AXL in cancer: a modulator of drug resistance and therapeutic target
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Title
AXL in cancer: a modulator of drug resistance and therapeutic target
Authors
Keywords
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Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 42, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-06-16
DOI
10.1186/s13046-023-02726-w
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Note: Only part of the references are listed.- Hallmarks of Cancer: New Dimensions
- (2022) Douglas Hanahan Cancer Discovery
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- (2022) Mazhar Salim Al-Zoubi et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
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- (2022) Shaina F. Bruce et al. MOLECULAR CANCER THERAPEUTICS
- Advancement of cancer immunotherapy using nanoparticles-based nanomedicine
- (2022) Vemana Gowd et al. SEMINARS IN CANCER BIOLOGY
- AXL/CDCP1/SRC axis confers acquired resistance to osimertinib in lung cancer
- (2022) Yuichi Murakami et al. Scientific Reports
- Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition
- (2022) Agnete S. T. Engelsen et al. Frontiers in Immunology
- Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer
- (2022) Anna Adam-Artigues et al. Science Advances
- Tissue Microarray Analyses Suggest Axl as a Predictive Biomarker in HPV-Negative Head and Neck Cancer
- (2022) Chia-Jung Busch et al. Cancers
- The Development of AXL Inhibitors in Lung Cancer: Recent Progress and Challenges
- (2022) Yun Beom Sang et al. Frontiers in Oncology
- Hallmarks of DNA replication stress
- (2022) Sneha Saxena et al. MOLECULAR CELL
- AXL and error-prone DNA replication confer drug resistance and offer strategies to treat EGFR-mutant lung cancer
- (2022) Ashish Noronha et al. Cancer Discovery
- Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
- (2022) Qi Sun et al. Cells
- AXL, along with PROS1, is overexpressed in papillary thyroid carcinoma and regulates its biological behaviour
- (2022) Mingze Wei et al. World Journal of Surgical Oncology
- MicroRNA-432 acts as a prognostic biomarker and an inhibitor of cell proliferation, migration, and invasion in breast cancer
- (2021) Jianhua Wu et al. Clinical Breast Cancer
- Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2021) Hyuna Sung et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Efficacy of newly discovered DNA aptamers targeting AXL in a lung cancer cell with acquired resistance to Erlotinib
- (2021) Ji An Hwang et al. Translational Cancer Research
- lncRNA GSEC Promotes the Progression of Triple Negative Breast Cancer (TNBC) by Targeting the miR-202-5p/AXL Axis
- (2021) Jianhua Zhang et al. OncoTargets and Therapy
- The Role of the Receptor Tyrosine Kinase Axl in Carcinogenesis and Development of Therapeutic Resistance: An Overview of Molecular Mechanisms and Future Applications
- (2021) Martha Wium et al. Cancers
- Association of AXL and PD-L1 expression with clinical outcomes in patients with advanced renal cell carcinoma treated with PD-1 blockade
- (2021) Stéphane Terry et al. CLINICAL CANCER RESEARCH
- Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer
- (2021) Mai Tanaka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels
- (2021) Marie-Anne Goyette et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AXL inhibition in macrophages stimulates host-versus-leukemia immunity and eradicates naive and treatment resistant leukemia
- (2021) Irene Tirado-Gonzalez et al. Cancer Discovery
- Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer
- (2021) Heidie Frisco Cabanos et al. Cancers
- Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer
- (2021) Xueli Tian et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Overcoming PLK1 inhibitor resistance by targeting mevalonate pathway to impair AXL-TWIST axis in colorectal cancer
- (2021) Sonia Solanes-Casado et al. BIOMEDICINE & PHARMACOTHERAPY
- Prognostic value and immunological role of AXL gene in clear cell renal cell carcinoma associated with identifying LncRNA/RBP/AXL mRNA networks
- (2021) Yi Wang et al. Cancer Cell International
- Distinct contributions of partial and full EMT to breast cancer malignancy
- (2021) Fabiana Lüönd et al. DEVELOPMENTAL CELL
- GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress
- (2021) Mary M. Mullen et al. MOLECULAR CANCER RESEARCH
- Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) sensitize melanoma cells to MEK inhibition and inhibit metastasis and relapse by inducing degradation of AXL
- (2021) Yingshi Chen et al. Pigment Cell & Melanoma Research
- Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis
- (2021) Neus Martínez-Bosch et al. EBioMedicine
- AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew
- (2021) Almira Auyez et al. Cancers
- Dual Role of p73 in Cancer Microenvironment and DNA Damage Response
- (2021) Julian M. Rozenberg et al. Cells
- Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis
- (2021) Li-Wei Sun et al. Cells
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- (2020) Minhai Dong et al. CANCER GENE THERAPY
- AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells
- (2020) Maria L. Lotsberg et al. Journal of Thoracic Oncology
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- (2020) Xiaoting Song et al. Cancer Research and Treatment
- Qigesan inhibits esophageal cancer cell invasion and migration by inhibiting Gas6/Axl-induced epithelial-mesenchymal transition
- (2020) Lingyu Kong et al. Aging-US
- AXL mediates cetuximab and radiation resistance through tyrosine 821 and the c-ABL kinase pathway in head and neck cancer
- (2020) Nellie K McDaniel et al. CLINICAL CANCER RESEARCH
- Challenges and Opportunities in Cancer Drug Resistance
- (2020) Richard A. Ward et al. CHEMICAL REVIEWS
- Therapeutic aspects of the Axl/Gas6 molecular system
- (2020) Rossella Di Stasi et al. DRUG DISCOVERY TODAY
- AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer
- (2020) Claudia Cardone et al. EUROPEAN JOURNAL OF CANCER
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- (2019) Hirokazu Taniguchi et al. Nature Communications
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- (2019) Chia‐Chang Hsu et al. Cancer Medicine
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- A view on drug resistance in cancer
- (2019) Neil Vasan et al. NATURE
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- (2019) de Miguel-Pérez et al. Cancers
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- (2018) Jing Wei et al. CELLULAR IMMUNOLOGY
- The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review
- (2018) Sheng Zhang et al. OncoTargets and Therapy
- Engineering Axl specific CAR and SynNotch receptor for cancer therapy
- (2018) Jang Hwan Cho et al. Scientific Reports
- The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression
- (2018) Marie-Anne Goyette et al. Cell Reports
- DNA Damage, Repair, and Cancer Metabolism
- (2018) Marc-Olivier Turgeon et al. Frontiers in Oncology
- Does Axl have potential as a therapeutic target in pancreatic cancer?
- (2018) Wenting Du et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy
- (2018) Dominik Schmiedel et al. Frontiers in Immunology
- Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p
- (2018) Yao-yin Li et al. EBioMedicine
- EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer
- (2018) Eugene Tulchinsky et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Transcriptional upregulation of c-MYC by AXL confers epirubicin resistance in esophageal adenocarcinoma
- (2018) Jun Hong et al. Molecular Oncology
- Role of LFA-1 and ICAM-1 in Cancer
- (2017) Manuel Reina et al. Cancers
- The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer
- (2016) J. Antony et al. Science Signaling
- Reprogramming the immunological microenvironment through radiation and targeting Axl
- (2016) Todd A. Aguilera et al. Nature Communications
- Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance
- (2016) M. A. Miller et al. Cancer Discovery
- Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling
- (2016) Cun Wang et al. Theranostics
- The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer
- (2016) J. Antony et al. Science Signaling
- Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells
- (2016) M Vouri et al. Oncogenesis
- Axl activates autocrine transforming growth factor-β signaling in hepatocellular carcinoma
- (2015) Patrick Reichl et al. HEPATOLOGY
- Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma
- (2015) Patrick Reichl et al. INTERNATIONAL JOURNAL OF CANCER
- Mechanisms of resistance to EGFR tyrosine kinase inhibitors
- (2015) Lihua Huang et al. Acta Pharmaceutica Sinica B
- The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
- (2014) Magdalena Paolino et al. NATURE
- Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET
- (2014) Erinn B. Rankin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities
- (2014) Erin D Lew et al. eLife
- MiR-134/487b/655 Cluster Regulates TGF- -Induced Epithelial-Mesenchymal Transition and Drug Resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma Cells
- (2013) K. Kitamura et al. MOLECULAR CANCER THERAPEUTICS
- The Receptor AXL Diversifies EGFR Signaling and Limits the Response to EGFR-Targeted Inhibitors in Triple-Negative Breast Cancer Cells
- (2013) A. S. Meyer et al. Science Signaling
- Biology of the TAM Receptors
- (2013) G. Lemke Cold Spring Harbor Perspectives in Biology
- ABL Regulation by AXL Promotes Cisplatin Resistance in Esophageal Cancer
- (2012) J. Hong et al. CANCER RESEARCH
- Axl is essential for VEGF-A-dependent activation of PI3K/Akt
- (2012) Guo-Xiang Ruan et al. EMBO JOURNAL
- Targeting Axl With an High-affinity Inhibitory Aptamer
- (2012) Laura Cerchia et al. MOLECULAR THERAPY
- Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
- (2012) Zhenfeng Zhang et al. NATURE GENETICS
- Cross-Phosphorylation, Signaling and Proliferative Functions of the Tyro3 and Axl Receptors in Rat2 Cells
- (2012) Jessica E. Brown et al. PLoS One
- PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells
- (2010) Giridhar Mudduluru et al. BIOLOGY OF THE CELL
- The human receptor tyrosine kinase Axl gene - promoter characterization and regulation of constitutive expression by Sp1, Sp3, and CpG methylation
- (2008) Giridhar Mudduluru et al. BIOSCIENCE REPORTS
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