Immunomodulatory quinazoline-based thalidomide analogs: Design, synthesis, apoptosis and anticancer evaluations

Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors

(2022) Abdallah E. Abdallah et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation

(2022) Abdallah E Abdallah et al.   Drug Design Development and Therapy

Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation

(2022) Alaa Elwan et al.   MOLECULES

In silico molecular docking, dynamics simulation and repurposing of some VEGFR-2 inhibitors based on the SARS-CoV-2-main-protease inhibitor N3

(2022) Sanadelaslam El-Hddad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

New bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and anticancer evaluation

(2021) Mohammed M. Alanazi et al.   BIOORGANIC CHEMISTRY

Design, synthesis and molecular modeling of new quinazolin-4(3H)-one based VEGFR-2 kinase inhibitors for potential anticancer evaluation

(2021) Abdallah E. Abdallah et al.   BIOORGANIC CHEMISTRY

Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site

(2021) Ibrahim H. Eissa et al.   BIOORGANIC CHEMISTRY

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies

(2021) Hazem Elkady et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel Nanocombinations of l-Tryptophan and l-Cysteine:  Preparation, Characterization, and Their Applications for Antimicrobial and Anticancer Activities

(2021) Ahmed I. Abd-Elhamid et al.   Pharmaceutics

Molecular mechanisms of thalidomide and its derivatives

(2020) Takumi ITO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The challenge of drug resistance in cancer treatment: a current overview

(2018) Michail Nikolaou et al.   CLINICAL & EXPERIMENTAL METASTASIS

Functional characterization of α7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay

(2018) Mohamed R. Elnagar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Vitamin E inhibits cyclosporin A-induced CTGF and TIMP-1 expression by repressing ROS-mediated activation of TGF-β/Smad signaling pathway in rat liver

(2018) Amany Balah et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Brighter Side to Thalidomide: Its Potential Use in Immunological Disorders

(2017) David Millrine et al.   TRENDS IN MOLECULAR MEDICINE

Design, synthesis, and biological evaluation of novel quinazolinyl-diaryl urea derivatives as potential anticancer agents

(2016) Jia-Nian Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

(2016) Sahar M. Abou-Seri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The molecular mechanism of thalidomide analogs in hematologic malignancies

(2016) Stefanie Lindner et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anti-arthritis effect of a novel quinazoline derivative through inhibiting production of TNF-α mediated by TNF-α converting enzyme in murine collagen-induced arthritis model

(2015) Yuzhi Pu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists

(2015) Nam-Chul Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

(2015) P. R. Hagner et al.   BLOOD

Synthesis, DNA binding, hemolysis assays and anticancer studies of copper(II), nickel(II) and iron(III) complexes of a pyrazoline-based ligand

(2013) Kishwar Saleem et al.   Future Medicinal Chemistry

Pomalidomide: a novel drug to treat relapsed and refractory multiple myeloma

(2013) Evangelos Terpos et al.   OncoTargets and Therapy

Cardiac Toxicity of Anticancer Agents

(2013) Alessandro Colombo et al.   Current Cardiology Reports

Molecular docking and synthesis of novel quinazoline analogues as inhibitors of transcription factors NF-κB activation and their anti-cancer activities

(2012) Lu Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

(2012) A Lopez-Girona et al.   LEUKEMIA

Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma

(2012) Yuan Xiao Zhu et al.   LEUKEMIA & LYMPHOMA

Thalidomide in the treatment of refractory cutaneous lupus erythematosus: prognostic factors of clinical outcome

(2011) J. Cortés-Hernández et al.   BRITISH JOURNAL OF DERMATOLOGY

Mechanism of action of immunomodulatory agents in multiple myeloma

(2010) Thomas Reske et al.   MEDICAL ONCOLOGY

Thalidomide as a Multi-Template for Development of Biologically Active Compounds

(2008) Yuichi Hashimoto   ARCHIV DER PHARMAZIE