Article
Genetics & Heredity
Katharine Press Callahan, Joshua Radack, Monica H. Wojcik, Sabrina Malone Jenkins, Russell T. Nye, Cara Skraban, Katherine Taylor Wild, Chris Feudtner
Summary: This study aimed to examine the variation in genetic testing among NICUs in different hospitals over time. A large-scale retrospective cohort study was conducted using data from the Pediatric Hospital Information System database between 2016 and 2021. It was found that the proportion of NICU patients undergoing genetic testing differed across hospitals and increased over time. The study suggests that clearer guidelines for NICU genetic testing are needed.
GENETICS IN MEDICINE
(2023)
Article
Obstetrics & Gynecology
Eman S. Haidari, Henry C. Lee, Jessica L. Illuzzi, Ciaran S. Phibbs, Haiqun Lin, Xiao Xu
Summary: The study found significant interhospital variation in neonatal intensive care unit (NICU) admissions, driven mainly by admissions for mild diagnoses, suggesting potential overuse. Births at hospitals with more NICU beds had a higher likelihood of NICU admission.
JOURNAL OF PERINATOLOGY
(2021)
Article
Infectious Diseases
Edyta Golinska, L. Kozien, A. Tomusiak-Plebanek, J. Kedzierska, M. Dorycka, R. Lauterbach, D. Pawlik, B. Rzepecka-Weglarz, M. Janiszewska, Pb Heczko, J. Wojkowska-Mach, M. Strus
Summary: This study compared demographic and clinical features of main pathogens related to neonatal sepsis in two neonatal intensive care units over a 24-month period. Results showed a predominance of CoNS resistant to methicillin in late-onset bloodstream infections and beta-lactam resistant E. coli in early-onset bloodstream infections. The campaign for controlling GBS carriage in pregnant women in Poland led to the disappearance of GBS as a cause of sepsis, but measures to control E.coli related sepsis are lacking.
BMC INFECTIOUS DISEASES
(2023)
Article
Pediatrics
Mohamed E. Abdel-Latif, Oyelola Adegboye, Gen Nowak, Faiz Elfaki, Barbara Bajuk, Kathryn Glass, David Harley
Summary: This study aims to evaluate and audit the performance variation in a regional Australian network of eight neonatal intensive care units (NICUs). The study found variations in the performance and outcome of NICUs, indicating the need for intervention. The use of hierarchical model-based risk adjustment and funnel plots is proposed to monitor and guide timely interventions.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Pediatrics
Fekadeselassie Belege Getaneh, Girum Sebsbie, Mekonen Adimasu, Natnael Moges Misganaw, Desalegn Abebaw Jember, Dires Birhanu Mihretie, Shiferaw Abeway, Zebenay Workneh Bitew
Summary: This study aimed to determine the survival status and predictors of asphyxia among neonates admitted in Neonatal Intensive Care Units of public hospitals in Addis Ababa, Ethiopia. The results showed that low birth weight, hypoxic ischemic encephalopathy, seizure, thrombocytopenia, and calcium gluconate were independent predictors of time to recovery of asphyxiated neonates.
Article
Public, Environmental & Occupational Health
Hillary J. J. Spencer, Keerti L. Dantuluri, Cary Thurm, Hannah Griffith, Carlos G. Grijalva, Ritu Banerjee, Leigh M. Howard
Summary: The study analyzed antibiotic use in US NICUs and found that patterns of antibiotic use varied depending on medical versus surgical service line, hospital, and geographic location.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Infectious Diseases
Severine Martin-Mons, Beatrice Gouyon, Severine Lorrain, Soumeth Abasse, Ceneric Alexandre, Guillaume Binson, Roselyne Brat, Laurence Caeymaex, Yvan Couringa, Cecile Desbruyeres, Marine Dorsi-Di Meglio, Guillaume Escourrou, Florence Flamein, Olivier Flechelles, Olivier Girard, Elsa Kermorvant-Duchemin, Alexandre Lapillonne, Catherine Lafon, Massimo Di Maio, Gael Mazeiras, Julien Mourdie, Amelie Moussy-Durandy, Anne-Sophie Pages, Duksha Ramful, Hasinirina Razafimahefa, Jean-Marc Rosenthal, Silvia Iacobelli, Jean-Bernard Gouyon
Summary: This study described aminoglycosides prescriptions in 23 French NICU over a 4-year period and associated with a benchmarking program. The results showed that the prescription strategy ensured a low rate of overdose and underdose.
Article
Obstetrics & Gynecology
Ankur Datta, Jason Z. Niehaus, Julie Weiner, Isabella Zaniletti, Nana Matoba, Kevin M. Sullivan, Robert DiGeronimo, Carl H. Coghill, Girija Natarajan, Steven R. Leuthner, Amy Brown Schlegel, Anita Shah, Karna Murthy, Jessica T. Fry
Summary: This study aimed to characterize infants who underwent autopsy in regional neonatal intensive care units (NICUs) and found significant inter-center variability in autopsy rates. Infants who underwent autopsy typically had higher birth weight and gestational age compared to those who did not, but there were no differences in terms of sex and primary cause of death.
JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Laura Bech Polcwiartek, P. Brian Smith, Daniel K. Benjamin, Kanecia Zimmerman, Alycia Love, Lance Tiu, Sylvia Murray, Phillip Kang, Finn Ebbesen, Soren Hagstrom, Reese H. Clark, Rachel G. Greenberg
Summary: The study identified group B Streptococcus as the most frequent cause of early-onset sepsis in term infants. Factors such as low Apgar score, Cesarean delivery, and small for gestational age were associated with lower risk of EOS, while factors like prolonged rupture of membranes and maternal age <19 years were associated with increased risk. Early recognition of risk factors can aid in the daily management of term infants in NICUs.
JOURNAL OF PERINATOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Mohadese Babaie, Manijeh Nourian, Foroozan Atashzadeh-Shoorideh, Houman Manoochehri, Malihe Nasiri
Summary: This study aimed to explain the concept of safety culture in neonatal intensive care units (NICUs) from the perspective of nurses and physicians. The dimensions of safety culture in NICUs include professional development, constructive interactions, organizational supportive climate, management commitment to neonatal safety, and planning and implementation of neonatal developmental care. Improving these dimensions can enhance neonatal safety, reduce harm to neonates, and save resources. Understanding the status of these dimensions in wards and hospitals can guide efforts in promoting neonate health and policy-making.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Infectious Diseases
Dimitrios Rallis, Vasileios Giapros, Anastasios Serbis, Chrysoula Kosmeri, Maria Baltogianni
Summary: Antibiotics are commonly prescribed in neonatal intensive care units due to complications from neonatal sepsis. However, inappropriate use of antimicrobial drugs in neonates has led to the emergence of multidrug-resistant pathogens, posing a global threat to public health. This review provides an overview of neonatal sepsis and updates on indications for antimicrobial therapy, selection of empirical antimicrobials, duration of therapy, and criteria for early discontinuation.
Review
Computer Science, Information Systems
Shehnila Zardari, Sana Alam, Hamad Abosaq Al Salem, Mana Saleh Al Reshan, Asadullah Shaikh, Aneeq Fayyaz Karim Malik, Muhammad Masood Ur Rehman, Haralambos Mouratidis
Summary: This research study provides a comprehensive bibliometric assessment of the field of Software Testing (ST), analyzing the publication rate, research themes, and collaboration networks over the past six years. The study reveals the significant impact of ST on other research domains, particularly in the Electrical and Electronics Domain. Most of the research publications originate from resourceful countries, with a majority coming from Asian countries. The analysis shows that higher collaboration networks lead to greater research output. Co-word analysis and topic dendrogram provide insights into keyword relatedness and identified research themes. The findings of this study are valuable for the field of software testing.
Article
Obstetrics & Gynecology
Brian C. King, Joseph Hagan, Troy Richardson, Jay Berry, Jonathan L. Slaughter
Summary: This retrospective cohort study aimed to estimate hospital variation in echocardiography use among very preterm infants in US children's hospitals. The study found that there was significant variation in the use of echocardiography, particularly in the first few days of life, and this variation was associated with the use of nitric oxide and vasoactive medications.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Christina Maratta, Kristen Hutchison, Jessica Nicoll, Sean M. Bagshaw, John Granton, Haresh Kirpalani, Henry Thomas Stelfox, Niall Ferguson, Deborah Cook, Christopher S. Parshuram, Gregory P. Moore
Summary: Most pediatric and level-3 neonatal intensive care units in Canada have dedicated in-house physicians overnight, primarily residents or fellows. However, there is significant variation in this arrangement, and the potential impact on patient outcomes, resident learning, and physician satisfaction remains unclear and requires further investigation.
FRONTIERS IN PEDIATRICS
(2023)
Article
Nursing
Heli Makela, Anna Axelin, Terhi Kolari, Tuula Kuivalainen, Hannakaisa Niela-Vilen
Summary: Implementing the Baby-Friendly Hospital Initiative led to significant improvements in healthcare professionals' breastfeeding attitudes and related hospital practices, including increased rates of skin-to-skin contact, early breastfeeding, and exclusive breastfeeding.
JOURNAL OF HUMAN LACTATION
(2022)
Article
Genetics & Heredity
Katerina S. Kucera, Beth Lincoln Boyea, Brooke Migliore, Sarah Nelson Potter, Veronica R. Robles, Oksana Kutsa, Heidi Cope, Katherine C. Okoniewski, Anne Wheeler, Catherine W. Rehder, Edward C. Smith, Holly L. Peay
Summary: Screening for elevated CK-MM levels in dried blood spots is a feasible method to identify newborns with DMD. Including specific cutoffs, repeat testing, and genetic sequencing can improve the accuracy and sensitivity of screening.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Madeline Currey, Ilana Solomon, Sarah Mcgraw, Jenny Shen, Francisco Munoz, Ernesto Sosa, Vanessa Puello-Lozano, Sam Wing, Lisa Lopez, Michelle Afkhami, Janine Lobello, Szabolcs Szelinger, Stacy W. Gray
Summary: This study conducted qualitative interviews with cancer patients and providers to identify gaps in clinical care and propose care delivery solutions for the return of secondary germline findings. The responses of patients varied depending on the amount of pre-test counseling they received, and providers identified insufficient clinic time as a major barrier to pretest education. Online support tools and standardized pre-test education models were favored by providers. There were differing perspectives on how pre-test education should be integrated into clinical workflows, but agreement on the inclusion of differences between somatic and germline testing, likelihood of medically actionable findings, and the possibility of being referred to a genetics provider.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Kiely N. James, Shimul Chowdhury, Yan Ding, Sergey Batalov, Kelly Watkins, Yong Hyun Kwon, Lucitia Van Der Kraan, Katarzyna Ellsworth, Stephen F. Kingsmore, Lucia Guidugli
Summary: This study used genome sequencing to detect a wide range of copy-number variants (CNVs) and other non-single nucleotide variant/indel variant types. These genetic alterations accounted for 15.8% of reported variants, with deletions being the most common type. The study also found that additional genetic tests were ordered in some cases, but failed to report the variants detected by genome sequencing.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Asem Berkalieva, Nicole R. Kelly, Ashley Fisher, Samuel F. Hohmann, Monisha Sebastin, Miranda Di Biase, Katherine E. Bonini, Priya Marathe, Jacqueline A. Odgis, Sabrina A. Suckiel, Michelle A. Ramos, Rosamond Rhodes, Noura S. Abul-Husn, John M. Greally, Carol R. Horowitz, Melissa P. Wasserstein, Eimear E. Kenny, Bruce D. Gelb, Bart S. Ferket
Summary: The study aims to understand the effects of returning diagnostic sequencing results on clinical actions and economic outcomes for pediatric patients with suspected genetic disorders. The results showed that patients with positive findings were more likely to receive specialist consultation, but there were no significant increases in overall physician services and costs. More large-scale studies are needed to confirm these findings.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Kirstine Stochholm, Camilla Holmgard, Shanlee M. Davis, Claus H. Gravholt, Agnethe Berglund
Summary: This study assessed the incidence, prevalence, and age at diagnosis of individuals with 45,X/46,XY mosaicism and described the associated mortality pattern. The study found an increasing incidence of 45,X/46,XY mosaicism in males and a stable incidence in females. Males were diagnosed at an older age than females. Additionally, 45,X/46,XY mosaicism was associated with increased all-cause mortality.
GENETICS IN MEDICINE
(2024)
Article
Genetics & Heredity
Yunjia Chen, Ender Karaca, Nathaniel H. Robin, Dana Goodloe, Ali Al-Beshri, S. Joy Dean, Anna C. E. Hurst, Andrew J. Carroll, Fady M. Mikhail
Summary: This study confirms the association between DLG2 intragenic deletions and neurodevelopmental disorders, supports the haploinsufficiency of the DLG2 gene, and suggests a potential association between these deletions and congenital anomalies and dysmorphism.
GENETICS IN MEDICINE
(2024)