CoronaVac vaccine does not affect ovarian reserve

Objectives: In this study, our aim is to investigate the effect of CoronaVac vaccine on ovarian reserve in female patients followed up for infertility.Material and methods: Our study is a retrospective study. Forty-six infertile patients who received two doses of CoronaVac vaccine one month apart and had not had a previous Covid 19 infection were included in the study. Anti-mullerian hormone (AMH) and folliculometry of 46 patients one month before CoronaVac vaccine and one month after the second dose of vaccine were compared. Results: There was no statistically significant difference in the change of AMH level and follicle number before and after vaccination (respectively p = 0.366; 0.610).Conclusions: Considering that having a COVID-19 infection has a negative effect on female fertility and causing ovarian damage in recent studies, vaccination is a rational and cost-effective approach to protect ovarian reserve. Knowing that the vaccine does not have a negative effect on fertility may increase the application of the vaccine in women of reproductive age.

Automated summary

This study investigated the effect of CoronaVac vaccine on the ovarian reserve of infertile female patients. A total of 46 patients who received two doses of CoronaVac vaccine and had no previous Covid-19 infection were included. AMH levels and follicle numbers were compared before and after vaccination. The results showed no statistically significant difference in AMH levels and follicle numbers before and after vaccination.