4.6 Meeting Abstract

Efficacy, safety and tolerability of MEDI4736 (durvalumab [D]), a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib (G): A phase I expansion in TKI-naive patients (pts) with EGFR mutant NSCLC

Journal

JOURNAL OF THORACIC ONCOLOGY
Volume 11, Issue 4, Pages S79-S79

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/S1556-0864(16)30171-X

Keywords

-

Funding

  1. MedImmune, the global biologics R&D arm of AstraZeneca

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Oncology

A Phase 1 study of gefitinib combined with durvalumab in EGFR TKI-naive patients withEGFRmutation-positive locally advanced/metastatic non-small-cell lung cancer

Benjamin C. Creelan, Tammie C. Yeh, Sang-We Kim, Naoyuki Nogami, Dong-Wan Kim, Laura Q. M. Chow, Shintaro Kanda, Rosemary Taylor, Weifeng Tang, Mei Tang, Helen K. Angell, Martine P. Roudier, Marcelo Marotti, Don L. Gibbons

Summary: This study evaluated the safety and efficacy of Durvalumab and gefitinib in combination for TKI-naive patients with advanced EGFRm NSCLC. The results showed that this combination therapy had higher toxicity than using either agent alone, and did not significantly increase progression-free survival compared to historical controls.

BRITISH JOURNAL OF CANCER (2021)

Article Oncology

Prospective Single-Arm Phase 1 and 2 Study: Ipilimumab and Nivolumab With Thoracic Radiation Therapy After Platinum Chemotherapy in Extensive-Stage Small Cell Lung Cancer

Bradford A. Perez, Sungjune Kim, Minhsuan Wang, Ahmad M. Karimi, Chase Powell, Jiannong Li, Thomas J. Dilling, Alberto Chiappori, Kujtim Latifi, Trevor Rose, Austin Lannon, Gretchen MacMillan, James Saller, G. Daniel Grass, Stephen Rosenberg, Jhanelle Gray, Eric Haura, Ben Creelan, Tawee Tanvetyanon, Andreas Saltos, Michael Shafique, Theresa A. Boyle, Michael J. Schell, Jose R. Conejo-Garcia, Scott J. Antonia

Summary: The study investigated the addition of ipilimumab and nivolumab after thoracic radiation therapy for patients with extensive stage small cell lung cancer, showing higher than expected overall survival rates. Increased CD3+CD8+ tumor infiltration was associated with favorable outcomes in terms of progression-free survival and overall survival.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Letter Oncology

Selpercatinib Overcomes CCDC6-RET-Mediated Resistance to Osimertinib

Misty D. Shields, J. Kevin Hicks, Theresa A. Boyle, Eric B. Haura, Benjamin C. Creelan

JOURNAL OF THORACIC ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial

Benjamin C. Creelan, Chao Wang, Jamie K. Teer, Eric M. Toloza, Jiqiang Yao, Sungjune Kim, Ana M. Landin, John E. Mullinax, James J. Saller, Andreas N. Saltos, David R. Noyes, Leighann B. Montoya, Wesley Curry, Shari A. Pilon-Thomas, Alberto A. Chiappori, Tawee Tanvetyanon, Frederic J. Kaye, Zachary J. Thompson, Sean J. Yoder, Bin Fang, John M. Koomen, Amod A. Sarnaik, Dung-Tsa Chen, Jose R. Conejo-Garcia, Eric B. Haura, Scott J. Antonia

Summary: Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) in combination with nivolumab showed potential safety and clinical activity in patients with advanced non-small cell lung cancer, indicating a promising new treatment strategy for metastatic lung cancer.

NATURE MEDICINE (2021)

Article Multidisciplinary Sciences

Utilization of target lesion heterogeneity for treatment efficacy assessment in late stage lung cancer

Dung-Tsa Chen, Wenyaw Chan, Zachary J. Thompson, Ram Thapa, Amer A. Beg, Andreas N. Saltos, Alberto A. Chiappori, Jhanelle E. Gray, Eric B. Haura, Trevor A. Rose, Ben Creelan

Summary: This study identified the presence of lesion heterogeneity in cancer treatment, which is important for RECIST response classification. Evaluating this heterogeneity can aid in personalized treatment strategies and improve the accuracy of RECIST response classification.

PLOS ONE (2021)

Article Oncology

Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer

Alberto A. Chiappori, Ben Creelan, Tawee Tanvetyanon, Jhanelle E. Gray, Eric B. Haura, Ram Thapa, Margaret L. Barlow, Zhihua Chen, Dung Tsa Chen, Amer A. Beg, Theresa A. Boyle, Julio Castro, Liza Morgan, Erick Morris, Mehreteab Aregay, Felipe K. Hurtado, Luigi Manenti, Scott Antonia

Summary: This study evaluated the efficacy of taminadenant in patients with non-small cell lung cancer (NSCLC). The results showed that taminadenant, either as a single agent or in combination with spartalizumab, was well tolerated in advanced NSCLC patients and demonstrated clinical benefits regardless of prior immunotherapy or programmed cell death ligand-1 status.

CLINICAL CANCER RESEARCH (2022)

Article Oncology

Phase 1/2 study of epacadostat in combination with durvalumab in patients with metastatic solid tumors

Aung Naing, Alain P. Algazi, Gerald S. Falchook, Benjamin C. Creelan, John Powderly, Seth Rosen, Minal Barve, Niharika B. Mettu, Pierre L. Triozzi, John Hamm, Gongfu Zhou, Chris Walker, Zhiwan Dong, Manish R. Patel

Summary: This study evaluated the safety and efficacy of the combination therapy of the IDO1 inhibitor epacadostat and the PD-L1 monoclonal antibody durvalumab in patients with advanced solid tumors. The study findings showed that the combination therapy had common adverse events and low objective response rate, and a higher dose of epacadostat was needed for sufficient drug effect.

CANCER (2023)

Article Oncology

Dose-Limiting Pulmonary Toxicity in a Phase 1/2 Study of Radiation and Chemotherapy with Ipilimumab Followed by Nivolumab for Patients With Stage 3 Unresectable Non-Small Cell Lung Cancer

Casey L. Liveringhouse, Kujtim Latifi, Amalin G. Asous, Nghi B. Lam, Stephen A. Rosenberg, Thomas J. Dilling, Gretchen MacMillan, Alberto A. Chiappori, Eric B. Haura, Ben Creelan, Jhanelle E. Gray, Tawee Tanvetyanon, Michael R. Shafique, Andreas N. Saltos, Ashley A. Weiner, Jeffrey Clarke, Christopher R. Kelsey, Sungjune Kim, James J. Caudell, Trevor A. Rose, Jose R. Conejo-Garcia, Jiannong Li, Michael J. Schell, Scott J. Antonia, Bradford A. Perez

Summary: This multi-institution prospective trial was discontinued early due to unacceptable toxicity when using concurrent ipilimumab with chemoradiation therapy for patients with unresectable stage III non-small cell lung cancer. Despite toxicities, the median progression-free survival was 19.2 months, and the overall survival has not reached the median value yet.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2023)

Meeting Abstract Oncology

Upfront Treatment With Osimertinib vs. Osimertinib and Radiotherapy for Patients With EGFR-Positive Non-Small Cell Lung Cancer Brain Metastases

A. E. Dohm, J. Tang, M. N. Mills, B. A. Perez, T. J. Robinson, B. Creelan, H. H. M. Yu, D. E. Oliver, K. A. Ahmed

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

Meeting Abstract Oncology

Clinical Outcomes of Non-Small Cell Lung Cancer Brain Metastases Treated With Stereotactic Radiosurgery and Immune Checkpoint Inhibitors, EGFR Tyrosine Kinase Inhibitors, Chemotherapy and Immune Checkpoint Inhibitors, or Chemotherapy Alone

A. E. Dohm, J. Tang, M. N. Mills, B. A. Perez, T. J. Robinson, B. Creelan, J. Gray, A. B. Etame, M. Vogelbaum, P. Forsyth, H. H. M. Yu, D. E. Oliver, K. A. Ahmed

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Meeting Abstract Oncology

Prospective Phase I/II Study of Radiation and Chemotherapy With Ipilimumab Followed by Nivolumab for Patients With Stage III Unresectable NSCLC

C. Liveringhouse, N. B. Lam, S. A. Rosenberg, T. J. Dilling, G. Macmillan, A. Chiappori, E. B. Haura, B. Creelan, J. Gray, T. Tanvetyanon, M. Shafique, A. N. Saltos, A. A. Weiner, C. R. Kelsey, M. Schell, S. J. Antonia, B. A. Perez

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Meeting Abstract Oncology

Sirt2 blockade promotes T cell metabolism and restores the anti-tumor immunity.

Imene Hamaidi, Lin Zhang, Nayoung Kim, Min Hsuan Wang, Cristina Iclozan, Bin Fang, Min Liu, John M. Koomen, Anders E. Berglund, Sean J. Yoder, Jiqiang Yao, Robert W. Engelman, Ben C. Creelan, Jose R. Conejo-Garcia, James J. Mule, Scott J. Antonia, Sungjune Kim

CANCER RESEARCH (2021)

Meeting Abstract Oncology

Phase IIa study of marrow infiltrating lymphocytes (MILs), an adoptive T cell therapy, alone or in combination with nivolumab in non-small cell lung cancer (NSCLC).

Martin Edelman, Aaron Elliott Lisberg, Marianna Koczywas, Ben C. Creelan, Amanda Seiz, Eric Lutz, Lakshmi Rudraraju, Elizabeth DeOliveria, Monil Shah, Kim Noonan, Melissa Lynne Johnson

JOURNAL OF CLINICAL ONCOLOGY (2020)

Meeting Abstract Oncology

Understanding of cancer clinical trial data and statistical opportunities

Dung-Tsa Chen, Ben Creelan, Trevor Rose, Wenyaw Chan

CANCER RESEARCH (2020)

Meeting Abstract Oncology

Durable complete responses to adoptive cell transfer using tumor infiltrating lymphocytes (TIL) in non-small cell lung cancer (NSCLC): A phase I trial

Ben Creelan, Chao Wang, Jamie Teer, Eric Toloza, John Mullinax, Jiqiang Yao, John Koomen, Sungjune Kim, Alberto Chiappori, James Saller, Leighann Montoya, Ana Marie Landin, Tawee Tanvetyanon, Bin Fang, Zachary Thompson, Xiaoping Yu, Andreas Saltos, Dung-Tsa Chen, Jose Conejo-Garcia, Eric Haura, Scott Antonia

CANCER RESEARCH (2020)

No Data Available