Review
Endocrinology & Metabolism
Jordan J. Baechle, Nan Chen, Priya Makhijani, Shawn Winer, David Furman, Daniel A. Winer
Summary: Aging is characterized by dysbiosis, disabled macroautophagy, and chronic inflammation. The bidirectional and cyclical relationship between chronic inflammation and age-related conditions is of interest in geroscience research. Understanding this interplay is important for developing anti-aging interventions.
MOLECULAR METABOLISM
(2023)
Review
Food Science & Technology
Giorgia Cioccoloni, Chrysa Soteriou, Alex Websdale, Lewis Wallis, Michael A. Zulyniak, James L. Thorne
Summary: Phytosterols and phytostanols have anti-cancer effects in preclinical cancer models, reducing tumor burden and expression of markers related to metastasis and proliferation. Very high dose treatment may lead to adverse events. They are already recommended for cardiovascular disease risk reduction, with a well understood mechanism of action.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cell Biology
Dingxi Zhou, Mariana Borsa, Anna Katharina Simon
Summary: The ageing population poses challenges to health and social care, with deteriorating immune systems contributing to chronic age-related diseases. More knowledge is needed on the aged immune system for developing COVID-19 treatments, with cellular senescence playing a key role in immune ageing. Deepening the understanding of immune cell senescence may lead to potential druggable pathways for reversing immune ageing.
Review
Agriculture, Multidisciplinary
Taotao Wang, Hong Xu, Shanshan Wu, Yuanxin Guo, Guangshan Zhao, Dongxu Wang
Summary: Sarcopenia is a common and detrimental condition in older populations. Tea catechins, particularly (-)-epigallocatechin-3-gallate (EGCG) in green tea, have shown potential benefits for skeletal muscle performance and prevention of sarcopenia. However, the underlying mechanisms of these protective effects are still not fully understood.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Nutrition & Dietetics
Lu Dai, Denise Mafra, Paul G. Shiels, Tilman M. Hackeng, Peter Stenvinkel, Leon J. Schurgers
Summary: Vitamin K and vitamin K-dependent proteins are associated with age-related diseases. The direct impact of vitamin K on cellular senescence is yet to be proven, but its status reflects the complex interactions between dietary intake, gut microbiome activity, and health. It is proposed to emphasize food quality and explore healthy eating patterns containing vitamin K rather than focusing on a single nutrient for dietary recommendations.
Review
Biotechnology & Applied Microbiology
Haiying Wang, Liqian Yang, Minghui Liu, Jianyuan Luo
Summary: Posttranslational modifications (PTMs) of proteins play important roles in regulating cellular physiological and pathological processes. New modifications like succinylation, hydroxybutyrylation, and lactylation introduce a new layer to protein regulation with wide application prospects.
CANCER GENE THERAPY
(2023)
Review
Cell Biology
Tomas Schmauck-Medina, Adrian Moliere, Sofie Lautrup, Jianying Zhang, Stefan Chlopicki, Helena Borland Madsen, Shuqin Cao, Casper Soendenbroe, Els Mansell, Mark Bitsch Vestergaard, Zhiquan Li, Yosef Shiloh, Patricia L. Opresko, Jean-Marc Egly, Thomas Kirkwood, Eric Verdin, Vilhelm A. Bohr, Lynne S. Cox, Tinna Stevnsner, Lene Juel Rasmussen, Evandro F. Fang
Summary: The nine original hallmarks of aging, along with new emerging ones, have played a crucial role in guiding and advancing research on the biology of aging. Understanding and studying these hallmarks can provide a more comprehensive explanation of aging and age-related diseases, leading to interventions and therapeutics for healthy, happy, and productive lives in the elderly.
Article
Chemistry, Applied
Luca Garcia, Stacy Deshaies, Thibaut Constantin, Francois Garcia, Cedric Saucier
Summary: This study selected 14 Syrah red wines with different initial composition and antioxidant properties and conducted three different accelerated ageing tests. The results showed high correlations between the initial phenolic composition and antioxidant properties of the samples. Partial least squares (PLS) regressions were used to establish models that can predict the AATs test results based on their different initial composition and antioxidant properties. The PLS regression models had overall very good accuracy with correlation coefficients (r2) > 0.89.
Article
Plant Sciences
Liang Zhang, Qingzheng Kang, Mengxiao Kang, Suwei Jiang, Feng Yang, Jun Gong, Gaozhi Ou, Song Wang
Summary: Plant polyphenols have potential anticancer effects and can modulate the expression of non-coding RNAs (including miRNA and lncRNA) involved in cancer initiation and progression. The regulation of ncRNAs by polyphenols involves epigenetic and transcriptional modification, as well as post-transcriptional processing. This finding suggests that polyphenols could be a novel approach for cancer treatment by targeting ncRNAs.
Review
Food Science & Technology
Zuomin Hu, Mengyuan Li, Yunyun Cao, Otobong Donald Akan, Tianyi Guo, Feijun Luo
Summary: Dietary polyphenols have shown potential in cancer treatment through regulating AMPK pathway, targeting cancer cells with metabolic abnormalities. Different dietary polyphenols affect cancer-related genes and pathways by modulating the AMPK pathway. The anti-cancer effects of dietary polyphenols are exerted through target molecules regulated by AMPK.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Cell Biology
Giulia Accardi, Filippa Bono, Giuseppe Cammarata, Anna Aiello, Maria Trinidad Herrero, Riccardo Alessandro, Giuseppa Augello, Ciriaco Carru, Paolo Colomba, Maria Assunta Costa, Immaculata De Vivo, Mattia Emanuela Ligotti, Alessia Lo Curto, Rosa Passantino, Simona Taverna, Carmela Zizzo, Giovanni Duro, Calogero Caruso, Giuseppina Candore
Summary: This study found that the levels of four circulating miRNAs gradually increase with age, except for the ultra-centenarians who show levels comparable to young individuals. These miRNAs may serve as biomarkers of ageing and have diagnostic/prognostic relevance for age-related diseases.
Review
Oncology
Klaudia Klicka, Tomasz M. Grzywa, Aleksandra Mielniczuk, Alicja Klinke, Pawel K. Wlodarski
Summary: miR-200 family is a dysregulated miRNA family in cancer that has the potential to be used as diagnostic and prognostic biomarkers. They regulate various features of cancer and their levels correlate with clinical parameters such as patients' survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Rohit Sharma, Bhawna Diwan
Summary: Lipids play critical roles in cellular homeostasis and modulating organismal ageing. This comprehensive review discusses the extent to which lipids regulate the hallmarks of ageing and highlights the age-dependent deficiencies in lipid metabolism and exogenous lipid changes. Impaired lipid metabolism is considered a key driver of the ageing process, although further research is needed to fully understand the mechanisms involved.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Biology
Jonathan M. Werner, Maraki Y. Negesse, Dominique L. Brooks, Allyson R. Caldwell, Jafira M. Johnson, Rachel M. Brewster
Summary: Primary neurulation is the process of forming the neural tube from the neural plate, with disruptions leading to neural tube defects. Zebrafish show similarities in neural tube formation with other vertebrates, making them a suitable model for understanding human neurulation. Jonathan Werner, Maraki Negesse et al. demonstrate the presence of key morphogenetic events in zebrafish neurulation, supporting its application in studies of neural tube formation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nathan Hayes, Mark Fogarty, Laura Sadofsky, Huw Simon Jones
Summary: Age-related frailty is a significant health and social care burden, and there is a lack of suitable cell culture model for screening compounds to promote healthy skeletal muscle function. This study used C2C12 cells to characterize the changes in reactive oxygen and nitrogen species (RONS) signaling in young and aged myoblasts and myotubes, and assessed the effect of dietary polyphenols on RONS signaling in aged cultures. The findings showed increased RONS levels in aged cells and identified kaempferol and resveratrol as compounds that can modulate RONS signaling in skeletal muscle cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
