Article
Engineering, Chemical
Emmanuel I. Epelle, Amy Emmerson, Marija Nekrasova, Andrew Macfarlane, Michael Cusack, Anthony Burns, William Mackay, Mohammed Yaseen
Summary: This study evaluates the antimicrobial efficacy of ozone in air and water and finds that ozone is more effective in air than in water against various microorganisms. The findings have important implications for selecting optimal treatment conditions for ozonation.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Immunology
Ko Harada, Hideharu Hagiya, Tomoko Funahashi, Toshihiro Koyama, Mitsunobu R. Kano, Fumio Otsuka
Summary: The study found that NTM-related mortality in Japan increased significantly between 1997 and 2016, particularly among elderly women. The mortality trend was stable in men but increased in women. The NTM-associated mortality rate exceeded tuberculosis mortality rate in women from 2014 to 2016.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Cheri Grigg, Kelly A. Jackson, Devra Barter, Christopher A. Czaja, Helen Johnston, Ruth Lynfield, Paula Snippes Vagnone, Laura Tourdot, Nancy Spina, Ghinwa Dumyati, P. Maureen Cassidy, Rebecca Pierce, Emily Henkle, D. Rebecca Prevots, Max Salfinger, Kevin L. Winthrop, Nadege Charles Toney, Shelley S. Magill
Summary: Surveillance for nontuberculous mycobacteria (NTM) infections is important for understanding the disease burden and patient characteristics. A pilot surveillance program was conducted in four geographic areas to monitor pulmonary and extrapulmonary NTM infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Barbara A. Brown-Elliott, Richard J. Wallace
Summary: Nontuberculous mycobacteria (NTM) infections, especially caused by Mycobacterium avium complex (MAC) and M. abscessus species, are increasing worldwide. This study tested the in vitro activity of a new tetracycline derivative, eravacycline, against 110 clinical isolates of NTM. The results showed that eravacycline was active against rapidly growing Mycobacterium species, including M. abscessus. However, its activity against slowly growing Mycobacterium species was limited.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Jacky Lu, Kanagavel Murugesan, Fiona Senchyna, Indre Budvytiene, Niaz Banaei
Summary: This study evaluated the sensitivity and specificity of QuantiFERON-TB Gold (QFT) in tuberculosis (TB) and non-tuberculous mycobacteria (NTM) patients. The results showed that QFT had a sensitivity of 78.0% in TB patients, with 86.0% in immunocompetent patients and 69.2% in immunocompromised patients. The specificity of QFT in NTM patients was 76.1%, but after excluding NTM patients with risk factors for latent TB infection, the specificity increased to 94.4%.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Aleksandr Ilinov, Akihito Nishiyama, Hiroki Namba, Yukari Fukushima, Hayato Takihara, Chie Nakajima, Anna Savitskaya, Gebremichal Gebretsadik, Mariko Hakamata, Yuriko Ozeki, Yoshitaka Tateishi, Shujiro Okuda, Yasuhiko Suzuki, Yuri S. Vinnik, Sohkichi Matsumoto
Summary: DNA is an intracellular molecule that stores genetic information and carries instructions for growth and reproduction in cellular organisms. In some bacteria, DNA can also play extracellular roles as eDNA, essential for biofilm formation and antibiotic tolerance. Slow-growing mycobacterial pathogens like Mycobacterium tuberculosis have eDNA present, while rapid-growing mycobacteria do not, impacting biofilm formation and drug tolerance.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Bubacarr J. B. Touray, Mostafa Hanafy, Yashdeep Phanse, Rachel Hildebrand, Adel M. Talaat
Summary: A nanoadjuvant system called QTAP, consisting of Quil-A and DOTAP, was developed for efficient delivery of mRNA vaccine constructs. The system showed high transfection efficiency and protein translation ability. In mice experiments, QTAP nanovaccines induced strong antibody and cytokine responses, and effectively reduced mycobacterial counts in the lungs and spleens. Overall, QTAP is a highly efficient transfection agent that improves the immunogenicity of mRNA vaccines against pulmonary tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Yeya dit Sadio Sarro, Matthew A. Butzler, Fanta Sanogo, Ousmane Kodio, Mohamed Tolofoudie, Mariam S. Goumane, Bocar Baya, Seydou Diabate, Ibrahim Boubacar Diallo, Djakaridja Daniogo, Bindongo P. P. Dembele, Issiaka Camara, Alisha Kumar, Etienne Dembele, Bourahima Kone, Chad J. Achenbach, Grant Theron, Khadidia Ouattara, Yacouba Toloba, Bassirou Diarra, Seydou Doumbia, Babafemi Taiwo, Jane L. Holl, Robert L. Murphy, Souleymane Diallo, Sally M. McFall, Mamoudou Maiga
Summary: This study evaluated a new Multiplex MTB/NTM assay that can differentiate between MTBC and NTM with high sensitivity and specificity. The assay showed 100% detection rate for MAC at 5 CFUs and demonstrated better specificity than Xpert, enhancing discrimination between TB and NTM infections.
Article
Multidisciplinary Sciences
Yasuhiko Matsumoto, Hanako Fukano, Naoki Hasegawa, Yoshihiko Hoshino, Takashi Sugita
Summary: The virulence of M. abscessus clinical isolates can be quantitatively evaluated using a silkworm infection model. The LD50 values of different isolates can differ significantly, and this model allows for a quick assessment of M. abscessus virulence.
Article
Microbiology
Dae Hun Kim, Su-Young Kim, Won-Jung Koh, Byung Woo Jhun
Summary: The in vitro activities of oxazolidinone antibiotics were evaluated against clinical nontuberculous mycobacteria isolates, with sutezolid showing the lowest MIC and MBC values for some NTM subtypes. Oxazolidinone antibiotics may be further investigated as a potential treatment for NTM.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Yutaka Morita, Yoshihiro Kondo, Eiji Takeuchi
Summary: In this case report, we present a rare pulmonary infection caused by M. peregrinum and discuss the relevant literature. Limited information is currently available on pulmonary infections caused by M. peregrinum, highlighting the need for further case reports and clarification of its clinical features.
Article
Immunology
Rebekah M. Dedrick, Bailey E. Smith, Madison Cristinziano, Krista G. Freeman, Deborah Jacobs-Sera, Yvonne Belessis, A. Whitney Brown, Keira A. Cohen, Rebecca M. Davidson, David van Duin, Andrew Gainey, Cristina Berastegui Garcia, C. R. Robert George, Ghady Haidar, Winnie Ip, Jonathan Iredell, Ameneh Khatami, Jessica S. Little, Kirsi Malmivaara, Brendan J. McMullan, David E. Michalik, Andrea Moscatelli, Jerry A. Nick, Maria G. Tupayachi Ortiz, Hari M. Polenakovik, Paul D. Robinson, Mikael Skurnik, Daniel A. Solomon, James Soothill, Helen Spencer, Peter Wark, Austen Worth, Robert T. Schooley, Constance A. Benson, Graham F. Hatfull
Summary: Bacteriophage therapy shows potential as an adjunctive treatment for nontuberculous Mycobacterium infections. This study observed no adverse reactions, favorable outcomes in at least 50% of patients, and no evidence of phage resistance.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Medicine, General & Internal
Xiao Jing Yu, Yu Dong Lin, Peng Hu, Chi Shing Zee, Shu Juan Ji, Fei Zhou
Summary: Diagnosing non-tuberculous mycobacterial (NTM) vertebral osteomyelitis is challenging and often misdiagnosed. This article reports 3 cases of NTM vertebral osteomyelitis, highlighting the importance of vigilance and accurate diagnosis.
Review
Environmental Sciences
Karim Kakaei, Mohsen Padervand, Yuksel Akinay, Elmuez Dawi, Akram Ashames, Lama Saleem, Chuanyi Wang
Summary: COVID-19 pandemic has caused significant impacts on society, economy, psychology, and public health. It spreads mainly through physical contact and airborne transmission. Disinfection measures, mask-wearing, social distancing, and ventilation are recommended for prevention. However, ozone, commonly used for air purification, is not effective against SARS-CoV-2 at nonharmful concentrations and can pose health risks at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Microbiology
Sanjay Singh, Tawanda Gumbo, Gunavanthi D. Boorgula, Prem Shankar, Scott K. Heysell, Shashikant Srivastava
Summary: This study found that omadacycline has efficacy against Mycobacterium kansasii pulmonary disease and could be used in combination with moxifloxacin and tedizolid to potentially shorten the currently recommended 12-month therapy duration.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
