Review
Medicine, General & Internal
Maaike H. T. van Hoesel, Ya Li Chen, Ai Zheng, Qi Wan, Selma M. Mourad
Summary: Endometriosis is a common gynecological condition that can cause pain and infertility in women. The effectiveness and safety of selective oestrogen receptor modulators (SERMs) in managing endometriosis are uncertain based on limited research. Further studies are needed to fully evaluate the role of SERMs in endometriosis treatment.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Chemistry, Medicinal
Alisa Lang, Laura Isigkeit, Manfred Schubert-Zsilavecz, Daniel Merk
Summary: LRH-1, a ligand-activated transcription factor, is involved in metabolic homeostasis regulation with therapeutic potential in various diseases. However, due to a lack of suitable ligands, the study of pharmacological control over LRH-1 has been insufficiently explored.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Francesco Fiorentino, Antonello Mai, Dante Rotili
Summary: SIRT6 is a NAD(+)-dependent protein deacylase and mono-ADP-ribosyltransferase with wide substrate specificity, showing beneficial effects on cellular processes but contrasting roles in cancer. Its central role in cellular homeostasis makes it a promising therapeutic target.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Shuying Hu, Feiying Yin, Litao Nie, Yuqin Wang, Jian Qin, Jian Chen
Summary: This study discusses the impact of coronavirus infection on breast cancer patients and the potential therapeutic strategy of selective estrogen receptor modulators (SERMs).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dermatology
Nicole Bechmann, Bruna Calsina, Susan Richter, Jens Pietzsch
Summary: Malignant melanoma has limited treatment options and poor prognosis. Targeting estrogen receptor (ER) signaling could be an effective therapeutic approach. High expression of ERα gene is associated with improved overall survival, while ERβ gene expression does not change with tumor progression. Targeting ERβ signaling combined with targeted nitric oxide release shows promise in preventing metastatic spread and reducing tumor growth in malignant melanoma.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Nutrition & Dietetics
Gonzalo Alba, Hala Dakhaoui, Consuelo Santa-Maria, Francisca Palomares, Marta Cejudo-Guillen, Isabel Geniz, Francisco Sobrino, Sergio Montserrat-de la Paz, Soledad Lopez-Enriquez
Summary: Nutraceuticals can regulate immune responses in an inflammatory microenvironment, aiding in the prevention and treatment of various pathologies. They impact immune cell metabolism, particularly in antigen-presenting cells (APCs) and T cells, resulting in phenotypical and functional changes. In chronic inflammatory processes associated with obesity and diabetes, nutraceuticals offer a promising strategy to modulate metabolic pathways and induce significant cellular changes.
Article
Biochemistry & Molecular Biology
Jan Heering, Nathalie Jores, Whitney Kilu, Espen Schallmayer, Evelyn Peelen, Andreas Muehler, Hella Kohlhof, Daniel Vitt, Verena Linhard, Santosh L. Gande, Apirat Chaikuad, Sridhar Sreeramulu, Harald Schwalbe, Daniel Merk
Summary: This study elucidates the molecular basis of FXR activation by systematically studying the response of FXR ligands. Different ligands have different effects on FXR activation, which align with structural changes in the ligand binding domain of FXR. The results suggest the potential application of selective modulation of FXR dimerization and co-regulator interactions for FXR ligands.
ACS CHEMICAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jane Y. Xu, Michele A. O'Connell, Lauren Notini, Ada S. Cheung, Sav Zwickl, Ken C. Pang
Summary: Gender dysphoria is the distress associated with having a gender identity different from one's birth-assigned sex. Hormonal treatment guidelines primarily cater to those transitioning from male to female or vice versa, leaving limited options for non-binary trans individuals seeking an androgynous appearance. There is potential for Selective Estrogen Receptor Modulators (SERMs) to be a gender-affirming treatment for non-binary individuals assigned male at birth (AMAB), but further research is needed on their effects and safety.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Psychiatry
Spencer B. Huggett, Jeffrey S. Hatfield, Joshua D. Walters, John E. McGeary, Justine W. Welsh, Trudy F. C. Mackay, Robert R. H. Anholt, Rohan H. C. Palmer
Summary: Research analyzed gene expression data to explore pharmaceutical treatments for cocaine use disorder, identifying ibrutinib as a potential candidate to reduce cocaine-induced responses despite increasing cocaine consumption.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Nutrition & Dietetics
Ellis Hall, Misha F. F. Vrolijk
Summary: This article reviews the interaction between selective androgen receptor modulators (SARMs) and the androgen receptor (AR) on cardiovascular health. It is found that SARMs may increase the risk of cardiovascular diseases through multiple factors, including the renin-angiotensin system, smooth muscle cells, sympathetic nervous system, lipid profile, inflammation, and platelet activity. However, there is a lack of clinical trials and literature on the relationship between SARMs, cardiovascular diseases, and the AR. More research is needed to understand the mechanisms and risk factors.
Review
Biochemistry & Molecular Biology
Bimal Prasad Jit, Biswajita Pradhan, Rutumbara Dash, Prajna Paramita Bhuyan, Chhandashree Behera, Rajendra Kumar Behera, Ashok Sharma, Miguel Alcaraz, Mrutyunjay Jena
Summary: Ionizing radiation causes extensive damage to biological systems, including inflammation, fibrosis, and atrophy. Phytochemicals derived from plants with potent antioxidant activities can efficiently target multiple signaling pathways and have potential roles in altering radiation response.
Review
Surgery
Steven L. Due, David I. Watson, Damian J. Hussey
Summary: Esophageal cancer, particularly adenocarcinoma, is a common malignancy with limited chemotherapeutic options. Recent efforts have been focused on targeted molecular therapies, while epidemiological evidence suggests a hormonal influence on disease development. Research on estrogen receptor expression in adenocarcinoma tissue and ER modulator therapy show promise for potential therapeutic benefit.
ANZ JOURNAL OF SURGERY
(2021)
Review
Chemistry, Medicinal
Yuan-Yuan Gao, Wen Tian, Hui-Nan Zhang, Yang Sun, Jing-Ru Meng, Wei Cao, Xiao-Qiang Li
Summary: TRPCs channels play crucial roles in human physiological and pathological processes, but finding selective TRPCs modulators remains challenging. Further exploration for more effective and selective TRPCs modulators is needed.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zi-Ying Zhan, Zhi-Hong Zhang, Hong-Xu Yang, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian
Summary: This study aimed to explore the mechanism of Costunolide (Cos) on improving psoriasis-like skin inflammation. The results showed that Cos improved the pathological changes of psoriasis-like skin inflammation by inhibiting epidermal damage and inflammation-related expression. The improvement might be through the P2X7R/IL-36 signaling pathway. Cos has potential skin health promoting benefits by preventing psoriasis-like skin inflammation.
Article
Biochemistry & Molecular Biology
Elena I. Solntseva, Julia V. Bukanova, Rodion Kondratenko, Eva Kudova
Summary: The negative impact of corticosteroids on mental illness is still unclear. This study found that corticosterone and other corticosteroids could accelerate the desensitization of glycine receptors, while some corticosteroids could also accelerate the desensitization of GABA-A receptors. The results suggest that increased desensitization of these receptors by corticosteroids may contribute to brain dysfunction under chronic stress and identify potential selective modulators of these receptors.
ACS CHEMICAL NEUROSCIENCE
(2023)