Review
Biochemistry & Molecular Biology
Shivshankar Thanigaimani, Muhammad Ibrahim, Jonathan Golledge
Summary: This review examined the potential role of biologic disease-modifying anti-rheumatic drugs (bDMARDs) as repurposed drugs for treating abdominal aortic aneurysms (AAA). Findings from animal models and human tissue samples suggest that tumor necrosis factor-alpha, interleukin-6, and IL-17 are implicated in the pathogenesis of AAA.
Article
Rheumatology
Benjamin Fernandez-Gutierrez, Leticia Leon, Alfredo Madrid, Luis Rodriguez-Rodriguez, Dalifer Freites, Judit Font, Arkaitz Mucientes, Esther Culebras, Jose Ignacio Colome, Juan Angel Jover, Lydia Abasolo
Summary: In patients with IRD, older age, male gender, comorbidities, and specific systemic autoimmune conditions (Sjogren, polychondritis, Raynaud, and mixed connective tissue disease) were associated with a higher risk of hospital admissions related to COVID-19. Exposure to ts/bDMARDs did not reach statistical significance in influencing the risk of hospital admission.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2021)
Review
Pharmacology & Pharmacy
Fang Lv, Suiyuan Hu, Chu Lin, Xiaoling Cai, Xingyun Zhu, Linong Ji
Summary: The use of biologic therapy significantly decreases the risk of major osteoporotic fracture, hip fracture, and osteoporotic non-vertebral fracture in patients with psoriasis (Ps) and psoriatic arthritis (PsA). However, there is no change in the risk of fracture with biologic treatment in patients with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), systemic lupus erythematosus (SLE), and inflammatory bowel diseases (IBD).
PHARMACOLOGICAL RESEARCH
(2022)
Article
Rheumatology
Kristin M. D'Silva, Zachary S. Wallace
Summary: Baseline glucocorticoid use is associated with severe COVID-19 outcomes in autoimmune disease patients, but DMARDs categories do not appear to increase risk. Randomized clinical trials show glucocorticoids reduce mortality in severe COVID-19, while other agents like baricitinib may improve outcomes in certain populations. More research is needed to guide DMARD management in autoimmune disease patients during the pandemic and their role in COVID-19 treatment.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Francesca Ideo, Sadia Niazi, Silvia Mezzena, Francesco Mannocci, Elisabetta Cotti
Summary: This retrospective cohort study investigated the prevalence of apical periodontitis (AP) in patients with autoimmune diseases (ADs) taking biologic medications (BMs). The study found that the status of the patients' immune system may have an effect on the development and prevalence of AP.
JOURNAL OF ENDODONTICS
(2022)
Article
Rheumatology
Behnaz Yousefghahari, Sanaz Navari, Mahmoud Sadeghi, Shima Soleimaniamiri, Mohammadjafar Soleimaniamiri, Behzad Heidari, Mansour Babaei, Kian Ghodrati, Ardeshir Guran, Hemmat Gholinia
Summary: This study found that patients with rheumatic disease taking DMARDs did not have a higher risk of COVID-19 infection compared to controls, and that HCQ therapy did not influence the risk of COVID-19 infection.
CLINICAL RHEUMATOLOGY
(2021)
Review
Nutrition & Dietetics
Fujie Yang, Rongmao Gao, Xiaoxiu Luo, Rongan Liu, Daqian Xiong
Summary: This review systematically and comprehensively summarizes the interactions between berberine and gut microbiota, as well as their effects on various diseases. It describes the changes of gut microbiota after the intervention of different doses of berberine and its potential clinical consequences, aiming to provide a basis for the rational application of berberine in future clinical treatment.
FRONTIERS IN NUTRITION
(2023)
Review
Health Care Sciences & Services
Mariangela Manfredi, Lieve Van Hoovels, Maurizio Benucci, Riccardo De Luca, Carmela Coccia, Pamela Bernardini, Edda Russo, Amedeo Amedei, Serena Guiducci, Valentina Grossi, Xavier Bossuyt, Carlo Perricone, Maria Infantino
Summary: uPAR is a membrane-bound glycoprotein, and its bioactive form, suPAR, is primarily expressed on the surface of immunologically active cells. Higher levels of suPAR have been associated with disease severity, relapse, and mortality in various inflammatory diseases. This review summarizes the current literature on the potential role of suPAR as a biomarker in autoimmune rheumatic and non-rheumatic diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Elizabet Mendez Eirin, Yago Suarez Ourens, Jose Luis Guerra Vazquez
Summary: Autoimmune rheumatic diseases can lead to cardiovascular complications that require early detection and treatment. Cardiac involvement in these patients may result in unfavorable prognosis, highlighting the importance of appropriate management.
Review
Medicine, General & Internal
Oscar Pizano-Martinez, Edgar Mendieta-Condado, Monica Vazquez-Del Mercado, Erika Aurora Martinez-Garcia, Efrain Chavarria-Avila, Daniel Ortuno-Sahagun, Ana Laura Marquez-Aguirre
Summary: Autoimmune rheumatic diseases are a group of heterogeneous disorders characterized by clinical symptoms such as pain, tissue damage, immune deregulation, and inflammation. Biologic disease-modifying antirheumatic drugs are effective treatments, but their complexity can induce the development of anti-drug antibodies. TNF inhibitors, widely used in rheumatoid arthritis, appear to be the main contributors to immunogenicity. This review provides an overview of the immunogenicity of biological agents in autoimmune rheumatic diseases, focusing on the prevalence of anti-drug antibodies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Maria Maslinska, Joanna Dmowska-Chalaba, Michal Jakubaszek
Summary: The role of IgG4 in IgG4-RD and other autoimmune diseases has attracted attention. IgG4, as a unique subclass of immunoglobulins, is generally considered non-inflammatory and tolerance inducing, but in IgG4-RD, it may play a pathogenic role in fibrogenesis and inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Kotaro Matsumoto, Katsuya Suzuki, Masaru Takeshita, Tsutomu Takeuchi, Yuko Kaneko
Summary: Giant cell arteritis and Takayasu arteritis are types of large-vessel vasculitis with high relapse rates. Glucocorticoids are the standard treatment, but recent trials have shown the effectiveness of biological disease-modifying anti-rheumatic drugs and JAK inhibitors in reducing relapse rates and glucocorticoid dosages. However, controlling residual inflammation and degenerative alterations in the vessel wall remains a challenge. Analyzing immune cell phenotypes may help predict treatment response and guide optimal use of these drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Anna P. Ralph, Sara Noonan, Vicki Wade, Bart J. Currie
Summary: Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are significant health issues among Australian Aboriginal and Torres Strait Islander peoples, leading to morbidity and premature mortality. The updated 2020 Australian guideline focuses on best practice care, including changes in diagnostic criteria, prophylaxis duration, pain management, and antibiotic regimens. Additionally, there is an emphasis on culturally appropriate care, primordial prevention strategies, echocardiographic screening, and expanded management guidance for women with RHD or ARF.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Article
Biology
Fulvia Ceccarelli, Francesco Natalucci, Licia Picciariello, Giulio Olivieri, Alessio Cirillo, Alain Gelibter, Vincenzo Picone, Andrea Botticelli, Fabrizio Conti
Summary: The introduction of immune checkpoint inhibitors (ICIs) has changed the history of cancer therapy, but it can also lead to the development of rheumatic immune-related adverse events (Rh-irAEs). In a joint oncology/rheumatology outpatient clinic, a descriptive study was conducted to examine rheumatic conditions developed during anti-PD1 treatment. The study included 32 patients, with various rheumatic conditions identified and requiring treatment with DMARDs.
Article
Hematology
Takuya Harada, Hiromi Iwasaki, Tsuyoshi Muta, Shingo Urata, Aiko Sakamoto, Kentaro Kohno, Ken Takase, Tomoya Miyamura, Takuya Sawabe, Hideki Asaoku, Kensuke Oryoji, Tomoaki Fujisaki, Yasuo Mori, Goichi Yoshimoto, Masahiro Ayano, Hiroki Mitoma, Toshihiro Miyamoto, Hiroaki Niiro, Hidetaka Yamamoto, Yumi Oshiro, Hiroaki Miyoshi, Koichi Ohshima, Morishige Takeshita, Koichi Akashi, Koji Kato
Summary: The study evaluated the clinical outcomes of MTX-LPD patients and found that the pathological subtype of lymphoma could predict the clinical outcome. Patients with polymorphic-type LPD had better event-free survival compared to other subtypes. Use of TNF-alpha inhibitors was associated with higher non-relapse mortality in DLBCL patients, while RA patients previously treated with JAK inhibitors more commonly required chemotherapy, indicating disease aggressiveness.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
I Aljulayfi, S. O'Toole, M. Healy, S. Sumaidaa, Z. Ali, D. Bartlett, R. Austin
Summary: The study aimed to compare the protective role of saliva against erosion and attrition challenges. The results showed a trend that saliva decreased wear, but this was only statistically significant for erosion/attrition dentine wear.
SAUDI DENTAL JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Polyvios Charalambous, Saoirse O'Toole, Rupert Austin, David Bartlett
Summary: This study investigated the threshold and accuracy of intraoral scanning in measuring freeform human enamel surfaces. The results showed that the combination of surface registration and subtraction allowed confident measurement of step height above 73 micrometers.
Article
Dentistry, Oral Surgery & Medicine
Erika Cadoni, Francesca Ideo, Giuseppe Marongiu, Silvia Mezzena, Luca Frigau, Quirico Mela, Antonio Capone, Henry F. Duncan, Elisabetta Cotti
Summary: This study aimed to assess the periapical status and the prevalence and progression of apical periodontitis (AP) in patients with osteoporosis (OP) treated with denosumab (D), bisphosphonates (BPs), or without medication. The results showed that OP does not appear to be associated with the development of AP. However, there was an increased prevalence of AP in root canal-treated teeth in OP patients, suggesting a possible relationship with the patients' medication.
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2022)
Article
Immunology
Yuchen Zhang, Sadia Ambreen Niazi, Yuguang Yang, Yiqing Wang, Xiao Cao, Yibing Liu, Yinhu Li, Qin Zhou
Summary: Smoking is a significant risk factor for peri-implant diseases, affecting the stability and topology of the peri-implant microbiome, resulting in poor responsiveness to treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Serpil Djemal, Mohammadreza Aryafar, Aviva Petrie, Nectaria Polycarpou, Edward Brady, Sadia Niazi
Summary: This survey reports on the incidence of traumatic dental injuries in an adult population attending a specialized dental trauma clinic in a London teaching hospital. The most common cause was accidental falls, the most common type of displacement injury was lateral luxation, and enamel-dentine fractures were the most common type of fracture injury.
BRITISH DENTAL JOURNAL
(2022)
Article
Microbiology
Sadaf Rasheed Mughal, Sadia Ambreen Niazi, Thuy Do, Steven C. Gilbert, Xavier Didelot, David R. Radford, David Beighton
Summary: The aim of this study was to use high-throughput sequencing techniques to investigate the taxonomy of Actinomyces naeslundii and its closely related species. The strains were classified as A. naeslundii and A. oris based on MLST data analysis. Whole genome sequencing was performed on selected strains of A. oris and A. naeslundii, and comparative genomic analysis was carried out. The results showed that A. oris forms six distinct groups, while A. naeslundii forms three. The correct designation of isolates will help in the identification of clinical Actinomyces isolates found in dental plaque and accelerate further research on the biochemical characterization and pathogenesis of this group of microorganisms.
Article
Chemistry, Multidisciplinary
Abdulaziz Bakhsh, Noor Al-Abdulla, Francesco Mannocci, Marwa Allihaibi, David Moyes, Gordon Proctor, Sadia Ambreen Niazi
Summary: This study aimed to evaluate the effect of apical periodontitis and its treatment on salivary inflammatory markers and investigate their correlation with serum markers. Saliva samples were collected from 115 participants and analysed using a multiplex immunoassay. Salivary cytokines, MMPs, and vascular adhesion molecules were higher at review appointments, while hs-CRP levels were significantly higher in the treatment group. Correlation between salivary and serum biomarkers suggests saliva sampling as a feasible non-invasive option for measuring inflammatory markers.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Noor Al-Abdulla, Abdulaziz Bakhsh, Francesco Mannocci, Gordon Proctor, David Moyes, Sadia Ambreen Niazi
Summary: The aim of this study was to investigate serum biomarkers of inflammation 2 years following non-surgical root canal re-treatment (Re-RCT) and peri-apical surgery (PS), and their correlation with signs and symptoms, treatment outcome, metabolic syndrome factors, infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) and COVID-19 vaccination. The results showed that hs-CRP, ADMA, and MMP-2 can be considered as prognostic biomarkers for successful Re-RCT and PS, as their levels reduced at the 2-year recall in cases with evidence of clinical and radiographic success. The successful treatment of chronic apical periodontitis is associated with improvements in metabolic syndrome indicators, better glycemic control, and reduction of certain systemic inflammatory markers related to cardiovascular disease risks at the 2-year mark.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
S. P. Jadeja, A. Leblanc, S. O'Toole, R. S. Austin, D. Bartlett
Summary: This study compared the surface change on natural and polished enamel exposed to a joint mechanical and chemical wear regimen. The results showed that natural enamel, when exposed to erosion alone, displayed less wear and minimal subsurface alterations. However, with added abrasion, natural enamel surfaces saw increased wear and notable subsurface changes compared to polished ones.
JOURNAL OF DENTISTRY
(2023)
Review
Chemistry, Multidisciplinary
Yuchen Zhang, Emily Ming-Chieh Lu, David Moyes, Sadia Ambreen Niazi
Summary: This systematic review evaluates the impact of peri-implantitis on metabolic syndrome and provides management suggestions for patients with metabolic disorders. The findings suggest an association between peri-implantitis and altered metabolic factors, including lipid profile and HbA1c level. However, more high-quality studies are needed to confirm these results.
APPLIED SCIENCES-BASEL
(2023)