Article
Cardiac & Cardiovascular Systems
Ana Blasco, Maria-Jose Coronado, Fernando Hernandez-Terciado, Paloma Martin, Ana Royuela, Elvira Ramil, Diego Garcia, Javier Goicolea, Maria Del Trigo, Javier Ortega, Juan M. Escudier, Lorenzo Silva, Carmen Bellas
Summary: Severe COVID-19 can lead to intense formation of neutrophil extracellular traps (NETs) which occlude microvessels, potentially causing ST-elevated myocardial infarction. In patients with COVID-19, a higher density of NETs was found in coronary thrombi compared to historical patients without COVID-19, suggesting a role of NETs in coronary thrombosis pathogenesis. Targeting intravascular NETs could be a relevant treatment goal for preventing coronary thrombosis in severe COVID-19 cases.
Article
Multidisciplinary Sciences
Yan Wang, Mao Yang, Yuanyuan Xu, Shujun Yan, Enze Jin, Xueqi Li
Summary: This study evaluated the association between circulating neutrophil extracellular traps (NETs) markers and coronary artery disease (CAD) in Chinese adults. The levels of dsDNA, MPO, and NE were significantly elevated in patients with CAD, and correlated with the risk factors of atherosclerosis. NET markers were identified as independent risk factors for severe coronary stenosis and also as predictors of severe CAD.
Article
Pharmacology & Pharmacy
Mengmeng Zhao, Zihui Zheng, Zheng Yin, Jishou Zhang, Shanshan Peng, Jianfang Liu, Wei Pan, Cheng Wei, Yao Xu, Juan-Juan Qin, Jun Wan, Menglong Wang
Summary: Recent studies have shown that neutrophils play a key role in the progression of heart failure, and Developmental Endothelial Locus-1 (DEL-1), an anti-inflammatory glycoprotein, has been found to have protective effects in various cardiovascular diseases. However, the specific role of DEL-1 in chronic heart failure is still unclear. This study used a mouse model of pressure overload-induced non-ischemic cardiac failure and found that DEL-1 deficiency worsened cardiac dysfunction and remodeling by promoting neutrophil infiltration and the formation of neutrophil extracellular traps (NETs) through the regulation of P38 signaling. In vitro experiments also showed that DEL-1 can inhibit P38 signaling and NETs formation in mouse neutrophils in a MAC-1-dependent manner.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Hematology
Ana Blasco, Maria-Jose Coronado, Paula Vela, Paloma Martin, Jorge Solano, Elvira Ramil, Aina Mesquida, Adrian Santos, Beatriz Cozar, Ana Royuela, Diego Garcia, Susana Camarzana, Carolina Parra, Juan F. Oteo, Javier Goicolea, Carmen Bellas
Summary: NETs were detected in 51% of coronary thrombi, and the presence of NETs was associated with a worse prognosis after STEMI, suggesting a feasible way to prevent reinfarction in some patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Kathryn E. Hally, Olivia M. Parker, Morgane M. Brunton-O'Sullivan, Scott A. Harding, Peter D. Larsen
Summary: Combining biomarkers of NETosis and platelet activation is important for predicting MACE in patients with AMI. Composite biomarker scores, inclusive of both NETosis and platelet activation biomarkers, were independent predictors of 1-year MACE, showing a stronger association when combined.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Engineering, Biomedical
Junsong Guo, Hao Wang, Ying Li, Shuang Zhu, Houxiang Hu, Zhanjun Gua
Summary: Coronary heart disease (CHD) is a leading cause of death and disability worldwide, particularly in low-income and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations, but nanotechnology offers promising alternatives for the diagnosis and treatment of CHD by utilizing the unique properties of nanomaterials. Nanomaterials can enhance early detection of CHD, facilitate targeted drug delivery and tissue engineering, and modulate inflammation and oxidative stress, addressing multiple aspects of CHD pathophysiology.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Pema Raj, Sijo Joseph Thandapilly, Jeffrey Wigle, Shelley Zieroth, Thomas Netticadan
Summary: Atherosclerosis, myocardial infarction, and heart failure are major global causes of mortality and morbidity, and resveratrol shows potential as a new therapeutic agent for these cardiovascular diseases. Although animal model studies have been promising, there is still insufficient evidence from clinical trials.
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Review
Immunology
Yingnan Liao, Kui Liu, Liyuan Zhu
Summary: Cardiovascular diseases are a major health problem globally, and inflammasomes play a significant role in these diseases. Among them, NLRP3 inflammasome has been extensively studied for its involvement in immune response and disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Giacomo Buso, Elisabetta Faggin, Nathalie Rosenblatt-Velin, Maxime Pellegrin, Silvia Galliazzo, Luca Calanca, Marcello Rattazzi, Lucia Mazzolai
Summary: In recent years, the role of neutrophils in cardiovascular disease (CVD) has received increasing attention. Neutrophils have been found to play a role in the initiation, progression, and rupture of atherosclerotic plaque. While there has been extensive research on the role of neutrophils in coronary artery and cerebrovascular diseases, there is limited information available on their role in peripheral artery disease (PAD). This review aims to summarize the current understanding of neutrophil biology, their role in atherosclerosis, and the available evidence on their role in PAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Xiaofan Yang, Yupeng Ma, Xin Chen, Jingjing Zhu, Wenlong Xue, Ke Ning
Summary: Cardiovascular diseases are a leading cause of illness and death globally, with atherosclerosis (AS)-caused cardiovascular disease being the main cause of death. Neutrophil extracellular traps (NETs) play a crucial role in promoting endothelial inflammation in AS. Understanding the mechanisms of NETs in AS is important as they could potentially serve as a new therapeutic target. This review summarizes the possible mechanisms of NETs in AS.
Article
Cell Biology
Xudong Li, Changhao Xu, Qiaoqiao Li, Qingxiang Shen, Long Zeng
Summary: In this study, the role of neutrophil extracellular traps (NETs) in heart failure (HF) was investigated using transcriptome sequencing and single-cell sequencing data analysis. Thirteen differentially expressed genes (DEGs) associated with NETs in HF were identified, and four diagnostic markers capable of predicting HF risk were pinpointed. The analysis also highlighted the close interactions between macrophages and T cells with neutrophils.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Valerie Josephine Dirjayanto, Mohammad Alkhalil, John Dodson, Gregory Mills, Graziella Pompei, Francesca Rubino, Vijay Kunadian
Summary: Cognitive impairment in older patients with NSTEACS undergoing invasive treatment is associated with long-term all-cause mortality, but not with MACE occurrence.
Article
Multidisciplinary Sciences
Hannes A. Baukmann, Justin L. Cope, Colin Bannard, Alexander R. E. C. Schwinges, Margaretha R. J. Lamparter, Sarah Groves, Charles N. J. Ravarani, Borko Amulic, Joern E. Klinger, Marco F. Schmidt
Summary: Despite the availability of vaccines to prevent SARS-CoV-2 infection, treating critically ill COVID-19 patients remains crucial. This study presents an alternative method for identifying drug repurposing targets by screening disease-causing traits, leading to the discovery of potential treatment targets for critical illness.
Article
Cardiac & Cardiovascular Systems
Andreas Mangold, Anna S. Ondracek, Thomas M. Hofbauer, Thomas Scherz, Tyler Artner, Noel Panagiotides, Dietrich Beitzke, Gerhard Ruzicka, Sonja Nistler, Evelyne Wohlschlaeger-Krenn, Robert Winker, Peter Quehenberger, Denise Traxler-Weidenauer, Andreas Spannbauer, Mariann Gyoengyoesi, Christoph Testori, Irene M. Lang
Summary: Extracellular chromatin and neutrophil activation play crucial roles in myocardial infarction, with high levels correlating with infarct size, microvascular obstruction, and cardiac function. DNase activity is important for maintaining microvascular patency and improving outcomes in STEMI patients.
CARDIOVASCULAR RESEARCH
(2022)
Article
Plant Sciences
Biao Gu, Wenxin Gao, Zeqi Liu, Guangda Shao, Qin Peng, Yinyu Mu, Qinhu Wang, Hua Zhao, Jianqiang Miao, Xili Liu
Summary: As a destructive plant pathogen, Phytophthora infestans secretes specific proteins called RxLR effectors that facilitate infection. One of these effectors, PiAvr3b, causes a specific immune response and also suppresses the general immune response. The molecular basis of these dual activities has been unknown, but this study found that specific amino acids in PiAvr3b were responsible for both activities. The localization of PiAv3b within the cell also plays a role in its ability to stimulate or suppress immune responses.
MOLECULAR PLANT PATHOLOGY
(2023)
Correction
Multidisciplinary Sciences
Claudia Calabrese, Natalie R. Davidson, Deniz Demircioglu, Nuno A. Fonseca, Yao He, Andre Kahles, Kjong-Van Lehmann, Fenglin Liu, Yuichi Shiraishi, Cameron M. Soulette, Lara Urban, Liliana Greger, Siliang Li, Dongbing Liu, Marc D. Perry, Qian Xiang, Fan Zhang, Junjun Zhang, Peter Bailey, Serap Erkek, Katherine A. Hoadley, Yong Hou, Matthew R. Huska, Helena Kilpinen, Jan O. Korbel, Maximillian G. Marin, Julia Markowski, Tannistha Nandi, Qiang Pan-Hammarstrom, Chandra Sekhar Pedamallu, Reiner Siebert, Stefan G. Stark, Hong Su, Patrick Tan, Sebastian M. Waszak, Christina Yung, Shida Zhu, Philip Awadalla, Chad J. Creighton, Matthew Meyerson, B. F. Francis Ouellette, Kui Wu, Huanming Yang, Alvis Brazma, Angela N. Brooks, Jonathan Goeke, Gunnar Raetsch, Roland F. Schwarz, Oliver Stegle, Zemin Zhang
Article
Geochemistry & Geophysics
Jing Wang, Ben-Xun Su, Bing-Yu Gao, Wen-Jun Li, Meng-Meng Cui, Xia Liu, Yang Luo, Qi-Qi Pan, Li-Hui Jia, Li Su, Kai-Yun Chen
Summary: Four natural chromite samples from China and the USA were analyzed for major and trace elements. The results showed that these samples are homogeneous and suitable as reference materials for in situ microanalysis.
GEOSTANDARDS AND GEOANALYTICAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Yang Wang, Jie Wang, Xiao-Wei Zheng, Ming-Fei Du, Xi Zhang, Chao Chu, Dan Wang, Yue-Yuan Liao, Qiong Ma, Hao Jia, Gui-Lin Hu, Yu Yan, Yue Sun, Chen Chen, Xiao-Yu Zhang, Hao Li, Ting Zou, Ze-Jiaxin Niu, Zi-Yue Man, Lan Wang, Wen-Jing Luo, Guan-Ji Wu, Yu-Ming Kang, John Chang, Christian Delles, Yao Lu, Jian-Jun Mu
Summary: This study found that the accumulation of individual cardiovascular risk factors from childhood to midlife was associated with vascular aging in midlife. Persistent increase and accumulation of cardiovascular risk factors were associated with arterial stiffness and thickening of arterial walls in midlife.
Article
Engineering, Biomedical
Kejun Dong, Li Zhao, Cairong Zou, Zhipeng Cai, Chang Yan, Yang Li, Jianqing Li, Chengyu Liu
Summary: This paper proposes a novel EDR method based on the feature derived from the first moment of the power spectrum. The IMM smoother is introduced to enhance the similarity of the EDR signal to the reference respiration. The proposed method shows good performance and provides a direction for improving the EDR waveform.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Civil
Yuewen Li, Xiaoling Wang, Qi Kang, Zheng Fan, Shuaiyu Yao
Summary: The airline crew pairing (ACP) problem is challenging due to the exponential growth of connections as the number of flights increases. Conventional approaches use a two-stage method, but it becomes difficult for large-scale instances. To address this, we propose an iterative optimization framework based on Monte Carlo tree search (MCTS) to efficiently solve large-scale ACP problems.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2023)
Article
Engineering, Chemical
Mingyu Luo, Junjie Chen, Qingbiao Li, Yuanpeng Wang
Summary: In this experiment, cotton-based activated carbon fiber was prepared by urea-enhanced low-temperature hydrothermal carbonization and activation method. The specific surface area of the activated carbon fiber prepared by low-temperature hydrothermal carbonization with urea enhancement was 2304.8 m(2)/g, which was higher than that of activated carbon fibers prepared by other biomass raw materials. The process of hydrothermal-assisted KOH activation can generate more pore structures in the carbon materials, and the activated carbon fiber shows a high adsorption capacity for iodine, reaching up to 2254.8 mg/g.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Yanzhi Liu, Kun Yuan, Mengyang Li, Pei Zhao, Yaoxiao Zhao, Xiang Zhao
Summary: A new carbonaceous nanohoop, [4]-cyclopara-1,2-diphenylethylene ([4]-CPDPE), is designed with two rational synthesis paths proposed. Density functional theory calculations are used to explore the structures and properties of the nanoscale Saturn-like systems formed with [4]-CPDPE and fullerene C-60/70. The results show a perfect geometry mutual matching between [4]-CPDPE and C-60/70, and the formation of [4]-CPDPE superset of C-60/70 complexes with high binding energies.
INORGANIC CHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Qinghui An, Jianghua Zheng, Jingyun Guan, Jianguo Wu, Jun Lin, Xifeng Ju, Rui Wu
Summary: Eolagurus luteus is a keystone species in the desert steppe of northern Xinjiang. Their behavior has led to the reduction of grassland vegetation and soil erosion, impacting the ecological balance of the grassland. Additionally, the pathogens carried by E. luteus pose a great threat to human health. Therefore, predicting the suitable habitat area of this species under climate change scenarios is crucial.
Article
Oncology
Liya Jiang, Fang Xu, Chenglong Li, Ting Liu, Qianwei Zhao, Yixian Liu, Ying Zhao, Yamei Li, Zhendong Zhang, Xiaolei Tang, Jintao Zhang
Summary: This study found that overexpression of SULT1C2 promoted the growth, survival, migration, and invasiveness of hepatocellular carcinoma (HCC) cells, while SULT1C2 knockdown resulted in extensive gene expression and metabolome changes in HCC cells. The study also showed that SULT1C2 knockdown significantly suppressed glycolysis and fatty acid metabolism in HCC cells. Therefore, SULT1C2 may be a potential diagnostic marker and therapeutic target for HCC.
Article
Neurosciences
Chunguo Zhang, Huan Jing, Haohao Yan, Xiaoling Li, Jiaquan Liang, Qinqin Zhang, Wenting Liang, Yangpan Ou, Can Peng, Yang Yu, Weibin Wu, Guojun Xie, Wenbin Guo
Summary: The study aimed to investigate the correlations between homotopic connectivity and clinical characteristics in patients with major depressive disorder (MDD). The results showed distinct differences in homotopic connectivity patterns between MDD patients and healthy controls, with abnormal connectivity in the insula and sensory-motor networks being potential neurobiological markers for MDD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Physiology
Hua Zhang, Chengyu Liu, Fangfang Tang, Mingyan Li, Dongxia Zhang, Ling Xia, Stuart Crozier, Hongping Gan, Nan Zhao, Wenlong Xu, Feng Liu
Summary: This study proposes a novel AF prediction method based on ECG data and the ParNet-adv model. By investigating a subset of ECG leads and using recurrent plots and 2D recurrence plot images, a shallow ParNet-adv Network is trained for AF prediction. The results show that the proposed method outperforms other solutions and has potential for clinical and wearable applications.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Respiratory System
Danyang Peng, Fan Zhang, Yinyin Chen, Congyi Zhao, Jingjing Niu, Jianxu Yang, Zhifeng Li, Chao Chen, Shi Qiu, Huifeng Zhang, Bingyu Qin, Xiang Fang, Suping Guo, Ying Liu, Huanzhang Shao
Summary: This study investigated the efficacy and safety of colistin sulfate in the treatment of severe infections caused by carbapenem-resistant organisms in critically ill patients. The results showed that colistin sulfate is a reasonable choice with the potential risk of kidney injury.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Immunology
Renquan Zhang, Hui Liang, Gaoli Liu, Wanli Jiang, Zheng Tang, Qinglu Fan, Zhihao Nie, Haifeng Hu, Ganjun Kang, Songping Xie
Summary: This study found that Nesfatin-1 has significant protective effects against pulmonary fibrosis by blocking the TGF-beta 1/Smad pathway in an AMPKa-dependent manner.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Automation & Control Systems
Yuan-Xin Li, Xiao Li, Bo Xu, Shaocheng Tong
Summary: This article addresses the stabilization problem of a reaction-diffusion equation described by a cascaded PDE-ODE system. The system is fundamentally different from most related studies due to the unknown nonlinearity and actuator failure. To simplify the stability analysis, the original system is redescribed using backstepping techniques. A novel fault-tolerant control strategy is developed to eliminate uncertainty and overcome actuator faults. The stability and convergence of the original system are proven using Lyapunov function theory. Simulation results show the effectiveness of the proposed control method.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
