Solid-liquid phase equilibrium and thermodynamic properties analysis of paliperidone palmitate in 21 kinds of mono-solvents

Solid-liquid equilibrium solubility paliperidone palmitate (PP) in 21 kinds of mono-solvents, including ethanol, n-propanol, i-propanol, n-butanol, i-butanol, s-butanol, n-pentanol, i-pentanol, 2-butanone, methyl isobutyl ketone, cyclohexanone, ethyl formate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, amyl acetate, N,N-dimethylformamide (DMF), tetrahydrofuran (THF), toluene, and 1,4-dioxane were determined by a gravimetric method at a various temperature. The solubility of PP increases with the increase of temperature. In alcoholic solvents, the solubility order is: n-pentanol > i-pentanol > i-butanol > s-butanol > n-butanol > npropanol > i-propanol > ethanol. In easter solvents, the solubility of PP ranking as: ethyl formate > amyl acetate > butyl acetate > propyl acetate > ethyl acetate > isopropyl acetate. For ketone solvent, the solubility order is: cyclohexanone > 2-butanone > methyl isobutyl ketone. In other solvents, the solubility order is: THF > toluene > 1,4-dioxane > DMF. The maximum solubility of PP is 0.1922 mol center dot mol(-1) (toluene, 353.15 K), and the minimum solubility is 0.0003788 mol center dot mol(-1) (ethanol, 318.15 K). Four thermodynamic models, i.e., the modified Apelblat model, the Yaws model, the NRTL model and the Wilson model were selected to correlate the solubility data in this paper. NRTL model fits best among all the models with RAD no larger 4.84 x 10(-2) (n-propanol) and RMSD value less than 12.55 x 10(-4) (1,4-dioxane). Furthermore, dissolution thermodynamic properties of PP were evaluated based on the Wilson model. The dissolution process of PP is demonstrated to be spontaneous in the chosen organic solvents.

Automated summary

The solubility of paliperidone palmitate (PP) in 21 mono-solvents was determined by a gravimetric method, and it was found that the solubility of PP increases with temperature. The solubility order varies according to the type of solvent used. Four thermodynamic models were used to correlate the solubility data, and the NRTL model provided the best fit. Based on the Wilson model, the dissolution process of PP was found to be spontaneous in the selected organic solvents.