Journal
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
Volume 10, Issue 4, Pages 336-345Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jash.2016.02.002
Keywords
Aerobic exercise; antihypertensive drug; blood pressure control; hypertension
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Funding
- African Population and Health Research Centre (APHRC), Nairobi, Kenya
- International Development Research Centre (IDRC)
- Ford Foundation, through African Doctoral Dissertation Research Fellowship
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There is a dearth of reports on possible additive blood pressure (BP) reducing effect of aerobic exercise on antihypertensive drug in humans. This study investigated the additive BP-reducing effect of aerobic exercise on BP in individuals with uncontrolled hypertension. In this 12-week double-blind study, 120 new-diagnosed individuals with mild-to-moderate hypertension were randomized to receive coamilozide + 5/10 mg of amlodipine + aerobic dance or coamilozide 5/10 mg of amlodipine alone. Forty-five and 43 participants in exercise and control groups, respectively, completed the 12-week intervention. Addition of aerobic exercise to antihypertensive drug therapy significantly reduced systolic BP (7.1 mm Hg [95% confidence interval: 5.0, 9.3]; P <.001) and diastolic BP (1.7 mm Hg [95% confidence interval: 0.4, 3.0]; P = .009) at 12 weeks. BP control rate differed significantly between exercise (53.9%) and control (35.3%) groups, P <.001. Postintervention, proportion of participants in exercise group who had their number of antihypertensive drug reduced to one (20.3%) differed from that in control group (11.1%); (chi(2) = 11.0; P = .001). Combination of aerobic dance and antihypertensive drugs reduces number of antihypertensive drugs needed to achieve BP control and enhances BP control in individuals with hypertension on two antihypertensive drugs. (C) 2016 American Society of Hypertension. All rights reserved.
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