Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes

Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH

(2022) Enrico Falcone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermediate Cu(II)-Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction

(2021) Iwona Ufnalska et al.   INORGANIC CHEMISTRY

Copper in tumors and the use of copper-based compounds in cancer treatment

(2021) Daniela Almeida da Silva et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The glutathione/metallothionein system challenges the design of efficient O2-activating Cu-complexes

(2020) Alice Santoro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High copper complex stability and slow reduction kinetics as key parameters for improved activity, paraptosis induction and impact on drug-resistant cells of anticancer thiosemicarbazones

(2020) Sonja Hager et al.   ANTIOXIDANTS & REDOX SIGNALING

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development

(2018) Petra Heffeter et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes

(2018) Sebastian Kallus et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Glutathione limits aquacopper(I) to sub-femtomolar concentrations through cooperative assembly of a tetranuclear cluster

(2017) M. Thomas Morgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention

(2016) Christian R. Kowol et al.   JOURNAL OF MEDICINAL CHEMISTRY

Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)

(2015) Patric J. Jansson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting copper in cancer therapy: ‘Copper That Cancer’

(2015) Delphine Denoyer et al.   Metallomics

Advances in Copper Complexes as Anticancer Agents

(2013) Carlo Santini et al.   CHEMICAL REVIEWS

Novel Chelators for Cancer Treatment: Where Are We Now?

(2012) Angelica M. Merlot et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds

(2011) Christian R. Kowol et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Impact of Metal Coordination on Cytotoxicity of 3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone (Triapine) and Novel Insights into Terminal Dimethylation

(2009) Christian R. Kowol et al.   JOURNAL OF MEDICINAL CHEMISTRY

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

(2009) Aleksandr V. Marenich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity

(2008) Paul V. Bernhardt et al.   JOURNAL OF MEDICINAL CHEMISTRY