Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume 97, Issue 2, Pages 434-443Publisher
WILEY
DOI: 10.1002/jsfa.7742
Keywords
ochratoxin A; Aspergillus strain; degradation product; ochratoxin; cytotoxic responses
Funding
- Fund training program of Beijing Technology and Business University [LKJJ2015-14]
- Youth Project of Beijing Natural Science Foundation [5144026]
- Development of Innovative Teams and Teachers' Occupation Advancement Project of Beijing Municipal Universities and Colleges - Beijing Municipal Education Commission [IDHT20130506]
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BACKGROUNDOchratoxin A (OTA) poses a serious health hazard throughout the world and is often reported in food commodities. At present, biological approaches to detoxifying OTA are now widely considered to be the most promising methods. RESULTSIn this study, a strain that was identified as Aspergillus niger was isolated, and it has a strong ability to detoxify OTA. The degradation product (compound 1) of OTA was treated with crude enzyme. The product has been isolated and identified as C11H9O5Cl (ochratoxin ), which is a weak lipophilic molecule, in contrast to fat-soluble OTA. The cytotoxic response of compound 1 was revealed to be different to that of OTA. Compound 1 does not induce cellular oxidative damage in comparison with OTA, which may cause lipid peroxidation (MDA), reduce SOD activity and induce DNA damage. CONCLUSIONThis study indicates that A. niger has the ability to detoxify OTA. The OTA degradation product, ochratoxin , does not exert cytotoxic effects on cell metabolism. A. niger has prospective uses for the OTA decontamination of food and agricultural fields. (c) 2016 Society of Chemical Industry
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