Article
Oncology
Chin-Yu Yang, Ines E. Tinhofer, Dung Nguyen, Ming-Huei Cheng
Summary: This study investigated the use of nanofibrillar collagen scaffold (BioBridge) in a rat model, and found that implanting BioBridge into the contralateral inguinal lymph node significantly reduced hind limb lymphedema.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ahmet Hamdi Sakarya, Chi-Wei Huang, Chin-Yu Yang, Hui-Yi Hsiao, Frank Chun-Shin Chang, Jung-Ju Huang
Summary: The study demonstrates that vascularized lymph node transplantation (VLNT) is an effective treatment for lymphedema. VLNT reduces the volume of lymphedema by restoring lymphatic drainage function and reducing inflammation and fibrosis. It also promotes lymphangiogenesis and restores immune function locally and systemically.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
H. Winters, H. J. P. Tielemans, S. Hummelink, N. J. Slater, D. J. O. Ulrich
Summary: In this study, it was found that vascularized lymph node transfer in combination with DIEP flap breast reconstruction can significantly improve lymphedema-related quality of life. Even without a decrease in volume difference, it can reduce the usage of compression garments and the need for physiotherapy.
Article
Medicine, General & Internal
Shinsuke Akita, Yuzuru Ikehara, Minami Arai, Hideki Tokumoto, Yoshihisa Yamaji, Kazuhiko Azuma, Yoshitaka Kubota, Hideaki Haneishi, Motoko Y. Kimura, Nobuyuki Mitsukawa
Summary: The study investigated the effects of partial blood flow impairment in lymph node flaps on the therapeutic results of vascularized lymph node transfer (VLNT) for lymphedema. Clinical and histological examinations showed significant differences in volume reduction and lymph flow recanalization rate between good and poor postoperative blood flow groups. Thrombi formation and immunocompetent cell aggregation were observed in congested lymph nodes in mouse models. Maintaining blood flow in transferred lymph nodes is crucial for the success of VLNT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hyo Jin Kang, Soo Young Moon, Baek-Kyu Kim, Yujin Myung, Ju-Hee Lee, Jae Hoon Jeong
Summary: To overcome the limitations of lymphedema treatment, human adipose-derived stem cells (hADSCs) were injected into decellularized lymph nodes to produce a recellularized lymph node-scaffold, and the effect of lymphangiogenesis was investigated in lymphedema animal models.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Chang-Cheng Chang, Wei-Ling Jan, Cheng-Huei Juan, Nai-Hsin Meng, Bor-Shyh Lin, Hung-Chi Chen
Summary: An innovative wireless device for bioimpedance analysis was developed for evaluating post-dual-site free vascularized lymph node transfer (VLNT). The device showed a significant increase in bioimpedance on the affected limbs postoperatively, especially in the distal limb, and these alterations were significantly correlated with follow-up time. This device has the potential for real-time monitoring of interstitial fluid alterations after surgery.
Article
Oncology
Gonzalo Mallarino-Restrepo, Miffy C. Y. Lin, Ming-Huei Cheng
Summary: This study investigated the outcomes of distal facial vein catheterization (DFVC) for venous thrombosis management in vascularized submental lymph nodes (VSLN) flap transplantations. The study found that DFVC significantly reduced the risk of late venous thrombosis.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Surgery
Harm Winters, Hanneke J. P. Tielemans, Vera Paulus, Stefan Hummelink, Nicholas J. Slater, Dietmar J. O. Ulrich
Summary: Vascularized lymph node transfer (VLNT) is an effective technique for treating lymphedema in breast cancer patients. The current evidence suggests that VLNT can improve the volume differences between the arms and have a positive effect on patients' quality of life, reducing skin infections and the need for compression garment usage. The complication rate is low.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Review
Surgery
Krystof Stanek, Filip Jonas, Pavla Ticha, Martin Molitor, Ondrej Mestak
Summary: This review evaluated animal models of vascularized lymph node transfer (VLNT) and compared their advantages and disadvantages. The study found that rats were the most commonly used animal model, and the main areas of research focused on lymphedema, ischemia, and lymphatic pathway reestablishment.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Surgery
Justin M. Broyles, Jeffrey M. Smith, Franklin C. Wong, Matthew M. Hanasono, Edward Chang, S. Cheenu Kappadath, Mark Schaverien
Summary: This study demonstrates the utility of SPECT/CT lymphoscintigraphy in presurgical planning for groin vascularized lymph node transplantation. It also evaluates the physiological lymphatic drainage to the superficial inguinal lymph nodes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Stav Brown, Babak J. Mehrara, Michelle Coriddi, Leslie McGrath, Michele Cavalli, Joseph H. Dayan
Summary: The purpose of this study was to evaluate the safety and efficacy of vascularized lymph node transplant (VLNT) using all available outcome measures. The results showed that VLNT significantly improved various indicators of lymphedema, with low complication rates. Using omentum as the donor site had a lower risk of lymphedema.
Editorial Material
Surgery
Giorgio De Santis, Bharat Saxena, Marta Starnoni, Marco Pappalardo, Vinay Jacob
Summary: The study suggests that a combination of antibiotics, decongestive therapy, and vascularized submental lymph node transfer can effectively improve early-stage lower limb filarial lymphedema.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Erika G. Kusajima, Yuhei Yamamoto, Kosuke Ishikawa, Takahiro Miura, Emi Funayama, Masayuki Osawa, Ryo Takagi, Taku Maeda
Summary: This study investigated the impact of vascularized lymph node transfer (VLNT) on dendritic cell (DC) dynamics against cancer in mouse models. It was found that mice with reconnected lymphatics after VLNT had reduced metastasis and an increased proportion of DCs, suggesting that VLNT may enhance the tumor immune response by promoting DC migration to lymph nodes.
Article
Surgery
Mark V. Schaverien, Wayne L. Hofstetter, Melissa S. Hall, Dawn N. Chen, Jesse C. Selber
Summary: Jejunal mesenteric vascularized lymph node transplantation is an effective surgical treatment for upper extremity lymphedema, resulting in reduced limb volume and extracellular fluid, and improved patient-reported limb function and outcomes measures compared with optimized conservative therapy alone.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Surgery
Julia Roka-Palkovits, Miffy Chia-Yu Lin, Chieh-Han J. Tzou, Ines Tinhofer, Ming-Huei Cheng
Summary: Vascularized lymph node transfer with retrograde manual lymphatic drainage significantly improves the treatment outcomes for extremity lymphedema patients, with better results observed in distal recipient sites.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2022)
Correction
Multidisciplinary Sciences
Stanley G. G. Rockson, Pinar Karaca-Mandic, Michelle Nguyen, Kristin Shadduck, Phyllis Gingerich, Elizabeth Campione, Heather Hetrrick
SCIENTIFIC REPORTS
(2023)
Review
Peripheral Vascular Disease
Sergio Gianesini, Yung-Wei Chi, Chantal Aguero, Deena Alqedrah, Miguel Amore, Mohammad Barbati, Adriana Baturone, Stephen Black, Denis Borsuk, Oscar Bottini, Joseph Caprini, Marylin Chamo, Meena Cherian, Larisa Chernuka, Marianne DE Maeseneer, Jose Diaz, Mark J. Garcia, Kathleen Gibson, Monika Gloviczki, Peter Gloviczki, Veronika Golovina, Elena Goranova, Lorena Grillo, Adam Gwozdz, Tobias Hirsch, Emad Hussein, Ernesto Intriago, Houman Jalaie, Aleksandra Jaworucka-kaczorowska, Ravul Jindal, Matthieu Josnin, Neil M. Khilnani, Dong-Ik Kim, Alejandro Latorre, Zaza Lazarashvili, Byung-Boong Lee, Luis Leon, Ngoh C. Liew, Kirill Lobastov, Fedor Lurie, Annalisa Maghetti, Erica Menegatti, Kasuo Miyake, M. O. Makoto, Sriram Narayanan, Diana Neuhardt, Felizitas Pannier, Alfredo Prego, Eberhard Rabe, Joseph Raffetto, Pauline Raymond-Martimbeau, Laura Redman, Lourdes Reina-Gutierrez, Rodrigo Rial, Stanley Rockson, Marco Romanelli, Fabricio R. Santiago, Raquel A. Santiago, Nuttawut Sermsathanasawadi, Evgeny Shaydakov, Carlos Simkin, Joel Sousa, Julianne Stoughton, Andrzej Szuba, Wassila Taha, Jorge Ulloa, Tomasz Urbanek, Marco Vitale, Marc Vuylsteke, Jinsong Wang, Janaina Weingartner, Spencer Wilson, Takashi Yamaki, N. G. Yeejia, Igor Zolotukhin, Armando Mansilha
Summary: Published scientific evidence reveals the widespread dissemination of healthcare misinformation in popular social networks and unofficial communication channels. A significant percentage (up to 40%) of medical websites were found to provide inappropriate information, which was shared over 450,000 times in just a five-year period. The issue is particularly prevalent in the fields of infectious diseases, oncology, and cardiovascular medicine. This document represents a collaborative effort by top experts to address these issues, providing evidence-based facts on vein and lymphatic management while also aiming to improve public awareness and fulfill research needs in the field.
INTERNATIONAL ANGIOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Rosie Friedman, Anna Rose Johnson, Kathy Shillue, Aaron Fleishman, Chris Mistretta, Leo Magrini, Bao Ngoc N. Tran, Stanley G. Rockson, Weidong Lu, Gloria Y. Yeh, Dhruv Singhal
Summary: This pilot study examined the safety and feasibility of acupuncture treatment for breast cancer-related lymphedema (BCRL). The results showed that acupuncture intervention improved patients' functional quality of life and had no safety concerns in a small sample. This suggests the need for further investigation of acupuncture treatment for BCRL.
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
S. Gianesini, E. Rimondi, J. D. Raffetto, E. Melloni, A. Pellati, E. Menegatti, G. P. Avruscio, F. Bassetto, A. L. Costa, S. Rockson
Summary: Blood flow is translated into biochemical signals in response to shear stress, which is recognized by sensitive endothelial receptors and plays a vital role in understanding vascular remodeling. While the role of glycocalyx structures in veins and arteries is known, the presence of such structures in the lymphatic system has not been identified in humans.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Stanley G. Rockson
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dung Nguyen, Dimitrios Dionyssiou, Tatiana S. Zaitseva, Anna T. Zhou, Gloria Sue, Peter Deptula, Maxim A. Moroz, Peter Tabada, Stanley G. Rockson, Michael V. Paukshto, Ming-Huei Cheng, Ngan F. Huang
Summary: Secondary lymphedema is a common condition among cancer survivors and there is high demand for treatment strategies. A preclinical rat hindlimb model of lymphedema has been developed and characterized to aid in the development and testing of novel diagnostic and therapeutic strategies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Health Policy & Services
Pinar Karaca-Mandic, Craig A. Solid, Jane M. Armer, Roman Skoracki, Elizabeth Campione, Stanley G. Rockson
Summary: Breast cancer-related lymphedema (BCRL) imposes a significant economic burden on patients, providers, and society, mainly due to adverse events, productivity reduction, and burden on caregivers. Self-care regimens can effectively manage BCRL, but poor adherence reduces their effectiveness and leads to costly complications.
COST EFFECTIVENESS AND RESOURCE ALLOCATION
(2023)
Meeting Abstract
Surgery
Stanley G. Rockson, Roman Skoracki, Jane Armer
JOURNAL OF VASCULAR SURGERY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Catharine Bowman, Stanley G. Rockson