Heroin- and Fentanyl-Induced Respiratory Depression in a Rat Plethysmography Model: Potency, Tolerance, and Sex Differences

Corticosteroid sensitization drives opioid addiction

(2022) Stephanie A. Carmack et al.   MOLECULAR PSYCHIATRY

Naloxone’s dose-dependent displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain

(2022) Yeona Kang et al.   Scientific Reports

S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats

(2022) Paulina M. Getsy et al.   Frontiers in Pharmacology

D-cysteine ethyl ester and D-cystine dimethyl ester reverse the deleterious effects of morphine on arterial blood-gas chemistry and Alveolar-arterial gradient in anesthetized rats

(2022) Paulina M. Getsy et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

D-Cysteine Ethyl Ester Reverses the Deleterious Effects of Morphine on Breathing and Arterial Blood–Gas Chemistry in Freely-Moving Rats

(2022) Paulina M. Getsy et al.   Frontiers in Pharmacology

S-nitroso-L-cysteine stereoselectively blunts the adverse effects of morphine on breathing and arterial blood gas chemistry while promoting analgesia

(2022) Paulina M. Getsy et al.   BIOMEDICINE & PHARMACOTHERAPY

L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry

(2022) Paulina M. Getsy et al.   BIOMEDICINE & PHARMACOTHERAPY

L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats

(2022) Paulina M. Getsy et al.   Frontiers in Pharmacology

The ventilatory depressant actions but not the antinociceptive effects of morphine are blunted in rats receiving intravenous infusion of L-cysteine ethyl ester

(2022) Tristan H.J. Lewis et al.   BIOMEDICINE & PHARMACOTHERAPY

κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

(2021) Renata C.N. Marchette et al.   Neurobiology of Stress

Nitrosyl factors play a vital role in the ventilatory depressant effects of fentanyl in unanesthetized rats

(2021) James M. Seckler et al.   BIOMEDICINE & PHARMACOTHERAPY

Comparison of rates of opioid withdrawal symptoms and reversal of opioid toxicity in patients treated with two naloxone dosing regimens: a retrospective cohort study

(2020) Roy Purssell et al.   CLINICAL TOXICOLOGY

Kölliker-Fuse/Parabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression

(2020) Sandy E. Saunders et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Drug and Opioid-Involved Overdose Deaths — United States, 2017–2018

(2020) Nana Wilson et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level

(2020) Ronald B. Moss et al.   PLoS One

Tolerance to Opioid‐Induced Respiratory Depression in Chronic High‐Dose Opioid Users: A Model‐Based Comparison With Opioid‐Naïve Individuals

(2020) Marijke Hyke Algera et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic variation regulates opioid-induced respiratory depression in mice

(2020) Jason A. Bubier et al.   Scientific Reports

Heroin addiction engages negative emotional learning brain circuits in rats

(2019) Stephanie A. Carmack et al.   JOURNAL OF CLINICAL INVESTIGATION

Electrocortical changes associating sedation and respiratory depression by the opioid analgesic fentanyl

(2019) Gaspard Montandon et al.   Scientific Reports

Averting Opioid-induced Respiratory Depression without Affecting Analgesia

(2018) Albert Dahan et al.   ANESTHESIOLOGY

Sex-dependent influences of morphine and its metabolites on pain sensitivity in the rat

(2018) H.H. Doyle et al.   PHYSIOLOGY & BEHAVIOR

The toxicology of heroin-related death: estimating survival times

(2016) Shane Darke et al.   ADDICTION

Opioid-induced Respiratory Depression Is Only Partially Mediated by the preBötzinger Complex in Young and Adult Rabbits In Vivo

(2015) Astrid G. Stucke et al.   ANESTHESIOLOGY

Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine

(2015) Rob Hill et al.   NEUROPSYCHOPHARMACOLOGY

Understanding Heroin Overdose: A Study of the Acute Respiratory Depressant Effects of Injected Pharmaceutical Heroin

(2015) Caroline J. Jolley et al.   PLoS One

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

Compulsive-Like Responding for Opioid Analgesics in Rats with Extended Access

(2014) Carrie L Wade et al.   NEUROPSYCHOPHARMACOLOGY

Dynamic vaccine blocks relapse to compulsive intake of heroin

(2013) J. E. Schlosburg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gender and strain contributions to the variability of buprenorphine-related respiratory toxicity in mice

(2013) Hisham Alhaddad et al.   TOXICOLOGY

The Metabolism of Opioid Agents and the Clinical Impact of Their Active Metabolites

(2011) Howard S. Smith   CLINICAL JOURNAL OF PAIN

Escalation patterns of varying periods of heroin access

(2011) Leandro F. Vendruscolo et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Comparative Profiles of Men and Women with Opioid Dependence: Results from a National Multisite Effectiveness Trial

(2011) Sudie E. Back et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Opioids Depress Cortical Centers Responsible for the Volitional Control of Respiration

(2009) K. T. S. Pattinson et al.   JOURNAL OF NEUROSCIENCE

Opioids and the control of respiration

(2008) K.T.S. Pattinson   BRITISH JOURNAL OF ANAESTHESIA