Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 62, Issue 2, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2023.106884
Keywords
Expert clinical pharmacological advice; programme; Therapeutic drug monitoring; TDM-guided tailored antimicrobial therapy; Turnaround time; PK; PD optimisation; Intranet
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This study aimed to assess the impact of an expert clinical pharmacological advice (ECPA) programme based on therapeutic drug monitoring (TDM) in tailoring antimicrobial treatment. The programme was successful in guiding treatment with a wide panel of antimicrobials hospital-wide.
Objectives: Therapeutic drug monitoring (TDM) may be helpful in tailoring antimicrobial treatment, and expert interpretation of the results may make it more clinically useful.Methods: This study aimed to assess retrospectively the first-year impact (July 2021 to June 2022) of a newly established expert clinical pharmacological advice (ECPA) programme based on TDM results in tailoring therapy with 18 antimicrobials hospital-wide in a tertiary university hospital. All patients hav-ing & GE;1 ECPA were grouped in five cohorts [haematology, intensive care unit (ICU), paediatrics, medical wards and surgical wards]. Four indicators of performance were identified: total ECPAs; total ECPAs rec-ommending dosing adjustments/total ECPAs both at first and at subsequent assessments; and turnaround time (TAT) of ECPAs, defined as optimal ( < 12 h), quasi-optimal (12-24 h), acceptable (24-48 h) or sub-optimal ( > 48 h).Results: A total of 8484 ECPAs were provided for tailoring treatment in 2961 patients, mostly admitted in the ICU (34.1%) and medical wards (32.0%). The proportion of ECPAs recommending dosing adjustments was > 40% at first assessment (40.9% haematology; 62.9% ICU; 53.9% paediatrics; 59.1% medical wards; and 59.7% surgical wards), and decreased consistently at subsequent TDM assessments (20.7% haematol-ogy; 40.6% ICU; 37.4% paediatrics; 32.9% medical wards; and 29.2% surgical wards). The overall median TAT of the ECPAs was optimal (8.11 h).Conclusion: The TDM-guided ECPA programme was successful in tailoring treatment with a wide panel of antimicrobials hospital-wide. Expert interpretation by medical clinical pharmacologists, short TATs, and strict interaction with infectious diseases consultants and clinicians were crucial in achieving this.& COPY; 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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