Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N′-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode

(2022) Nikolaos Georgakopoulos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N′-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction

(2022) Sumi Lee et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation

(2021) Dhulfiqar Ali Abed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction

(2020) Dhulfiqar Ali Abed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

(2020) Sumi Lee et al.   MEDICINAL CHEMISTRY RESEARCH

Development of a Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for the Inhibition of Keap1–Nrf2 Protein–Protein Interaction

(2020) Sumi Lee et al.   SLAS Discovery

Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

(2020) Meng-Chen Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability

(2019) Phillip R. Lazzara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors

(2018) Benjamin G. Richardson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

(2016) Daisuke Yasuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Double C–H amination by consecutive SET oxidations

(2016) Christopher J. Evoniuk et al.   CHEMICAL COMMUNICATIONS

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

(2016) Thomas G. Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY

Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway

(2015) B.G. Richardson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators

(2015) Atul D. Jain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

(2015) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

Dimethyl Fumarate (Tecfidera)

(2014) Jineane V. Venci et al.   ANNALS OF PHARMACOTHERAPY

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis

(2014) Zheng-Yu Jiang et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search

(2014) Chunlin Zhuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

(2014) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

(2013) Longqin Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment of relapsing–remitting multiple sclerosis: a systematic review and mixed treatment comparison

(2013) Michael Hutchinson et al.   CURRENT MEDICAL RESEARCH AND OPINION

Amelioration of Alzheimer’s disease by neuroprotective effect of sulforaphane in animal model

(2012) Hyunjin Vincent Kim et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Mechanism of the Nrf2/Keap1/ARE signaling system

(2011) V. O. Tkachev et al.   BIOCHEMISTRY-MOSCOW

Synthesis of Dibenzazepinones by Palladium-Catalyzed Intramolecular Arylation ofo-(2′-Bromophenyl)anilide Enolates

(2010) Xiaohong Pan et al.   JOURNAL OF ORGANIC CHEMISTRY

Role of oxidatively induced DNA lesions in human pathogenesis

(2010) Olga A. Sedelnikova et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH