Article
Immunology
Ikram Omar Osman, Clea Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andreas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A. Devaux
Summary: SARS-CoV-2 infection can lead to variations in ACE2 expression and Ang II plasma concentration, potentially affecting blood pressure regulation and COVID-19 outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Minela Aida Maranduca, Daniela Maria Tanase, Cristian Tudor Cozma, Nicoleta Dima, Andreea Clim, Alin Constantin Pinzariu, Dragomir Nicolae Serban, Ionela Lacramioara Serban
Summary: The COVID-19 pandemic has placed significant stress on the medical community. ACE2, a cellular receptor for the virus, has been identified as a crucial component in the renin-angiotensin-aldosterone system (RAAS) and is responsible for various processes in different organs. Infection with SARS-CoV-2 leads to downregulation of ACE2 and disrupts the balance between ACE and ACE2 in organs, resulting in observed effects of COVID-19 infection.
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Article
Gastroenterology & Hepatology
Mariana Ferreira-Duarte, Lilian Caroline Goncalves Oliveira, Clara Quintas, Marisa Esteves-Monteiro, Margarida Duarte-Araujo, Teresa Sousa, Dulce Elena Casarini, Manuela Morato
Summary: This study evaluated the catalytic activity of ACE and ACE2 in the intestinal content and corresponding intestinal tissue of Wistar Han rats. The results showed that ACE and ACE2 have catalytic activity in the rat gut, with higher activity of the ACE N-domain compared to the C-domain. Additionally, ACE and ACE2 were more active in the intestinal content than in the corresponding intestinal tissue. In the intestinal tissue, there was a distal-to-proximal prevalence of ACE2 over ACE. This study is the first to report the presence of catalytically active ACE and ACE2 in the rat intestinal content, supporting future research on the regulatory role of the intestinal RAAS on gut function and a putative link to the microbiome.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Peripheral Vascular Disease
Brasilina Caroccia, Paul-Emmanuel Vanderriele, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Selene Prisco, Francesca Torresan, Oliver Domenig, Maurizio Iacobone, Marko Poglitsch, Gian Paolo Rossi
Summary: This study found that ACE-2 mRNA and Ang II were present in human adrenocortical tissues, but not Ang-(1-7) and Ang-(1-5). Ang-(1-7) and ACE-2 do not seem to play a significant role in regulating aldosterone and cortisol biosynthesis.
JOURNAL OF HYPERTENSION
(2021)
Article
Neurosciences
Ankit Goyal, Alvee Saluja, Kallur N. Saraswathy, Priya Bansal, Rajinder K. Dhamija
Summary: The study demonstrates a strong association between ACE insertion/deletion polymorphism and the risk of acute ischemic stroke (AIS), with the DD genotype independently associated with an increased risk. This finding suggests the potential of ACE polymorphism as a genetic risk factor for AIS.
Article
Biochemistry & Molecular Biology
Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui
Summary: The study revealed that thymosin-alpha 1 prevents COVID-19 by binding with ACE and reducing ACE2 expression in human lung epithelial cells, suggesting its potential clinical applications in preventing SARS-CoV-2 infection.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Pharmacology & Pharmacy
Qi-Qiang Zhang, Feng-Hua Chen, Fei Wang, Xue-Mei Di, Wei Li, Hai Zhang
Summary: This study found that benzoylaconitine (BAC) in Aconitum carmichaelii has antihypertensive effects by targeting ACE/ACE2 to enhance endothelium-dependent vasorelaxation and reduce vascular inflammation, attenuating hypertension.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhipeng Yu, Li Wang, Sijia Wu, Wenjun Xue, Wenzhu Zhao, Jianrong Li
Summary: This study used a non-targeted metabolomics approach to investigate the anti-hypertensive effects of RVPSL on SHRs. The results suggested that RVPSL potentially alleviated hypertension in SHRs mainly through integrated regulations of metabolism and production of specific metabolites.
Article
Biochemistry & Molecular Biology
Ingrid Fricke-Galindo, Ivette Buendia-Roldan, Daniel I. I. Ponce-Aguilar, Gloria Perez-Rubio, Leslie Chavez-Galan, Jesus Alanis-Ponce, Karina Perez-Torres, Daniela Valencia-Perez Rea, Fernanda Tellez-Quijada, Karol J. J. Nava-Quiroz, Rafael de Jesus Hernandez-Zenteno, Angelica Gutierrez-Nava, Ramces Falfan-Valencia
Summary: This paper examines the relationship between the ACE insertion/deletion variant and serum ACE activity with the severity of COVID-19 and its impact on post-COVID-19 patients, comparing it with non-COVID-19 respiratory disorder patients. The DD genotype is associated with an increased risk of invasive mechanical ventilation requirement in COVID-19 patients, and it is more prevalent in COVID-19 and post-COVID-19 groups compared to non-COVID-19 subjects. Serum ACE activity is lower in COVID-19 patients and may be related to disease severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Priya Tiwari, Virendra Tiwari, Shivangi Gupta, Shubha Shukla, Kashif Hanif
Summary: This study reveals the important role of ACE2/Ang (1-7)/MasR axis in neuroinflammation. It decreases glial activation, neuroinflammation, and cell apoptosis, while improving mitochondrial health, thus providing neuroprotection.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Li-Fang Wang, Yang-Yang Sun, Qian Pan, Yi-Qing Yin, Xiao-Ming Tian, Yue Liu, Tegeleqi Bu, Qingy Zhang, Yong-An Wang, Jing Zhao, Yuan Luo
Summary: Lung ischemia-reperfusion (IR) injury depends on the loss of ACE2 and ACE2 enzyme dysfunction, while the ACE2 protectant DIZE maintains enzyme activity and protects the lungs by reducing ADAM17 levels. DIZE also inhibits oxidative and nitrosative stress, leading to reduced inflammation in lung tissue.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mansoureh Barzegar, Karen Y. Stokes, Oleg Chernyshev, Roger E. Kelley, Jonathan S. Alexander
Summary: Ischemic stroke is the leading cause of neurologically based morbidity and mortality, and current treatments are limited to two classes of FDA-approved drugs with a narrow time-window for administration. There is a desperate need for new stroke therapies to suppress the deleterious effects of ischemic injury.
Review
Biochemistry & Molecular Biology
Thays Calista Santiago, Larissa Parra, Joao V. Nani, Thiago M. Fidalgo, Nicholas J. Bradshaw, Mirian A. F. Hayashi
Summary: The renin-angiotensin system (RAS) has recently been recognized for its potential roles in the brain, with angiotensin-converting enzyme (ACE) and other RAS components implicated in brain disorders. This review identifies the functions of the RAS and ACEs in the brain, and their association with neurodegenerative and psychiatric illnesses. The findings suggest that ACE inhibitors and angiotensin receptor blockers could be valuable as a novel integrated treatment approach for various brain disorders, particularly psychiatric illnesses.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Karen Melissa Hallow, Ishaan Dave
Summary: ACE inhibitors and Angiotensin receptor blockers are standard treatments for hypertension and diabetes, but their use in the context of COVID-19 has been debated due to interactions with ACE2. A study predicted that pre-existing RAAS blockade may increase anti-inflammatory effects and changes in ACE2 expression may have minimal impact on COVID-19 pathophysiology.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Neuroimaging
Nimer Adeeb, Mahmoud Dibas, Jose Danilo Bengzon Diestro, Kevin Phan, Hugo H. Cuellar-Saenz, Ahmad Sweid, Sovann Lay, Adrien Guenego, Assala Aslan, Leonardo Renieri, Sri Hari Sundararajan, Guillaume Saliou, Markus Mohlenbruch, Robert W. Regenhardt, Justin E. Vranic, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani, Vedran Zupancic, Muhammad U. Hafeez, Caleb Rutledge, Muhammad Waqas, Vincent M. Tutino, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Mariangela Piano, Anna L. Kuhn, Caterina Michelozzi, Stephanie Elens, Robert M. Starke, Ameer Hassan, Arsalaan Salehani, Alex Brehm, MajdEddin MohammedAli, Jesse Jones, Marios Psychogios, Julian Spears, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Andrew Ducruet, Felipe C. Albuquerque, Rose Du, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Christopher J. Stapleton, Srikanth Boddu, Jared Knopman, Mohammad A. Aziz-Sultan, Nicola Limbucci, Pascal Jabbour, Christophe Cognard, Aman B. Patel, Adam A. Dmytriw
Summary: This study compared the angiographic and clinical outcomes of using the WEB device for the treatment of bifurcation aneurysms at various locations. The results showed that basilar tip and ICA bifurcation aneurysms had significantly higher rates of aneurysm occlusion compared to other locations.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Andrew W. Kraft, Amine Awad, Joseph A. Rosenthal, Adam A. Dmytriw, Justin E. Vranic, Anna K. Bonkhoff, Martin Bretzner, Joshua A. Hirsch, James D. Rabinov, Christopher J. Stapleton, Lee H. Schwamm, Natalia S. Rost, Thabele M. Leslie-Mazwi, Aman B. Patel, Robert W. Regenhardt
Summary: This study found that spoke-administered intravenous thrombolysis (IVT) in patients with large vessel occlusion stroke can reduce the procedure time, fluoroscopy time, and number of passes during mechanical thrombectomy (MT), while also improving reperfusion.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Neuroimaging
Jose Danilo Bengzon Diestro, Mahmoud Dibas, Nimer Adeeb, Robert W. Regenhardt, Justin E. Vranic, Adrien Guenego, Sovann Lay, Leonardo Renieri, Ali Al Balushi, Eimad Shotar, Kevin Premat, Kareem El Naamani, Guillaume Saliou, Markus A. Moehlenbruch, Ivan Lylyk, Paul M. Foreman, Jay A. Vachhani, Vedran Zupancic, Muhammad U. Hafeez, Caleb Rutledge, Hamid Rai, Vincent M. Tutino, Shervin Mirshani, Sherief Ghozy, Pablo Harker, Naif M. Alotaibi, James D. Rabinov, Yifan Ren, Clemens M. Schirmer, Oded Goren, Mariangela Piano, Anna Luisa Kuhn, Caterina Michelozzi, Stephanie Elens, Robert M. Starke, Ameer Hassan, Arsalaan Salehani, Anh Nguyen, Jesse Jones, Marios Psychogios, Julian Spears, Carmen Parra-Farinas, Maria Bres Bullrich, Michael Mayich, Mohamed M. Salem, Jan-Karl Burkhardt, Brian T. Jankowitz, Ricardo A. Domingo, Thien Huynh, Rabih Tawk, Christian Ulfert, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Andrew F. Ducruet, Felipe C. Albuquerque, Rose Du, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Reddy Boddu, Christopher J. Stapleton, Jared Knopman, Pascal Jabbour, Stavropoula Tjoumakaris, Frederic Clarencon, Nicola Limbucci, Mohammad A. Aziz-Sultan, Hugo H. Cuellar-Saenz, Christophe Cognard, Aman B. Patel, Adam A. Dmytriw
Summary: There was no significant difference in both the occlusion rate and complications between ruptured and unruptured aneurysms treated with the WEB device, supporting the feasibility of using the WEB device to treat ruptured aneurysms.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Xuesong Bai, Fan Yu, Qiuyue Tian, Wei Li, Araman Sha, Wenbo Cao, Yao Feng, Bin Yang, Yanfei Chen, Peng Gao, Yabing Wang, Jian Chen, Adam A. Dmytriw, Robert W. Regenhardt, Renjie Yang, Zhaolin Fu, Qingfeng Ma, Jie Lu, Liqun Jiao
Summary: The study investigated the impact of microvascular tissue reperfusion and its influencing factors in acute ischemic stroke patients. The findings revealed that microvascular tissue reperfusion was strongly associated with good functional outcomes after successful reperfusion, and higher mTICI grade and lower perioperative glucose level may predict microvascular tissue reperfusion.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neuroimaging
Zachary A. Kons, Justin E. Vranic, Adam A. Dmytriw, Robert W. Regenhardt, Aman B. Patel, Christopher J. Stapleton
Summary: We present a case of superficial temporal arteriovenous fistula that developed after frontotemporoparietal hemicraniectomy. This patient had intracerebral hemorrhage and arteriovenous malformation rupture, and subsequently developed a superficial temporal arteriovenous fistula.
NEURORADIOLOGY JOURNAL
(2023)
Article
Neurosciences
Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Sungmin Hong, Robert W. Regenhardt, Kathleen L. Donahue, Marco J. Nardin, Adrian Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa C. McIntosh, John Attia, John W. Cole, Amanda Donatti, Christoph J. Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven J. Kittner, Robin Lemmens, Christopher R. Levi, Caitrin W. McDonough, James F. Meschia, Chia-Ling Phuah, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick F. McArdle, Bradford B. Worrall, Christina Jern, Arne G. Lindgren, Jane Maguire, Ona Wu, Natalia S. Rost
Summary: This study aimed to investigate the influence of stroke lesions in rich-club brain regions on functional outcome post-stroke, determine their spatial specificity and explore the effects of biological sex. The analysis showed that rich-club regions had substantial relevance in explaining unfavorable functional outcome and the effect was more pronounced in women.
HUMAN BRAIN MAPPING
(2023)
Meeting Abstract
Clinical Neurology
Anthony P. Bourached, Anna K. Bonkhoff, Markus D. Schirmer, Robert W. Regenhardt, Sungmin Hong, Martin Bretzner, Ona Wu, Christina Jern, Arne G. Lindgren, Jane Maguire, John Rhee, Eyal Kimchi, Natalia S. Rost
Review
Clinical Neurology
Nishita Singh, Bijoy K. Menon, Adam A. Dmytriw, Robert W. Regenhardt, Joshua A. Hirsch, Aravind Ganesh
Summary: This review focuses on recent advances in thrombolysis for acute ischemic stroke, comparing alteplase and TNK in terms of clinical, imaging, and safety outcomes. It highlights the potential of TNK as an alternative choice, with similar efficacy and safety as alteplase. Further research is needed to determine the advantages and applications of TNK in different subgroups.
Article
Clinical Neurology
Omer Doron, Rachel McLellan, Justin E. Vranic, Robert W. Regenhardt, Christopher J. Stapleton, Aman B. Patel
Summary: This study reports the experience of using the FRED Jr stent for the treatment of subarachnoid hemorrhage. The results show that the FRED Jr stent could be a potential treatment strategy for ruptured aneurysms arising from small-caliber or distal vessels beyond the circle of Willis, with no significant complications.
NEUROSURGICAL FOCUS
(2023)
Article
Multidisciplinary Sciences
Robert W. Regenhardt, Michael H. Lev, Julian He, Adam A. Dmytriw, Justin E. Vranic, James D. Rabinov, Christopher J. Stapleton, Aman B. Patel, Aneesh B. Singhal, R. Gilberto Gonzalez
Summary: Endovascular thrombectomy (EVT) has revolutionized stroke management by providing a promising treatment option for large vessel occlusion (LVO). This study suggests that the collateral pattern on CT angiograms can be used as a potential alternative for selecting suitable candidates for EVT. The presence of a symmetric collateral pattern on CTA predicts favorable outcomes after EVT for LVO stroke, while a malignant collateral pattern is associated with poor clinical outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert W. Regenhardt, Christopher A. Potter, Samuel S. Huang, Michael H. Lev
RADIOLOGIC CLINICS OF NORTH AMERICA
(2023)
Editorial Material
Clinical Neurology
Syed Daniyal Asad, Minali Nigam, John Y. Rhee, Robert W. Regenhardt, Justin E. Vranic, James D. Rabinov, Erica Camargo Faye, Scott B. Silverman
Article
Neurosciences
James Withers, Robert W. Regenhardt, Adam A. Dmytriw, Justin E. Vranic, Rudolph Marciano, Christopher J. Stapleton, Aman B. Patel
Summary: Headache and pulsatile tinnitus were the patient's symptoms. Treatment of the occlusive arteriovenous fistula with interventional radiology was successful. This case demonstrates that minimally invasive surgery is an effective alternative when conventional methods cannot be performed.
Article
Health Care Sciences & Services
Bisheng Shen, Baoxin Chen, Kuangyi Li, Weiyin Cheng, Mohammad Mofatteh, Robert W. Regenhardt, Jack Wellington, Zhangrong Liang, Qi Tang, Jingli Chen, Yimin Chen
Summary: This study aimed to assess the impact of the COVID-19 pandemic lockdown on non-COVID-19 emergency department (ED) visits in a tertiary hospital. The results showed a significant reduction in ED visits during the lockdown period in 2020 compared to 2019, with a subsequent increase in 2021. Additionally, the proportion of critically ill patients with respiratory system involvement, severe trauma, and poisoning decreased in 2020, while the rates of emergency ambulance calls, hospitalizations, and deaths increased.
RISK MANAGEMENT AND HEALTHCARE POLICY
(2023)
Review
Biochemistry & Molecular Biology
Michael Kim, Galadu Subah, Jared Cooper, Michael Fortunato, Bridget Nolan, Christian Bowers, Kartik Prabhakaran, Rolla Nuoman, Krishna Amuluru, Sauson Soldozy, Alvin S. Das, Robert W. Regenhardt, Saef Izzy, Chirag Gandhi, Fawaz Al-Mufti
Summary: This article provides a review of neuroendovascular surgical techniques for craniocervical trauma. With the development of technology, there are increasing treatment options available for traumatic injuries, such as embolization of lesions and thrombectomy. Neuroendovascular techniques have proven to be valuable in cases where surgical options are limited.