Article
Medicine, General & Internal
Edward Tranah, Amy MacBrayne, Naveen Bhadauria, Dev Mukerjee
Summary: This case describes a previously healthy man presenting with respiratory symptoms and lung involvement during the COVID-19 pandemic. Initially diagnosed with community-acquired pneumonia, further investigation revealed the possibility of an autoimmune disease, leading to appropriate treatment.
Article
Medicine, General & Internal
Peter Korsten, Jan-Gerd Rademacher, Linn Riedel, Eva-Maria Schnitzler, Ulrike Olgemoller, Cornelia Sabine Seitz, Jens Schmidt, Jorg Larsen, Radovan Vasko
Summary: The study found that immunosuppressive therapy in ASyS patients can improve radiological alterations in ILD, with stable lung function observed in pulmonary function tests. Although myositis and relapsing disease were more common in the RTX treatment group, there were no significant differences in clinical and radiographic outcomes compared to the non-RTX-treated group.
FRONTIERS IN MEDICINE
(2021)
Article
Respiratory System
Vasilios Tzilas, Petros P. Sfikakis, Demosthenes Bouros
Summary: Interstitial lung diseases (ILDs) are a diverse group of disorders with both known and unknown causes. Diagnosis can be challenging, particularly in distinguishing between idiopathic pulmonary fibrosis, fibrotic hypersensitivity pneumonitis, and connective tissue disease-associated ILD. Antisynthetase syndrome (ASyS) can present a diagnostic challenge, especially when lung involvement is predominant or extrapulmonary manifestations are subclinical. Coordination between pulmonologists and rheumatologists is essential for accurate diagnosis and management.
Article
Immunology
Teresa Quintero-Puerta, Juan Alberto Lira-Lucio, Ramces Falfan-Valencia, Angel E. Vega-Sanchez, Eduardo Marquez-Garcia, Mayra Mejia, Brandon Bautista-Becerril, Jorge Rojas-Serrano, Espiridion Ramos-Martinez, Ivette Buendia-Roldan, Gloria Perez-Rubio
Summary: This study aimed to characterize the lung microbiome in the bronchoalveolar lavage fluid (BALF) of patients with Antisynthetase Syndrome (ASSD) and evaluate its correlation with differential cell count and other bacterial genera in BALF. The results showed that patients with anti-Jo1 autoantibodies had a lower abundance of Veillonella genus, which was strongly correlated with levels of eosinophils, lymphocytes, and Prevotella genus, and negatively correlated with the percentage of macrophages.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Matthew Wells, Sughra Alawi, Kyaing Yi Mon Thin, Harsha Gunawardena, Adrian R. Brown, Anthony Edey, John D. Pauling, Shaney L. Barratt, Huzaifa I. Adamali
Summary: Antisynthetase syndrome is a subtype of idiopathic inflammatory myopathy that is strongly associated with interstitial lung disease. Diagnosis is made by detecting specific antibodies and relevant clinical and radiologic features. A multidisciplinary team, including rheumatologists, respiratory physicians, and radiologists, is needed for accurate diagnosis.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Na Zhao, Wei Jiang, Hongliang Wu, Ping Wang, Xiaoni Wang, Yu Bai, Yao Li, Yanchun Tang, Ying Liu
Summary: The study found that the number of CD3-CD19+ cells and initial glucocorticoid dosage were correlated with imaging progression and may be independent risk factors for ILD deterioration. Factors such as dyspnea as the first symptom, hypohemoglobinemia, serum ferritin level, oxygen partial pressure at diagnosis, and different treatment types were important for survival, with the initial serum ferritin level potentially being an independent risk factor.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Xin Li, Qian Zhou, Pengchao Wu, Qian Chen, Zhenyu Ren, Xue Yang, Xiaokui Tang
Summary: This study aimed to analyze prognostic factors of ASS-related ILD. The retrospective study of 77 patients revealed that respiratory failure and elevated muscle enzymes were independent risk factors, while mechanic's hands and anti-Jo-1 antibody were protective factors.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Aleksandra Halina Opinc, Joanna Samanta Makowska
Summary: Antisynthetase syndrome (ASS) is a heterogeneous disease with diverse clinical manifestations, requiring treatment based on glucocorticosteroids and immunosuppressive agents. Current classification criteria may not fully correspond with the clinical patterns of the disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei Wu, Bridget F. F. Collins, Gregory C. C. Gardner, Daniel S. S. Hippe, Lawrence A. A. Ho, Ganesh Raghu, Sudhakar N. J. Pipavath
Summary: This study analyzed the CT patterns of 47 patients with antisynthetase syndrome-related interstitial lung disease (ASyS-ILD) and its impact on survival. The study found that 56.7% of patients presented with non-fibrotic patterns on CT, with 23.3% showing improvement and 82.4% exhibiting fibrotic patterns, among which 17.6% had progression. Age and CT progression were associated with reduced survival, while the presence of ground-glass opacities and predominant lower lobe distribution were associated with increased survival.
EUROPEAN RADIOLOGY
(2023)
Article
Immunology
Fang Chen, Jinping Wang, Puli Zhang, Yu Zuo, Lifang Ye, Guochun Wang, Xiaoming Shu
Summary: This study demonstrates that DM-ILD patients with negative MSA/MAA have favorable long-term outcomes. Decreased baseline PaO2/FiO2 is identified as an independent prognostic factor for this group of patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisa Baratella, Cristina Marrocchio, Rossella Cifaldi, Mario Santagiuliana, Alessandro Marco Bozzato, Paola Crivelli, Barbara Ruaro, Francesco Salton, Marco Confalonieri, Maria Assunta Cova
Summary: Antisynthetase syndrome (ASS) is a rare autoimmune condition associated with anti-aminoacyl-tRNA synthetase antibodies, often presenting as interstitial lung disease (ILD). HRCT findings in ASS-associated ILD are typically non-specific, but should be considered in patients with acute onset of symptoms.
JAPANESE JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, General & Internal
Youngeun Jang, Hee-Young Yoon, Hyun-Sook Kim
Summary: This study aimed to investigate the efficacy and safety of rituximab in patients with idiopathic inflammatory myopathy-associated interstitial lung disease (IIM-ILD). The results showed that rituximab can stabilize lung function decline and has acceptable safety in IIM-ILD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Beatriz Lima Correa de Araujo, David R. Victor, Heloisa Maria Farias Fontes, Rayana Maria Caminha Mendes Gomes, Leonardo Lima Correa de Araujo
Summary: Antisynthetase syndrome is an autoimmune disease characterized by the presence of aminoacyl-transfer RNA synthetase antibodies. Its clinical presentation is variable and may involve interstitial lung disease, myositis, and arthritis. This case report describes a 42-year-old female patient with severe lung disease and persistent fever, who was diagnosed with antisynthetase syndrome after the detection of anti-Jo1 autoantibodies.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Bess M. Flashner, Paul A. VanderLaan, Lina Nurhussien, Mary B. Rice, Robert W. Hallowell
Summary: The frequency of histopathologic findings varies significantly by antibody type in ILD cases with anti-ARS positivity, with NSIP occurring in less than half of the cases.
RESPIRATORY MEDICINE
(2022)
Article
Rheumatology
Wenhao Zhang, Yiming Zheng, Yikang Wang, Hui Xiong, Chengli Que, Xiaohui Zhang, Ying Zhu, Yawen Zhao, Meng Yu, Lingchao Meng, He Lv, Wei Zhang, Hongjun Hao, Jiangxi Xiao, Yun Yuan, Zhaoxia Wang
Summary: MRI evaluation of patients with antisynthetase syndrome (ASS), dermatomyositis (DM), and immune-mediated necrotizing myopathy (IMNM) revealed frequent muscle and myofascial edema in ASS patients. Compared to IMNM, ASS and DM were associated with more adductor-muscle sparing and subcutaneous-tissue edema. While similar edema patterns were observed in ASS and DM, there were subtle differences between the two groups, including less symmetry and more myofascial edema of the tensor fasciae latae in the ASS group.
Review
Radiology, Nuclear Medicine & Medical Imaging
Shinji Tsukamoto, Andreas F. Mavrogenis, Kirsten van Langevelde, Niels van Vucht, Akira Kido, Costantino Errani
Summary: Age, location, and patient history are important factors in narrowing down the diagnosis of spinal bone lesions. Computed tomography and magnetic resonance imaging play crucial roles in evaluating the characteristics of spinal bone tumors. Growth speed and Lodwick margin description can distinguish malignant from benign tumors to some extent. Biopsy is often necessary for a definitive diagnosis.
CURRENT MEDICAL IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Ryogo Shobatake, Hiroyo Ota, Nobuyuki Takahashi, Satoshi Ueno, Kazuma Sugie, Shin Takasawa
Summary: Sleep apnea syndrome (SAS) is associated with intermittent hypoxia (IH) during sleep, which can affect insulin secretion and insulin resistance, potentially leading to obesity. The direct contribution of SAS to obesity is still debated. This review summarizes recent epidemiological findings on the relationship between SAS and feeding behavior, focusing on the effects of IH on the gut-brain axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Kazuma Sugie
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Kaoru Kinugawa, Tomoo Mano, Yuya Yamatani, Toshiteru Miyasaka, Hiroshi Kataoka, Kazuma Sugie
Summary: The study found that pain intensity in patients with Parkinson's disease fluctuates between on and off states, with a correlation to the functional connectivity of the nucleus accumbens (NAc) with pain-related brain regions. These results contribute to understanding the mechanism of pain development in PD patients.
Article
Clinical Neurology
Satoshi Yamashita, Nozomu Tawara, Ziwei Zhang, Shunya Nakane, Kazuma Sugie, Naoki Suzuki, Ichizo Nishino, Masashi Aoki
Summary: This study investigated the pathogenic properties of autoantibodies against cN1A in sporadic inclusion body myositis (sIBM) using active cN1A peptide immunisation. The results showed that mice injected with cN1A peptide exhibited weight loss, decreased motor activity, and histological changes resembling sIBM. Therefore, the study concluded that anti-cN1A autoantibodies have pathogenic properties in causing sIBM-like histological changes.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Hiroshi Kataoka, Kazuma Sugie
Summary: Parkinson's disease patients may experience nocturnal movement related to primary sleep disorders. This case report highlights an unusual occurrence of nocturnal tremor in a patient with PD. Treatment for such tremor can be challenging, but successful with the use of a long-acting ropinirole patch.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2023)
Article
Oncology
Tomoya Masunaga, Shinji Tsukamoto, Kanya Honoki, Hiromasa Fujii, Akira Kido, Manabu Akahane, Yasuhito Tanaka, Andreas F. Mavrogenis, Costantino Errani, Akira Kawai
Summary: There was no difference in local recurrence, survival or incidence of wound complications between pre- and post-operative radiotherapy for localized myxoid liposarcoma. Therefore, pre-operative radiotherapy for myxoid liposarcoma provides clinical results equivalent to post-operative radiotherapy.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Naoya Kikutsuji, Hiroshi Kataoka, Takao Kiriyama, Kazuma Sugie
Summary: There is limited research on encephalitis/encephalopathy, a neurological complication of the less common coronavirus disease 2019 (COVID-19). This study describes a case of COVID-19-related encephalopathy mimicking stroke that was successfully treated with high-dose steroid pulse therapy.
JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE
(2022)
Article
Medicine, General & Internal
Tomoo Mano, Shigeto Soyama, Kazuma Sugie
Summary: Dysphagia is a known symptom of dermatomyositis, but it can be challenging to diagnose and treat sudden-onset dysphagia without other symptoms. Two patients without severe muscle weakness experienced sudden inability to swallow solids and liquids. Muscle biopsy results confirmed the diagnosis of dermatomyositis, and videofluoroscopy revealed pharyngeal contraction and upper esophageal sphincter opening issues. Both patients showed low tongue pressures. Treatment with methylprednisolone and immunoglobulin led to improvement in swallowing function, with tongue pressure improvement preceding subjective and objective measurements of dysphagia.
CLINICS AND PRACTICE
(2022)
Article
Audiology & Speech-Language Pathology
Shigeto Soyama, Tomoo Mano, Akira Kido
Summary: Telerehabilitation offers advantages in the management of dysphagia during the COVID-19 pandemic by reducing the risk of infection and the need for personal protective equipment.
Article
Clinical Neurology
Kaoru Kinugawa, Tomoo Mano, Tsunenori Takatani, Akira Kido, Kazuma Sugie
Summary: Visual dysfunction is a significant nonmotor symptom of Parkinson's disease (PD), and visual hallucinations and visuospatial dysfunctions are common in PD patients. This study used electroencephalographic coherence analysis to evaluate neuronal synchronization in PD patients with and without visual hallucinations or visuospatial dysfunctions. The findings suggest that reduced coherence in the frontal regions of the brain may be involved in visuospatial dysfunctions in PD patients.
EUROPEAN NEUROLOGY
(2022)
Review
Clinical Neurology
Hiroshi Kataoka, Yohei Okada, Takao Kiriyama, Yorihiro Kita, Junji Nakamura, Koji Shomoto, Kazuma Sugie
Summary: Postural imbalance, abnormal axial posture, and axial rigidity are characteristic features of Parkinson's disease. Galvanic vestibular stimulation (GVS) has shown potential in improving these axial symptoms without adverse effects.
JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE
(2022)
