (LR) and local tumor destruction (LTD) improve overall survival (OS) in patients with intermediate/advanced hepatocellular carcinoma (HCC). A nomogram model was developed to predict OS and select suitable patients for LR/LTD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Ehab Elhanafy, Mohamed Aboelinin, Rami Said, Yousef Elmahdy, Ahmed Aboelenin, Amgad Fouad, Mohamed Abdelwahab, Ahmed Shehta
Summary: This study evaluated the outcomes of resection for huge hepatocellular carcinoma (HCC) exceeding 10 cm in diameter. The patients were divided into minor group and major group based on the extent of liver resection. The major group had longer operation time, hospital stay, and more severe complications. The overall survival (OS) and disease-free survival (DFS) rates did not show significant differences between the two groups.
AMERICAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Wei Li, Haitao Xiao, Hong Wu, Xuewen Xu, Yange Zhang
Summary: This study compared the long-term outcomes of liver transplantation (LT) and liver resection (LR) for patients with stage I and II hepatocellular carcinoma (HCC). The results showed that LT provided significant prognostic advantages in overall survival and disease-free survival compared to LR. Increasing the LT rate may lead to better long-term survival, but caution is needed when selecting LT for special populations like elderly patients due to similar outcomes with LR.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Xin-Fei Xu, Han Wu, Ju-Dong Li, Lan-Qing Yao, Bin Huang, Yong-Kang Diao, Ting-Hao Chen, Wei-Min Gu, Zhong Chen, Jie Li, Yao-Ming Zhang, Hong Wang, Ying-Jian Liang, Ya-Hao Zhou, Chao Li, Ming-Da Wang, Cheng-Wu Zhang, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study found that the prognosis of solitary huge hepatocellular carcinoma (HCC) is associated with tumor morphology, with patients having balloon-shaped HCC (BS-HCC) showing better long-term survival after liver resection. This finding helps guide the treatment strategy for patients with solitary huge HCC.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Oncology
Gordana Rasic, Susanna W. L. de Geus, Brendin Beaulieu-Jones, Gyulnara G. Kasumova, Tara S. Kent, Sing Chau Ng, David McAneny, Jennifer F. Tseng, Teviah E. Sachs
Summary: This study compared the outcomes of ablation and resection for early-stage hepatocellular carcinoma (HCC) and found that resection provides better long-term survival rates for tumors ≤ 50 mm. Ablation may serve as a feasible bridging strategy for patients awaiting transplantation.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Omid Salehi, Eduardo A. Vega, Onur C. Kutlu, Keri Lunsford, Richard Freeman, Keren Ladin, Sylvia V. Alarcon, Vera Kazakova, Claudius Conrad
Summary: This study found that the differentiation of hepatocellular carcinoma and liver fibrosis synergistically determine the efficacy of resection and transplantation. Therefore, the current criteria for liver transplantation should incorporate tumor grade or liver fibrosis for optimal organ allocation.
Review
Oncology
Charles-Henri Wassmer, Beat Moeckli, Thierry Berney, Christian Toso, Lorenzo A. Orci
Summary: Liver pedicle clamping during hepatocellular carcinoma surgery can reduce bleeding risks but may be associated with tumor recurrence and shorter survival. Further evidence is needed to support the relationship between liver pedicle clamping and long-term clinical outcomes.
Review
Gastroenterology & Hepatology
Jin Hean Koh, Darren Jun Hao Tan, Yuki Ong, Wen Hui Lim, Cheng Han Ng, Phoebe Wen Lin Tay, Jie Ning Yong, Mark D. Muthiah, Eunice X. Tan, Ning Qi Pang, Beom Kyung Kim, Nicholas Syn, Alfred Kow, Brian K. P. Goh, Daniel Q. Huang
Summary: Mortality after LR for HCC is nearly 50% higher compared to LT. Survival between LR and LT were similar in uninodular disease. The risk of recurrence after LR is threefold that of LT.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Review
Oncology
Ilias D. Vachliotis, Ioannis Valsamidis, Stergios A. Polyzos
Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing rapidly. The mechanisms of progression from NAFLD to HCC are not fully understood, but tumor necrosis factor-alpha (TNF-alpha) and adiponectin may play a role. TNF-alpha initially aims to protect against hepatocarcinogenesis, but during the progression of NAFLD, TNF-alpha is increased, thus possibly inducing hepatocarcinogenesis. On the other hand, adiponectin, which is expected to have anti-tumorigenic effects, is decreased during the progression of the disease, but paradoxically increased at the end stage when cirrhosis and HCC are present. Both TNF-alpha and adiponectin may serve as diagnostic biomarkers and therapeutic targets in the treatment of NAFLD-associated HCC, possibly in combination with immune checkpoint inhibitors.
Review
Surgery
Seong Wook Shin, Keun Soo Ahn, Sang Woo Kim, Tae-Seok Kim, Yong Hoon Kim, Koo Jeong Kang
Summary: This study found that liver resection (LR) is more effective than local ablation therapies (such as RFA, MWA, and RFA plus TACE) in treating HCC within the Milan criteria. Specifically, LR has better 5-year recurrence-free survival and lower local recurrence rates compared to local ablation therapies.
Article
Oncology
Victor Amado, Sandra Gonzalez-Rubio, Javier Zamora, Rafael Alejandre, Maria Lola Espejo-Cruz, Clara Linares, Marina Sanchez-Frias, Gema Garcia-Jurado, Jose Luis Montero, Ruben Ciria, Manuel Rodriguez-Peralvarez, Gustavo Ferrin, Manuel De la Mata
Summary: Liver transplantation and surgical resection are potential curative options for patients with liver cirrhosis and hepatocellular carcinoma, but tumor recurrence remains a frequent issue. This study aimed to assess the role of circulating tumor cells in HCC patients undergoing surgery and their association with other markers of poor prognosis. Results suggest that incomplete clearance of circulating tumor cells post-surgery may serve as a surrogate marker of HCC aggressiveness.
Article
Oncology
Yi-Hao Yen, Yueh-Wei Liu, Wei-Feng Li, Chih-Chi Wang, Chee-Chien Yong, Chih-Che Lin, Chih-Yun Lin
Summary: This study evaluated whether combining radiographic tumor burden score (TBS) and alpha-fetoprotein (AFP) level could stratify overall survival (OS) among hepatocellular carcinoma (HCC) patients after liver resection (LR). The results showed that the combination of TBS and AFP levels could effectively predict the overall survival of HCC patients.
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)