Article
Engineering, Biomedical
Yunyun Liang, Pei Mo, Xinguang Yang, Yihua He, Weijin Zhang, Xianfan Zeng, Longchang Xie, Qingchun Gao
Summary: This study compared the estimation of cerebral critical closing pressure and resistance-area product using blood pressure measurements from the common carotid artery and radial artery, and found that the values obtained from both methods were consistent.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Endocrinology & Metabolism
Ronney B. Panerai, Victoria J. Haunton, Osian Llwyd, Jatinder S. Minhas, Emmanuel Katsogridakis, Angela S. M. Salinet, Paola Maggio, Thompson G. Robinson
Summary: This study found that the dynamic cerebral autoregulation index decreases with age in men, but remains stable in women. Additionally, factors such as cerebral blood flow velocity and resistance-area product exhibit significant age-related influences on step response patterns during blood pressure fluctuations.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Jiayi Zhong, Wanrong Lin, Junru Chen, Qingchun Gao
Summary: This study investigated the association between cerebral hemodynamic parameters and EPVS. The results showed a positive correlation between CCP and BG-EPVS, while no significant association was found between CCP and CSO-EPVS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Xian Fu, Weijin Zhang, Xianliang Li, Hongying Liu, Yin Zhang, Qingchun Gao
Summary: The purpose of this study was to investigate the cerebrovascular hemodynamics, including critical closing pressure (CrCP) and pulsatility index (PI), and their independent relationship with cerebral small vessel disease (CSVD) burden. The results showed that CrCP was an independent determinant and predictor of CSVD burden, and it was significantly correlated with age, BMI, and systolic blood pressure. These findings provide new insights into the development of CSVD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Elif Gokcal, Mitchell J. Horn, J. Alex Becker, Alvin S. Das, Kristin Schwab, Alessandro Biffi, Natalia Rost, Jonathan Rosand, Anand Viswanathan, Jonathan R. Polimeni, Keith A. Johnson, Steven M. Greenberg, M. Edip Gurol
Summary: This study suggests that vascular dysfunction mediates the relationship between amyloid load and white matter disease in cerebral amyloid angiopathy (CAA). By lowering amyloid load, pathophysiological processes leading to vascular dysfunction can be prevented, thus reducing ischemic brain injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Emma L. L. Reed, Morgan L. L. Worley, Paul J. J. Kueck, Leonard D. D. Pietrafasa, Zachary J. J. Schlader, Blair D. D. Johnson
Summary: The acute consumption of sugar- and artificially-sweetened beverages may lead to alterations in cerebral vascular function, particularly with a more pronounced effect seen with artificially-sweetened beverages.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Yucheng Shen, Qihong Wang, Hiren R. Modi, Arvind P. Pathak, Romergryko G. Geocadin, Nitish V. Thakor, Janaka Senarathna
Summary: Cerebral vascular autoregulation is impaired following resuscitation from cardiac arrest, but three novel metrics have been developed to quantify the changes in cerebrovascular resistance and cerebral perfusion pressure. These metrics may help assess brain injury post-resuscitation.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel P. Klein, Veerle De Sloovere, Geert Meyfroidt, Bart Depreitere
Summary: This study provides new insights into the quadriphasic physiology of cerebrovascular autoregulation (CA) and reveals substantial intersubject variability in the limits of CA.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Physiology
Eline Kho, Nicolaas H. Sperna Weiland, Alexander P. J. Vlaar, Denise P. Veelo, Bjorn J. P. van der Ster, Oskar T. Corsmit, Dave R. Koolbergen, Jose Dilai, Rogier Immink
Summary: This study assessed cerebral autoregulation during sustained hypotension, revealing its behavior during hypotension. Results showed that CA was disturbed during sustained hypotension but improved after blood pressure restoration, suggesting the absence of ischemic hyperemia and an unlikely adaptation mechanism during sustained hypotension.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Debra Fong, Kelly Gradon, Carolyn J. Barrett, Sarah-Jane Guild, Yu Chieh Tzeng, Julian F. R. Paton, Fiona D. McBryde
Summary: This study introduces a new technique for studying dynamic cerebral autoregulation in conscious rats without the use of vasoactive drugs. By inducing transient reductions in blood pressure through occlusion of the vena cava, it was found that decreases in blood pressure were accompanied by gradual decreases in internal carotid blood flow (iCBF) with no significant changes in internal carotid vascular resistance (iCVR). On the other hand, intravenous infusions of the vasoactive drug sodium nitroprusside (SNP) led to increased iCBF and decreased iCVR, indicating a narrower and less stable autoregulatory plateau in the dynamic cerebral pressure-flow relationship.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Neurosciences
Jason Yang, Alexander Ruesch, Jana M. Kainerstorfer
Summary: Significance: Cerebrovascular impedance (CVI) is related to cerebral autoregulation (CA) and can serve as a biomarker for cerebral health. This study developed a method to quantify CVI based on a combination of diffuse correlation spectroscopy (DCS) and continuous wave near-infrared spectroscopy (NIRS) and validated the method on healthy human volunteers. The results showed that CVI changes can be reversed with postural changes, making it a potential tool for assessing cerebral health, especially in patients with altered cerebral perfusion pressure (CPP).
Article
Clinical Neurology
Xiuyun Liu, Aylin Tekes, Jamie Perin, May W. Chen, Bruno P. Soares, An N. Massaro, Rathinaswamy B. Govindan, Charlamaine Parkinson, Raul Chavez-Valdez, Frances J. Northington, Ken M. Brady, Jennifer K. Lee
Summary: This study suggests that maintaining blood pressure above the optimal mean arterial pressure (MAPopt) during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE) may reduce the risk of brain injury. Wavelet methodology and correlation-derived indices may help identify these blood pressure values associated with brain injury, with potential for future randomized studies in neonates with HIE.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Min Liu, Enling He, Xiyao Fu, Sizhu Gong, Yue Han, Fang Deng
Summary: Cerebral blood flow self-regulation is significantly impaired in depressed patients, potentially due to factors such as endothelial dysfunction, overactivation of microglia, changes of cytokines, etc.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Navpreet Reehal, Stephanie Cummings, Michael T. Mullen, Wesley B. Baker, David Kung, William Tackett, Christopher G. Favilla
Summary: This study compared cerebral autoregulation in all major cerebral vessels and found that while the time course of autoregulation was similar in all vessels, the magnitude of hemodynamic regulation was lower in the posterior cerebral artery. However, after adjusting for baseline flow differences, normalized gain was similar in all vessels.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Kulsum Abdali, Xiaoan Chen, Sarah Ross, Sandra Davis, Zhengyang Zhou, Robert T. Mallet, Xiangrong Shi
Summary: This study found that the ability of elderly individuals to recover cerebral perfusion during systemic hypotension is weakened. This is due to the diminished cerebrovascular autoregulation and cardiovascular reflex mechanisms in the elderly, resulting in prolonged recovery time for cerebral perfusion. The vasomotor factor is more important than the cardiac factor in restoring cerebral perfusion during hypotension-induced cerebral hypoperfusion.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan Ince, Andrea Lecchini-Visintini, Alanoud Almudayni, Mark A. Horsfield, Joanne Wormleighton, Caroline Banahan, Emma M. L. Chung, Jatinder S. Minhas
Summary: Current literature primarily focuses on healthy brain tissue and limited studies have looked at the effects of disease on brain motion, making it unclear. Further research in this area may provide insights for guiding clinical applications.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Xia Wang, Jatinder S. Minhas, Tom J. Moullaali, Gian Luca Di Tanna, Richard Lindley, Xiaoying Chen, Hisatomi Arima, Guofang Chen, Candice Delcourt, Philip M. Bath, Joseph P. Broderick, Andrew M. Demchuk, Geoffrey A. Donnan, Alice C. Durham, Pablo M. Lavados, Tsong-Hai Lee, Christopher Levi, Sheila O. Martins, Veronica V. Olavarria, Jeyaraj D. Pandian, Mark W. Parsons, Octavio M. Pontes-Neto, Stefano Ricci, Shoichiro Sato, Vijay K. Sharma, Federico Silva, Nguyen H. Thang, Ji-Guang Wang, Mark Woodward, John Chalmers, Lili Song, Craig S. Anderson, Thompson G. Robinson
Summary: Post hoc analysis of thrombolyzed acute ischemic stroke patients showed that reducing systolic blood pressure and decreasing systolic blood pressure variability were associated with better recovery outcomes, while the magnitude of systolic blood pressure reduction did not affect the outcomes. Higher systolic blood pressure and greater systolic blood pressure variability were associated with an increased risk of intracranial hemorrhage.
Review
Clinical Neurology
Jennifer K. Nicholls, Jonathan Ince, Jatinder S. Minhas, Emma M. L. Chung
Summary: This review explored literature on novel and advancements in pre-existing detection methods for large vessel occlusion (LVO). The results highlight LVO detection techniques, such as stroke scales and biomarkers, with good sensitivity and specificity performance, while also showing advancements to support existing LVO confirmatory methods, such as neuroimaging.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Jatinder S. Minhas, Tom J. Moullaali, Gabriel J. E. Rinkel, Craig S. Anderson
Summary: Blood pressure is an important factor in managing intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage. However, there are controversies surrounding the management of blood pressure for these conditions. Current research involves analyzing patient data to determine the strength and direction of blood pressure changes and provide recommendations for clinical practice and future research.
Review
Neurosciences
Lucy C. Beishon, Patrick Hosford, Dewaker Gurung, Patrice Brassard, Jatinder S. Minhas, Thompson G. Robinson, Victoria Haunton, Ronney B. Panerai
Summary: This review examines the role of the autonomic nervous system in the control of cerebral blood flow in dementia, finding reductions in CBF, increased cerebrovascular resistance, and reduced vasoreactivity. While cerebral autoregulation remains largely intact, the coupling between neuronal activity and CBF is lost in dementia, potentially driving cognitive dysfunction.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2022)
Article
Physiology
Rebecca H. Clough, Jatinder S. Minhas, Victoria J. Haunton, Martha F. Hanby, Thompson G. Robinson, Ronney B. Panerai
Summary: The dynamic response of critical closing pressure (CrCP) and resistance-area product (RAP) in the cerebral circulation was investigated during paced hyperventilation (PHPV). Contrary to hypercapnia, hypocapnia showed an initial depression of cerebral autoregulation, followed by improvements controlled by changes in RAP.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ronney B. Panerai, Patrice Brassard, Joel S. Burma, Pedro Castro, Jurgen A. H. R. Claassen, Johannes J. van Lieshout, Jia Liu, Samuel Je Lucas, Jatinder S. Minhas, Georgios D. Mitsis, Ricardo C. Nogueira, Shigehiko Ogoh, Stephen J. Payne, Caroline A. Rickards, Andrew D. Robertson, Gabriel D. Rodrigues, Jonathan D. Smirl, David M. Simpson
Summary: This study improved the evaluation method of cerebral autoregulation (CA) by introducing guidelines for data acquisition, analysis, and reporting, and proposed new recommendations to reflect recent advances in the field. The implementation of these recommendations is crucial for improving the reliability and reproducibility of studies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Meeriam Kadicheeni, Jatinder S. Minhas, Briana Coles, Shazia T. Hussain, Kamlesh Khunti, Thompson G. Robinson, David J. Eveson, Amit K. Mistri
Summary: This study aims to assess the mortality rate of TIA patients in a rapid-access clinic. The results showed that the mortality rate was higher following a CV diagnosis, and it was associated with males, older individuals, white ethnicity, and orthostatic hypotension.
CEREBROVASCULAR DISEASES
(2023)
Review
Medicine, General & Internal
Kailash Krishnan, Zhe Kang Law, Jatinder S. Minhas, Philip M. Bath, Thompson G. Robinson, Nikola Sprigg, Akash Mavilakandy, Timothy J. England, David Eveson, Amit Mistri, Jesse Dawson, Jason P. Appleton
Summary: Acute stroke is a leading cause of disability and mortality, necessitating urgent evaluation and treatment. This review examines four antiplatelet treatments for non-cardioembolic stroke prevention and highlights gaps in the evidence for potential future trials.
Editorial Material
Clinical Neurology
Jatinder S. Minhas, Tamara Chithiramohan, Xia Wang, Sam C. Barnes, Rebecca H. Clough, Meeriam Kadicheeni, Lucy C. Beishon, Thompson G. Robinson
Letter
Critical Care Medicine
Sergio Brasil, Juliana Caldas, Lucy Beishon, Jatinder S. Minhas, Ricardo C. Nogueira
NEUROCRITICAL CARE
(2023)
Article
Acoustics
Jennifer K. Nicholls, Poppy Turner, Andrea Lecchini-Visintini, Jonathan Ince, Georgina de Vries, Laurie Cappellugola, Mitsuhiro Oura, Kelechi U. Ebirim, Edward Pallett, Kumar V. Ramnarine, Emma M. L. Chung
Summary: This study aimed to explore the relationship between blood pressure parameters (mean arterial pressure and pulse pressure) and brain tissue pulsations (BTPs). A phantom brain model was developed to observe BP changes without confounding variables. The regression model showed that BTP amplitude significantly increased with pulse pressure, with every 1 mm Hg increase resulting in a 0.29 μm increase in BTP amplitude. Further research should confirm the relationship between BP and BTPs and explore other physiological factors affecting BTP measurements.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Alanoud Almudayni, Meshal Alharbi, Alimul Chowdhury, Jonathan Ince, Fatmah Alablani, Jatinder Singh Minhas, Andrea Lecchini-Visintini, Emma Ming Lin Chung
Summary: This study is a systematic review of literature on magnetic resonance imaging (MRI) methods for measuring natural brain tissue pulsations (BTPs) in humans. The study found that the amplitude of BTPs varies regionally in the brain, with larger displacements occurring closer to the center and base of the brain. Current MRI BTP measurements in brain pathology are limited to tumor characterization, idiopathic intracranial hypertension (IIH), and Chiari malformation type 1 (CM-I). Further research is needed to establish normative data for systematic characterization of BTPs in health and disease.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
