Review
Cardiac & Cardiovascular Systems
Guy Rozen, Gilad Margolis, Ibrahim Marai, Ariel Roguin, Eldad Rahamim, David Planer, Edwin Kevin Heist, Offer Amir, Ilgar Tahiroglu, Jeremy Ruskin, Moussa Mansour, Gabby Elbaz-Greener
Summary: The paper reviews the evolution of surgical techniques for left atrial appendage (LAA) exclusion and the use of percutaneous LAA occlusion techniques as alternative stroke prevention methods. The article focuses on recently published randomized data supporting surgical LAA occlusion during cardiac surgery and the emerging trans-catheter techniques for LAA occlusion. The study also highlights the favorable results of Watchman and Amulet devices in reducing stroke risk in atrial fibrillation (AF) patients with contraindications for oral anticoagulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Ralf Martz Sulague, Tarik Whitham, Lester Mico Lopez Danganan, Victory Effiom, Katherine Candelario, Nida Latif, Irbaz Hameed
Summary: This article provides a comprehensive review of the clinical utility of the left atrial appendage and its associated procedures in preventing thromboembolism in patients with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yoichi Takaya, Rie Nakayama, Fumi Yokohama, Norihisa Toh, Koji Nakagawa, Masakazu Miyamoto, Hiroshi Ito
Summary: The size of the left atrial appendage (LAA) increases as atrial fibrillation (AF) progresses, with patients with long-standing persistent AF having larger LAA ostial diameter and depth. LAA ostial diameter is correlated with left atrial volume index and the duration of continuous AF.
Article
Cardiac & Cardiovascular Systems
James Freeman, Angela Y. Higgins, Yongfei Wang, Chengan Du, Daniel J. Friedman, Usama A. Daimee, Karl E. Minges, Lucy Pereira, Andrew M. Goldsweig, Matthew J. Price, Vivek Y. Reddy, Douglas Gibson, Shephal K. Doshi, Paul D. Varosy, Frederick A. Masoudi, Jeptha P. Curtis
Summary: This study evaluated the postprocedure care patterns and compared the risk of adverse events for different discharge antithrombotic strategies after left atrial appendage occlusion (LAAO) with the Watchman device. The study found that practitioners rarely followed the recommended postprocedure treatment protocols and that discharge on warfarin or direct oral anticoagulants (DOACs) without aspirin was associated with a lower risk of adverse outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lu-Shen Jin, Jin-Yan Ke, Yuan-Nan Lin, Ling Li, Jia-Yang Fu, Yi-Lian Chen, Yi-Xuan Qiu, Xiao-Wei Li, Yang-Qi Pan, Yue-Chun Li
Summary: This study investigated the efficacy and safety of a modified left atrial appendage closure (LAAC) procedure using the LAmbre device in patients with persistent left atrial appendage thrombus (LAAT) despite adequate anticoagulation. The results showed that LAAC with the LAmbre device was effective and safe in these highly selected patients, with no thromboembolic or bleeding events occurring.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Jurij M. Kalisnik, Giuseppe Santarpino, Andrea Balbierer, Janez Zibert, Ferdinand A. Vogt, Matthias Fittkau, Theodor Fischlein
Summary: This study aimed to evaluate the thromboembolic risk in patients with atrial fibrillation (AF) and aortic stenosis undergoing aortic valve replacement (AVR) with or without left atrial appendage (LAA) amputation. The results showed that patients who underwent LAA amputation had a lower incidence of ischemic stroke during the follow-up period, without increasing perioperative risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Derek S. Chew, Ke Zhou, Sean D. Pokorney, David B. Matchar, Sreekanth Vemulapalli, Larry A. Allen, Kevin P. Jackson, Zainab Samad, Manesh R. Patel, James V. Freeman, Jonathan P. Piccini
Summary: Left atrial appendage occlusion (LAAO) is a potential alternative to oral anticoagulants in patients with atrial fibrillation (AF) to reduce major bleeding risk. However, there is uncertainty regarding the risk for ischemic stroke compared with anticoagulation. The overall benefit from LAAO depends on the combination of stroke and bleeding risks in individual patients.
ANNALS OF INTERNAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Fareed Moses S. Collado, Claudia M. Lama von Buchwald, Christina K. Anderson, Nidhi Madan, Hussam S. Suradi, Henry D. Huang, Hani Jneid, Clifford J. Kavinsky
Summary: The majority of embolic strokes in patients with nonvalvular atrial fibrillation are caused by thrombi in the left atrial appendage. It is projected that strokes related to atrial fibrillation will increase unless effective mitigation strategies are implemented. Systemic anticoagulation is effective in reducing stroke risk, but bleeding complications and nonadherence can be barriers. Surgical and percutaneous left atrial appendage occlusion devices are nonpharmacologic strategies to mitigate drug therapy challenges.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Oncology
Samuel A. Shabtaie, Nicholas Y. Tan, Robert C. Ward, Bradley R. Lewis, Eric H. Yang, David R. Holmes Jr, Joerg Herrmann
Summary: This study evaluated left atrial appendage occlusion (LAAO) as a safe and effective strategy for reducing stroke risk in atrial fibrillation (AF) patients with cancer, without increasing bleeding risk. The results showed that LAAO in cancer patients had similar reduction in stroke risk and bleeding risk compared to non-cancer patients.
JACC: CARDIOONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pavel Osmancik, Dalibor Herman, Petr Neuzil, Pavel Hala, Milos Taborsky, Petr Kala, Martin Poloczek, Josef Stasek, Ludek Haman, Marian Branny, Jan Chovancik, Pavel Cervinka, Jiri Holy, Tomas Kovarnik, David Zemanek, Stepan Havranek, Vlastimil Vancura, Petr Peichl, Petr Tousek, Veronika Lekesova, Jiri Jarkovsky, Martina Novackova, Klara Benesova, Petr Widimsky, Vivek Y. Reddy
Summary: The long-term follow-up of the PRAGUE-17 trial demonstrates that left atrial appendage closure is noninferior to direct oral anticoagulants in preventing major cardiovascular, neurological, or bleeding events, and it significantly reduces nonprocedural bleeding.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Runxin Fang, Yang Li, Jun Wang, Zidun Wang, John Allen, Chi Keong Ching, Liang Zhong, Zhiyong Li
Summary: Left atrial appendage (LAA) is a common site of thrombus formation in atrial fibrillation (AF) patients. Traditional stroke risk assessment models do not take into account the structural and hemodynamic features of LAA. Recent studies have suggested that incorporating LAA geometry and hemodynamics is important for evaluating the risk of thrombus formation, leading to better stroke prevention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jin-Yan Ke, Lu-Shen Jin, Yuan-Nan Lin, Jing Xu, Wei-Ke Liu, Jia-Yang Fu, Ling Li, Yi-Lian Chen, Yi-Xuan Qiu, Yue-Chun Li
Summary: This study compared the efficacy and safety of the Watchman device and the LAmbre device in combined left atrial appendage closure and radiofrequency catheter ablation for non-valvular atrial fibrillation. The results showed that both devices had similar rates of adverse events and AF recurrence. However, the LAmbre device had a higher rate of minimal peri-device leakage at short-term follow-up.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jihoon Kim, Sung-Ji Park, Dong Seop Jeong, Suryeun Chung, Kina Jeon, Minjung Bak, Darae Kim, Eun Kyoung Kim, Sung-A Chang, Sang-Chol Lee, Seung Woo Park
Summary: This study investigated the association between left atrial (LA) strain and LA fibrosis in patients undergoing totally thoracoscopic ablation (TTA) for atrial fibrillation (AF). The results showed that patients with mild LA fibrosis had a significantly lower rate of AF recurrence at 5 years after TTA compared to those with moderate or severe fibrosis. Peak LA strain was the only predictor of mild LA fibrosis, with a cutoff value of approximately 14.7%.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yankai Mao, Huajie Zhao, Chan Yu, Yuan Yang, Mingming Ma, Yunhe Wang, Ruhong Jiang, Bowen Zhao, Zhelan Zheng, Chenyang Jiang
Summary: This study aimed to investigate the relationship between left atrial appendage (LAA) mechanical dispersion (MD) and LAA dense spontaneous echo contrast (SEC) or thrombus, and compare its usefulness in identifying thrombogenesis with left atrial (LA) MD or LA/LAA strain parameters in patients with atrial fibrillation (AF).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Edward V. Kogan, Christopher T. Sciria, Christopher F. Liu, S. Chiu Wong, Geoffrey Bergman, James E. Ip, George Thomas, Steven M. Markowitz, Bruce B. Lerman, Luke K. Kim, Jim W. Cheung
Summary: This study analyzed the rates and predictors of early stroke and mortality following left atrial appendage occlusion (LAAO). The results showed low rates of early stroke and mortality, with majority of events occurring within 45 days of LAAO.
Article
Cardiac & Cardiovascular Systems
Lisa M. Fleming, Philip Jones, Paul S. Chan, Adin-Christian Andrei, Thomas M. Maddox, Steven A. Farmer
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2016)
Letter
Cardiac & Cardiovascular Systems
Adin-Cristian Andrei
ANNALS OF THORACIC SURGERY
(2016)
Article
Critical Care Medicine
Ankit Bharat, Nicole Graf, Andrew Mullen, Jacob Kanter, Adin-Cristian Andrei, Peter H. S. Sporn, Malcolm M. DeCamp, Jacob I. Sznajder
Article
Cardiac & Cardiovascular Systems
Kathleen L. Grady, Adin-Cristian Andrei, Zhi Li, Bruce Rybarczyk, Connie White-Williams, Robert Gordon, Edwin C. McGee
Article
Cardiac & Cardiovascular Systems
Holly E. M. Mewhort, Jeannine D. Turnbull, Alessandro Satriano, Kelvin Chow, Jacqueline A. Flewitt, Adin-Cristian Andrei, David G. Guzzardi, Daniyil A. Svystonyuk, James A. White, Paul W. M. Fedak
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2016)
Article
Cardiac & Cardiovascular Systems
Daniel H. Enter, Anthony Zaki, Brett F. Duncan, Jane Kruse, Adin-Cristian Andrei, Zhi Li, S. Chris Malaisrie, Sanjiv J. Shah, James D. Thomas, Patrick M. McCarthy
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Adin-Cristian Andrei
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2016)
Editorial Material
Surgery
Adin-Cristian Andrei
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2017)
Article
Cardiac & Cardiovascular Systems
Kathleen L. Grady, Kathleen Van't Hof, Adin-Cristian Andrei, Tamara Shankel, Richard Chinnock, Shelley Miyamoto, Amrut V. Ambardekar, Allen Anderson, Linda Addonizio, Farhana Latif, Debra Lefkowitz, Lee Goldberg, Seth A. Hollander, Michael Pham, Jill Weissberg-Benchell, Nichole Cool, Clyde Yancy, Elfriede Pahl
PEDIATRIC CARDIOLOGY
(2018)
Article
Pharmacology & Pharmacy
Daniel H. Enter, Anthony L. Zaki, Megan Marsh, Nikki Cool, Jane Kruse, Zhi Li, Adin-Cristian Andrei, Adam Iddriss, Patrick M. McCarthy, S. Chris Malaisrie, Allen Anderson, Jonathan D. Rich, Duc Thinh Pham
Article
Cardiac & Cardiovascular Systems
Kathleen L. Grady, Philip G. Jones, Adin Cristian-Andrei, David C. Naftel, Susan Myers, Mary Amanda Dew, Katharine Idrissi, Gerdi Weidner, Sherri A. Wissman, James K. Kirklin, John A. Spertus
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2017)
Article
Cardiac & Cardiovascular Systems
S. Chris Malaisrie, Patrick M. McCarthy, Jane Kruse, Roland Matsouaka, Adin-Cristian Andrei, Maria V. Grau-Sepulveda, Daniel J. Friedman, James L. Cox, J. Matthew Brennan
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2018)
Article
Health Care Sciences & Services
Seungbong Han, Kam-Wah Tsui, Adin-Cristian Andrei
STATISTICAL METHODS IN MEDICAL RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Andrei Churyla, Adam Iddriss, Adin-Christian Andrei, Jane Kruse, S. Chris Malaisrie, Rod Passman, Zhi Li, Richard Lee, Patrick M. McCarthy
ANNALS OF THORACIC SURGERY
(2017)
Article
Endocrinology & Metabolism
Elizabeth Lowden, Kathleen Schmidt, Irena Mulla, Adin-Cristian Andrei, John Cashy, Diana Johnson Oakes, Grazia Aleppo, Kathleen L. Grady, Amisha Wallia, Mark E. Molitch
ENDOCRINE PRACTICE
(2017)