4.7 Article

Polystyrene microplastics induce endoplasmic reticulum stress, apoptosis and inflammation by disrupting the gut microbiota in carp intestines

Journal

ENVIRONMENTAL POLLUTION
Volume 323, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2023.121233

Keywords

Polystyrene microplastics; Gut microbiota; ERS; Inflammation; Cell death

Ask authors/readers for more resources

Microplastics have been identified as a widespread pollutant in nature, causing various diseases in carp. A model of microplastic ingestion was successfully established, and the gut microbiota was analyzed. The results showed a reduction in specific bacteria after treatment with PS-MPs, and related intestinal flora disorders were found. Ingestion of PS-MPs resulted in intestinal tissue damage, apoptosis, and increased inflammation. The occurrence of ERS and apoptosis in carp intestines was confirmed. These findings indicate that the accumulation of PS-MPs in the aquatic environment can disrupt the carp gut microbiota and induce ERS, apoptosis, and inflammation in the intestinal tissue.
Microplastics have been recognized as a widespread new pollutant in nature and have induced an increase in the occurrence of a variety of diseases in carp. An animal model of microplastic ingestion was successfully established in an aqueous environment. The gut microbiota was analysed using a metagenomic approach. The results showed a significant reduction in the relative abundances of Lactococcus garvieae, Bacteroides_paurosaccharolyticus, and Romboutsia_ilealis after PS-MPs treatment. The 16S Silva database was used to predict and analyse the known genes. Intestinal flora disorders related to infectious diseases, cancers, neurodegenerative diseases, endocrine and metabolic diseases, cardiovascular diseases, and other diseases were found. The intake of PS-MPs resulted in damage to carp intestinal tissue and apoptosis of intestinal epithelial cells. The levels of the inflammatory cytokines IL-1 beta, IL-6, and TNF-alpha were significantly increased with the intake of PS-MPs. The gene and protein levels of GRP78, Caspase-3, Caspase-7, Caspase-9, Caspase-12, PERK, IRE1, and ATF6 were further examined in PS group. The occurrence of ERS and apoptosis in carp intestines was confirmed. These results suggest that the accumulation of PS-MPs in the aquatic environment can disturb the carp gut microbiota and induce ERS, apoptosis, and inflammation in the intestinal tissue.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biochemistry & Molecular Biology

Exosomal lnc-AFTR as a novel translation regulator of FAS ameliorates Staphylococcus aureus-induced mastitis

Yu Chen, Jing Yang, Zhi Huang, Hongyuan Jing, Baoyi Yin, Shuai Guo, Ganzhen Deng, Mengyao Guo

Summary: This study identified an lncRNA associated with FAS translational regulation that plays a crucial role in mastitis by inhibiting cell damage, promoting proliferation, and suppressing apoptosis and inflammation induced by Staphylococcus aureus. The lncRNA interacts with FAS mRNA to hinder translation, providing insights into anti-inflammatory and anti-apoptotic effects through TNF and MAPK signaling pathways.

BIOFACTORS (2022)

Article Biochemistry & Molecular Biology

Ammonia induces autophagy via circ-IFNLR1/miR-2188-5p/RNF182 axis in tracheas of chickens

Tian-Yi Zhang, Ting Chen, Wan-Ying Hu, Ji-Chang Li, Meng-Yao Guo

Summary: This study investigated the toxic effects of NH3 exposure on tracheal cells in chickens and LMH cells. NH3 exposure induced autophagy in tracheal tissues, and differential expression of circRNAs was observed. The circ-IFNLR1/miR-2188-5p/RNF182 pathway was found to be involved in NH3-induced autophagy, providing new insights for the study of environmental toxicology.

BIOFACTORS (2022)

Article Biochemistry & Molecular Biology

Zinc Deficiency Aggravates Oxidative Stress Leading to Inflammation and Fibrosis in Lung of Mice

Qirui Zhang, Yao Xue, Yuxin Fu, Bowen Bao, Meng-yao Guo

Summary: The study confirmed that zinc deficiency exacerbated the oxidative stress response of lung tissue, leading to fibrosis in the lung.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

Article Biochemistry & Molecular Biology

LncRNAs Transcriptome Analysis Revealed Potential Mechanisms of Selenium to Mastitis in Dairy Cows

Hongyuan Jing, Yu Chen, Changwei Qiu, Meng-yao Guo

Summary: This study characterized the lncRNA profiles in mammary epithelial cells of dairy cows using RNA-sequencing technology, and identified 14 specific lncRNAs related to selenium and their predicted target genes. Functional annotation was used to elucidate the biological function and potential pathways involved. The findings provide novel insights for exploring molecular markers for protecting against mastitis in dairy cows.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

Article Business

My knowledge: The negative impact of territorial feelings on employee's own innovation through knowledge hiding

Mengyao Guo, Graham Brown, Lihua Zhang

Summary: Innovation is crucial for organizational success, but employee's willingness to share knowledge plays a significant role. This study explores the relationship between knowledge hiding behavior and innovation, drawing on psychological ownership theory and social exchange theory. Affect-based trust is found to mitigate the negative impact of territorial feelings on both knowledge hiding behavior and innovative behavior.

JOURNAL OF ORGANIZATIONAL BEHAVIOR (2022)

Article Biochemistry & Molecular Biology

Selenium Deficiency Caused Fibrosis as an Oxidative Stress-induced Inflammatory Injury in the Lungs of Mice

Yu-xin Fu, Yi-bo Wang, Qing-wei Bu, Meng-yao Guo

Summary: This study investigated the molecular mechanism of how selenium deficiency worsens inflammation and fibrosis in the lung. The results showed that selenium deficiency led to excessive accumulation of reactive oxygen species (ROS), causing inflammation and disrupting extracellular matrix (ECM) homeostasis, thereby aggravating fibrosis in the lung.

BIOLOGICAL TRACE ELEMENT RESEARCH (2023)

Article Biochemistry & Molecular Biology

Selenium Deficiency Leads to Reduced Skeletal Muscle Cell Differentiation by Oxidative Stress in Mice

Bo-wen Bao, Zibo Kang, Yu Zhang, Kan Li, Ran Xu, Meng-yao Guo

Summary: This study investigated the effect and mechanism of selenium deficiency on skeletal muscle cell differentiation. The results showed that selenium deficiency led to changes in skeletal muscle tissue, increased apoptosis of muscle cells, and reduced expression of genes and proteins related to cell differentiation, ultimately resulting in a decrease in the differentiation capacity of muscle cells.

BIOLOGICAL TRACE ELEMENT RESEARCH (2023)

Article Chemistry, Physical

Antiferroelectric-ferroelectric phase transition and negative electrocaloric effect in alkaline-earth element doped PbZrO3 thin films

Ye Yuan, Buwei Sun, Mengyao Guo, Ming Wu, Yangfei Gao, Xiaopei Zhu, Haonan Sun, Jiantuo Zhao, Yongbin Liu, Jinghui Gao, Qida Liu, Xiaojie Lou

Summary: The electrocaloric effect in dielectric materials has been studied in alkaline-earth doped PbZrO3 thin films using a sol-gel method. It was found that Ca2+ and Sr2+ expand the antiferroelectric phase region while Ba2+ reduces it. The Pb0.9Sr0.1ZrO3 thin film exhibits an enhanced negative ECE, while the Pb0.9Ba0.1ZrO3 thin film shows a decreased negative ECE compared to the pristine PbZrO3 thin films.

JOURNAL OF ALLOYS AND COMPOUNDS (2022)

Article Environmental Sciences

Polystyrene microplastics induced inflammation with activating the TLR2 signal by excessive accumulation of ROS in hepatopancreas of carp (Cyprinus carpio)

Jie Cui, Yanhe Zhang, Lin Liu, Qirui Zhang, Shiwen Xu, Meng-yao Guo

Summary: By feeding carp with polystyrene microplastics (PS-MPs) particles of 8 μm in size and a concentration of 1000 ng/L water, a PS-MPs model of carp was established. An abnormal increase in the activities of AKP, ALT, AST, and LDH in the hepatopancreas indicated damage to this organ's function caused by PS-MPs. PS-MPs also induced oxidative stress, with a decrease in the activities of antioxidant enzymes and excessive accumulation of reactive oxygen species. Furthermore, PS-MPs activated the Toll-like receptor-2 (TLR2) signaling pathway, leading to increased expression of inflammatory molecules in both hepatopancreas and hepatocytes.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023)

Article Fisheries

Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills

Jingwen Cao, Ran Xu, Fuhan Wang, Yuan Geng, Tianchao Xu, Mengran Zhu, Hongli Lv, Shiwen Xu, Meng-yao Guo

Summary: Microplastics cause damage to aquatic organisms, particularly the gills which are among the first tissues to be affected. This study found that polyethylene microplastics induce inflammation, vascular remodeling, mucus cell proliferation, oxidative stress, cell apoptosis, and inflammatory immune responses in the gills. These findings provide a new target for preventing toxin-induced gill injury from polyethylene microplastics.

FISH & SHELLFISH IMMUNOLOGY (2023)

Article Environmental Sciences

Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-KB signal in mice

Jingwen Cao, Ran Xu, Yuan Geng, Shiwen Xu, Mengyao Guo

Summary: Microplastics are common pollutants that have various plastic applications. They can now be found in the air and inhaled into the lungs, leading to respiratory diseases. This study utilized mice models to demonstrate that exposure to polystyrene microplastics (PS-MPS) of different sizes caused severe inflammatory responses, apoptosis, and collagen deposition in the lungs, with smaller sizes having more noticeable damage. The study also found that PS-MPS targeted binding to Toll-like receptor 2 (TLR2), exacerbating fibrosis by promoting inflammation, oxidative stress, and apoptosis through activation of the NF-KB signal pathway.

ENVIRONMENTAL POLLUTION (2023)

Article Fisheries

Zinc deficiency causes oxidative stress, endoplasmic reticulum stress, apoptosis and inflammation in hepatocytes in grass carp

Jie Cui, Tianchao Xu, Hongli Lv, Meng-yao Guo

Summary: A lack of zinc in freshwater environments causes slow growth, malnutrition, and abnormal biological functions in organisms. In this study, a zinc deficiency model of grass carp hepatocytes was established using TPEN. The results showed increased LDH, AST, ALT, and AKP activities, as well as ROS levels and decreased antioxidant enzyme activities in a zinc-deficient environment. RT-PCR and ELISA demonstrated increased expression levels of genes related to endoplasmic reticulum stress, apoptosis, and inflammation. These findings suggest that zinc deficiency induces inflammation and apoptosis in grass carp hepatocytes in the presence of calcium, highlighting the adverse effects of zinc deficiency in freshwater environments.

FISH & SHELLFISH IMMUNOLOGY (2023)

Article Marine & Freshwater Biology

Microplastics induced inflammation and apoptosis via ferroptosis and the NF-KB pathway in carp

Tianchao Xu, Jie Cui, Ran Xu, Jingwen Cao, Meng-yao Guo

Summary: In this study, a model of carp exposed to microplastics was successfully established. It was observed that exposure to microplastics caused damage to the intestinal mucosal surface and an increase in goblet cells. The study also found that microplastic exposure led to lymphocyte proliferation and aggregation in the intestinal wall, resulting in cellular apoptosis. The activation of NF-KB pathway and ferroptosis induced by lipid peroxidation were identified as the potential mechanisms underlying microplastic-induced intestinal damage.

AQUATIC TOXICOLOGY (2023)

Article Fisheries

Selenium deficiency induced inflammation and apoptosis via NF-KB and MAPKs pathways in muscle of common carp (Cyprinus carpio L.)

Ran Xu, Jing-wen Cao, Tian-chao Xu, Tian-jing Liu, Meng-ran Zhu, Meng-yao Guo

Summary: Se deficiency caused fragmentation, dissolution, and disarrangement of muscle fibers in carp, as well as increased myocyte apoptosis. Transcriptome analysis revealed differential expression of genes involved in oxidation-reduction, inflammation, and apoptosis, particularly related to the NF-KB and MAPK pathways. Further investigation showed that Se deficiency led to excessive accumulation of ROS, decreased activity of antioxidant enzymes, and upregulation of the NF-KB and MAPK pathways.

FISH & SHELLFISH IMMUNOLOGY (2023)

Review Environmental Sciences

Efficiency of the bank filtration for removing organic priority substances and contaminants of emerging concern: A critical review

Attila Csaba Kondor, Anna Viktoria Vancsik, Laszlo Bauer, Lili Szabo, Zoltan Szalai, Gergely Jakab, Gabor Maasz, Marta Pedrosa, Maria Jose Sampaio, Ana Rita Lado Ribeiro

Summary: This review provides a critical overview of research on the removal efficiency of priority substances and compounds of emerging concern through bank filtration, discussing influencing factors and future challenges. The findings show that the efficiency of bank filtration is influenced by multiple factors and varies for different substances.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Association of exposure to ozone and fine particulate matter with ovarian reserve among women with infertility

Xinyan Wang, Shuai Zhang, Huihui Yan, Zhao Ma, Yunshan Zhang, Haining Luo, Xueli Yang

Summary: This study investigated the association between ambient PM2.5, O3 pollution, and ovarian reserve in reproductive-aged Chinese women. The results showed that increased exposure to PM2.5 and O3 was associated with decreased AMH levels, indicating reduced ovarian reserve. Notably, the effects of O3 exposure on ovarian reserve were different from those of PM2.5 exposure.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Effects of acute and chronic chromium stress on the expression of heat shock protein genes and activities of antioxidant enzymes in larvae of Orthetrum albistylum

Tingting Ma, Yanjuan Ding, Fengjiao Xu, Chen Zhang, Min Zhou, Ya Tang, Yanrong Chen, Yating Wen, Rufei Chen, Bin Tang, Shigui Wang

Summary: The dragonfly species Orthetrum albistylum can accumulate heavy metals, and its heat shock protein genes have the potential to serve as biomarkers for monitoring environmental pollutants.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Can warming accelerate the decline of Odonata species in experimental paddies due to insecticide fipronil exposure?

Naoto Ishiwaka, Koya Hashimoto, Masayoshi K. Hiraiwa, Francisco Sanchez-Bayo, Taku Kadoya, Daisuke Hayasaka

Summary: Systemic insecticides and rising temperatures have combined effects on the abundance of Odonata nymphs in paddy fields. The standalone effect of insecticide exposure decreased the Odonata community, while nymphs decreased synergistically with temperature rise in paddy water. However, the impacts of each stressor alone varied among species.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

The seasonal change of PAHs in Svalbard surface snow

Marco Vecchiato, Carlo Barbante, Elena Barbaro, Francois Burgay, Warren R. L. Cairns, Alice Callegaro, David Cappelletti, Federico Dallo, Marianna D'Amico, Matteo Feltracco, Jean-Charles Gallet, Andrea Gambaro, Catherine Larose, Niccolo Maffezzoli, Mauro Mazzola, Ivan Sartorato, Federico Scoto, Clara Turetta, Massimiliano Varde, Zhiyong Xie, Andrea Spolaor

Summary: The Arctic region is facing contamination from long-range pollution and local human activities. Polycyclic Aromatic Hydrocarbons (PAHs) are used as environmental indicators for emission, transport, and deposition processes. Research conducted in the Arctic surface snow in Ny-Ålesund, Svalbard from October 2018 to May 2019 shows that long-range inputs of PAHs mainly occur in winter, while the most abundant analyte retene exhibits opposite seasonal trends.

ENVIRONMENTAL POLLUTION (2024)

Review Environmental Sciences

A broad horizon for sustainable catalytic oxidation of microplastics

Maoshui Zhuo, Zhijie Chen, Xiaoqing Liu, Wei Wei, Yansong Shen, Bing-Jie Ni

Summary: This paper discusses the application of three catalytic processes (photocatalysis, electrocatalysis, and biocatalysis) in the management of microplastic pollution, and introduces the efficiency and catalytic mechanisms of different catalysts. It also proposes the development prospects for sustainable management of microplastic pollution.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

A physiologically based pharmacokinetic model of diethyl phthalates in humans

Shiyu Chen, Zhenzhen Shi, Qiang Zhang

Summary: In this study, a human physiologically based pharmacokinetic (PBPK) model of diethyl phthalate (DEP) was developed to assess its toxicity. The model considers the distribution and metabolism of DEP and its active metabolite monoethyl phthalate (MEP) in different tissue compartments. Sensitivity analysis and Bayesian Markov chain Monte Carlo (MCMC) simulations were performed to evaluate the uncertainty and variability of the model parameters. The results suggest that dermal absorption is an important route of exposure to DEP in the environment.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Exploring a chemical input free advanced oxidation process based on nanobubble technology to treat organic micropollutants

Bangguo Wang, Lijing Wang, Wenxi Cen, Tao Lyu, Peter Jarvis, Yang Zhang, Yuanxun Zhang, Yinghui Han, Lei Wang, Gang Pan, Kaili Zhang, Wei Fan

Summary: This study investigates the feasibility and mechanisms of a chemical-free nanobubble-based AOP for treating organic micropollutants in water. The results show that the oxygen nanobubble AOP has a significantly higher removal efficiency compared to air and nitrogen nanobubbles. The treatment performance is not affected by pH and the presence of ions. Higher initial concentrations of the micropollutant lead to slower treatment processes, but similar removal performance is achieved in the end. The presence of organic matter reduces the removal rate of the micropollutant. The results have practical feasibility for water and wastewater treatment.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Insights into the reduction of methylmercury accumulation in rice grains through biochar application: Hg transformation, isotope fractionation, and transcriptomic analysis

Yingmei Huang, Jicai Yi, Yao Huang, Songxiong Zhong, Bin Zhao, Jing Zhou, Yuxuan Wang, Yiwen Zhu, Yanhong Du, Fangbai Li

Summary: This study investigates the impact of biochar on methylmercury (MeHg) accumulation in rice. The results show that biochar reduces MeHg levels in paddy soils by decreasing bioavailable Hg and microbial Hg methylation. Additionally, biochar decreases the uptake and translocation of MeHg in rice plants, resulting in a reduction of MeHg accumulation in rice grains.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Expeditious profiling of polycyclic aromatic hydrocarbons transport and obstruction mechanisms in crop xylem sap proteins via proteomics and molecular docking

Nengde Zeng, Fei Huang, Jiani Du, Chenghao Huang, Qian Yang, Xinhua Zhan, Baoshan Xing

Summary: This study investigates the protein targets and protein-ligand interactions related to PAH contamination in crop xylem sap using computational tools. The results show that phenanthrene has a more pronounced effect on the xylem sap proteins of maize and wheat, with maize DEPs associated with lipid biosynthesis and wheat DEPs exhibiting an increase in ABC transporters. This study provides insights into the regulation and movement of PAHs within plant xylem.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Plasma-assisted assembly of Co3O4/TiO2-NRs for photoelectrocatalytic degradation of bisphenol A in solution and muddy systems

Xinwei Chen, Hao Ma, Run Wang, Man Wang, Binbin Zhu, Yanqing Cong, Xiayue Zhu, Guoqin Wang, Yi Zhang

Summary: Co3O4/TiO2-NRs electrodes with excellent photoresponse were prepared via plasma-assisted modification of Co3O4 on TiO2. The combination of Co3O4 and TiO2 improved the light utilization efficiency and showed potential for degradation of pollutants.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Carbon emissions from various natural gas end-use sectors for 31 Chinese provinces between 2017 and 2021

Wenjing Ji, Liying Song, Jing Wang, Hongqing Song

Summary: This study conducted a life-cycle assessment to examine the correlation between natural gas consumption and carbon emissions in different end uses in China. The results showed that both natural gas consumption and life-cycle carbon emissions have been increasing since 2017. Significant variations in NG life-cycle carbon emissions were found across different provinces and sectors, highlighting the need for targeted efforts to reduce carbon emissions.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Synergistic effects of trace sulfadiazine and corrosion scales on disinfection by-product formation in bulk water of cast iron pipe

Youyi Chen, Boxuan Zhang, Pojun Zhang, Guogui Shi, Hao Liang, Wu Cai, Jingyu Gao, Sumin Zhuang, Kaiyin Luo, Jiaqi Zhu, Chaoxiang Chen, Kunyu Ma, Jinrong Chen, Chun Hu, Xueci Xing

Summary: The synergistic effects of trace sulfadiazine and cast-iron corrosion scales on the formation of disinfection by-products in drinking water distribution systems were investigated. The presence of magnetite resulted in increased concentrations of DBPs due to the higher microbial activity and enhanced microbial extracellular electron transport pathway. The study highlights the importance of considering trace antibiotics pollution and corrosion scales in water sources for DBP control.

ENVIRONMENTAL POLLUTION (2024)

Review Environmental Sciences

The update and transport of aluminum nanoparticles in plants and their biochemical and molecular phototoxicity on plant growth and development: A systematic review

Bishwa Raj Pokharel, Vijay Sheri, Manoj Kumar, Zhiyong Zhang, Baohong Zhang

Summary: This review summarizes the interactions, uptake, and transport of aluminum nanoparticles (Al-NPs) in plants, highlighting their negative effects on plant growth and development, as well as their potential to alter plant defense systems and gene expression.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Disturbance mitigation of thiencarbazone-methyl•isoxaflutole on bacterial communities through nitrification inhibitor and attapulgite

Yonglu Wang, Fengsong Zhang, Xiaoyong Liao, Xiao Yang, Guixiang Zhang, Liyun Zhang, Chaojun Wei, Pengge Shi, Jiongxin Wen, Xiaorong Ju, Can Xu, Yang Liu, Ying Lan

Summary: This study aims to explore the effects of thiencarbazone-methyl center dot isoxaflutole on soil microflora and the potential mitigation mechanisms to bacterial communities. It was found that increasing the application of thiencarbazone-methyl center dot isoxaflutole resulted in increased stress on soil bacterial community structure and diversity. Increasing soil pH was recognized as a key factor in improving the diversity and structure of soil microflora. Supplemental use of nitrapyrin or modified attapulgite can increase soil pH and improve bacterial diversity.

ENVIRONMENTAL POLLUTION (2024)