Bias correction for inverse variance weighting Mendelian randomization

Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization

(2022) Qian Yang et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

An empirical investigation into the impact of winner’s curse on estimates from Mendelian randomization

(2022) Tao Jiang et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Ten simple rules for conducting a mendelian randomization study

(2021) Sarah A. Gagliano Taliun et al.   PLoS Computational Biology

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

(2021) Liza Darrous et al.   Nature Communications

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

(2021) Veronika W Skrivankova et al.   BMJ-British Medical Journal

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

(2020) Jean Morrison et al.   NATURE GENETICS

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

(2020) Qingyuan Zhao et al.   ANNALS OF STATISTICS

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

(2020) Ben Brumpton et al.   Nature Communications

MR-Clust: Clustering of genetic variants in Mendelian randomization with similar causal estimates

(2020) Christopher N Foley et al.   BIOINFORMATICS

Powerful three-sample genome-wide design and robust statistical inference in summary-data Mendelian randomization

(2019) Qingyuan Zhao et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

(2019) Andrew D. Grotzinger et al.   Nature Human Behaviour

Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health

(2019) Neil Martin Davies et al.   eLife

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis

(2019) Alex J Cornish et al.   Lancet Gastroenterology & Hepatology

Signatures of negative selection in the genetic architecture of human complex traits

(2018) Jian Zeng et al.   NATURE GENETICS

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

(2017) Jack Bowden et al.   STATISTICS IN MEDICINE

Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

(2017) Cameron Palmer et al.   PLoS Genetics

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Bias due to participant overlap in two-sample Mendelian randomization

(2016) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic

(2016) Jack Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Bias in causal estimates from Mendelian randomization studies with weak instruments

(2011) Stephen Burgess et al.   STATISTICS IN MEDICINE

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Bias-reduced estimators and confidence intervals for odds ratios in genome-wide association studies

(2008) H. Zhong et al.   BIOSTATISTICS

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE